ISMARA results: ARNT

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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ARNT

Z-value: 3.04

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Transcription factors associated with ARNT

Gene Symbol	Gene ID	Gene Info
ARNT Ensembl NCBI GeneCards UniProt NextProt	ENSG00000143437.16	aryl hydrocarbon receptor nuclear translocator

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ARNT	hg19_v2_chr1_-_150849047_150849085, hg19_v2_chr1_-_150849174_150849200	-0.34	2.5e-07	Click!

Activity profile of ARNT motif

Sorted Z-values of ARNT motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chrX_+_77359671 Show fit	113.67	ENST00000373316.4	PGK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	phosphoglycerate kinase 1
chrX_+_77359726 Show fit	110.68	ENST00000442431.1	PGK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	phosphoglycerate kinase 1
chr11_-_64014379 Show fit	102.48	ENST00000309318.3	PPP1R14B Ensembl NCBI GeneCards UniProt NextProt Show fit	protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_-_8939265 Show fit	94.11	ENST00000489867.1	ENO1 Ensembl NCBI GeneCards UniProt NextProt Show fit	enolase 1, (alpha)
chr2_-_10587897 Show fit	86.02	ENST00000405333.1 ENST00000443218.1	ODC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ornithine decarboxylase 1
chrX_+_23685653 Show fit	78.85	ENST00000379331.3	PRDX4 Ensembl NCBI GeneCards UniProt NextProt Show fit	peroxiredoxin 4
chrX_+_23685563 Show fit	69.12	ENST00000379341.4	PRDX4 Ensembl NCBI GeneCards UniProt NextProt Show fit	peroxiredoxin 4
chr17_-_47492164 Show fit	64.01	ENST00000512041.2 ENST00000446735.1 ENST00000504124.1	PHB Ensembl NCBI GeneCards UniProt NextProt Show fit	prohibitin
chr3_-_195808980 Show fit	59.39	ENST00000360110.4	TFRC Ensembl NCBI GeneCards UniProt NextProt Show fit	transferrin receptor
chr19_+_50180507 Show fit	59.12	ENST00000454376.2 ENST00000524771.1	PRMT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	protein arginine methyltransferase 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ARNT

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.7	224.4	GO:0031639	plasminogen activation(GO:0031639)
25.5	153.3	GO:0046985	positive regulation of hemoglobin biosynthetic process(GO:0046985)
10.2	152.9	GO:0006089	lactate metabolic process(GO:0006089)
29.6	148.0	GO:2000255	negative regulation of male germ cell proliferation(GO:2000255)
20.9	146.3	GO:0010756	positive regulation of plasminogen activation(GO:0010756)
1.7	138.6	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
6.2	117.0	GO:0045780	positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
1.1	102.5	GO:0002181	cytoplasmic translation(GO:0002181)
5.3	101.1	GO:0032802	low-density lipoprotein particle receptor catabolic process(GO:0032802)
19.9	99.7	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)

Showing 1 to 10 of 240 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	506.1	GO:0070062	extracellular exosome(GO:0070062)
0.2	174.4	GO:0005730	nucleolus(GO:0005730)
3.9	170.0	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
9.3	167.5	GO:0034709	methylosome(GO:0034709)
0.7	135.4	GO:1904813	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
20.7	124.2	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.6	119.7	GO:0043209	myelin sheath(GO:0043209)
0.3	119.2	GO:0045121	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
9.0	117.0	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
4.3	106.3	GO:0070971	endoplasmic reticulum exit site(GO:0070971)

Showing 1 to 10 of 128 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	278.3	GO:0003723	RNA binding(GO:0003723)
74.8	224.4	GO:0004618	phosphoglycerate kinase activity(GO:0004618)
0.9	179.6	GO:0003735	structural constituent of ribosome(GO:0003735)
25.9	155.2	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
18.5	148.0	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
3.0	142.6	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
3.1	126.7	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
2.7	124.6	GO:0003785	actin monomer binding(GO:0003785)
20.7	124.2	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
2.3	119.9	GO:0016831	carboxy-lyase activity(GO:0016831)

Showing 1 to 10 of 186 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.4	644.9	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
3.2	246.8	PID ILK PATHWAY	Integrin-linked kinase signaling
1.8	198.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
6.1	109.2	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
4.4	105.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
1.7	95.7	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.5	91.0	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
1.1	74.9	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.3	68.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.3	63.8	PID PLK1 PATHWAY	PLK1 signaling events

Showing 1 to 10 of 48 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.6	389.2	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
9.9	168.4	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.8	150.8	REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	Genes involved in 3' -UTR-mediated translational regulation
2.3	143.4	REACTOME G1 PHASE	Genes involved in G1 Phase
1.5	136.4	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
3.7	117.0	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
3.0	102.1	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
2.0	100.3	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
5.1	92.7	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
2.0	88.8	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing

Showing 1 to 10 of 78 entries

Results for ARNT

Z-value: 3.04

Motif logo

Transcription factors associated with ARNT

Activity-expression correlation:

Activity profile of ARNT motif

Sorted Z-values of ARNT motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ARNT

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: