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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for AIRE

Z-value: 0.95

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Transcription factors associated with AIRE

Gene Symbol Gene ID Gene Info
AIRE
ENSG00000160224.12 autoimmune regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
AIREhg19_v2_chr21_+_45705752_457057670.385.4e-09Click!

Activity profile of AIRE motif

Sorted Z-values of AIRE motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_88450612 26.51 ENST00000418378.1
ENST00000282470.6
SPARCL1
SPARC-like 1 (hevin)
chr6_-_31514333 16.02 ENST00000376151.4
ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr4_-_57524061 15.33 ENST00000508121.1
HOPX
HOP homeobox
chr6_-_31514516 13.45 ENST00000303892.5
ENST00000483251.1
ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr19_+_18208603 11.73 ENST00000262811.6
MAST3
microtubule associated serine/threonine kinase 3
chr19_-_36643329 11.36 ENST00000589154.1
COX7A1
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
chrM_+_12331 10.91 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr10_-_69597810 10.66 ENST00000483798.2
DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr20_+_44036900 9.85 ENST00000443296.1
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr20_+_44036620 9.71 ENST00000372710.3
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr3_-_49466686 9.34 ENST00000273598.3
ENST00000436744.2
NICN1
nicolin 1
chr12_-_6580094 8.95 ENST00000361716.3
VAMP1
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr17_+_41857793 7.99 ENST00000449302.3
C17orf105
chromosome 17 open reading frame 105
chr12_-_6579808 7.45 ENST00000535180.1
ENST00000400911.3
VAMP1
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr19_-_21950362 7.41 ENST00000358296.6
ZNF100
zinc finger protein 100
chr7_+_150498783 7.07 ENST00000475536.1
ENST00000468689.1
TMEM176A
transmembrane protein 176A
chr11_-_85376121 7.05 ENST00000527447.1
CREBZF
CREB/ATF bZIP transcription factor
chr19_+_45417921 6.96 ENST00000252491.4
ENST00000592885.1
ENST00000589781.1
APOC1
apolipoprotein C-I
chr9_-_70429731 6.81 ENST00000377413.1
FOXD4L4
forkhead box D4-like 4
chr7_+_20686946 6.70 ENST00000443026.2
ENST00000406935.1
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr9_+_42717234 6.53 ENST00000377590.1
FOXD4L2
forkhead box D4-like 2
chr7_-_36764004 6.26 ENST00000431169.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr7_-_137028534 6.20 ENST00000348225.2
PTN
pleiotrophin
chr9_-_113761720 6.14 ENST00000541779.1
ENST00000374430.2
LPAR1
lysophosphatidic acid receptor 1
chr19_+_45418067 6.09 ENST00000589078.1
ENST00000586638.1
APOC1
apolipoprotein C-I
chr19_+_45417812 5.89 ENST00000592535.1
APOC1
apolipoprotein C-I
chr7_-_137028498 5.66 ENST00000393083.2
PTN
pleiotrophin
chr7_-_36764142 5.58 ENST00000258749.5
ENST00000535891.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr2_+_166150541 5.52 ENST00000283256.6
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr4_+_71587669 5.47 ENST00000381006.3
ENST00000226328.4
RUFY3
RUN and FYVE domain containing 3
chr9_-_70178815 5.05 ENST00000377420.1
FOXD4L5
forkhead box D4-like 5
chr2_-_127977654 5.00 ENST00000409327.1
CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr9_+_100615536 4.90 ENST00000375123.3
FOXE1
forkhead box E1 (thyroid transcription factor 2)
chr14_-_24911971 4.84 ENST00000555365.1
ENST00000399395.3
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr12_-_113772835 4.66 ENST00000552014.1
ENST00000548186.1
ENST00000202831.3
ENST00000549181.1
SLC8B1
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr4_-_17513851 4.66 ENST00000281243.5
QDPR
quinoid dihydropteridine reductase
chr5_-_107703556 4.63 ENST00000496714.1
FBXL17
F-box and leucine-rich repeat protein 17
chr12_+_7282795 4.40 ENST00000266546.6
CLSTN3
calsyntenin 3
chr3_+_46412345 4.23 ENST00000292303.4
CCR5
chemokine (C-C motif) receptor 5 (gene/pseudogene)
chr22_+_36649170 4.05 ENST00000438034.1
ENST00000427990.1
ENST00000347595.7
ENST00000397279.4
ENST00000433768.1
ENST00000440669.2
APOL1
apolipoprotein L, 1
chr21_+_39644214 4.04 ENST00000438657.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr14_-_24912047 3.68 ENST00000553930.1
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chrM_+_4431 3.63 ENST00000361453.3
MT-ND2
mitochondrially encoded NADH dehydrogenase 2
chr15_-_22448819 3.59 ENST00000604066.1
IGHV1OR15-1
immunoglobulin heavy variable 1/OR15-1 (non-functional)
chr21_+_39644305 3.55 ENST00000398930.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr22_+_25202232 3.55 ENST00000400358.4
ENST00000400359.4
SGSM1
small G protein signaling modulator 1
chr4_-_186696425 3.54 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2
sorbin and SH3 domain containing 2
chr3_+_193965426 3.46 ENST00000455821.1
RP11-513G11.3
RP11-513G11.3
chr17_-_38721711 3.44 ENST00000578085.1
ENST00000246657.2
CCR7
chemokine (C-C motif) receptor 7
chr12_+_20848486 3.23 ENST00000545102.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr16_+_56672571 3.12 ENST00000290705.8
MT1A
metallothionein 1A
chr2_-_225811747 3.05 ENST00000409592.3
DOCK10
dedicator of cytokinesis 10
chr3_+_189507460 3.03 ENST00000434928.1
TP63
tumor protein p63
chr19_-_36304201 2.83 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr16_+_3254247 2.80 ENST00000304646.2
OR1F1
olfactory receptor, family 1, subfamily F, member 1
chr4_-_120243545 2.80 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr21_+_39644172 2.79 ENST00000398932.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr19_-_10491234 2.77 ENST00000524462.1
ENST00000531836.1
ENST00000525621.1
TYK2
tyrosine kinase 2
chr2_-_166060552 2.56 ENST00000283254.7
ENST00000453007.1
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr3_-_133648656 2.55 ENST00000408895.2
C3orf36
chromosome 3 open reading frame 36
chr16_+_14802801 2.53 ENST00000526520.1
ENST00000531598.2
NPIPA3
nuclear pore complex interacting protein family, member A3
chr21_-_44495964 2.41 ENST00000398168.1
ENST00000398165.3
CBS
cystathionine-beta-synthase
chr7_-_15601595 2.40 ENST00000342526.3
AGMO
alkylglycerol monooxygenase
chr22_+_40322623 2.36 ENST00000399090.2
GRAP2
GRB2-related adaptor protein 2
chr15_-_99789736 2.33 ENST00000560235.1
ENST00000394132.2
ENST00000560860.1
ENST00000558078.1
ENST00000394136.1
ENST00000262074.4
ENST00000558613.1
ENST00000394130.1
ENST00000560772.1
TTC23
tetratricopeptide repeat domain 23
chr12_+_12223867 2.28 ENST00000308721.5
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr14_-_106967788 2.28 ENST00000390622.2
IGHV1-46
immunoglobulin heavy variable 1-46
chr1_+_206223941 2.24 ENST00000367126.4
AVPR1B
arginine vasopressin receptor 1B
chr2_-_166060571 2.18 ENST00000360093.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr22_+_40322595 2.13 ENST00000420971.1
ENST00000544756.1
GRAP2
GRB2-related adaptor protein 2
chr9_-_104198042 2.09 ENST00000374855.4
ALDOB
aldolase B, fructose-bisphosphate
chr13_-_26795840 2.08 ENST00000381570.3
ENST00000399762.2
ENST00000346166.3
RNF6
ring finger protein (C3H2C3 type) 6
chr15_+_27112948 2.06 ENST00000555060.1
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr11_+_6947647 2.04 ENST00000278319.5
ZNF215
zinc finger protein 215
chr12_-_6579833 1.97 ENST00000396308.3
VAMP1
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr11_+_64794875 1.95 ENST00000377244.3
ENST00000534637.1
ENST00000524831.1
SNX15
sorting nexin 15
chr14_-_106668095 1.93 ENST00000390606.2
IGHV3-20
immunoglobulin heavy variable 3-20
chrX_-_153191674 1.93 ENST00000350060.5
ENST00000370016.1
ARHGAP4
Rho GTPase activating protein 4
chr12_-_15038779 1.93 ENST00000228938.5
ENST00000539261.1
MGP
matrix Gla protein
chr1_+_207669573 1.91 ENST00000400960.2
ENST00000534202.1
CR1
complement component (3b/4b) receptor 1 (Knops blood group)
chr11_-_8954491 1.83 ENST00000526227.1
ENST00000525780.1
ENST00000326053.5
C11orf16
chromosome 11 open reading frame 16
chr19_-_59084922 1.81 ENST00000215057.2
ENST00000599369.1
MZF1
myeloid zinc finger 1
chr16_+_72088376 1.78 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
HP
HPR
haptoglobin
haptoglobin-related protein
chr20_-_43150601 1.76 ENST00000541235.1
ENST00000255175.1
ENST00000342374.4
SERINC3
serine incorporator 3
chr20_+_44637526 1.75 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr21_+_39644395 1.75 ENST00000398934.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr4_+_76649797 1.72 ENST00000538159.1
ENST00000514213.2
USO1
USO1 vesicle transport factor
chr8_+_105352050 1.62 ENST00000297581.2
DCSTAMP
dendrocyte expressed seven transmembrane protein
chr1_+_207669613 1.60 ENST00000367049.4
ENST00000529814.1
CR1
complement component (3b/4b) receptor 1 (Knops blood group)
chr1_-_161208013 1.59 ENST00000515452.1
ENST00000367983.4
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr1_-_167883327 1.54 ENST00000476818.2
ENST00000367851.4
ENST00000367848.1
ADCY10
adenylate cyclase 10 (soluble)
chrX_-_100307076 1.52 ENST00000338687.7
ENST00000545398.1
ENST00000372931.5
TRMT2B
tRNA methyltransferase 2 homolog B (S. cerevisiae)
chr18_+_39766626 1.51 ENST00000593234.1
ENST00000585627.1
ENST00000591199.1
ENST00000586990.1
ENST00000593051.1
ENST00000593316.1
ENST00000591381.1
ENST00000585639.1
ENST00000589068.1
LINC00907
long intergenic non-protein coding RNA 907
chr2_+_204732487 1.46 ENST00000302823.3
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr6_+_167525277 1.45 ENST00000400926.2
CCR6
chemokine (C-C motif) receptor 6
chrX_-_100307043 1.43 ENST00000372939.1
ENST00000372935.1
ENST00000372936.3
TRMT2B
tRNA methyltransferase 2 homolog B (S. cerevisiae)
chr2_+_1417228 1.38 ENST00000382269.3
ENST00000337415.3
ENST00000345913.4
ENST00000346956.3
ENST00000349624.3
ENST00000539820.1
ENST00000329066.4
ENST00000382201.3
TPO
thyroid peroxidase
chr1_-_35497506 1.35 ENST00000317538.5
ENST00000373340.2
ENST00000357182.4
ZMYM6
zinc finger, MYM-type 6
chrX_-_101694853 1.32 ENST00000372749.1
NXF2B
nuclear RNA export factor 2B
chr16_-_29499154 1.29 ENST00000354563.5
RP11-231C14.4
Uncharacterized protein
chr4_+_71588372 1.27 ENST00000536664.1
RUFY3
RUN and FYVE domain containing 3
chr12_-_11463353 1.23 ENST00000279575.1
ENST00000535904.1
ENST00000445719.2
PRB4
proline-rich protein BstNI subfamily 4
chr8_-_16043780 1.21 ENST00000445506.2
MSR1
macrophage scavenger receptor 1
chr13_-_46756351 1.17 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_-_208994548 1.17 ENST00000282141.3
CRYGC
crystallin, gamma C
chrX_-_153191708 1.17 ENST00000393721.1
ENST00000370028.3
ARHGAP4
Rho GTPase activating protein 4
chr21_-_44495919 1.13 ENST00000398158.1
CBS
cystathionine-beta-synthase
chr3_-_121468602 1.10 ENST00000340645.5
GOLGB1
golgin B1
chr9_+_90112117 1.04 ENST00000358077.5
DAPK1
death-associated protein kinase 1
chr1_-_52344471 1.00 ENST00000352171.7
ENST00000354831.7
NRD1
nardilysin (N-arginine dibasic convertase)
chr14_-_107283278 0.93 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr9_+_71986182 0.91 ENST00000303068.7
FAM189A2
family with sequence similarity 189, member A2
chr9_+_117904097 0.89 ENST00000374016.1
DEC1
deleted in esophageal cancer 1
chr14_+_58894706 0.85 ENST00000261244.5
KIAA0586
KIAA0586
chr12_+_12224331 0.84 ENST00000396367.1
ENST00000266434.4
ENST00000396369.1
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr22_-_32767017 0.83 ENST00000400234.1
RFPL3S
RFPL3 antisense
chr12_+_12202774 0.74 ENST00000589718.1
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr15_+_52043758 0.63 ENST00000249700.4
ENST00000539962.2
TMOD2
tropomodulin 2 (neuronal)
chr2_+_62423242 0.59 ENST00000301998.4
B3GNT2
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
chr12_-_25101920 0.58 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr17_+_3323862 0.55 ENST00000291231.1
OR3A3
olfactory receptor, family 3, subfamily A, member 3
chr3_-_121468513 0.49 ENST00000494517.1
ENST00000393667.3
GOLGB1
golgin B1
chr12_+_12202785 0.45 ENST00000586576.1
ENST00000464885.2
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr19_-_48753104 0.43 ENST00000447740.2
CARD8
caspase recruitment domain family, member 8
chr11_+_30252549 0.41 ENST00000254122.3
ENST00000417547.1
FSHB
follicle stimulating hormone, beta polypeptide
chr11_-_5173599 0.41 ENST00000328942.1
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr14_+_21236586 0.40 ENST00000326783.3
EDDM3B
epididymal protein 3B
chr19_-_52551814 0.38 ENST00000594154.1
ENST00000598745.1
ENST00000597273.1
ZNF432
zinc finger protein 432
chr4_-_123843597 0.34 ENST00000510735.1
ENST00000304430.5
NUDT6
nudix (nucleoside diphosphate linked moiety X)-type motif 6
chr5_+_32788945 0.27 ENST00000326958.1
AC026703.1
AC026703.1
chr1_+_152627927 0.20 ENST00000444515.1
ENST00000536536.1
LINC00302
long intergenic non-protein coding RNA 302
chr1_-_158300747 0.17 ENST00000451207.1
CD1B
CD1b molecule
chr19_-_23869999 0.16 ENST00000601935.1
ENST00000359788.4
ENST00000600313.1
ENST00000596211.1
ENST00000599168.1
ZNF675
zinc finger protein 675
chr1_+_47603109 0.15 ENST00000371890.3
ENST00000294337.3
ENST00000371891.3
CYP4A22
cytochrome P450, family 4, subfamily A, polypeptide 22
chr1_-_52456352 0.08 ENST00000371655.3
RAB3B
RAB3B, member RAS oncogene family
chr6_-_32806506 0.07 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr6_+_26538566 0.06 ENST00000377575.2
HMGN4
high mobility group nucleosomal binding domain 4
chr19_-_48752812 0.05 ENST00000359009.4
CARD8
caspase recruitment domain family, member 8
chr22_+_36649056 0.01 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
APOL1
apolipoprotein L, 1

Network of associatons between targets according to the STRING database.

First level regulatory network of AIRE

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 18.9 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
4.0 11.9 GO:1904395 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
1.7 6.7 GO:0048749 compound eye development(GO:0048749)
1.6 4.7 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
1.5 6.1 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
1.2 4.9 GO:0060023 soft palate development(GO:0060023)
1.2 3.5 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
1.2 3.5 GO:0030451 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957)
1.1 3.4 GO:2000525 dendritic cell dendrite assembly(GO:0097026) regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) regulation of dendritic cell dendrite assembly(GO:2000547)
0.9 18.4 GO:0035493 SNARE complex assembly(GO:0035493)
0.9 29.5 GO:0090383 phagosome acidification(GO:0090383)
0.8 3.0 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.7 2.1 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.7 2.1 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.7 15.3 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.6 4.2 GO:0044800 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.6 1.8 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.6 4.7 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.5 7.1 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.5 4.4 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.5 1.5 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.5 1.5 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.5 2.8 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.4 5.5 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.4 1.6 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.4 2.2 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.3 2.4 GO:0046485 ether lipid metabolic process(GO:0046485)
0.3 5.0 GO:0042574 retinal metabolic process(GO:0042574)
0.3 1.7 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.3 3.1 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
0.3 12.1 GO:0010107 potassium ion import(GO:0010107)
0.3 3.0 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.3 1.8 GO:0009597 detection of virus(GO:0009597)
0.3 1.8 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.2 3.2 GO:0070327 thyroid hormone transport(GO:0070327)
0.2 6.7 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.2 0.6 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.1 1.2 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.1 11.4 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.1 7.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 3.1 GO:0071294 cellular response to zinc ion(GO:0071294)
0.1 0.6 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 3.5 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.6 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1 4.7 GO:0019228 neuronal action potential(GO:0019228)
0.1 1.0 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.1 1.5 GO:0003351 epithelial cilium movement(GO:0003351)
0.1 1.9 GO:0001502 cartilage condensation(GO:0001502)
0.1 4.1 GO:0019835 cytolysis(GO:0019835)
0.1 3.8 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 1.2 GO:0051639 actin filament network formation(GO:0051639)
0.1 4.9 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 2.8 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 1.4 GO:0006590 thyroid hormone generation(GO:0006590)
0.1 2.1 GO:0060384 innervation(GO:0060384)
0.1 0.4 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.1 3.0 GO:0001510 RNA methylation(GO:0001510)
0.1 6.0 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 0.5 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.1 17.1 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.1 24.8 GO:0043687 post-translational protein modification(GO:0043687)
0.0 3.0 GO:0045814 negative regulation of gene expression, epigenetic(GO:0045814)
0.0 0.1 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.0 0.2 GO:0002933 lipid hydroxylation(GO:0002933)
0.0 1.6 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.0 0.1 GO:0051582 peptidyl-cysteine methylation(GO:0018125) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
0.0 12.5 GO:0006954 inflammatory response(GO:0006954)
0.0 0.2 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 1.6 GO:0007030 Golgi organization(GO:0007030)
0.0 0.8 GO:0031338 regulation of vesicle fusion(GO:0031338)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 29.5 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.8 18.9 GO:0042627 chylomicron(GO:0042627)
0.7 4.7 GO:0030061 mitochondrial crista(GO:0030061)
0.6 10.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.5 4.1 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.4 1.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.4 37.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 6.7 GO:0071437 invadopodium(GO:0071437)
0.2 19.0 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.1 11.9 GO:0031594 neuromuscular junction(GO:0031594)
0.1 6.1 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 4.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 1.2 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 2.1 GO:0034451 centriolar satellite(GO:0034451)
0.1 2.1 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1 30.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 1.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 3.5 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 0.5 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.0 3.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.5 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.0 1.7 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 6.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 5.3 GO:0030426 growth cone(GO:0030426)
0.0 1.6 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.7 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 3.5 GO:0030018 Z disc(GO:0030018)
0.0 4.4 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 4.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.1 GO:0016605 PML body(GO:0016605)
0.0 1.6 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 0.9 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.6 GO:0043197 dendritic spine(GO:0043197)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.8 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
3.0 11.9 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
2.4 18.9 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
1.3 5.0 GO:0005502 11-cis retinal binding(GO:0005502)
1.2 3.5 GO:0070025 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
1.2 3.5 GO:0001861 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
1.0 6.7 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.9 4.7 GO:0070404 NADH binding(GO:0070404)
0.7 2.8 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.7 9.1 GO:0019957 C-C chemokine binding(GO:0019957)
0.7 6.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.7 12.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.6 3.0 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.5 4.7 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.4 10.3 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.4 3.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.4 18.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.4 11.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 26.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 2.4 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.3 1.8 GO:0030492 hemoglobin binding(GO:0030492)
0.3 1.6 GO:0004882 androgen receptor activity(GO:0004882)
0.2 2.2 GO:0005000 vasopressin receptor activity(GO:0005000)
0.2 3.0 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.2 2.8 GO:0005131 growth hormone receptor binding(GO:0005131)
0.2 1.4 GO:0004447 iodide peroxidase activity(GO:0004447)
0.2 0.6 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.2 29.5 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820)
0.2 2.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 0.5 GO:0032089 NACHT domain binding(GO:0032089)
0.1 1.8 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 7.6 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 3.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 2.1 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.6 GO:0052655 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 4.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 3.8 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 7.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 2.8 GO:0005504 fatty acid binding(GO:0005504)
0.1 1.5 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 1.2 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 11.7 GO:0000287 magnesium ion binding(GO:0000287)
0.0 4.1 GO:0005254 chloride channel activity(GO:0005254)
0.0 1.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 2.1 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.6 GO:0005523 tropomyosin binding(GO:0005523)
0.0 1.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0030883 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 24.1 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.2 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 11.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.3 12.1 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.3 2.8 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.2 4.5 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 28.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.7 PID ARF 3PATHWAY Arf1 pathway
0.1 6.6 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.1 3.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 3.1 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 4.2 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 7.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 2.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.0 PID IFNG PATHWAY IFN-gamma pathway
0.0 1.5 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 1.5 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 29.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.8 4.2 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.7 18.4 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.3 12.1 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 6.7 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.2 5.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 2.8 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 1.5 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.1 3.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 3.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 4.5 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 3.8 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 1.0 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 2.1 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 3.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 1.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.5 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 2.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 8.4 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 0.4 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 5.2 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 3.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.6 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 1.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway