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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CCACAGG

Z-value: 0.30

Motif logo

miRNA associated with seed CCACAGG

NamemiRBASE accession

Activity profile of CCACAGG motif

Sorted Z-values of CCACAGG motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_96811170 1.59 ENST00000288943.4
dual specificity phosphatase 2
chr10_+_11206925 1.40 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CUGBP, Elav-like family member 2
chr3_-_18466787 1.35 ENST00000338745.6
ENST00000450898.1
SATB homeobox 1
chr16_+_50775948 1.03 ENST00000569681.1
ENST00000569418.1
ENST00000540145.1
cylindromatosis (turban tumor syndrome)
chr19_+_19322758 0.92 ENST00000252575.6
neurocan
chr2_-_136873735 0.92 ENST00000409817.1
chemokine (C-X-C motif) receptor 4
chr20_+_10199468 0.92 ENST00000254976.2
ENST00000304886.2
synaptosomal-associated protein, 25kDa
chr1_-_65432171 0.90 ENST00000342505.4
Janus kinase 1
chr4_-_174320687 0.84 ENST00000296506.3
stimulator of chondrogenesis 1
chr17_+_38296576 0.78 ENST00000264645.7
cancer susceptibility candidate 3
chr3_+_49591881 0.76 ENST00000296452.4
bassoon presynaptic cytomatrix protein
chr17_-_62502639 0.76 ENST00000225792.5
ENST00000581697.1
ENST00000584279.1
ENST00000577922.1
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr10_+_111767720 0.76 ENST00000356080.4
ENST00000277900.8
adducin 3 (gamma)
chr4_+_47033345 0.76 ENST00000295454.3
gamma-aminobutyric acid (GABA) A receptor, beta 1
chr19_-_47616992 0.73 ENST00000253048.5
zinc finger CCCH-type containing 4
chr10_-_75634260 0.73 ENST00000372765.1
ENST00000351293.3
calcium/calmodulin-dependent protein kinase II gamma
chr20_-_50384864 0.72 ENST00000311637.5
ENST00000402822.1
ATPase, class II, type 9A
chr12_+_74931551 0.69 ENST00000519948.2
ataxin 7-like 3B
chr7_-_139876812 0.68 ENST00000397560.2
lysine (K)-specific demethylase 7A
chr10_+_111967345 0.64 ENST00000332674.5
ENST00000453116.1
MAX interactor 1, dimerization protein
chr3_-_57199397 0.60 ENST00000296318.7
interleukin 17 receptor D
chr15_+_64443905 0.58 ENST00000325881.4
sorting nexin 22
chr3_-_170303845 0.58 ENST00000231706.5
solute carrier family 7, member 14
chr8_-_98290087 0.57 ENST00000322128.3
TSPY-like 5
chr11_+_119076745 0.57 ENST00000264033.4
Cbl proto-oncogene, E3 ubiquitin protein ligase
chr2_-_43453734 0.57 ENST00000282388.3
ZFP36 ring finger protein-like 2
chr10_+_63661053 0.57 ENST00000279873.7
AT rich interactive domain 5B (MRF1-like)
chr17_+_61699766 0.56 ENST00000579585.1
ENST00000584573.1
ENST00000361733.3
ENST00000361357.3
mitogen-activated protein kinase kinase kinase 3
chr1_-_32801825 0.55 ENST00000329421.7
MARCKS-like 1
chr11_+_35684288 0.54 ENST00000299413.5
tripartite motif containing 44
chrX_+_23352133 0.52 ENST00000379361.4
patched domain containing 1
chr6_-_116601044 0.51 ENST00000368608.3
TSPY-like 1
chr5_-_175964366 0.49 ENST00000274811.4
ring finger protein 44
chr3_-_114790179 0.49 ENST00000462705.1
zinc finger and BTB domain containing 20
chr10_-_75571341 0.49 ENST00000309979.6
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
chr1_+_10271674 0.48 ENST00000377086.1
kinesin family member 1B
chr5_+_67511524 0.48 ENST00000521381.1
ENST00000521657.1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr5_+_152870106 0.47 ENST00000285900.5
glutamate receptor, ionotropic, AMPA 1
chr15_+_80696666 0.47 ENST00000303329.4
aryl-hydrocarbon receptor nuclear translocator 2
chr1_-_230561475 0.47 ENST00000391860.1
piggyBac transposable element derived 5
chr10_-_23003460 0.47 ENST00000376573.4
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr18_-_53255766 0.46 ENST00000566286.1
ENST00000564999.1
ENST00000566279.1
ENST00000354452.3
ENST00000356073.4
transcription factor 4
chr1_+_118148556 0.46 ENST00000369448.3
family with sequence similarity 46, member C
chr12_-_49393092 0.45 ENST00000421952.2
dendrin
chr17_-_40897043 0.45 ENST00000428826.2
ENST00000592492.1
ENST00000585893.1
ENST00000593214.1
ENST00000590078.1
ENST00000586382.1
ENST00000415827.2
ENST00000592743.1
ENST00000586089.1
ENST00000435174.1
enhancer of zeste homolog 1 (Drosophila)
chr7_+_94139105 0.44 ENST00000297273.4
CAS1 domain containing 1
chr8_+_38614807 0.43 ENST00000330691.6
ENST00000348567.4
transforming, acidic coiled-coil containing protein 1
chr3_-_50374869 0.43 ENST00000327761.3
Ras association (RalGDS/AF-6) domain family member 1
chr1_+_52870227 0.41 ENST00000257181.9
pre-mRNA processing factor 38A
chr9_+_82186872 0.41 ENST00000376544.3
ENST00000376520.4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr3_-_49907323 0.39 ENST00000296471.7
ENST00000488336.1
ENST00000467248.1
ENST00000466940.1
ENST00000463537.1
ENST00000480398.2
CaM kinase-like vesicle-associated
chr6_+_35265586 0.39 ENST00000542066.1
ENST00000316637.5
differentially expressed in FDCP 6 homolog (mouse)
chr9_-_131592058 0.38 ENST00000361256.5
chromosome 9 open reading frame 114
chr10_-_126432619 0.38 ENST00000337318.3
family with sequence similarity 53, member B
chr6_-_53213780 0.38 ENST00000304434.6
ENST00000370918.4
ELOVL fatty acid elongase 5
chr3_-_66551351 0.38 ENST00000273261.3
leucine-rich repeats and immunoglobulin-like domains 1
chr10_+_99344104 0.37 ENST00000555577.1
ENST00000370649.3
phosphatidylinositol 4-kinase type 2 alpha
Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein
chr4_-_90758227 0.37 ENST00000506691.1
ENST00000394986.1
ENST00000506244.1
ENST00000394989.2
ENST00000394991.3
synuclein, alpha (non A4 component of amyloid precursor)
chr2_-_2334888 0.37 ENST00000428368.2
ENST00000399161.2
myelin transcription factor 1-like
chr1_+_16010779 0.35 ENST00000375799.3
ENST00000375793.2
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr12_+_121837844 0.34 ENST00000361234.5
ring finger protein 34, E3 ubiquitin protein ligase
chr19_-_14316980 0.33 ENST00000361434.3
ENST00000340736.6
latrophilin 1
chr17_+_73452545 0.33 ENST00000314256.7
KIAA0195
chr9_+_37753795 0.32 ENST00000377753.2
ENST00000537911.1
ENST00000377754.2
ENST00000297994.3
tRNA methyltransferase 10 homolog B (S. cerevisiae)
chr7_+_65338230 0.31 ENST00000360768.3
vitamin K epoxide reductase complex, subunit 1-like 1
chr10_+_57358750 0.30 ENST00000512524.2
MT-RNR2-like 5
chr1_+_203595903 0.30 ENST00000367218.3
ENST00000367219.3
ENST00000391954.2
ATPase, Ca++ transporting, plasma membrane 4
chr17_+_47865917 0.30 ENST00000259021.4
ENST00000454930.2
ENST00000509773.1
ENST00000510819.1
ENST00000424009.2
K(lysine) acetyltransferase 7
chr20_-_43280361 0.30 ENST00000372874.4
adenosine deaminase
chr14_+_70078303 0.29 ENST00000342745.4
KIAA0247
chr12_-_42538657 0.28 ENST00000398675.3
glucoside xylosyltransferase 1
chr14_+_23776024 0.27 ENST00000553781.1
ENST00000556100.1
ENST00000557236.1
ENST00000557579.1
BCL2L2-PABPN1 readthrough
BCL2-like 2
chr7_+_106809406 0.27 ENST00000468410.1
ENST00000478930.1
ENST00000464009.1
ENST00000222574.4
HMG-box transcription factor 1
chr3_-_72496035 0.27 ENST00000477973.2
RING1 and YY1 binding protein
chr16_+_22825475 0.26 ENST00000261374.3
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr16_+_11038345 0.26 ENST00000409790.1
C-type lectin domain family 16, member A
chr12_+_94542459 0.25 ENST00000258526.4
plexin C1
chr16_+_31085714 0.25 ENST00000300850.5
ENST00000564189.1
ENST00000428260.1
zinc finger protein 646
chrX_-_137793826 0.25 ENST00000315930.6
fibroblast growth factor 13
chr3_-_52312636 0.24 ENST00000296490.3
WD repeat domain 82
chr14_+_65171099 0.24 ENST00000247226.7
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr1_-_16678914 0.24 ENST00000375592.3
F-box protein 42
chr4_-_83350580 0.24 ENST00000349655.4
ENST00000602300.1
heterogeneous nuclear ribonucleoprotein D-like
chr17_+_61851157 0.23 ENST00000578681.1
ENST00000583590.1
DEAD (Asp-Glu-Ala-Asp) box helicase 42
chr5_+_61602055 0.22 ENST00000381103.2
kinesin heavy chain member 2A
chr22_+_21271714 0.22 ENST00000354336.3
v-crk avian sarcoma virus CT10 oncogene homolog-like
chr5_+_112312416 0.22 ENST00000389063.2
decapping mRNA 2
chr1_+_60280458 0.21 ENST00000455990.1
ENST00000371208.3
hook microtubule-tethering protein 1
chr11_-_130786400 0.21 ENST00000265909.4
sorting nexin 19
chr6_+_126112001 0.21 ENST00000392477.2
nuclear receptor coactivator 7
chr6_-_34113856 0.21 ENST00000538487.2
glutamate receptor, metabotropic 4
chr17_+_7452189 0.21 ENST00000293825.6
tumor necrosis factor (ligand) superfamily, member 12
chr10_+_76871454 0.21 ENST00000372687.4
sterile alpha motif domain containing 8
chr1_+_12290121 0.21 ENST00000358136.3
ENST00000356315.4
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr19_-_11591848 0.21 ENST00000359227.3
ELAV like neuron-specific RNA binding protein 3
chr1_-_92351769 0.21 ENST00000212355.4
transforming growth factor, beta receptor III
chr1_+_40505891 0.20 ENST00000372797.3
ENST00000372802.1
ENST00000449311.1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr14_+_23790655 0.20 ENST00000397276.2
poly(A) binding protein, nuclear 1
chr16_+_2587998 0.20 ENST00000441549.3
ENST00000268673.7
3-phosphoinositide dependent protein kinase-1
chr3_+_5229356 0.20 ENST00000256497.4
ER degradation enhancer, mannosidase alpha-like 1
chr12_-_90049828 0.20 ENST00000261173.2
ENST00000348959.3
ATPase, Ca++ transporting, plasma membrane 1
chr17_-_4167142 0.19 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ankyrin repeat and FYVE domain containing 1
chr1_+_43855560 0.19 ENST00000562955.1
seizure threshold 2 homolog (mouse)
chr7_-_138666053 0.19 ENST00000440172.1
ENST00000422774.1
KIAA1549
chr19_-_19739007 0.19 ENST00000586703.1
ENST00000591042.1
ENST00000407877.3
lysophosphatidic acid receptor 2
chr9_+_133884469 0.19 ENST00000361069.4
laminin, gamma 3
chr5_-_180242534 0.19 ENST00000333055.3
ENST00000513431.1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr16_+_30968615 0.19 ENST00000262519.8
SET domain containing 1A
chr22_-_38669030 0.18 ENST00000361906.3
transmembrane protein 184B
chr15_+_41851211 0.18 ENST00000263798.3
TYRO3 protein tyrosine kinase
chr2_-_232329186 0.18 ENST00000322723.4
nucleolin
chr14_+_71108460 0.18 ENST00000256367.2
tetratricopeptide repeat domain 9
chr22_+_39853258 0.18 ENST00000341184.6
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr19_-_14629224 0.18 ENST00000254322.2
DnaJ (Hsp40) homolog, subfamily B, member 1
chr7_+_100136811 0.18 ENST00000300176.4
ENST00000262935.4
ArfGAP with FG repeats 2
chr3_-_119813264 0.17 ENST00000264235.8
glycogen synthase kinase 3 beta
chr1_+_11072696 0.17 ENST00000240185.3
ENST00000476201.1
TAR DNA binding protein
chr8_-_101734907 0.17 ENST00000318607.5
ENST00000521865.1
ENST00000520804.1
ENST00000522720.1
ENST00000521067.1
poly(A) binding protein, cytoplasmic 1
chr12_+_69004619 0.17 ENST00000250559.9
ENST00000393436.5
ENST00000425247.2
ENST00000489473.2
ENST00000422358.2
ENST00000541167.1
ENST00000538283.1
ENST00000341355.5
ENST00000537460.1
ENST00000450214.2
ENST00000545270.1
ENST00000538980.1
ENST00000542018.1
ENST00000543393.1
RAP1B, member of RAS oncogene family
chr5_+_138629417 0.17 ENST00000510056.1
ENST00000511249.1
ENST00000503811.1
ENST00000511378.1
matrin 3
chr14_-_77279153 0.16 ENST00000251089.2
angel homolog 1 (Drosophila)
chr18_+_9136758 0.16 ENST00000383440.2
ENST00000262126.4
ENST00000577992.1
ankyrin repeat domain 12
chr2_+_71558858 0.16 ENST00000437658.2
ENST00000355812.3
ENST00000377802.2
ENST00000264447.4
ENST00000409544.1
ENST00000455226.1
ENST00000454278.1
ENST00000417778.1
ENST00000454122.1
zinc finger protein 638
chr5_+_149109825 0.16 ENST00000360453.4
ENST00000394320.3
ENST00000309241.5
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr1_-_21671968 0.16 ENST00000415912.2
endothelin converting enzyme 1
chr1_-_110284384 0.16 ENST00000540225.1
glutathione S-transferase mu 3 (brain)
chr6_+_24495067 0.15 ENST00000357578.3
ENST00000546278.1
ENST00000491546.1
aldehyde dehydrogenase 5 family, member A1
chr2_-_239112347 0.15 ENST00000457149.1
ENST00000254654.3
integrin-linked kinase-associated serine/threonine phosphatase
chr6_-_34664612 0.15 ENST00000374023.3
ENST00000374026.3
chromosome 6 open reading frame 106
chr6_-_62996066 0.14 ENST00000281156.4
KH domain containing, RNA binding, signal transduction associated 2
chr6_-_30585009 0.14 ENST00000376511.2
protein phosphatase 1, regulatory subunit 10
chr2_-_55237484 0.14 ENST00000394609.2
reticulon 4
chr14_+_57046500 0.13 ENST00000261556.6
transmembrane protein 260
chr14_-_95786200 0.13 ENST00000298912.4
calmin (calponin-like, transmembrane)
chr17_+_1958388 0.13 ENST00000399849.3
hypermethylated in cancer 1
chr1_+_160051319 0.13 ENST00000368088.3
potassium inwardly-rectifying channel, subfamily J, member 9
chr17_-_79885576 0.13 ENST00000574686.1
ENST00000357736.4
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
chr5_+_102594403 0.12 ENST00000319933.2
chromosome 5 open reading frame 30
chr20_-_4982132 0.12 ENST00000338244.1
ENST00000424750.2
solute carrier family 23 (ascorbic acid transporter), member 2
chr2_-_166060571 0.12 ENST00000360093.3
sodium channel, voltage-gated, type III, alpha subunit
chr12_-_117628333 0.12 ENST00000427718.2
F-box protein 21
chr17_-_39890893 0.12 ENST00000393939.2
ENST00000347901.4
ENST00000341193.5
ENST00000310778.5
huntingtin-associated protein 1
chr9_+_92219919 0.12 ENST00000252506.6
ENST00000375769.1
growth arrest and DNA-damage-inducible, gamma
chr15_+_89164520 0.12 ENST00000332810.3
apoptosis enhancing nuclease
chr14_-_21905395 0.12 ENST00000430710.3
ENST00000553283.1
chromodomain helicase DNA binding protein 8
chr13_+_111365602 0.11 ENST00000333219.7
inhibitor of growth family, member 1
chr9_-_33264676 0.11 ENST00000472232.3
ENST00000379704.2
BCL2-associated athanogene
chr15_+_77712993 0.11 ENST00000336216.4
ENST00000381714.3
ENST00000558651.1
high mobility group 20A
chr9_-_95432536 0.11 ENST00000287996.3
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
chr17_-_42298331 0.11 ENST00000343638.5
upstream binding transcription factor, RNA polymerase I
chr8_-_101965146 0.11 ENST00000395957.2
ENST00000395948.2
ENST00000457309.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr7_-_26240357 0.11 ENST00000354667.4
ENST00000356674.7
heterogeneous nuclear ribonucleoprotein A2/B1
chr22_-_42466782 0.11 ENST00000396398.3
ENST00000403363.1
ENST00000402937.1
N-acetylgalactosaminidase, alpha-
chr19_-_18632861 0.10 ENST00000262809.4
elongation factor RNA polymerase II
chr2_+_113033164 0.10 ENST00000409871.1
ENST00000343936.4
zinc finger CCCH-type containing 6
chr12_+_62654119 0.10 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
ubiquitin specific peptidase 15
chr11_-_36531774 0.10 ENST00000348124.5
ENST00000526995.1
TNF receptor-associated factor 6, E3 ubiquitin protein ligase
chr19_-_49140692 0.10 ENST00000222122.5
D site of albumin promoter (albumin D-box) binding protein
chr5_+_140044261 0.10 ENST00000358337.5
WD repeat domain 55
chr16_+_68298405 0.10 ENST00000219343.6
ENST00000566834.1
ENST00000566454.1
solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
chr12_+_56367697 0.09 ENST00000553116.1
ENST00000360299.5
ENST00000548068.1
ENST00000549915.1
ENST00000551459.1
ENST00000448789.2
RAB5B, member RAS oncogene family
chr14_-_77843390 0.09 ENST00000216468.7
transmembrane emp24 protein transport domain containing 8
chr9_-_20622478 0.09 ENST00000355930.6
ENST00000380338.4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr1_+_26485511 0.09 ENST00000374268.3
family with sequence similarity 110, member D
chr14_-_20020272 0.09 ENST00000551509.1
POTE ankyrin domain family, member M
chr5_+_154092396 0.09 ENST00000336314.4
La ribonucleoprotein domain family, member 1
chr11_+_129939779 0.09 ENST00000533195.1
ENST00000533713.1
ENST00000528499.1
ENST00000539648.1
ENST00000263574.5
amyloid beta (A4) precursor-like protein 2
chr1_-_151319710 0.09 ENST00000290524.4
ENST00000437327.1
ENST00000452513.2
ENST00000368870.2
ENST00000452671.2
regulatory factor X, 5 (influences HLA class II expression)
chr14_-_77787198 0.09 ENST00000261534.4
protein-O-mannosyltransferase 2
chr9_-_27529726 0.09 ENST00000262244.5
MOB kinase activator 3B
chr16_+_70332956 0.09 ENST00000288071.6
ENST00000393657.2
ENST00000355992.3
ENST00000567706.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
Uncharacterized protein
chr16_+_23652700 0.09 ENST00000300087.2
dynactin 5 (p25)
chr15_+_51200859 0.08 ENST00000261842.5
adaptor-related protein complex 4, epsilon 1 subunit
chr18_-_31803435 0.08 ENST00000589544.1
ENST00000269185.4
ENST00000261592.5
nucleolar protein 4
chr12_+_57943781 0.08 ENST00000455537.2
ENST00000286452.5
kinesin family member 5A
chr12_-_49110613 0.07 ENST00000261900.3
cyclin T1
chr15_+_91473403 0.07 ENST00000394275.2
unc-45 homolog A (C. elegans)
chrX_+_100474711 0.07 ENST00000402866.1
dystrophin related protein 2
chr19_-_46000251 0.07 ENST00000590526.1
ENST00000344680.4
ENST00000245923.4
reticulon 2
chr1_-_151300160 0.07 ENST00000368874.4
phosphatidylinositol 4-kinase, catalytic, beta
chr10_+_99400443 0.07 ENST00000370631.3
phosphatidylinositol 4-kinase type 2 alpha
chr2_-_166930131 0.07 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
sodium channel, voltage-gated, type I, alpha subunit
chrX_+_30671476 0.07 ENST00000378946.3
ENST00000378943.3
ENST00000378945.3
ENST00000427190.1
ENST00000378941.3
glycerol kinase
chr6_-_111804393 0.06 ENST00000368802.3
ENST00000368805.1
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr6_+_87865262 0.06 ENST00000369577.3
ENST00000518845.1
ENST00000339907.4
ENST00000496806.2
zinc finger protein 292
chr19_+_34745442 0.06 ENST00000299505.6
ENST00000588470.1
ENST00000589583.1
ENST00000588338.2
KIAA0355
chr14_+_19553365 0.06 ENST00000409832.3
POTE ankyrin domain family, member G
chr11_+_118754475 0.05 ENST00000292174.4
chemokine (C-X-C motif) receptor 5
chr1_-_109940550 0.05 ENST00000256637.6
sortilin 1
chr12_-_82153087 0.05 ENST00000547623.1
ENST00000549396.1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr11_-_62494821 0.05 ENST00000301785.5
heterogeneous nuclear ribonucleoprotein U-like 2
chr17_-_43568062 0.05 ENST00000421073.2
ENST00000584420.1
ENST00000589780.1
ENST00000430334.3
pleckstrin homology domain containing, family M (with RUN domain) member 1
chr1_-_114355083 0.04 ENST00000261441.5
round spermatid basic protein 1
chr5_-_137090028 0.04 ENST00000314940.4
heterogeneous nuclear ribonucleoprotein A0
chr2_+_45878790 0.04 ENST00000306156.3
protein kinase C, epsilon
chr16_-_18937726 0.04 ENST00000389467.3
ENST00000446231.2
SMG1 phosphatidylinositol 3-kinase-related kinase
chr3_-_178790057 0.04 ENST00000311417.2
zinc finger, matrin-type 3
chr5_-_39425068 0.04 ENST00000515700.1
ENST00000339788.6
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr5_+_32788945 0.04 ENST00000326958.1
AC026703.1
chrX_+_128872998 0.03 ENST00000371106.3
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound

Network of associatons between targets according to the STRING database.

First level regulatory network of CCACAGG

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:1990108 protein linear deubiquitination(GO:1990108)
0.2 0.9 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.2 0.5 GO:1904647 response to rotenone(GO:1904647)
0.1 0.4 GO:0002276 basophil activation involved in immune response(GO:0002276)
0.1 0.9 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.1 0.9 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.1 0.4 GO:0032474 otolith morphogenesis(GO:0032474)
0.1 0.3 GO:2000374 regulation of oxygen metabolic process(GO:2000374)
0.1 0.3 GO:1900081 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.1 0.3 GO:0046102 hypoxanthine salvage(GO:0043103) inosine metabolic process(GO:0046102)
0.1 1.4 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 0.6 GO:1904628 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.1 0.4 GO:0051621 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470)
0.1 0.3 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 0.2 GO:1990502 dense core granule maturation(GO:1990502)
0.1 0.8 GO:0008298 intracellular mRNA localization(GO:0008298)
0.1 0.3 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.1 0.2 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.1 0.2 GO:1904245 regulation of polynucleotide adenylyltransferase activity(GO:1904245) positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.1 0.5 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 0.2 GO:0071109 superior temporal gyrus development(GO:0071109)
0.1 0.9 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 0.5 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.1 0.3 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.1 0.3 GO:1990834 response to odorant(GO:1990834)
0.1 0.2 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.0 0.2 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.3 GO:0090650 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.0 0.3 GO:1901098 regulation of autophagosome maturation(GO:1901096) positive regulation of autophagosome maturation(GO:1901098)
0.0 0.1 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.0 1.4 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.2 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.2 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.3 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 1.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.7 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.0 0.9 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.7 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.2 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.0 0.5 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.2 GO:1901668 regulation of superoxide dismutase activity(GO:1901668) negative regulation of TORC1 signaling(GO:1904262)
0.0 0.5 GO:0021794 thalamus development(GO:0021794)
0.0 0.2 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.2 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.2 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.0 0.3 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 0.1 GO:1901355 response to rapamycin(GO:1901355)
0.0 0.2 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0 0.2 GO:0006540 glutamate decarboxylation to succinate(GO:0006540) gamma-aminobutyric acid catabolic process(GO:0009450)
0.0 0.1 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.1 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.0 0.6 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 0.1 GO:1902659 regulation of glucose mediated signaling pathway(GO:1902659)
0.0 0.1 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.0 0.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.2 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 0.4 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.0 0.2 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.0 GO:1901535 regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536)
0.0 0.2 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.0 0.4 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.0 0.6 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.0 0.2 GO:0030210 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 0.2 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.1 GO:1904100 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.0 0.1 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.1 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.2 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0 0.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.6 GO:0016577 histone demethylation(GO:0016577)
0.0 0.1 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.3 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.0 0.1 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.0 0.2 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0045945 positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.0 0.4 GO:0048665 neuron fate specification(GO:0048665)
0.0 0.6 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.4 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 0.3 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.1 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.1 GO:1900016 negative regulation of cytokine production involved in inflammatory response(GO:1900016)
0.0 0.3 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 0.8 GO:0035418 protein localization to synapse(GO:0035418)
0.0 0.2 GO:0010608 posttranscriptional regulation of gene expression(GO:0010608)
0.0 0.4 GO:0035411 catenin import into nucleus(GO:0035411)
0.0 0.7 GO:0003333 amino acid transmembrane transport(GO:0003333)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 0.4 GO:0097447 dendritic tree(GO:0097447)
0.1 0.5 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 0.4 GO:0035838 growing cell tip(GO:0035838)
0.1 0.5 GO:0044308 axonal spine(GO:0044308)
0.1 0.2 GO:0070695 FHF complex(GO:0070695)
0.1 0.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.6 GO:0016600 flotillin complex(GO:0016600)
0.0 0.2 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.2 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.4 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726) interchromatin granule(GO:0035061)
0.0 0.6 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.8 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.2 GO:1990130 Iml1 complex(GO:1990130)
0.0 1.2 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.8 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.0 GO:0097542 ciliary tip(GO:0097542)
0.0 0.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.5 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.8 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.4 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.3 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.0 GO:0043159 perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150) acrosomal matrix(GO:0043159)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.2 0.5 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 0.8 GO:0035500 MH2 domain binding(GO:0035500)
0.1 0.4 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.1 1.1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 1.0 GO:1990380 Lys63-specific deubiquitinase activity(GO:0061578) Lys48-specific deubiquitinase activity(GO:1990380)
0.1 0.3 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.1 0.9 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 1.0 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.1 0.6 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 0.3 GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.1 0.8 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.1 0.4 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.1 0.2 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.2 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.1 0.5 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.3 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.1 0.7 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.2 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.0 0.2 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.3 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.1 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.0 0.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.3 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 1.5 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.3 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.0 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.2 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.3 GO:0051400 BH domain binding(GO:0051400)
0.0 0.9 GO:0019894 kinesin binding(GO:0019894)
0.0 0.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.0 0.6 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.1 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.4 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.2 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.3 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.0 GO:0035276 ethanol binding(GO:0035276)
0.0 0.1 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.1 GO:0015925 galactosidase activity(GO:0015925)
0.0 0.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.5 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 2.1 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.1 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.9 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.6 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.4 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.6 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.1 1.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 0.9 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.9 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.0 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.4 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.5 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 1.3 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.6 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.8 REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism
0.0 0.4 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.1 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.2 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)