Project
averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CCAGUGU
Z-value: 0.68
Motif logo
miRNA associated with seed CCAGUGU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-199a-5p
|
MIMAT0000231 |
|
hsa-miR-199b-5p
|
MIMAT0000263 |
Activity profile of CCAGUGU motif
Sorted Z-values of CCAGUGU motif
Network of associatons between targets according to the STRING database.
First level regulatory network of CCAGUGU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 8.1 | GO:1900085 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 2.1 | 6.2 | GO:0021589 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
| 1.9 | 7.7 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) |
| 1.7 | 5.0 | GO:2000097 | chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 1.7 | 6.7 | GO:0035905 | ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) |
| 1.6 | 4.9 | GO:0051295 | establishment of meiotic spindle localization(GO:0051295) |
| 1.4 | 5.5 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
| 1.1 | 3.2 | GO:0061073 | ciliary body morphogenesis(GO:0061073) |
| 1.0 | 3.1 | GO:1903572 | regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572) |
| 0.9 | 2.8 | GO:0006738 | nicotinamide riboside catabolic process(GO:0006738) inosine metabolic process(GO:0046102) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638) |
| 0.8 | 2.3 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 0.8 | 2.3 | GO:0035928 | rRNA import into mitochondrion(GO:0035928) |
| 0.7 | 2.0 | GO:0048250 | mitochondrial iron ion transport(GO:0048250) |
| 0.6 | 1.8 | GO:0009447 | putrescine catabolic process(GO:0009447) |
| 0.6 | 8.2 | GO:0039532 | negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway(GO:0039532) |
| 0.6 | 9.5 | GO:0070831 | basement membrane assembly(GO:0070831) |
| 0.5 | 1.6 | GO:0038098 | sequestering of BMP from receptor via BMP binding(GO:0038098) |
| 0.5 | 0.5 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 0.5 | 2.0 | GO:0042256 | mature ribosome assembly(GO:0042256) |
| 0.5 | 2.9 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.5 | 1.5 | GO:0003383 | apical constriction(GO:0003383) |
| 0.4 | 4.0 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 0.4 | 0.8 | GO:0033632 | regulation of cell-cell adhesion mediated by integrin(GO:0033632) |
| 0.4 | 4.1 | GO:2000643 | positive regulation of early endosome to late endosome transport(GO:2000643) |
| 0.4 | 2.1 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.3 | 1.0 | GO:0060535 | trachea cartilage morphogenesis(GO:0060535) renal inner medulla development(GO:0072053) renal outer medulla development(GO:0072054) |
| 0.3 | 1.0 | GO:1902568 | positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568) |
| 0.3 | 2.0 | GO:0035672 | oligopeptide transmembrane transport(GO:0035672) |
| 0.3 | 2.0 | GO:0060613 | fat pad development(GO:0060613) |
| 0.3 | 1.0 | GO:0060448 | dichotomous subdivision of terminal units involved in lung branching(GO:0060448) |
| 0.3 | 1.5 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.3 | 3.9 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.3 | 1.1 | GO:0002408 | myeloid dendritic cell chemotaxis(GO:0002408) |
| 0.3 | 4.5 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.3 | 2.9 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
| 0.3 | 3.2 | GO:0001711 | endodermal cell fate commitment(GO:0001711) |
| 0.3 | 1.6 | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) |
| 0.3 | 1.0 | GO:0010814 | neuropeptide catabolic process(GO:0010813) substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
| 0.3 | 1.8 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.3 | 0.8 | GO:1904637 | response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) regulation of progesterone biosynthetic process(GO:2000182) |
| 0.2 | 0.5 | GO:0032489 | regulation of Cdc42 protein signal transduction(GO:0032489) |
| 0.2 | 2.1 | GO:0060686 | negative regulation of prostatic bud formation(GO:0060686) |
| 0.2 | 1.2 | GO:0090625 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.2 | 1.8 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.2 | 2.0 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.2 | 0.2 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
| 0.2 | 1.9 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.2 | 1.2 | GO:0001712 | ectodermal cell fate commitment(GO:0001712) |
| 0.2 | 1.2 | GO:1903593 | regulation of histamine secretion by mast cell(GO:1903593) |
| 0.2 | 1.0 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.2 | 3.4 | GO:0034384 | high-density lipoprotein particle clearance(GO:0034384) |
| 0.2 | 2.0 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
| 0.2 | 0.5 | GO:2001045 | closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.2 | 5.2 | GO:0000717 | nucleotide-excision repair, DNA duplex unwinding(GO:0000717) |
| 0.2 | 0.5 | GO:0030327 | prenylated protein catabolic process(GO:0030327) |
| 0.2 | 0.7 | GO:0031291 | Ran protein signal transduction(GO:0031291) |
| 0.2 | 4.0 | GO:2000637 | positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637) |
| 0.2 | 0.6 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 0.1 | 0.9 | GO:0055064 | chloride ion homeostasis(GO:0055064) |
| 0.1 | 2.6 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
| 0.1 | 1.4 | GO:0033299 | secretion of lysosomal enzymes(GO:0033299) |
| 0.1 | 0.4 | GO:1900041 | negative regulation of interleukin-2 secretion(GO:1900041) |
| 0.1 | 0.8 | GO:0003344 | pericardium morphogenesis(GO:0003344) |
| 0.1 | 0.4 | GO:0071109 | superior temporal gyrus development(GO:0071109) |
| 0.1 | 2.1 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
| 0.1 | 1.6 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.1 | 2.9 | GO:0019054 | modulation by virus of host process(GO:0019054) |
| 0.1 | 1.2 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.1 | 1.3 | GO:0060391 | positive regulation of SMAD protein import into nucleus(GO:0060391) |
| 0.1 | 2.2 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.1 | 1.0 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.1 | 1.5 | GO:0006907 | pinocytosis(GO:0006907) |
| 0.1 | 0.9 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.1 | 2.2 | GO:1990126 | retrograde transport, endosome to plasma membrane(GO:1990126) |
| 0.1 | 2.0 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.1 | 2.2 | GO:0007172 | signal complex assembly(GO:0007172) |
| 0.1 | 8.3 | GO:0048199 | vesicle targeting, to, from or within Golgi(GO:0048199) |
| 0.1 | 0.5 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.1 | 2.2 | GO:1903432 | regulation of TORC1 signaling(GO:1903432) |
| 0.1 | 0.5 | GO:0070295 | renal water absorption(GO:0070295) |
| 0.1 | 4.0 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
| 0.1 | 1.1 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.1 | 2.6 | GO:2000758 | positive regulation of peptidyl-lysine acetylation(GO:2000758) |
| 0.1 | 1.3 | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166) |
| 0.1 | 3.9 | GO:0048009 | insulin-like growth factor receptor signaling pathway(GO:0048009) |
| 0.1 | 0.5 | GO:0070862 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
| 0.1 | 0.6 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.1 | 2.2 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.1 | 0.4 | GO:0090230 | enucleate erythrocyte differentiation(GO:0043353) regulation of centromere complex assembly(GO:0090230) |
| 0.1 | 0.6 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.1 | 0.5 | GO:0009838 | abscission(GO:0009838) |
| 0.1 | 2.1 | GO:0032094 | response to food(GO:0032094) |
| 0.1 | 0.5 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.1 | 0.8 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 0.1 | 0.5 | GO:1902455 | negative regulation of stem cell population maintenance(GO:1902455) |
| 0.1 | 0.4 | GO:0090481 | pyrimidine nucleotide-sugar transmembrane transport(GO:0090481) |
| 0.1 | 1.4 | GO:0035067 | negative regulation of histone acetylation(GO:0035067) |
| 0.1 | 1.2 | GO:0033622 | integrin activation(GO:0033622) |
| 0.1 | 0.2 | GO:0061304 | retinal blood vessel morphogenesis(GO:0061304) |
| 0.0 | 1.9 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 2.2 | GO:1903959 | regulation of anion transmembrane transport(GO:1903959) |
| 0.0 | 0.5 | GO:0090151 | establishment of protein localization to mitochondrial membrane(GO:0090151) |
| 0.0 | 0.2 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) |
| 0.0 | 2.4 | GO:0031102 | neuron projection regeneration(GO:0031102) |
| 0.0 | 0.0 | GO:0035470 | positive regulation of vascular wound healing(GO:0035470) |
| 0.0 | 1.7 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
| 0.0 | 0.3 | GO:0036166 | phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239) |
| 0.0 | 0.3 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.0 | 0.9 | GO:0002643 | regulation of tolerance induction(GO:0002643) |
| 0.0 | 1.1 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
| 0.0 | 2.0 | GO:0046579 | positive regulation of Ras protein signal transduction(GO:0046579) |
| 0.0 | 0.2 | GO:0046549 | amacrine cell differentiation(GO:0035881) retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549) |
| 0.0 | 0.7 | GO:0007220 | Notch receptor processing(GO:0007220) |
| 0.0 | 0.3 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.0 | 0.2 | GO:0045617 | negative regulation of keratinocyte differentiation(GO:0045617) |
| 0.0 | 2.5 | GO:0032465 | regulation of cytokinesis(GO:0032465) |
| 0.0 | 0.9 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.0 | 0.2 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.0 | 3.1 | GO:0006446 | regulation of translational initiation(GO:0006446) |
| 0.0 | 2.0 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 1.1 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 0.0 | 3.4 | GO:0048704 | embryonic skeletal system morphogenesis(GO:0048704) |
| 0.0 | 0.4 | GO:0051775 | response to redox state(GO:0051775) |
| 0.0 | 0.1 | GO:0036484 | trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) |
| 0.0 | 0.4 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.0 | 0.2 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.0 | 1.6 | GO:0050766 | positive regulation of phagocytosis(GO:0050766) |
| 0.0 | 0.1 | GO:1900125 | regulation of hyaluronan biosynthetic process(GO:1900125) |
| 0.0 | 1.5 | GO:0043647 | inositol phosphate metabolic process(GO:0043647) |
| 0.0 | 0.1 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.0 | 0.1 | GO:0098904 | pulmonary valve formation(GO:0003193) atrial ventricular junction remodeling(GO:0003294) foramen ovale closure(GO:0035922) atrial cardiac muscle cell to AV node cell communication by electrical coupling(GO:0086044) bundle of His cell to Purkinje myocyte communication by electrical coupling(GO:0086054) Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling(GO:0086055) regulation of AV node cell action potential(GO:0098904) regulation of Purkinje myocyte action potential(GO:0098906) vasomotion(GO:1990029) |
| 0.0 | 2.4 | GO:0070268 | cornification(GO:0070268) |
| 0.0 | 0.9 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 0.4 | GO:0097237 | cellular response to toxic substance(GO:0097237) |
| 0.0 | 0.6 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 0.1 | GO:1903949 | positive regulation of cardiac conduction(GO:1903781) positive regulation of atrial cardiac muscle cell action potential(GO:1903949) positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736) |
| 0.0 | 2.0 | GO:0007266 | Rho protein signal transduction(GO:0007266) |
| 0.0 | 0.6 | GO:1901998 | toxin transport(GO:1901998) |
| 0.0 | 0.2 | GO:0016180 | snRNA processing(GO:0016180) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 9.5 | GO:0043259 | laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260) |
| 1.6 | 4.9 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.7 | 2.2 | GO:0030906 | retromer, cargo-selective complex(GO:0030906) |
| 0.7 | 5.5 | GO:0036057 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.6 | 8.1 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.6 | 5.0 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.5 | 4.1 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.5 | 1.0 | GO:1903349 | omegasome membrane(GO:1903349) |
| 0.4 | 1.2 | GO:0097422 | tubular endosome(GO:0097422) |
| 0.4 | 2.2 | GO:0034448 | EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.3 | 3.9 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) lateral loop(GO:0043219) |
| 0.3 | 6.2 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.3 | 3.2 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.3 | 5.2 | GO:0000109 | nucleotide-excision repair complex(GO:0000109) |
| 0.3 | 2.1 | GO:0031415 | NatA complex(GO:0031415) |
| 0.3 | 1.0 | GO:0031302 | intrinsic component of endosome membrane(GO:0031302) |
| 0.3 | 1.5 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.2 | 1.9 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.2 | 7.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.2 | 3.8 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.2 | 0.7 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.2 | 2.2 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.2 | 2.6 | GO:0090543 | Flemming body(GO:0090543) |
| 0.2 | 4.0 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.2 | 0.5 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 0.1 | 0.4 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 0.1 | 1.2 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.1 | 4.6 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 0.5 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.1 | 0.2 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.1 | 2.2 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.1 | 1.6 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.1 | 1.3 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.1 | 1.3 | GO:0005685 | U1 snRNP(GO:0005685) |
| 0.1 | 10.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 0.9 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.1 | 0.7 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.1 | 2.4 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 2.0 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.1 | 2.7 | GO:0090544 | BAF-type complex(GO:0090544) |
| 0.1 | 1.0 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 1.4 | GO:0030904 | retromer complex(GO:0030904) |
| 0.1 | 0.7 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.1 | 0.2 | GO:0031213 | RSF complex(GO:0031213) |
| 0.1 | 0.5 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.1 | 4.8 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 3.4 | GO:0005844 | polysome(GO:0005844) |
| 0.1 | 0.8 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 0.5 | GO:0098642 | network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) |
| 0.1 | 0.4 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.0 | 0.5 | GO:0034385 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.0 | 3.5 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 1.7 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 2.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.8 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.2 | GO:0044614 | nuclear pore cytoplasmic filaments(GO:0044614) |
| 0.0 | 4.0 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 0.6 | GO:0032059 | bleb(GO:0032059) |
| 0.0 | 1.1 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 0.1 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.0 | 0.3 | GO:0097433 | dense body(GO:0097433) |
| 0.0 | 0.7 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.0 | 0.5 | GO:0030660 | Golgi-associated vesicle membrane(GO:0030660) |
| 0.0 | 4.0 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 2.9 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 3.4 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 2.4 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.4 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 0.6 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 2.2 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.2 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 1.5 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 1.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 1.2 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 1.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 3.4 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 0.2 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 2.8 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 0.2 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.0 | 0.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 4.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.4 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.5 | GO:0016235 | aggresome(GO:0016235) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 8.1 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 1.3 | 4.0 | GO:0098626 | methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626) |
| 0.9 | 2.8 | GO:0004731 | purine-nucleoside phosphorylase activity(GO:0004731) |
| 0.7 | 2.1 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.7 | 2.0 | GO:0015235 | cobalamin transporter activity(GO:0015235) |
| 0.5 | 2.1 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.5 | 3.1 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.5 | 5.3 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.4 | 1.8 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.4 | 2.0 | GO:1990189 | peptide-serine-N-acetyltransferase activity(GO:1990189) |
| 0.4 | 2.3 | GO:0004792 | thiosulfate sulfurtransferase activity(GO:0004792) |
| 0.4 | 1.5 | GO:0052827 | inositol pentakisphosphate phosphatase activity(GO:0052827) |
| 0.3 | 6.2 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.3 | 2.1 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.3 | 1.0 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.2 | 4.9 | GO:0043495 | protein anchor(GO:0043495) |
| 0.2 | 1.6 | GO:0016015 | morphogen activity(GO:0016015) |
| 0.2 | 5.1 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.2 | 1.7 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.2 | 2.2 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.2 | 1.3 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
| 0.2 | 1.3 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.2 | 0.5 | GO:0090556 | apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
| 0.2 | 0.5 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.1 | 2.9 | GO:0005537 | mannose binding(GO:0005537) |
| 0.1 | 3.0 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 4.3 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.1 | 1.1 | GO:0090599 | alpha-glucosidase activity(GO:0090599) |
| 0.1 | 1.1 | GO:0097506 | uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506) |
| 0.1 | 1.5 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.1 | 3.4 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 5.2 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 1.9 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 0.5 | GO:0043398 | HLH domain binding(GO:0043398) |
| 0.1 | 4.0 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 2.0 | GO:0005381 | iron ion transmembrane transporter activity(GO:0005381) |
| 0.1 | 2.0 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.1 | 0.7 | GO:0035500 | MH2 domain binding(GO:0035500) |
| 0.1 | 3.9 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.1 | 0.6 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.1 | 1.2 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.1 | 3.6 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 1.3 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.1 | 2.3 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 2.7 | GO:0043236 | laminin binding(GO:0043236) |
| 0.1 | 1.4 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 2.6 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 1.6 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 1.5 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 8.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 0.4 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 0.1 | 0.5 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.1 | 2.5 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.1 | 0.5 | GO:0016670 | oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) |
| 0.1 | 3.8 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 5.6 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 2.2 | GO:0008308 | voltage-gated anion channel activity(GO:0008308) |
| 0.1 | 0.3 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.1 | 0.9 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.1 | 0.9 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.1 | 0.8 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.1 | 5.0 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.1 | 1.4 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 0.9 | GO:0005072 | transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072) |
| 0.1 | 4.3 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 0.8 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.0 | 0.4 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 0.0 | 5.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 4.0 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 3.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 1.9 | GO:0061650 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 0.0 | 0.8 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 1.4 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 0.5 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.0 | 0.9 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 0.2 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.0 | 3.3 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 4.5 | GO:0004872 | receptor activity(GO:0004872) molecular transducer activity(GO:0060089) |
| 0.0 | 2.3 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 1.8 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 0.0 | 1.0 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.1 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
| 0.0 | 0.1 | GO:0086078 | gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling(GO:0086076) gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling(GO:0086078) gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling(GO:0086079) |
| 0.0 | 1.0 | GO:0017046 | peptide hormone binding(GO:0017046) |
| 0.0 | 0.4 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.0 | 0.8 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 5.0 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 0.2 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.0 | 0.7 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.6 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 0.5 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 5.6 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 0.5 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 0.3 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 1.3 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.0 | 0.7 | GO:0016860 | intramolecular oxidoreductase activity(GO:0016860) |
| 0.0 | 0.4 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 1.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.5 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.3 | 8.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.2 | 6.9 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.2 | 7.1 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 4.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 2.0 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.1 | 2.1 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 1.5 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 2.1 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 2.2 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 3.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 3.0 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.0 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 2.8 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 2.7 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 1.5 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 6.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.9 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 0.7 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 1.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.4 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.2 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 1.9 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.9 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.4 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 0.5 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 2.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.6 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 0.8 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.3 | 3.2 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.3 | 8.1 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.3 | 2.8 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.2 | 5.2 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.2 | 3.1 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 6.6 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 7.6 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 4.0 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 2.0 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.1 | 8.0 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 2.3 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 2.9 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 1.1 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.1 | 1.8 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 9.6 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 0.7 | REACTOME SIGNALING BY NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.1 | 0.9 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 0.9 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 1.6 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 2.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 3.4 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 1.0 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 1.4 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 1.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.9 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 0.4 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.0 | 0.5 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 0.9 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.3 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.6 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 0.0 | 2.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 1.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 0.7 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 3.1 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.0 | 0.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.7 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |