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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AHR_ARNT2
Z-value: 1.92
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Transcription factors associated with AHR_ARNT2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ARNT2 | hg19_v2_chr15_+_80696666_80696700, hg19_v2_chr15_+_80733570_80733659 | 0.34 | 2.9e-07 | Click! |
| AHR | hg19_v2_chr7_+_17338239_17338262 | -0.13 | 5.7e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of AHR_ARNT2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 52.1 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 2.8 | 39.0 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.5 | 32.6 | GO:0070125 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 7.2 | 29.0 | GO:0070982 | L-asparagine biosynthetic process(GO:0070981) L-asparagine metabolic process(GO:0070982) |
| 0.8 | 25.4 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.6 | 24.7 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 1.3 | 21.6 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.4 | 21.5 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 1.8 | 21.3 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.5 | 20.1 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 89.6 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 80.1 | GO:0005730 | nucleolus(GO:0005730) |
| 0.3 | 62.5 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 10.5 | 52.6 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 0.1 | 42.7 | GO:0005874 | microtubule(GO:0005874) |
| 0.3 | 37.8 | GO:0043679 | axon terminus(GO:0043679) |
| 0.4 | 30.5 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.1 | 27.4 | GO:0098794 | postsynapse(GO:0098794) |
| 1.3 | 23.4 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.2 | 23.3 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 52.3 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.1 | 35.2 | GO:0005525 | GTP binding(GO:0005525) |
| 5.8 | 29.0 | GO:0004066 | asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066) |
| 9.2 | 27.5 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 0.1 | 25.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.3 | 23.4 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.0 | 23.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 21.9 | GO:0003723 | RNA binding(GO:0003723) |
| 0.2 | 21.3 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.4 | 20.4 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 55.8 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.9 | 36.6 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.6 | 32.1 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.7 | 24.8 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 18.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.9 | 16.9 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 16.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.7 | 13.9 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.2 | 12.6 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.1 | 12.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 69.5 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.8 | 47.4 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.9 | 43.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 1.5 | 42.6 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 1.3 | 35.2 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 1.2 | 27.2 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.7 | 23.7 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.9 | 21.4 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.5 | 21.4 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.8 | 19.6 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |