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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for AGUGGUU

Z-value: 0.66

Motif logo

miRNA associated with seed AGUGGUU

NamemiRBASE accession
MIMAT0000431

Activity profile of AGUGGUU motif

Sorted Z-values of AGUGGUU motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_68299130 8.40 ENST00000370982.3
guanine nucleotide binding protein (G protein), gamma 12
chr3_-_149688896 6.97 ENST00000239940.7
profilin 2
chr1_+_182992545 6.81 ENST00000258341.4
laminin, gamma 1 (formerly LAMB2)
chr15_-_48937982 6.77 ENST00000316623.5
fibrillin 1
chr1_+_11994715 6.09 ENST00000449038.1
ENST00000376369.3
ENST00000429000.2
ENST00000196061.4
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr2_-_183903133 5.79 ENST00000361354.4
NCK-associated protein 1
chr4_+_55095264 5.73 ENST00000257290.5
platelet-derived growth factor receptor, alpha polypeptide
chr9_+_112810878 5.35 ENST00000434623.2
ENST00000374525.1
A kinase (PRKA) anchor protein 2
chr7_-_30029367 4.70 ENST00000242059.5
secernin 1
chr9_+_112542572 4.65 ENST00000374530.3
PALM2-AKAP2 readthrough
chr8_+_26435359 4.24 ENST00000311151.5
dihydropyrimidinase-like 2
chr5_-_77844974 3.82 ENST00000515007.2
lipoma HMGIC fusion partner-like 2
chr5_-_172756506 3.82 ENST00000265087.4
stanniocalcin 2
chr12_-_7245125 3.81 ENST00000542285.1
ENST00000540610.1
complement component 1, r subcomponent
chr15_+_81071684 3.54 ENST00000220244.3
ENST00000394685.3
ENST00000356249.5
KIAA1199
chr3_-_124774802 3.26 ENST00000311127.4
heart development protein with EGF-like domains 1
chr8_+_38854418 3.20 ENST00000481513.1
ENST00000487273.2
ADAM metallopeptidase domain 9
chr2_+_242255275 3.14 ENST00000391971.2
septin 2
chr16_-_66785699 3.05 ENST00000258198.2
dynein, cytoplasmic 1, light intermediate chain 2
chr15_-_83876758 2.89 ENST00000299633.4
Hepatoma-derived growth factor-related protein 3
chr14_+_85996471 2.88 ENST00000330753.4
fibronectin leucine rich transmembrane protein 2
chr7_+_39663061 2.66 ENST00000005257.2
v-ral simian leukemia viral oncogene homolog A (ras related)
chr2_-_217560248 2.62 ENST00000233813.4
insulin-like growth factor binding protein 5
chr5_+_32788945 2.56 ENST00000326958.1
AC026703.1
chr14_+_23775971 2.52 ENST00000250405.5
BCL2-like 2
chr15_-_30114622 2.44 ENST00000495972.2
ENST00000346128.6
tight junction protein 1
chr1_-_20812690 2.40 ENST00000375078.3
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr5_-_127873659 2.37 ENST00000262464.4
fibrillin 2
chr12_-_46766577 2.18 ENST00000256689.5
solute carrier family 38, member 2
chr20_-_10654639 2.10 ENST00000254958.5
jagged 1
chr6_+_57037089 1.92 ENST00000370693.5
BCL2-associated athanogene 2
chr21_-_28338732 1.88 ENST00000284987.5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr4_+_124320665 1.80 ENST00000394339.2
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr1_+_82266053 1.79 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
latrophilin 2
chr1_-_205719295 1.77 ENST00000367142.4
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr5_+_149887672 1.74 ENST00000261797.6
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr10_+_60272814 1.72 ENST00000373886.3
bicaudal C homolog 1 (Drosophila)
chr20_-_48729670 1.72 ENST00000371657.5
ubiquitin-conjugating enzyme E2 variant 1
chr1_-_109825719 1.71 ENST00000369904.3
ENST00000369903.2
ENST00000429031.1
ENST00000418914.2
ENST00000409267.1
proline/serine-rich coiled-coil 1
chr8_+_70378852 1.69 ENST00000525061.1
ENST00000458141.2
ENST00000260128.4
sulfatase 1
chr5_-_16936340 1.69 ENST00000507288.1
ENST00000513610.1
myosin X
chr11_+_9406169 1.69 ENST00000379719.3
ENST00000527431.1
importin 7
chr7_+_128379346 1.68 ENST00000535011.2
ENST00000542996.2
ENST00000535623.1
ENST00000538546.1
ENST00000249364.4
ENST00000449187.2
calumenin
chr16_+_69221028 1.63 ENST00000336278.4
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr10_-_51623203 1.63 ENST00000444743.1
ENST00000374065.3
ENST00000374064.3
ENST00000260867.4
translocase of inner mitochondrial membrane 23 homolog (yeast)
chr6_-_108395907 1.62 ENST00000193322.3
osteopetrosis associated transmembrane protein 1
chr6_+_43737939 1.57 ENST00000372067.3
vascular endothelial growth factor A
chr6_-_82462425 1.56 ENST00000369754.3
ENST00000320172.6
ENST00000369756.3
family with sequence similarity 46, member A
chr11_-_66115032 1.52 ENST00000311181.4
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr1_+_78470530 1.50 ENST00000370763.5
DnaJ (Hsp40) homolog, subfamily B, member 4
chr2_-_178128528 1.50 ENST00000397063.4
ENST00000421929.1
nuclear factor, erythroid 2-like 2
chr21_-_15755446 1.46 ENST00000544452.1
ENST00000285667.3
heat shock protein 70kDa family, member 13
chr9_-_99801592 1.44 ENST00000259470.5
cathepsin V
chr2_-_200322723 1.41 ENST00000417098.1
SATB homeobox 2
chr20_-_48770174 1.38 ENST00000341698.2
TMEM189-UBE2V1 readthrough
chr18_-_34409116 1.34 ENST00000334295.4
tubulin polyglutamylase complex subunit 2
chr1_+_160313062 1.28 ENST00000294785.5
ENST00000368063.1
ENST00000437169.1
nicastrin
chr5_+_65222299 1.27 ENST00000284037.5
erbb2 interacting protein
chrX_-_119603138 1.24 ENST00000200639.4
ENST00000371335.4
ENST00000538785.1
ENST00000434600.2
lysosomal-associated membrane protein 2
chrX_-_77395186 1.23 ENST00000341864.5
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
chr6_+_143929307 1.18 ENST00000427704.2
ENST00000305766.6
phosphatase and actin regulator 2
chr3_-_50396978 1.16 ENST00000266025.3
transmembrane protein 115
chr5_-_141704566 1.12 ENST00000344120.4
ENST00000434127.2
sprouty homolog 4 (Drosophila)
chr12_-_27167233 1.09 ENST00000535819.1
ENST00000543803.1
ENST00000535423.1
ENST00000539741.1
ENST00000343028.4
ENST00000545600.1
ENST00000543088.1
transmembrane 7 superfamily member 3
chrX_+_37208521 1.06 ENST00000378628.4
proline rich Gla (G-carboxyglutamic acid) 1
chr1_-_117210290 1.05 ENST00000369483.1
ENST00000369486.3
immunoglobulin superfamily, member 3
chr11_+_46299199 1.03 ENST00000529193.1
ENST00000288400.3
cAMP responsive element binding protein 3-like 1
chr1_+_147013182 1.03 ENST00000234739.3
B-cell CLL/lymphoma 9
chr17_-_33416231 0.93 ENST00000584655.1
ENST00000447669.2
ENST00000315249.7
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr15_+_91073111 0.84 ENST00000420329.2
CREB regulated transcription coactivator 3
chr15_-_56757329 0.84 ENST00000260453.3
meiosis-specific nuclear structural 1
chr9_+_120466650 0.79 ENST00000355622.6
toll-like receptor 4
chr11_-_31839488 0.78 ENST00000419022.1
ENST00000379132.3
ENST00000379129.2
paired box 6
chr10_+_60028818 0.78 ENST00000333926.5
CDGSH iron sulfur domain 1
chr5_-_34916871 0.77 ENST00000382038.2
RAD1 homolog (S. pombe)
chr3_+_150126101 0.76 ENST00000361875.3
ENST00000361136.2
TSC22 domain family, member 2
chr11_-_46940074 0.75 ENST00000378623.1
ENST00000534404.1
low density lipoprotein receptor-related protein 4
chr10_+_96162242 0.75 ENST00000225235.4
TBC1 domain family, member 12
chr6_-_110500905 0.73 ENST00000392587.2
WAS protein family, member 1
chr22_-_18507279 0.69 ENST00000441493.2
ENST00000444520.1
ENST00000207726.7
ENST00000429452.1
microtubule associated monooxygenase, calponin and LIM domain containing 3
chr19_+_48972459 0.68 ENST00000427476.1
cytohesin 2
chr9_+_132815985 0.68 ENST00000372410.3
G protein-coupled receptor 107
chr7_-_120498357 0.68 ENST00000415871.1
ENST00000222747.3
ENST00000430985.1
tetraspanin 12
chrX_-_20284958 0.67 ENST00000379565.3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr7_-_32931387 0.66 ENST00000304056.4
kelch repeat and BTB (POZ) domain containing 2
chr15_-_34502278 0.65 ENST00000559515.1
ENST00000256544.3
ENST00000560108.1
ENST00000559462.1
katanin p80 subunit B-like 1
chr20_-_48770244 0.64 ENST00000371650.5
ENST00000371652.4
ENST00000557021.1
transmembrane protein 189
chr2_-_37384175 0.60 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
eukaryotic translation initiation factor 2-alpha kinase 2
chr22_-_36784035 0.57 ENST00000216181.5
myosin, heavy chain 9, non-muscle
chr10_-_104262426 0.55 ENST00000487599.1
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr20_+_6748311 0.55 ENST00000378827.4
bone morphogenetic protein 2
chr5_-_180242534 0.54 ENST00000333055.3
ENST00000513431.1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr3_+_32147997 0.53 ENST00000282541.5
glycerol-3-phosphate dehydrogenase 1-like
chr17_+_46908350 0.52 ENST00000258947.3
ENST00000509507.1
ENST00000448105.2
ENST00000570513.1
ENST00000509415.1
ENST00000513119.1
ENST00000416445.2
ENST00000508679.1
ENST00000505071.1
calcium binding and coiled-coil domain 2
chr9_-_107690420 0.52 ENST00000423487.2
ENST00000374733.1
ENST00000374736.3
ATP-binding cassette, sub-family A (ABC1), member 1
chr5_+_122110691 0.52 ENST00000379516.2
ENST00000505934.1
ENST00000514949.1
sorting nexin 2
chr5_+_138629417 0.52 ENST00000510056.1
ENST00000511249.1
ENST00000503811.1
ENST00000511378.1
matrin 3
chr1_+_25664408 0.51 ENST00000374358.4
transmembrane protein 50A
chr8_-_80680078 0.50 ENST00000337919.5
ENST00000354724.3
hes-related family bHLH transcription factor with YRPW motif 1
chr12_+_107168342 0.48 ENST00000392837.4
RIC8 guanine nucleotide exchange factor B
chr11_-_102323489 0.48 ENST00000361236.3
transmembrane protein 123
chr5_+_14143728 0.47 ENST00000344204.4
ENST00000537187.1
trio Rho guanine nucleotide exchange factor
chr7_-_79082867 0.45 ENST00000419488.1
ENST00000354212.4
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr4_-_54930790 0.43 ENST00000263921.3
cysteine-rich hydrophobic domain 2
chr10_+_104535994 0.43 ENST00000369889.4
WW domain binding protein 1-like
chr1_+_161736072 0.42 ENST00000367942.3
activating transcription factor 6
chr1_+_10271674 0.42 ENST00000377086.1
kinesin family member 1B
chr1_+_87380299 0.42 ENST00000370551.4
ENST00000370550.5
heparan sulfate 2-O-sulfotransferase 1
chr6_+_21593972 0.39 ENST00000244745.1
ENST00000543472.1
SRY (sex determining region Y)-box 4
chr6_+_158733692 0.38 ENST00000367094.2
ENST00000367097.3
tubby like protein 4
chr9_-_73029540 0.38 ENST00000377126.2
Kruppel-like factor 9
chr20_-_35374456 0.36 ENST00000373803.2
ENST00000359675.2
ENST00000540765.1
ENST00000349004.1
NDRG family member 3
chr14_-_82000140 0.35 ENST00000555824.1
ENST00000557372.1
ENST00000336735.4
sel-1 suppressor of lin-12-like (C. elegans)
chr18_-_55253989 0.34 ENST00000262093.5
ferrochelatase
chr3_-_46037299 0.34 ENST00000296137.2
FYVE and coiled-coil domain containing 1
chr1_+_64239657 0.32 ENST00000371080.1
ENST00000371079.1
receptor tyrosine kinase-like orphan receptor 1
chr15_-_42264702 0.31 ENST00000220325.4
EH-domain containing 4
chr14_-_55878538 0.30 ENST00000247178.5
autophagy related 14
chr1_+_171810606 0.30 ENST00000358155.4
ENST00000367733.2
ENST00000355305.5
ENST00000367731.1
dynamin 3
chr4_-_85887503 0.27 ENST00000509172.1
ENST00000322366.6
ENST00000295888.4
ENST00000502713.1
WD repeat and FYVE domain containing 3
chr17_-_53499310 0.26 ENST00000262065.3
monocyte to macrophage differentiation-associated
chr10_+_70091812 0.24 ENST00000265866.7
heterogeneous nuclear ribonucleoprotein H3 (2H9)
chr16_-_20911641 0.24 ENST00000564349.1
ENST00000324344.4
ERI1 exoribonuclease family member 2
DCN1, defective in cullin neddylation 1, domain containing 3
chrX_+_28605516 0.23 ENST00000378993.1
interleukin 1 receptor accessory protein-like 1
chr2_+_48541776 0.23 ENST00000413569.1
ENST00000340553.3
forkhead box N2
chr9_+_132934835 0.22 ENST00000372398.3
neuronal calcium sensor 1
chr5_+_32711419 0.22 ENST00000265074.8
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr6_+_149068464 0.21 ENST00000367463.4
uronyl-2-sulfotransferase
chr3_+_20081515 0.20 ENST00000263754.4
K(lysine) acetyltransferase 2B
chr1_-_43424500 0.18 ENST00000415851.2
ENST00000426263.3
ENST00000372500.3
solute carrier family 2 (facilitated glucose transporter), member 1
chr12_+_67663056 0.18 ENST00000545606.1
cullin-associated and neddylation-dissociated 1
chr1_+_159141397 0.18 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
cell adhesion molecule 3
chr7_-_112430647 0.17 ENST00000312814.6
transmembrane protein 168
chr18_-_24445729 0.17 ENST00000383168.4
aquaporin 4
chr4_+_174292058 0.17 ENST00000296504.3
Sin3A-associated protein, 30kDa
chr20_+_1099233 0.17 ENST00000246015.4
ENST00000335877.6
ENST00000438768.2
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chrX_-_83442915 0.15 ENST00000262752.2
ENST00000543399.1
ribosomal protein S6 kinase, 90kDa, polypeptide 6
chr3_+_196594727 0.12 ENST00000445299.2
ENST00000323460.5
ENST00000419026.1
SUMO1/sentrin specific peptidase 5
chr12_+_69004619 0.11 ENST00000250559.9
ENST00000393436.5
ENST00000425247.2
ENST00000489473.2
ENST00000422358.2
ENST00000541167.1
ENST00000538283.1
ENST00000341355.5
ENST00000537460.1
ENST00000450214.2
ENST00000545270.1
ENST00000538980.1
ENST00000542018.1
ENST00000543393.1
RAP1B, member of RAS oncogene family
chr3_+_180630090 0.11 ENST00000357559.4
ENST00000305586.7
fragile X mental retardation, autosomal homolog 1
chr19_+_39616410 0.09 ENST00000602004.1
ENST00000599470.1
ENST00000321944.4
ENST00000593480.1
ENST00000358301.3
ENST00000593690.1
ENST00000599386.1
p21 protein (Cdc42/Rac)-activated kinase 4
chr19_+_9945962 0.09 ENST00000587625.1
ENST00000247970.4
ENST00000588695.1
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
chr3_-_114790179 0.08 ENST00000462705.1
zinc finger and BTB domain containing 20
chr22_-_22221900 0.07 ENST00000215832.6
ENST00000398822.3
mitogen-activated protein kinase 1
chr14_+_69865401 0.07 ENST00000556605.1
ENST00000336643.5
ENST00000031146.4
solute carrier family 39, member 9
chr18_-_57027194 0.06 ENST00000251047.5
lectin, mannose-binding, 1
chr11_+_117014983 0.04 ENST00000527958.1
ENST00000419197.2
ENST00000304808.6
ENST00000529887.2
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
chr9_+_126773880 0.01 ENST00000373615.4
LIM homeobox 2

Network of associatons between targets according to the STRING database.

First level regulatory network of AGUGGUU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.1 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
1.9 5.7 GO:0072275 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
1.4 6.8 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
1.1 3.2 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.9 2.6 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.8 2.4 GO:1901350 cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.7 2.1 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.7 6.5 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.6 1.8 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.6 7.0 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.6 0.6 GO:1903921 protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
0.6 0.6 GO:0003133 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134)
0.5 1.6 GO:0038086 VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091)
0.5 2.9 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.5 3.8 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.5 3.3 GO:0090269 fibroblast growth factor production(GO:0090269) regulation of fibroblast growth factor production(GO:0090270)
0.4 1.8 GO:0019046 release from viral latency(GO:0019046)
0.4 6.8 GO:0070831 basement membrane assembly(GO:0070831)
0.4 1.5 GO:0046223 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.4 2.2 GO:0032328 alanine transport(GO:0032328)
0.4 2.5 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.3 2.4 GO:0071694 sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.3 1.4 GO:1990834 response to odorant(GO:1990834)
0.3 0.8 GO:0070428 negative regulation of interleukin-23 production(GO:0032707) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.3 0.8 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.2 0.9 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.2 0.5 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.2 2.7 GO:0051665 membrane raft localization(GO:0051665)
0.2 1.9 GO:0006477 protein sulfation(GO:0006477)
0.2 0.8 GO:0033313 meiotic cell cycle checkpoint(GO:0033313)
0.2 1.9 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.2 1.7 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.2 8.4 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.2 0.8 GO:0003322 pancreatic A cell development(GO:0003322)
0.1 0.6 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.1 0.9 GO:1901098 regulation of autophagosome maturation(GO:1901096) positive regulation of autophagosome maturation(GO:1901098)
0.1 0.4 GO:1904647 response to rotenone(GO:1904647)
0.1 1.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 0.5 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.1 0.5 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072) negative regulation of protein kinase C signaling(GO:0090038)
0.1 0.5 GO:0090107 aminophospholipid transport(GO:0015917) regulation of high-density lipoprotein particle assembly(GO:0090107)
0.1 1.0 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.1 0.5 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.1 0.5 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1 0.3 GO:0070541 response to platinum ion(GO:0070541)
0.1 1.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 2.9 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 0.4 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.1 1.2 GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy(GO:0061740)
0.1 0.3 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.1 1.0 GO:0032808 lacrimal gland development(GO:0032808)
0.1 0.6 GO:0044415 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1 1.3 GO:0007220 Notch receptor processing(GO:0007220)
0.1 3.0 GO:0051642 centrosome localization(GO:0051642)
0.1 0.8 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 0.3 GO:0035973 aggrephagy(GO:0035973)
0.1 0.2 GO:0005988 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989) dehydroascorbic acid transport(GO:0070837)
0.1 0.3 GO:0016240 autophagosome docking(GO:0016240)
0.1 1.2 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.1 2.6 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.1 0.4 GO:0051414 response to cortisol(GO:0051414)
0.0 0.6 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 1.7 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 4.2 GO:0030516 regulation of axon extension(GO:0030516)
0.0 0.5 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.4 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.2 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.0 3.8 GO:0030449 regulation of complement activation(GO:0030449)
0.0 0.7 GO:0010842 retina layer formation(GO:0010842)
0.0 5.0 GO:0002576 platelet degranulation(GO:0002576)
0.0 5.2 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.1 GO:0019858 cytosine metabolic process(GO:0019858)
0.0 0.8 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.0 1.0 GO:0043403 skeletal muscle tissue regeneration(GO:0043403)
0.0 0.7 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.0 0.7 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.0 1.5 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.1 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 2.1 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 0.2 GO:0010265 SCF complex assembly(GO:0010265)
0.0 1.3 GO:1900046 regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.0 1.2 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0 0.2 GO:0045116 response to UV-C(GO:0010225) protein neddylation(GO:0045116)
0.0 0.2 GO:0002158 osteoclast proliferation(GO:0002158)
0.0 1.4 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.0 0.1 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.4 GO:0061512 protein localization to cilium(GO:0061512)
0.0 0.6 GO:0030042 actin filament depolymerization(GO:0030042)
0.0 1.2 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.4 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.0 0.4 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 0.3 GO:0014002 astrocyte development(GO:0014002)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.8 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260)
0.5 6.5 GO:0031209 SCAR complex(GO:0031209)
0.4 9.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.3 1.7 GO:0035370 UBC13-UEV1A complex(GO:0035370)
0.3 1.2 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.3 2.6 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.2 3.1 GO:0097227 sperm annulus(GO:0097227)
0.2 6.1 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.2 0.8 GO:0030896 checkpoint clamp complex(GO:0030896)
0.2 0.6 GO:0005826 actomyosin contractile ring(GO:0005826)
0.2 2.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.2 5.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 0.8 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.2 8.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 1.7 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.1 3.2 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 1.6 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 1.3 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 3.0 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.3 GO:1903349 omegasome membrane(GO:1903349)
0.1 0.6 GO:0002177 manchette(GO:0002177)
0.1 1.7 GO:0032433 filopodium tip(GO:0032433)
0.1 0.5 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.5 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 7.2 GO:0005902 microvillus(GO:0005902)
0.1 1.2 GO:0017119 Golgi transport complex(GO:0017119)
0.1 1.2 GO:0000124 SAGA complex(GO:0000124)
0.1 2.4 GO:0005921 gap junction(GO:0005921)
0.1 7.0 GO:0043195 terminal bouton(GO:0043195)
0.1 0.4 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 0.8 GO:0016600 flotillin complex(GO:0016600)
0.1 0.5 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.3 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 1.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306) Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.2 GO:0000125 PCAF complex(GO:0000125)
0.0 2.5 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0001939 female pronucleus(GO:0001939)
0.0 0.1 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.0 1.6 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 2.2 GO:0005903 brush border(GO:0005903)
0.0 1.0 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 1.2 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.5 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.7 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 3.6 GO:0072562 blood microparticle(GO:0072562)
0.0 1.7 GO:0005643 nuclear pore(GO:0005643)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)
0.0 4.4 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.8 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.7 GO:0005776 autophagosome(GO:0005776)
0.0 4.2 GO:0005874 microtubule(GO:0005874)
0.0 1.4 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.1 GO:0032587 ruffle membrane(GO:0032587)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
1.9 5.7 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
1.4 4.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
1.1 9.1 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.7 8.4 GO:0042301 phosphate ion binding(GO:0042301)
0.5 1.4 GO:0030984 kininogen binding(GO:0030984)
0.4 1.7 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.4 1.7 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.4 2.4 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.3 1.6 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.2 2.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 0.6 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.2 1.7 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.2 4.7 GO:0016805 dipeptidase activity(GO:0016805)
0.2 2.9 GO:0045499 chemorepellent activity(GO:0045499)
0.2 0.5 GO:0034188 apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.2 1.6 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.2 1.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 7.0 GO:0003785 actin monomer binding(GO:0003785)
0.2 3.0 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 0.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.5 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1 0.8 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 0.5 GO:0035939 microsatellite binding(GO:0035939)
0.1 2.4 GO:0051400 BH domain binding(GO:0051400)
0.1 0.5 GO:1990460 leptin receptor binding(GO:1990460)
0.1 6.6 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 3.2 GO:0043236 laminin binding(GO:0043236)
0.1 0.8 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 1.2 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 0.3 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936) coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.1 1.6 GO:0005112 Notch binding(GO:0005112)
0.1 6.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.2 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.1 0.7 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 0.8 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.6 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 1.0 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.5 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.4 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.0 0.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 1.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 2.7 GO:0017022 myosin binding(GO:0017022)
0.0 0.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 3.8 GO:0005179 hormone activity(GO:0005179)
0.0 0.1 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 1.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.2 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.3 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 0.7 GO:0071949 FAD binding(GO:0071949)
0.0 1.6 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 0.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 4.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 3.3 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.2 GO:0015250 water channel activity(GO:0015250)
0.0 0.3 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.2 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0002151 G-quadruplex RNA binding(GO:0002151) RNA strand annealing activity(GO:0033592)
0.0 3.2 GO:0008017 microtubule binding(GO:0008017)
0.0 0.9 GO:0002039 p53 binding(GO:0002039)
0.0 1.4 GO:0003697 single-stranded DNA binding(GO:0003697)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.8 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 5.7 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 8.4 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.2 5.7 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 7.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.6 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 2.7 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 2.2 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 3.9 PID CDC42 PATHWAY CDC42 signaling events
0.1 14.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 0.7 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.7 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 2.1 PID NOTCH PATHWAY Notch signaling pathway
0.0 4.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.9 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.6 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.7 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.8 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.5 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.2 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.4 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.2 3.4 REACTOME SIGNALING BY NOTCH2 Genes involved in Signaling by NOTCH2
0.1 7.1 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.4 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 5.1 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.1 6.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 13.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 2.7 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 2.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.8 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 1.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.8 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 2.2 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 2.2 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 2.2 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.5 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.8 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 5.3 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.5 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 3.6 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.5 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 2.9 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.6 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.8 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.0 0.6 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins