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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ALX1_ARX

Z-value: 0.38

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Transcription factors associated with ALX1_ARX

Gene Symbol Gene ID Gene Info
ALX1
ENSG00000180318.3 ALX homeobox 1
ARX
ENSG00000004848.6 aristaless related homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ALX1hg19_v2_chr12_+_85673868_856738850.054.3e-01Click!

Activity profile of ALX1_ARX motif

Sorted Z-values of ALX1_ARX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_176733897 6.92 ENST00000393658.2
GPM6A
glycoprotein M6A
chr6_+_34204642 5.35 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr1_+_50569575 5.06 ENST00000371827.1
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr2_+_102413726 4.54 ENST00000350878.4
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr12_-_118797475 4.34 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chrX_+_119737806 3.94 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr1_+_84630645 3.78 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr10_-_75226166 3.58 ENST00000544628.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr2_-_55496174 3.51 ENST00000417363.1
ENST00000412530.1
ENST00000394600.3
ENST00000366137.2
ENST00000420637.1
MTIF2
mitochondrial translational initiation factor 2
chr18_-_21891460 3.01 ENST00000357041.4
OSBPL1A
oxysterol binding protein-like 1A
chr8_+_26150628 2.71 ENST00000523925.1
ENST00000315985.7
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr1_+_206557366 2.62 ENST00000414007.1
ENST00000419187.2
SRGAP2
SLIT-ROBO Rho GTPase activating protein 2
chr1_-_21377383 2.49 ENST00000374935.3
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr3_+_138340049 2.39 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chrX_+_107288197 2.36 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr12_+_104337515 2.18 ENST00000550595.1
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chrX_+_107288239 2.11 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr3_-_33759699 2.07 ENST00000399362.4
ENST00000359576.5
ENST00000307312.7
CLASP2
cytoplasmic linker associated protein 2
chr5_+_145826867 1.81 ENST00000296702.5
ENST00000394421.2
TCERG1
transcription elongation regulator 1
chr8_-_102803163 1.75 ENST00000523645.1
ENST00000520346.1
ENST00000220931.6
ENST00000522448.1
ENST00000522951.1
ENST00000522252.1
ENST00000519098.1
NCALD
neurocalcin delta
chr15_+_80733570 1.68 ENST00000533983.1
ENST00000527771.1
ENST00000525103.1
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr4_+_113568207 1.65 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr3_+_130569429 1.60 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr3_-_98241760 1.57 ENST00000507874.1
ENST00000502299.1
ENST00000508659.1
ENST00000510545.1
ENST00000511667.1
ENST00000394185.2
ENST00000394181.2
ENST00000508902.1
ENST00000341181.6
ENST00000437922.1
ENST00000394180.2
CLDND1
claudin domain containing 1
chr2_-_145278475 1.52 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr7_-_93520259 1.51 ENST00000222543.5
TFPI2
tissue factor pathway inhibitor 2
chr12_-_118628350 1.43 ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr2_+_75873902 1.43 ENST00000393909.2
ENST00000358788.6
ENST00000409374.1
MRPL19
mitochondrial ribosomal protein L19
chr6_-_150067696 1.43 ENST00000340413.2
ENST00000367403.3
NUP43
nucleoporin 43kDa
chr8_+_107738240 1.38 ENST00000449762.2
ENST00000297447.6
OXR1
oxidation resistance 1
chr10_+_18689637 1.34 ENST00000377315.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr3_-_141747439 1.33 ENST00000467667.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr6_-_99797522 1.31 ENST00000389677.5
FAXC
failed axon connections homolog (Drosophila)
chr5_-_134735568 1.24 ENST00000510038.1
ENST00000304332.4
H2AFY
H2A histone family, member Y
chr15_+_57511609 1.23 ENST00000543579.1
ENST00000537840.1
ENST00000343827.3
TCF12
transcription factor 12
chr5_+_36152091 1.22 ENST00000274254.5
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr7_-_93520191 1.21 ENST00000545378.1
TFPI2
tissue factor pathway inhibitor 2
chr6_-_134639180 1.20 ENST00000367858.5
SGK1
serum/glucocorticoid regulated kinase 1
chr3_-_141747950 1.18 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr4_-_100356551 1.17 ENST00000209665.4
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr3_-_130465604 1.12 ENST00000356763.3
PIK3R4
phosphoinositide-3-kinase, regulatory subunit 4
chr4_-_87028478 1.11 ENST00000515400.1
ENST00000395157.3
MAPK10
mitogen-activated protein kinase 10
chr3_+_140660743 1.09 ENST00000453248.2
SLC25A36
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36
chr16_+_24549014 1.09 ENST00000564314.1
ENST00000567686.1
RBBP6
retinoblastoma binding protein 6
chr7_+_90338712 1.06 ENST00000265741.3
ENST00000406263.1
CDK14
cyclin-dependent kinase 14
chr1_-_154600421 0.98 ENST00000368471.3
ENST00000292205.5
ADAR
adenosine deaminase, RNA-specific
chr2_-_70529180 0.97 ENST00000450256.1
ENST00000037869.3
FAM136A
family with sequence similarity 136, member A
chr21_-_43346790 0.95 ENST00000329623.7
C2CD2
C2 calcium-dependent domain containing 2
chr3_-_194188956 0.95 ENST00000256031.4
ENST00000446356.1
ATP13A3
ATPase type 13A3
chr5_-_9630463 0.89 ENST00000382492.2
TAS2R1
taste receptor, type 2, member 1
chr19_-_54619006 0.87 ENST00000391759.1
TFPT
TCF3 (E2A) fusion partner (in childhood Leukemia)
chr15_-_34331243 0.85 ENST00000306730.3
AVEN
apoptosis, caspase activation inhibitor
chr15_+_44092784 0.82 ENST00000458412.1
HYPK
huntingtin interacting protein K
chr5_+_140227048 0.82 ENST00000532602.1
PCDHA9
protocadherin alpha 9
chr3_+_138340067 0.82 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr5_+_36152163 0.81 ENST00000274255.6
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr4_-_83769996 0.79 ENST00000511338.1
SEC31A
SEC31 homolog A (S. cerevisiae)
chr8_-_91095099 0.78 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr12_-_89746173 0.77 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr3_+_140660634 0.77 ENST00000446041.2
ENST00000507429.1
ENST00000324194.6
SLC25A36
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36
chr8_-_122653630 0.73 ENST00000303924.4
HAS2
hyaluronan synthase 2
chr4_-_143227088 0.72 ENST00000511838.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr1_+_244214577 0.72 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr10_-_112064665 0.69 ENST00000369603.5
SMNDC1
survival motor neuron domain containing 1
chr9_+_42671887 0.62 ENST00000456520.1
ENST00000377391.3
CBWD7
COBW domain containing 7
chr14_-_101036119 0.62 ENST00000355173.2
BEGAIN
brain-enriched guanylate kinase-associated
chr5_+_140762268 0.62 ENST00000518325.1
PCDHGA7
protocadherin gamma subfamily A, 7
chr12_+_12878829 0.61 ENST00000326765.6
APOLD1
apolipoprotein L domain containing 1
chr6_-_41039567 0.61 ENST00000468811.1
OARD1
O-acyl-ADP-ribose deacylase 1
chr3_-_47934234 0.61 ENST00000420772.2
MAP4
microtubule-associated protein 4
chr2_-_145275228 0.59 ENST00000427902.1
ENST00000409487.3
ENST00000470879.1
ENST00000435831.1
ZEB2
zinc finger E-box binding homeobox 2
chr2_-_166930131 0.59 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr1_+_158978768 0.59 ENST00000447473.2
IFI16
interferon, gamma-inducible protein 16
chr1_-_94147385 0.58 ENST00000260502.6
BCAR3
breast cancer anti-estrogen resistance 3
chr2_+_54683419 0.58 ENST00000356805.4
SPTBN1
spectrin, beta, non-erythrocytic 1
chr2_+_58655461 0.57 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
AC007092.1
long intergenic non-protein coding RNA 1122
chr4_-_174320687 0.56 ENST00000296506.3
SCRG1
stimulator of chondrogenesis 1
chr13_-_47471155 0.51 ENST00000543956.1
ENST00000542664.1
HTR2A
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
chr7_-_14880892 0.48 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
DGKB
diacylglycerol kinase, beta 90kDa
chr3_-_164914640 0.47 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chr3_-_9291063 0.43 ENST00000383836.3
SRGAP3
SLIT-ROBO Rho GTPase activating protein 3
chr2_+_196313239 0.42 ENST00000413290.1
AC064834.1
AC064834.1
chr7_-_82792215 0.41 ENST00000333891.9
ENST00000423517.2
PCLO
piccolo presynaptic cytomatrix protein
chr1_+_158323755 0.36 ENST00000368157.1
ENST00000368156.1
ENST00000368155.3
ENST00000368154.1
ENST00000368160.3
ENST00000368161.3
CD1E
CD1e molecule
chr4_+_169013666 0.35 ENST00000359299.3
ANXA10
annexin A10
chr8_-_61880248 0.34 ENST00000525556.1
AC022182.3
AC022182.3
chr1_+_92632542 0.33 ENST00000409154.4
ENST00000370378.4
KIAA1107
KIAA1107
chr2_+_185463093 0.31 ENST00000302277.6
ZNF804A
zinc finger protein 804A
chr6_-_111804905 0.31 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr14_-_78083112 0.30 ENST00000216484.2
SPTLC2
serine palmitoyltransferase, long chain base subunit 2
chr2_+_44001172 0.29 ENST00000260605.8
ENST00000406852.3
ENST00000443170.3
ENST00000398823.2
ENST00000605786.1
DYNC2LI1
dynein, cytoplasmic 2, light intermediate chain 1
chr5_+_137203557 0.28 ENST00000515645.1
MYOT
myotilin
chr7_+_107224364 0.27 ENST00000491150.1
BCAP29
B-cell receptor-associated protein 29
chr4_-_83765613 0.27 ENST00000503937.1
SEC31A
SEC31 homolog A (S. cerevisiae)
chr17_+_68071458 0.27 ENST00000589377.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chrX_+_149887090 0.27 ENST00000538506.1
MTMR1
myotubularin related protein 1
chr1_+_104615595 0.26 ENST00000418362.1
RP11-364B6.1
RP11-364B6.1
chr8_-_62602327 0.26 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH
aspartate beta-hydroxylase
chr17_+_68071389 0.25 ENST00000283936.1
ENST00000392671.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr3_-_141747459 0.23 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr19_-_6393465 0.23 ENST00000394456.5
GTF2F1
general transcription factor IIF, polypeptide 1, 74kDa
chr2_+_161993412 0.21 ENST00000259075.2
ENST00000432002.1
TANK
TRAF family member-associated NFKB activator
chr9_+_135854091 0.20 ENST00000450530.1
ENST00000534944.1
GFI1B
growth factor independent 1B transcription repressor
chr18_-_19994830 0.20 ENST00000525417.1
CTAGE1
cutaneous T-cell lymphoma-associated antigen 1
chr8_+_38677850 0.19 ENST00000518809.1
ENST00000520611.1
TACC1
transforming, acidic coiled-coil containing protein 1
chr3_+_155860751 0.18 ENST00000471742.1
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr9_-_27005686 0.17 ENST00000380055.5
LRRC19
leucine rich repeat containing 19
chr11_+_95523621 0.16 ENST00000325542.5
ENST00000325486.5
ENST00000544522.1
ENST00000541365.1
CEP57
centrosomal protein 57kDa
chr12_-_67197760 0.15 ENST00000539540.1
ENST00000540433.1
ENST00000541947.1
ENST00000538373.1
GRIP1
glutamate receptor interacting protein 1
chr5_+_140743859 0.15 ENST00000518069.1
PCDHGA5
protocadherin gamma subfamily A, 5
chr3_-_124774802 0.14 ENST00000311127.4
HEG1
heart development protein with EGF-like domains 1
chr11_+_120973375 0.14 ENST00000264037.2
TECTA
tectorin alpha
chr4_-_100356291 0.14 ENST00000476959.1
ENST00000482593.1
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr9_+_77230499 0.13 ENST00000396204.2
RORB
RAR-related orphan receptor B
chr9_-_21202204 0.13 ENST00000239347.3
IFNA7
interferon, alpha 7
chr16_+_1728257 0.12 ENST00000248098.3
ENST00000562684.1
ENST00000561516.1
ENST00000382711.5
ENST00000566742.1
HN1L
hematological and neurological expressed 1-like
chr17_-_3030875 0.12 ENST00000328890.2
OR1G1
olfactory receptor, family 1, subfamily G, member 1
chr11_-_102709441 0.11 ENST00000434103.1
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr4_-_143226979 0.11 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr3_-_157824292 0.10 ENST00000483851.2
SHOX2
short stature homeobox 2
chr1_-_110933611 0.10 ENST00000472422.2
ENST00000437429.2
SLC16A4
solute carrier family 16, member 4
chr3_+_39424828 0.09 ENST00000273158.4
ENST00000431510.1
SLC25A38
solute carrier family 25, member 38
chr12_-_43833515 0.08 ENST00000549670.1
ENST00000395541.2
ADAMTS20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr1_+_183774240 0.07 ENST00000360851.3
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr2_+_161993465 0.05 ENST00000457476.1
TANK
TRAF family member-associated NFKB activator
chr18_-_52989525 0.05 ENST00000457482.3
TCF4
transcription factor 4
chr3_+_190105909 0.04 ENST00000456423.1
CLDN16
claudin 16
chr5_-_111312622 0.04 ENST00000395634.3
NREP
neuronal regeneration related protein
chr5_-_55412774 0.03 ENST00000434982.2
ANKRD55
ankyrin repeat domain 55
chr2_+_101437487 0.03 ENST00000427413.1
ENST00000542504.1
NPAS2
neuronal PAS domain protein 2
chr17_+_7155819 0.03 ENST00000570322.1
ENST00000576496.1
ENST00000574841.2
ELP5
elongator acetyltransferase complex subunit 5
chr6_+_26199737 0.03 ENST00000359985.1
HIST1H2BF
histone cluster 1, H2bf
chr1_+_52682052 0.03 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr5_+_137203465 0.01 ENST00000239926.4
MYOT
myotilin
chr16_+_68119247 0.01 ENST00000575270.1
NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Network of associatons between targets according to the STRING database.

First level regulatory network of ALX1_ARX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.3 GO:0090402 oncogene-induced cell senescence(GO:0090402)
1.3 3.9 GO:0002188 translation reinitiation(GO:0002188)
0.8 3.8 GO:0097338 response to clozapine(GO:0097338)
0.6 1.9 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.6 3.5 GO:0032790 ribosome disassembly(GO:0032790)
0.5 2.1 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.4 1.3 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.4 1.2 GO:1901837 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184) negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) negative regulation of protein localization to chromosome, telomeric region(GO:1904815)
0.3 1.7 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.3 1.0 GO:1900369 regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369)
0.3 3.6 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.3 1.1 GO:0030242 pexophagy(GO:0030242)
0.3 1.6 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.3 2.6 GO:0021815 modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration(GO:0021815)
0.3 2.1 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 5.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.2 1.3 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.2 4.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 0.8 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
0.2 6.9 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.2 1.2 GO:0070294 renal sodium ion absorption(GO:0070294)
0.2 2.2 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)
0.1 0.7 GO:0070295 renal water absorption(GO:0070295)
0.1 0.6 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.1 2.7 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.1 1.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 2.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 0.5 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 0.6 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.8 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.1 1.4 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 0.3 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 2.7 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.1 0.3 GO:1904504 regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.1 3.0 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.1 0.6 GO:0042118 endothelial cell activation(GO:0042118)
0.1 2.7 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 0.6 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.3 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.9 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:0045636 positive regulation of melanocyte differentiation(GO:0045636)
0.0 0.9 GO:0007635 chemosensory behavior(GO:0007635)
0.0 0.4 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 1.4 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 2.5 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.3 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.3 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.1 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.1 GO:0090270 fibroblast growth factor production(GO:0090269) regulation of fibroblast growth factor production(GO:0090270)
0.0 0.6 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 1.4 GO:0070125 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.0 0.2 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.2 GO:0060539 diaphragm development(GO:0060539)
0.0 0.1 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.6 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 1.1 GO:0061053 somite development(GO:0061053)
0.0 0.5 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.1 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 0.5 GO:0010107 potassium ion import(GO:0010107)
0.0 0.3 GO:0042276 error-prone translesion synthesis(GO:0042276)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.3 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.4 3.6 GO:0005955 calcineurin complex(GO:0005955)
0.4 1.1 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.3 1.0 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.3 6.9 GO:0044295 axonal growth cone(GO:0044295)
0.2 2.6 GO:0044327 dendritic spine head(GO:0044327)
0.2 2.1 GO:0045180 basal cortex(GO:0045180)
0.2 1.2 GO:0001740 Barr body(GO:0001740)
0.2 1.0 GO:0044530 supraspliceosomal complex(GO:0044530)
0.2 3.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.7 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 2.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 2.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 1.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.6 GO:0032437 cuticular plate(GO:0032437)
0.1 2.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.2 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 0.3 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 0.5 GO:0070852 cell body fiber(GO:0070852)
0.1 3.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.9 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.9 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.6 GO:0043194 voltage-gated sodium channel complex(GO:0001518) axon initial segment(GO:0043194)
0.0 1.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.3 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 2.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.7 GO:0045171 intercellular bridge(GO:0045171)
0.0 2.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.2 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.4 GO:0099738 cell cortex region(GO:0099738)
0.0 0.7 GO:0015030 Cajal body(GO:0015030)
0.0 0.3 GO:0035869 ciliary transition zone(GO:0035869)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.6 4.5 GO:0004111 creatine kinase activity(GO:0004111)
0.4 5.0 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.4 3.6 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.3 1.3 GO:0035276 aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
0.3 3.5 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.2 1.0 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.2 0.7 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 3.8 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.2 2.2 GO:0046790 virion binding(GO:0046790)
0.2 1.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.2 1.3 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.2 0.8 GO:0034597 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.1 2.7 GO:0048156 tau protein binding(GO:0048156)
0.1 5.1 GO:0017091 AU-rich element binding(GO:0017091)
0.1 1.2 GO:0000182 rDNA binding(GO:0000182)
0.1 1.7 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 4.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 2.5 GO:0000339 RNA cap binding(GO:0000339)
0.1 0.3 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.5 GO:0005499 vitamin D binding(GO:0005499)
0.1 3.0 GO:0015248 sterol transporter activity(GO:0015248)
0.1 2.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 2.1 GO:0002162 dystroglycan binding(GO:0002162)
0.1 1.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 3.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.8 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.7 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 1.2 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 1.2 GO:0035497 cAMP response element binding(GO:0035497)
0.1 6.5 GO:0005262 calcium channel activity(GO:0005262)
0.1 0.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 2.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.5 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.4 GO:0030883 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 0.6 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.4 GO:0005522 profilin binding(GO:0005522)
0.0 0.6 GO:0030506 ankyrin binding(GO:0030506)
0.0 1.5 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 1.0 GO:0030332 cyclin binding(GO:0030332)
0.0 0.2 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.8 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 0.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 1.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.6 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 4.7 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 4.5 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 3.8 PID IL3 PATHWAY IL3-mediated signaling events
0.1 5.3 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 2.9 PID FOXO PATHWAY FoxO family signaling
0.0 3.2 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.7 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 2.7 PID E2F PATHWAY E2F transcription factor network
0.0 1.2 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 2.2 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.3 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2 1.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 2.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 3.8 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.9 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 0.8 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 3.0 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 4.4 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 1.7 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 3.1 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 3.9 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.5 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.7 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.9 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.5 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 2.7 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.6 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.7 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 1.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling