ISMARA results: CDX1

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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CDX1

Z-value: 1.09

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Transcription factors associated with CDX1

Gene Symbol	Gene ID	Gene Info
CDX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000113722.12	caudal type homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CDX1	hg19_v2_chr5_+_149546334_149546364	0.58	1.1e-20	Click!

Activity profile of CDX1 motif

Sorted Z-values of CDX1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_9268707 Show fit	16.86	ENST00000318602.7	A2M Ensembl NCBI GeneCards UniProt NextProt Show fit	alpha-2-macroglobulin
chr12_-_91573249 Show fit	14.20	ENST00000550099.1 ENST00000546391.1 ENST00000551354.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr10_-_69597810 Show fit	13.58	ENST00000483798.2	DNAJC12 Ensembl NCBI GeneCards UniProt NextProt Show fit	DnaJ (Hsp40) homolog, subfamily C, member 12
chr10_-_90712520 Show fit	13.43	ENST00000224784.6	ACTA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	actin, alpha 2, smooth muscle, aorta
chr12_-_91573132 Show fit	13.32	ENST00000550563.1 ENST00000546370.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr15_-_45670924 Show fit	10.68	ENST00000396659.3	GATM Ensembl NCBI GeneCards UniProt NextProt Show fit	glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr16_+_56672571 Show fit	9.91	ENST00000290705.8	MT1A Ensembl NCBI GeneCards UniProt NextProt Show fit	metallothionein 1A
chr11_+_114168085 Show fit	9.87	ENST00000541754.1	NNMT Ensembl NCBI GeneCards UniProt NextProt Show fit	nicotinamide N-methyltransferase
chr12_-_52779433 Show fit	9.83	ENST00000257951.3	KRT84 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 84
chr16_+_56685796 Show fit	9.35	ENST00000334346.2 ENST00000562399.1	MT1B Ensembl NCBI GeneCards UniProt NextProt Show fit	metallothionein 1B

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of CDX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	27.5	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.9	24.0	GO:0071294	cellular response to zinc ion(GO:0071294)
1.3	16.9	GO:0001867	complement activation, lectin pathway(GO:0001867)
2.4	14.3	GO:0016554	cytidine to uridine editing(GO:0016554)
2.2	13.4	GO:0090131	mesenchyme migration(GO:0090131)
0.1	12.2	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.0	12.1	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
1.0	10.7	GO:0006600	creatine metabolic process(GO:0006600)
0.7	10.4	GO:0035878	nail development(GO:0035878)
1.7	10.0	GO:0010751	negative regulation of nitric oxide mediated signal transduction(GO:0010751)

Showing 1 to 10 of 167 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	86.8	GO:0005615	extracellular space(GO:0005615)
2.0	27.5	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2	25.1	GO:0031093	platelet alpha granule lumen(GO:0031093)
4.9	14.8	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.3	14.0	GO:0045095	keratin filament(GO:0045095)
3.4	13.4	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.1	13.2	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1	12.5	GO:0001669	acrosomal vesicle(GO:0001669)
0.7	11.5	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.1	10.2	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)

Showing 1 to 10 of 76 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	33.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	31.2	GO:0005509	calcium ion binding(GO:0005509)
0.4	27.5	GO:0050840	extracellular matrix binding(GO:0050840)
0.2	17.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	17.0	GO:0008270	zinc ion binding(GO:0008270)
5.6	16.9	GO:0019959	interleukin-8 binding(GO:0019959)
0.1	14.4	GO:0003725	double-stranded RNA binding(GO:0003725)
0.4	10.7	GO:0016769	transferase activity, transferring nitrogenous groups(GO:0016769)
0.7	10.1	GO:0030280	structural constituent of epidermis(GO:0030280)
2.5	9.9	GO:0030760	nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)

Showing 1 to 10 of 133 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	38.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.2	17.2	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.2	15.3	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.2	13.7	PID AURORA B PATHWAY	Aurora B signaling
0.2	11.2	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	10.1	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.2	10.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	9.9	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.2	8.9	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	8.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Showing 1 to 10 of 37 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	30.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
1.0	26.1	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.2	19.6	REACTOME PHASE II CONJUGATION	Genes involved in Phase II conjugation
0.8	16.9	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.3	16.7	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.2	9.0	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.2	8.3	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.1	8.1	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.5	7.8	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.5	7.3	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters

Showing 1 to 10 of 57 entries

Results for CDX1

Z-value: 1.09

Motif logo

Transcription factors associated with CDX1

Activity-expression correlation:

Activity profile of CDX1 motif

Sorted Z-values of CDX1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of CDX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: