ISMARA results: CEBPA

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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CEBPA

Z-value: 1.76

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Transcription factors associated with CEBPA

Gene Symbol	Gene ID	Gene Info
CEBPA Ensembl NCBI GeneCards UniProt NextProt	ENSG00000245848.2	CCAAT enhancer binding protein alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CEBPA	hg19_v2_chr19_-_33793430_33793470	0.61	3.1e-23	Click!

Activity profile of CEBPA motif

Sorted Z-values of CEBPA motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_+_69742121 Show fit	41.01	ENST00000261267.2 ENST00000549690.1 ENST00000548839.1	LYZ Ensembl NCBI GeneCards UniProt NextProt Show fit	lysozyme
chr20_-_43883197 Show fit	39.77	ENST00000338380.2	SLPI Ensembl NCBI GeneCards UniProt NextProt Show fit	secretory leukocyte peptidase inhibitor
chr6_-_32557610 Show fit	32.18	ENST00000360004.5	HLA-DRB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DR beta 1
chr9_+_130911770 Show fit	27.71	ENST00000372998.1	LCN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	lipocalin 2
chr9_+_130911723 Show fit	26.64	ENST00000277480.2 ENST00000373013.2 ENST00000540948.1	LCN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	lipocalin 2
chr17_+_1665345 Show fit	21.00	ENST00000576406.1 ENST00000571149.1	SERPINF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr12_-_10007448 Show fit	20.36	ENST00000538152.1	CLEC2B Ensembl NCBI GeneCards UniProt NextProt Show fit	C-type lectin domain family 2, member B
chr10_-_21786179 Show fit	19.11	ENST00000377113.5	CASC10 Ensembl NCBI GeneCards UniProt NextProt Show fit	cancer susceptibility candidate 10
chr19_-_6720686 Show fit	17.79	ENST00000245907.6	C3 Ensembl NCBI GeneCards UniProt NextProt Show fit	complement component 3
chr8_-_6837602 Show fit	17.17	ENST00000382692.2	DEFA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	defensin, alpha 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of CEBPA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	77.9	GO:0019731	antibacterial humoral response(GO:0019731)
2.7	62.8	GO:0006957	complement activation, alternative pathway(GO:0006957)
10.9	54.3	GO:0015891	iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
8.5	42.3	GO:0002399	MHC class II protein complex assembly(GO:0002399)
8.4	42.2	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
6.6	32.9	GO:0071279	cellular response to cobalt ion(GO:0071279)
1.7	25.4	GO:0042167	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.4	24.7	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
2.0	24.0	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.5	23.8	GO:0006953	acute-phase response(GO:0006953)

Showing 1 to 10 of 249 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	177.2	GO:0035580	specific granule lumen(GO:0035580)
0.5	111.1	GO:0072562	blood microparticle(GO:0072562)
0.9	84.3	GO:0035578	azurophil granule lumen(GO:0035578)
0.0	59.3	GO:0005887	integral component of plasma membrane(GO:0005887)
2.4	50.0	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	38.2	GO:0016021	integral component of membrane(GO:0016021)
0.1	31.7	GO:0016323	basolateral plasma membrane(GO:0016323)
2.6	31.0	GO:0043203	axon hillock(GO:0043203)
0.2	28.1	GO:0035579	specific granule membrane(GO:0035579)
1.8	25.6	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)

Showing 1 to 10 of 97 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	95.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.4	59.7	GO:0002020	protease binding(GO:0002020)
1.6	58.4	GO:0042605	peptide antigen binding(GO:0042605)
0.2	56.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
7.0	42.2	GO:0003796	lysozyme activity(GO:0003796)
1.3	32.5	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.1	30.5	GO:0030246	carbohydrate binding(GO:0030246)
0.3	27.7	GO:0004866	endopeptidase inhibitor activity(GO:0004866)
0.4	27.3	GO:0050840	extracellular matrix binding(GO:0050840)
6.5	26.1	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)

Showing 1 to 10 of 174 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	95.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	64.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4	54.9	PID CMYB PATHWAY	C-MYB transcription factor network
0.9	46.5	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	39.1	NABA MATRISOME ASSOCIATED	Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.6	39.0	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
1.5	35.5	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.7	33.7	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.7	22.4	ST G ALPHA S PATHWAY	G alpha s Pathway
0.6	15.4	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin

Showing 1 to 10 of 54 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	64.5	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.7	59.3	REACTOME AMYLOIDS	Genes involved in Amyloids
2.6	46.4	REACTOME DEFENSINS	Genes involved in Defensins
2.2	43.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
1.8	39.8	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.6	35.1	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
1.2	25.6	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	25.4	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.3	23.8	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.4	22.9	REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	Genes involved in Integrin alphaIIb beta3 signaling

Showing 1 to 10 of 83 entries

Results for CEBPA

Z-value: 1.76

Motif logo

Transcription factors associated with CEBPA

Activity-expression correlation:

Activity profile of CEBPA motif

Sorted Z-values of CEBPA motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of CEBPA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: