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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ACCCUGU

Z-value: 0.43

Motif logo

logo of

miRNA associated with seed ACCCUGU

NamemiRBASE accession
hsa-miR-10a-5p
MIMAT0000253
hsa-miR-10b-5p
MIMAT0000254

Activity profile of ACCCUGU motif

Sorted Z-values of ACCCUGU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_50187556 3.68 ENST00000561678.1
ENST00000357464.3
PAPD5
PAP associated domain containing 5
chr2_-_206950781 3.68 ENST00000403263.1
INO80D
INO80 complex subunit D
chr7_-_44924939 3.25 ENST00000395699.2
PURB
purine-rich element binding protein B
chr2_+_10183651 3.21 ENST00000305883.1
KLF11
Kruppel-like factor 11
chr11_-_18656028 2.75 ENST00000336349.5
SPTY2D1
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr3_+_14989076 2.62 ENST00000413118.1
ENST00000425241.1
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr16_-_70719925 2.58 ENST00000338779.6
MTSS1L
metastasis suppressor 1-like
chr6_+_107811162 2.48 ENST00000317357.5
SOBP
sine oculis binding protein homolog (Drosophila)
chr15_-_61521495 2.42 ENST00000335670.6
RORA
RAR-related orphan receptor A
chr12_+_69864129 2.39 ENST00000547219.1
ENST00000299293.2
ENST00000549921.1
ENST00000550316.1
ENST00000548154.1
ENST00000547414.1
ENST00000550389.1
ENST00000550937.1
ENST00000549092.1
ENST00000550169.1
FRS2
fibroblast growth factor receptor substrate 2
chr9_-_127533519 2.39 ENST00000487099.2
ENST00000344523.4
ENST00000373584.3
NR6A1
nuclear receptor subfamily 6, group A, member 1
chr7_+_20370746 2.18 ENST00000222573.4
ITGB8
integrin, beta 8
chr5_-_160973649 2.11 ENST00000393959.1
ENST00000517547.1
GABRB2
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr12_+_4918342 1.92 ENST00000280684.3
ENST00000433855.1
KCNA6
potassium voltage-gated channel, shaker-related subfamily, member 6
chr4_+_3076388 1.88 ENST00000355072.5
HTT
huntingtin
chr6_+_117002339 1.86 ENST00000413340.1
ENST00000368564.1
ENST00000356348.1
KPNA5
karyopherin alpha 5 (importin alpha 6)
chr2_-_37193606 1.81 ENST00000379213.2
ENST00000263918.4
STRN
striatin, calmodulin binding protein
chr6_-_91006461 1.78 ENST00000257749.4
ENST00000343122.3
ENST00000406998.2
ENST00000453877.1
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr3_-_142166904 1.70 ENST00000264951.4
XRN1
5'-3' exoribonuclease 1
chr1_-_9970227 1.69 ENST00000377263.1
CTNNBIP1
catenin, beta interacting protein 1
chr2_+_64681219 1.59 ENST00000238875.5
LGALSL
lectin, galactoside-binding-like
chr7_-_138666053 1.57 ENST00000440172.1
ENST00000422774.1
KIAA1549
KIAA1549
chr21_+_45285050 1.56 ENST00000291572.8
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr15_+_42066632 1.56 ENST00000457542.2
ENST00000221214.6
ENST00000260357.7
ENST00000456763.2
MAPKBP1
mitogen-activated protein kinase binding protein 1
chr1_+_28052456 1.54 ENST00000373954.6
ENST00000419687.2
FAM76A
family with sequence similarity 76, member A
chr9_-_23821273 1.50 ENST00000380110.4
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr9_+_112403088 1.41 ENST00000448454.2
PALM2
paralemmin 2
chr21_-_32931290 1.41 ENST00000286827.3
TIAM1
T-cell lymphoma invasion and metastasis 1
chrX_-_54384425 1.39 ENST00000375169.3
ENST00000354646.2
WNK3
WNK lysine deficient protein kinase 3
chr14_+_33408449 1.31 ENST00000346562.2
ENST00000341321.4
ENST00000548645.1
ENST00000356141.4
ENST00000357798.5
NPAS3
neuronal PAS domain protein 3
chr10_-_62149433 1.31 ENST00000280772.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr8_+_1449532 1.30 ENST00000421627.2
DLGAP2
discs, large (Drosophila) homolog-associated protein 2
chr5_+_149109825 1.30 ENST00000360453.4
ENST00000394320.3
ENST00000309241.5
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr17_-_4167142 1.28 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ANKFY1
ankyrin repeat and FYVE domain containing 1
chr4_-_53525406 1.24 ENST00000451218.2
ENST00000441222.3
USP46
ubiquitin specific peptidase 46
chr9_+_100263912 1.22 ENST00000259365.4
TMOD1
tropomodulin 1
chr11_+_113930291 1.22 ENST00000335953.4
ZBTB16
zinc finger and BTB domain containing 16
chr18_+_9136758 1.22 ENST00000383440.2
ENST00000262126.4
ENST00000577992.1
ANKRD12
ankyrin repeat domain 12
chr19_+_10527449 1.21 ENST00000592685.1
ENST00000380702.2
PDE4A
phosphodiesterase 4A, cAMP-specific
chr19_+_3880581 1.20 ENST00000450849.2
ENST00000301260.6
ENST00000398448.3
ATCAY
ataxia, cerebellar, Cayman type
chr18_+_43914159 1.18 ENST00000588679.1
ENST00000269439.7
ENST00000543885.1
RNF165
ring finger protein 165
chr10_+_180987 1.12 ENST00000381591.1
ZMYND11
zinc finger, MYND-type containing 11
chr1_+_57110972 1.11 ENST00000371244.4
PRKAA2
protein kinase, AMP-activated, alpha 2 catalytic subunit
chr17_-_48207157 1.10 ENST00000330175.4
ENST00000503131.1
SAMD14
sterile alpha motif domain containing 14
chr3_-_9994021 1.10 ENST00000411976.2
ENST00000412055.1
PRRT3
proline-rich transmembrane protein 3
chr14_+_85996471 1.05 ENST00000330753.4
FLRT2
fibronectin leucine rich transmembrane protein 2
chr10_+_103113802 1.05 ENST00000370187.3
BTRC
beta-transducin repeat containing E3 ubiquitin protein ligase
chr2_-_69870835 0.98 ENST00000409085.4
ENST00000406297.3
AAK1
AP2 associated kinase 1
chr3_+_238273 0.96 ENST00000256509.2
CHL1
cell adhesion molecule L1-like
chr11_-_115375107 0.94 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
CADM1
cell adhesion molecule 1
chr7_+_94139105 0.93 ENST00000297273.4
CASD1
CAS1 domain containing 1
chr13_-_29069232 0.90 ENST00000282397.4
ENST00000541932.1
ENST00000539099.1
FLT1
fms-related tyrosine kinase 1
chr2_+_121103706 0.83 ENST00000295228.3
INHBB
inhibin, beta B
chr14_+_99947715 0.82 ENST00000389879.5
ENST00000557441.1
ENST00000555049.1
ENST00000555842.1
CCNK
cyclin K
chr4_+_47033345 0.75 ENST00000295454.3
GABRB1
gamma-aminobutyric acid (GABA) A receptor, beta 1
chr3_+_178866199 0.74 ENST00000263967.3
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr7_-_44365020 0.72 ENST00000395747.2
ENST00000347193.4
ENST00000346990.4
ENST00000258682.6
ENST00000353625.4
ENST00000421607.1
ENST00000424197.1
ENST00000502837.2
ENST00000350811.3
ENST00000395749.2
CAMK2B
calcium/calmodulin-dependent protein kinase II beta
chr2_-_2334888 0.70 ENST00000428368.2
ENST00000399161.2
MYT1L
myelin transcription factor 1-like
chr9_+_77112244 0.70 ENST00000376896.3
RORB
RAR-related orphan receptor B
chr2_+_111878483 0.66 ENST00000308659.8
ENST00000357757.2
ENST00000393253.2
ENST00000337565.5
ENST00000393256.3
BCL2L11
BCL2-like 11 (apoptosis facilitator)
chr9_+_129567282 0.66 ENST00000449886.1
ENST00000373464.4
ENST00000450858.1
ZBTB43
zinc finger and BTB domain containing 43
chr6_-_11044509 0.66 ENST00000354666.3
ELOVL2
ELOVL fatty acid elongase 2
chr3_-_179754706 0.64 ENST00000465751.1
ENST00000467460.1
PEX5L
peroxisomal biogenesis factor 5-like
chr22_+_45559722 0.61 ENST00000347635.4
ENST00000407019.2
ENST00000424634.1
ENST00000417702.1
ENST00000425733.2
ENST00000430547.1
NUP50
nucleoporin 50kDa
chr1_+_169337172 0.61 ENST00000367807.3
ENST00000367808.3
ENST00000329281.2
ENST00000420531.1
BLZF1
basic leucine zipper nuclear factor 1
chr22_+_40573921 0.60 ENST00000454349.2
ENST00000335727.9
TNRC6B
trinucleotide repeat containing 6B
chr19_-_14316980 0.57 ENST00000361434.3
ENST00000340736.6
LPHN1
latrophilin 1
chr17_-_76713100 0.56 ENST00000585509.1
CYTH1
cytohesin 1
chr1_+_199996702 0.54 ENST00000367362.3
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr1_-_217262969 0.53 ENST00000361525.3
ESRRG
estrogen-related receptor gamma
chrX_-_46618490 0.53 ENST00000328306.4
SLC9A7
solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
chr10_-_30348439 0.52 ENST00000375377.1
KIAA1462
KIAA1462
chr11_+_18344106 0.52 ENST00000534641.1
ENST00000525831.1
ENST00000265963.4
GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chrX_+_49687216 0.51 ENST00000376088.3
CLCN5
chloride channel, voltage-sensitive 5
chr8_+_22857048 0.51 ENST00000251822.6
RHOBTB2
Rho-related BTB domain containing 2
chr11_+_66025167 0.49 ENST00000394067.2
ENST00000316924.5
ENST00000421552.1
ENST00000394078.1
KLC2
kinesin light chain 2
chr12_-_54673871 0.49 ENST00000209875.4
CBX5
chromobox homolog 5
chr8_-_41655107 0.48 ENST00000347528.4
ENST00000289734.7
ENST00000379758.2
ENST00000396945.1
ENST00000396942.1
ENST00000352337.4
ANK1
ankyrin 1, erythrocytic
chr16_+_69599861 0.42 ENST00000354436.2
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr17_-_49198216 0.42 ENST00000262013.7
ENST00000357122.4
SPAG9
sperm associated antigen 9
chr9_-_115983641 0.38 ENST00000238256.3
FKBP15
FK506 binding protein 15, 133kDa
chr12_-_133405288 0.37 ENST00000204726.3
GOLGA3
golgin A3
chr10_+_72972281 0.37 ENST00000335350.6
UNC5B
unc-5 homolog B (C. elegans)
chr3_+_48956249 0.34 ENST00000452882.1
ENST00000430423.1
ENST00000356401.4
ENST00000449376.1
ENST00000420814.1
ENST00000449729.1
ENST00000433170.1
ARIH2
ariadne RBR E3 ubiquitin protein ligase 2
chr8_-_30891078 0.33 ENST00000339382.2
ENST00000475541.1
PURG
purine-rich element binding protein G
chr2_-_166060571 0.30 ENST00000360093.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr1_-_85156216 0.30 ENST00000342203.3
ENST00000370612.4
SSX2IP
synovial sarcoma, X breakpoint 2 interacting protein
chr2_-_208030647 0.29 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr2_+_176981307 0.25 ENST00000249501.4
HOXD10
homeobox D10
chr1_+_202976493 0.25 ENST00000367242.3
TMEM183A
transmembrane protein 183A
chr2_+_166326157 0.24 ENST00000421875.1
ENST00000314499.7
ENST00000409664.1
CSRNP3
cysteine-serine-rich nuclear protein 3
chr4_+_154125565 0.20 ENST00000338700.5
TRIM2
tripartite motif containing 2
chr10_+_8096631 0.18 ENST00000379328.3
GATA3
GATA binding protein 3
chr1_+_89990431 0.17 ENST00000330947.2
ENST00000358200.4
LRRC8B
leucine rich repeat containing 8 family, member B
chr7_-_92463210 0.16 ENST00000265734.4
CDK6
cyclin-dependent kinase 6
chr17_+_46125707 0.15 ENST00000584137.1
ENST00000362042.3
ENST00000585291.1
ENST00000357480.5
NFE2L1
nuclear factor, erythroid 2-like 1
chr22_+_30279144 0.14 ENST00000401950.2
ENST00000333027.3
ENST00000445401.1
ENST00000323630.5
ENST00000351488.3
MTMR3
myotubularin related protein 3
chr4_+_79697495 0.10 ENST00000502871.1
ENST00000335016.5
BMP2K
BMP2 inducible kinase
chr11_+_20620946 0.08 ENST00000525748.1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 5
chr3_-_196159268 0.07 ENST00000381887.3
ENST00000535858.1
ENST00000428095.1
ENST00000296328.4
UBXN7
UBX domain protein 7
chr1_+_36396677 0.04 ENST00000373191.4
ENST00000397828.2
AGO3
argonaute RISC catalytic component 3
chr4_-_114900831 0.01 ENST00000315366.7
ARSJ
arylsulfatase family, member J

Network of associatons between targets according to the STRING database.

First level regulatory network of ACCCUGU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.6 1.9 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.6 1.7 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.5 3.7 GO:0043634 polyadenylation-dependent ncRNA catabolic process(GO:0043634)
0.4 1.6 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.3 1.4 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.3 1.3 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.3 2.7 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.3 1.2 GO:0045763 negative regulation of cellular amino acid metabolic process(GO:0045763) regulation of glutamate metabolic process(GO:2000211)
0.3 0.8 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.3 0.8 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.3 1.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.2 0.7 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.2 1.2 GO:0042078 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728)
0.2 0.9 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 1.4 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.2 0.7 GO:1902263 apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.2 1.3 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.2 1.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.2 1.7 GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633)
0.2 0.5 GO:0061113 pancreas morphogenesis(GO:0061113)
0.2 2.4 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.1 1.3 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 2.9 GO:0071420 cellular response to histamine(GO:0071420)
0.1 1.2 GO:0008343 adult feeding behavior(GO:0008343) righting reflex(GO:0060013)
0.1 0.7 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 2.2 GO:0001573 ganglioside metabolic process(GO:0001573)
0.1 0.6 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560)
0.1 1.6 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.1 0.2 GO:1901536 regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536)
0.1 1.1 GO:0055089 fatty acid homeostasis(GO:0055089)
0.1 0.4 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 3.2 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 0.4 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 2.6 GO:0097178 ruffle assembly(GO:0097178)
0.1 1.0 GO:0048665 neuron fate specification(GO:0048665)
0.0 2.5 GO:0090102 cochlea development(GO:0090102)
0.0 1.2 GO:0060384 innervation(GO:0060384)
0.0 1.0 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.7 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.0 0.9 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.0 1.1 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 1.2 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)
0.0 0.6 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.7 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.0 0.5 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 1.0 GO:0035640 exploration behavior(GO:0035640)
0.0 1.1 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.5 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:1904628 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.0 0.5 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0 1.8 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 5.5 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.6 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.4 GO:0019054 modulation by virus of host process(GO:0019054)
0.0 0.3 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.1 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 3.4 GO:0006310 DNA recombination(GO:0006310)
0.0 0.6 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 2.6 GO:0045637 regulation of myeloid cell differentiation(GO:0045637)
0.0 0.4 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.5 GO:1903959 regulation of anion transmembrane transport(GO:1903959)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.3 0.8 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.3 1.3 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.2 3.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.2 0.5 GO:0016938 kinesin I complex(GO:0016938)
0.1 0.7 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.4 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 1.7 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 1.6 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 1.3 GO:0005883 neurofilament(GO:0005883)
0.1 1.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 2.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 1.4 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.3 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 1.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.5 GO:0000439 core TFIIH complex(GO:0000439)
0.0 1.3 GO:0016592 mediator complex(GO:0016592)
0.0 0.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 1.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 3.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.9 GO:0005776 autophagosome(GO:0005776)
0.0 2.9 GO:0043679 axon terminus(GO:0043679)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.9 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.0 GO:0043657 host(GO:0018995) host cell(GO:0043657)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0032184 SUMO polymer binding(GO:0032184)
0.5 3.7 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.4 2.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.4 1.1 GO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity(GO:0047322) [acetyl-CoA carboxylase] kinase activity(GO:0050405)
0.3 2.4 GO:0008142 oxysterol binding(GO:0008142)
0.3 2.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.3 3.0 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.3 1.8 GO:0050682 AF-2 domain binding(GO:0050682)
0.2 2.7 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.2 2.4 GO:0019211 phosphatase activator activity(GO:0019211)
0.2 1.7 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.2 3.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 0.6 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 1.4 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 0.7 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 1.9 GO:0005522 profilin binding(GO:0005522) dynein intermediate chain binding(GO:0045505)
0.1 0.9 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 1.6 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.9 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 1.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.1 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 1.1 GO:0045499 chemorepellent activity(GO:0045499)
0.1 6.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 1.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.7 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.1 2.6 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.2 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 0.5 GO:0015386 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 1.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 2.1 GO:0019894 kinesin binding(GO:0019894)
0.0 1.8 GO:0030507 spectrin binding(GO:0030507)
0.0 1.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 2.6 GO:0046332 SMAD binding(GO:0046332)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.8 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 1.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 1.5 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.3 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.4 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 2.6 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.9 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 3.1 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.8 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.1 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.7 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 2.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.7 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.1 PID LKB1 PATHWAY LKB1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 2.9 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 2.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 0.8 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 1.6 REACTOME PROLONGED ERK ACTIVATION EVENTS Genes involved in Prolonged ERK activation events
0.1 1.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 1.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.6 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 4.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.9 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.0 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.7 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 2.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.7 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.4 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.7 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.5 REACTOME KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 1.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.6 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 1.3 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression