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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ATF4
Z-value: 1.41
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Transcription factors associated with ATF4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF4 | hg19_v2_chr22_+_39916558_39916579 | 0.65 | 3.4e-27 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.8 | 110.6 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 17.6 | 52.8 | GO:0006435 | threonyl-tRNA aminoacylation(GO:0006435) |
| 9.3 | 46.6 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 9.2 | 36.9 | GO:0036229 | glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803) |
| 5.9 | 35.4 | GO:0055129 | proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129) |
| 3.7 | 29.7 | GO:2000825 | positive regulation of androgen receptor activity(GO:2000825) |
| 9.7 | 29.0 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
| 6.7 | 26.9 | GO:0015965 | diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966) |
| 0.9 | 25.9 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 3.1 | 24.6 | GO:0006116 | NADH oxidation(GO:0006116) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.8 | 110.6 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 71.7 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.1 | 70.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 46.1 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 1.6 | 30.2 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.1 | 29.7 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.1 | 28.7 | GO:0005840 | ribosome(GO:0005840) |
| 0.1 | 23.3 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.3 | 21.8 | GO:0015030 | Cajal body(GO:0015030) |
| 0.3 | 17.9 | GO:0031201 | SNARE complex(GO:0031201) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.8 | 110.6 | GO:0008732 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 17.6 | 52.8 | GO:0004829 | threonine-tRNA ligase activity(GO:0004829) |
| 9.3 | 46.6 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 5.3 | 36.9 | GO:0015186 | L-glutamine transmembrane transporter activity(GO:0015186) |
| 8.8 | 35.4 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 9.7 | 29.0 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
| 1.7 | 26.9 | GO:0004551 | nucleotide diphosphatase activity(GO:0004551) |
| 1.3 | 25.9 | GO:0005283 | sodium:amino acid symporter activity(GO:0005283) |
| 0.3 | 25.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 8.2 | 24.6 | GO:0004611 | phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 29.0 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.2 | 24.6 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.5 | 23.6 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 9.0 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 8.1 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.2 | 6.4 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 5.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 3.7 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 3.2 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.9 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.7 | 205.2 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 1.7 | 70.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 2.2 | 62.9 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.8 | 48.1 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.2 | 21.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 16.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.4 | 12.9 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.7 | 9.1 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 6.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 5.4 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |