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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ACCCGUA

Z-value: 0.06

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miRNA associated with seed ACCCGUA

NamemiRBASE accession
hsa-miR-99a-5p
MIMAT0000097
hsa-miR-99b-5p
MIMAT0000689
hsa-miR-100-5p
MIMAT0000098

Activity profile of ACCCGUA motif

Sorted Z-values of ACCCGUA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_152017181 0.36 ENST00000498502.1
ENST00000324196.5
ENST00000545754.1
ENST00000357472.3
MBNL1
muscleblind-like splicing regulator 1
chr2_+_12857015 0.22 ENST00000155926.4
TRIB2
tribbles pseudokinase 2
chr8_+_126442563 0.18 ENST00000311922.3
TRIB1
tribbles pseudokinase 1
chr6_-_90121938 0.11 ENST00000369415.4
RRAGD
Ras-related GTP binding D
chr11_+_86748863 0.10 ENST00000340353.7
TMEM135
transmembrane protein 135
chr6_-_75994536 0.09 ENST00000475111.2
ENST00000230461.6
TMEM30A
transmembrane protein 30A
chr2_-_72375167 0.07 ENST00000001146.2
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr2_+_28974668 0.04 ENST00000296122.6
ENST00000395366.2
PPP1CB
protein phosphatase 1, catalytic subunit, beta isozyme
chr4_+_144434584 0.04 ENST00000283131.3
SMARCA5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr22_+_30279144 0.04 ENST00000401950.2
ENST00000333027.3
ENST00000445401.1
ENST00000323630.5
ENST00000351488.3
MTMR3
myotubularin related protein 3
chr4_-_102268628 0.03 ENST00000323055.6
ENST00000512215.1
ENST00000394854.3
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr2_+_86947296 0.02 ENST00000283632.4
RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr12_-_57030115 0.02 ENST00000379441.3
ENST00000179765.5
ENST00000551812.1
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr2_-_208634287 0.02 ENST00000295417.3
FZD5
frizzled family receptor 5
chr7_-_27135591 0.01 ENST00000343060.4
ENST00000355633.5
HOXA1
homeobox A1
chr10_-_35930219 0.01 ENST00000374694.1
FZD8
frizzled family receptor 8
chr8_+_75736761 0.01 ENST00000260113.2
PI15
peptidase inhibitor 15

Network of associatons between targets according to the STRING database.

First level regulatory network of ACCCGUA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0045659 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.0 0.2 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.1 GO:0034653 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653) skeletal muscle fiber differentiation(GO:0098528) regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0 0.1 GO:0071233 cellular response to leucine(GO:0071233)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.0 GO:0031213 RSF complex(GO:0031213)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.4 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)