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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CEBPE_CEBPD

Z-value: 1.50

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Transcription factors associated with CEBPE_CEBPD

Gene Symbol Gene ID Gene Info
CEBPE
ENSG00000092067.5 CCAAT enhancer binding protein epsilon
CEBPD
ENSG00000221869.4 CCAAT enhancer binding protein delta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CEBPDhg19_v2_chr8_-_48651648_486516480.611.9e-23Click!
CEBPEhg19_v2_chr14_-_23588816_235888360.073.2e-01Click!

Activity profile of CEBPE_CEBPD motif

Sorted Z-values of CEBPE_CEBPD motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_7167980 26.84 ENST00000360817.5
ENST00000402681.3
C1S
complement component 1, s subcomponent
chr19_-_6720686 24.81 ENST00000245907.6
C3
complement component 3
chr9_-_94186131 24.43 ENST00000297689.3
NFIL3
nuclear factor, interleukin 3 regulated
chr4_-_185747188 16.44 ENST00000507295.1
ENST00000504900.1
ENST00000281455.2
ENST00000454703.2
ACSL1
acyl-CoA synthetase long-chain family member 1
chr14_-_23285069 16.41 ENST00000554758.1
ENST00000397528.4
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr14_-_23285011 16.20 ENST00000397532.3
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr5_+_49963239 15.96 ENST00000505554.1
PARP8
poly (ADP-ribose) polymerase family, member 8
chr12_-_91573132 15.62 ENST00000550563.1
ENST00000546370.1
DCN
decorin
chr19_-_40971667 15.45 ENST00000263368.4
BLVRB
biliverdin reductase B (flavin reductase (NADPH))
chr15_+_45926919 15.43 ENST00000561735.1
ENST00000260324.7
SQRDL
sulfide quinone reductase-like (yeast)
chr12_-_91573249 15.06 ENST00000550099.1
ENST00000546391.1
ENST00000551354.1
DCN
decorin
chr10_+_17270214 14.27 ENST00000544301.1
VIM
vimentin
chr19_-_40971643 14.09 ENST00000595483.1
BLVRB
biliverdin reductase B (flavin reductase (NADPH))
chr12_-_96390063 13.87 ENST00000541929.1
HAL
histidine ammonia-lyase
chr3_+_186330712 13.68 ENST00000411641.2
ENST00000273784.5
AHSG
alpha-2-HS-glycoprotein
chr15_+_58430368 13.46 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr12_-_123201337 13.12 ENST00000528880.2
HCAR3
hydroxycarboxylic acid receptor 3
chr2_+_102721023 12.74 ENST00000409589.1
ENST00000409329.1
IL1R1
interleukin 1 receptor, type I
chr8_-_134309823 12.02 ENST00000414097.2
NDRG1
N-myc downstream regulated 1
chr15_+_58430567 12.02 ENST00000536493.1
AQP9
aquaporin 9
chr3_+_157154578 11.69 ENST00000295927.3
PTX3
pentraxin 3, long
chr12_-_123187890 11.63 ENST00000328880.5
HCAR2
hydroxycarboxylic acid receptor 2
chr6_-_133055815 10.93 ENST00000509351.1
ENST00000417437.2
ENST00000414302.2
ENST00000423615.2
ENST00000427187.2
ENST00000275223.3
ENST00000519686.2
VNN3
vanin 3
chr5_+_95997918 10.73 ENST00000395812.2
ENST00000395813.1
ENST00000359176.4
ENST00000325674.7
CAST
calpastatin
chr6_+_31895467 10.67 ENST00000556679.1
ENST00000456570.1
CFB
CFB
complement factor B
Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B
chr5_-_140013275 10.44 ENST00000512545.1
ENST00000302014.6
ENST00000401743.2
CD14
CD14 molecule
chr2_+_219247021 10.36 ENST00000539932.1
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr17_-_34625719 10.35 ENST00000422211.2
ENST00000542124.1
CCL3L1
chemokine (C-C motif) ligand 3-like 1
chr2_-_216300784 10.11 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
FN1
fibronectin 1
chr8_-_134309335 9.87 ENST00000522890.1
ENST00000323851.7
ENST00000518176.1
ENST00000354944.5
ENST00000537882.1
ENST00000522476.1
ENST00000518066.1
ENST00000521544.1
ENST00000518480.1
ENST00000523892.1
NDRG1
N-myc downstream regulated 1
chr17_-_34417479 9.61 ENST00000225245.5
CCL3
chemokine (C-C motif) ligand 3
chr6_-_133055896 9.60 ENST00000367927.5
ENST00000425515.2
ENST00000207771.3
ENST00000392393.3
ENST00000450865.2
ENST00000392394.2
VNN3
vanin 3
chr1_-_186649543 9.44 ENST00000367468.5
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr8_-_6735451 9.33 ENST00000297439.3
DEFB1
defensin, beta 1
chr5_+_95998070 9.24 ENST00000421689.2
ENST00000510756.1
ENST00000512620.1
CAST
calpastatin
chr16_+_72088376 9.15 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
HP
HPR
haptoglobin
haptoglobin-related protein
chr16_-_84651647 9.04 ENST00000564057.1
COTL1
coactosin-like 1 (Dictyostelium)
chr17_+_7461849 9.03 ENST00000338784.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr10_-_82049424 8.97 ENST00000372213.3
MAT1A
methionine adenosyltransferase I, alpha
chr17_+_7461781 8.95 ENST00000349228.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr17_+_7462103 8.95 ENST00000396545.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr20_-_43883197 8.73 ENST00000338380.2
SLPI
secretory leukocyte peptidase inhibitor
chr20_-_17662878 8.49 ENST00000377813.1
ENST00000377807.2
ENST00000360807.4
ENST00000398782.2
RRBP1
ribosome binding protein 1
chr6_-_32557610 8.26 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr19_+_859425 8.23 ENST00000327726.6
CFD
complement factor D (adipsin)
chr4_+_55095264 8.23 ENST00000257290.5
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr16_-_84651673 8.22 ENST00000262428.4
COTL1
coactosin-like 1 (Dictyostelium)
chr2_-_113594279 8.14 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
IL1B
interleukin 1, beta
chr3_+_46395219 8.04 ENST00000445132.2
ENST00000292301.4
CCR2
chemokine (C-C motif) receptor 2
chr1_+_154377669 7.84 ENST00000368485.3
ENST00000344086.4
IL6R
interleukin 6 receptor
chr19_-_2042065 7.82 ENST00000591588.1
ENST00000591142.1
MKNK2
MAP kinase interacting serine/threonine kinase 2
chr17_-_34524157 7.79 ENST00000378354.4
ENST00000394484.1
CCL3L3
chemokine (C-C motif) ligand 3-like 3
chr12_-_96390108 7.64 ENST00000538703.1
ENST00000261208.3
HAL
histidine ammonia-lyase
chr19_+_859654 7.58 ENST00000592860.1
CFD
complement factor D (adipsin)
chr3_-_58200398 7.58 ENST00000318316.3
ENST00000460422.1
ENST00000483681.1
DNASE1L3
deoxyribonuclease I-like 3
chr6_+_31895480 7.44 ENST00000418949.2
ENST00000383177.3
ENST00000477310.1
C2
CFB
complement component 2
Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B
chr3_-_46506358 7.34 ENST00000417439.1
ENST00000431944.1
LTF
lactotransferrin
chr6_+_31895254 7.33 ENST00000299367.5
ENST00000442278.2
C2
complement component 2
chr5_+_95997769 7.20 ENST00000338252.3
ENST00000508830.1
CAST
calpastatin
chr17_+_7462031 7.17 ENST00000380535.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr3_+_186435137 7.14 ENST00000447445.1
KNG1
kininogen 1
chr2_+_219246746 7.04 ENST00000233202.6
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr3_+_186383741 6.95 ENST00000232003.4
HRG
histidine-rich glycoprotein
chr3_-_46506563 6.92 ENST00000231751.4
LTF
lactotransferrin
chr12_+_102271129 6.88 ENST00000258534.8
DRAM1
DNA-damage regulated autophagy modulator 1
chr17_-_7017968 6.74 ENST00000355035.5
ASGR2
asialoglycoprotein receptor 2
chr16_-_21663919 6.39 ENST00000569602.1
IGSF6
immunoglobulin superfamily, member 6
chr19_+_6887571 6.36 ENST00000250572.8
ENST00000381407.5
ENST00000312053.4
ENST00000450315.3
ENST00000381404.4
EMR1
egf-like module containing, mucin-like, hormone receptor-like 1
chr3_-_158450475 6.28 ENST00000237696.5
RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr8_-_27468842 6.27 ENST00000523500.1
CLU
clusterin
chr17_-_7018128 6.15 ENST00000380952.2
ENST00000254850.7
ASGR2
asialoglycoprotein receptor 2
chr12_-_91573316 6.05 ENST00000393155.1
DCN
decorin
chr8_-_27468945 6.00 ENST00000405140.3
CLU
clusterin
chr3_-_158450231 5.96 ENST00000479756.1
RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr3_+_186435065 5.92 ENST00000287611.2
ENST00000265023.4
KNG1
kininogen 1
chr5_+_49962772 5.67 ENST00000281631.5
ENST00000513738.1
ENST00000503665.1
ENST00000514067.2
ENST00000503046.1
PARP8
poly (ADP-ribose) polymerase family, member 8
chr8_+_12808834 5.48 ENST00000400069.3
KIAA1456
KIAA1456
chr20_+_56136136 5.15 ENST00000319441.4
ENST00000543666.1
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr7_-_36764004 4.92 ENST00000431169.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr3_+_11314099 4.54 ENST00000446450.2
ENST00000354956.5
ENST00000354449.3
ENST00000419112.1
ATG7
autophagy related 7
chr7_+_22766766 4.47 ENST00000426291.1
ENST00000401651.1
ENST00000258743.5
ENST00000420258.2
ENST00000407492.1
ENST00000401630.3
ENST00000406575.1
IL6
interleukin 6 (interferon, beta 2)
chr6_-_112194484 4.45 ENST00000518295.1
ENST00000484067.2
ENST00000229470.5
ENST00000356013.2
ENST00000368678.4
ENST00000523238.1
ENST00000354650.3
FYN
FYN oncogene related to SRC, FGR, YES
chr16_-_21663950 4.41 ENST00000268389.4
IGSF6
immunoglobulin superfamily, member 6
chr8_-_27469196 4.39 ENST00000546343.1
ENST00000560566.1
CLU
clusterin
chr13_-_46679185 4.38 ENST00000439329.3
CPB2
carboxypeptidase B2 (plasma)
chr11_-_18270182 4.35 ENST00000528349.1
ENST00000526900.1
ENST00000529528.1
ENST00000414546.2
ENST00000256733.4
SAA2
serum amyloid A2
chr13_-_46679144 4.32 ENST00000181383.4
CPB2
carboxypeptidase B2 (plasma)
chr11_+_18287801 4.19 ENST00000532858.1
ENST00000405158.2
SAA1
serum amyloid A1
chr11_+_18287721 4.08 ENST00000356524.4
SAA1
serum amyloid A1
chr6_+_1389989 4.06 ENST00000259806.1
FOXF2
forkhead box F2
chr11_+_33279850 3.79 ENST00000531504.1
ENST00000456517.1
HIPK3
homeodomain interacting protein kinase 3
chr17_+_20059302 3.75 ENST00000395530.2
SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr15_+_39873268 3.71 ENST00000397591.2
ENST00000260356.5
THBS1
thrombospondin 1
chr9_+_33290491 3.70 ENST00000379540.3
ENST00000379521.4
ENST00000318524.6
NFX1
nuclear transcription factor, X-box binding 1
chr2_+_46769798 3.69 ENST00000238738.4
RHOQ
ras homolog family member Q
chr2_-_178128250 3.65 ENST00000448782.1
ENST00000446151.2
NFE2L2
nuclear factor, erythroid 2-like 2
chr3_-_99594948 3.63 ENST00000471562.1
ENST00000495625.2
FILIP1L
filamin A interacting protein 1-like
chr11_-_104972158 3.61 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1
CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr11_-_77185094 3.61 ENST00000278568.4
ENST00000356341.3
PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chrX_+_138612889 3.56 ENST00000218099.2
ENST00000394090.2
F9
coagulation factor IX
chr4_-_155511887 3.55 ENST00000302053.3
ENST00000403106.3
FGA
fibrinogen alpha chain
chrY_+_2709527 3.30 ENST00000250784.8
RPS4Y1
ribosomal protein S4, Y-linked 1
chr14_+_58765103 3.19 ENST00000355431.3
ENST00000348476.3
ENST00000395168.3
ARID4A
AT rich interactive domain 4A (RBP1-like)
chr13_-_29292956 3.14 ENST00000266943.6
SLC46A3
solute carrier family 46, member 3
chr1_+_209941827 3.07 ENST00000367023.1
TRAF3IP3
TRAF3 interacting protein 3
chr1_-_1711508 3.06 ENST00000378625.1
NADK
NAD kinase
chr1_-_111743285 3.04 ENST00000357640.4
DENND2D
DENN/MADD domain containing 2D
chr20_+_44098346 3.03 ENST00000372676.3
WFDC2
WAP four-disulfide core domain 2
chr3_+_133465228 2.97 ENST00000482271.1
ENST00000264998.3
TF
transferrin
chr11_+_82868030 2.91 ENST00000298281.4
ENST00000530660.1
PCF11
PCF11 cleavage and polyadenylation factor subunit
chr1_+_82266053 2.84 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2
latrophilin 2
chr14_+_21423611 2.74 ENST00000304625.2
RNASE2
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
chr1_+_209941942 2.72 ENST00000487271.1
ENST00000477431.1
TRAF3IP3
TRAF3 interacting protein 3
chr4_+_25657444 2.68 ENST00000504570.1
ENST00000382051.3
SLC34A2
solute carrier family 34 (type II sodium/phosphate contransporter), member 2
chr4_-_186732048 2.68 ENST00000448662.2
ENST00000439049.1
ENST00000420158.1
ENST00000431808.1
ENST00000319471.9
SORBS2
sorbin and SH3 domain containing 2
chr20_+_44098385 2.67 ENST00000217425.5
ENST00000339946.3
WFDC2
WAP four-disulfide core domain 2
chr6_-_24489842 2.65 ENST00000230036.1
GPLD1
glycosylphosphatidylinositol specific phospholipase D1
chr11_-_104905840 2.62 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
CASP1
caspase 1, apoptosis-related cysteine peptidase
chr3_-_99595037 2.49 ENST00000383694.2
FILIP1L
filamin A interacting protein 1-like
chr14_-_64971288 2.48 ENST00000394715.1
ZBTB25
zinc finger and BTB domain containing 25
chr4_+_71263599 2.41 ENST00000399575.2
PROL1
proline rich, lacrimal 1
chr5_-_121413974 2.37 ENST00000231004.4
LOX
lysyl oxidase
chr4_-_76928641 2.27 ENST00000264888.5
CXCL9
chemokine (C-X-C motif) ligand 9
chr12_+_66582919 2.18 ENST00000545837.1
ENST00000457197.2
IRAK3
interleukin-1 receptor-associated kinase 3
chr19_-_41356347 2.17 ENST00000301141.5
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr12_-_12491608 2.16 ENST00000545735.1
MANSC1
MANSC domain containing 1
chr5_-_10761206 2.16 ENST00000432074.2
ENST00000230895.6
DAP
death-associated protein
chr19_-_52148798 2.13 ENST00000534261.2
SIGLEC5
sialic acid binding Ig-like lectin 5
chr20_-_1600642 2.11 ENST00000381603.3
ENST00000381605.4
ENST00000279477.7
ENST00000568365.1
ENST00000564763.1
SIRPB1
RP4-576H24.4
signal-regulatory protein beta 1
Uncharacterized protein
chr11_+_15095108 2.07 ENST00000324229.6
ENST00000533448.1
CALCB
calcitonin-related polypeptide beta
chr19_-_41388657 2.03 ENST00000301146.4
ENST00000291764.3
CYP2A7
cytochrome P450, family 2, subfamily A, polypeptide 7
chr14_-_45722605 1.97 ENST00000310806.4
MIS18BP1
MIS18 binding protein 1
chr2_-_178128528 1.96 ENST00000397063.4
ENST00000421929.1
NFE2L2
nuclear factor, erythroid 2-like 2
chr5_+_134368954 1.91 ENST00000432382.3
CTC-349C3.1
chromosome 5 open reading frame 66
chr3_+_88188254 1.88 ENST00000309495.5
ZNF654
zinc finger protein 654
chr9_-_99381660 1.82 ENST00000375240.3
ENST00000463569.1
CDC14B
cell division cycle 14B
chr10_+_90750378 1.72 ENST00000355740.2
ENST00000352159.4
FAS
Fas cell surface death receptor
chr6_+_108977520 1.71 ENST00000540898.1
FOXO3
forkhead box O3
chr19_+_11350278 1.70 ENST00000252453.8
C19orf80
chromosome 19 open reading frame 80
chr11_-_14993819 1.65 ENST00000396372.2
ENST00000361010.3
ENST00000359642.3
ENST00000331587.4
CALCA
calcitonin-related polypeptide alpha
chr11_-_18258342 1.63 ENST00000278222.4
SAA4
serum amyloid A4, constitutive
chr2_-_191878874 1.62 ENST00000392322.3
ENST00000392323.2
ENST00000424722.1
ENST00000361099.3
STAT1
signal transducer and activator of transcription 1, 91kDa
chr1_-_151032040 1.62 ENST00000540998.1
ENST00000357235.5
CDC42SE1
CDC42 small effector 1
chr16_+_3507985 1.60 ENST00000421765.3
ENST00000360862.5
ENST00000414063.2
ENST00000610180.1
ENST00000608993.1
NAA60
NAA60
N(alpha)-acetyltransferase 60, NatF catalytic subunit
N-alpha-acetyltransferase 60
chr10_+_90750493 1.54 ENST00000357339.2
ENST00000355279.2
FAS
Fas cell surface death receptor
chr2_-_209118974 1.51 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
IDH1
isocitrate dehydrogenase 1 (NADP+), soluble
chrX_+_46937745 1.50 ENST00000397180.1
ENST00000457380.1
ENST00000352078.4
RGN
regucalcin
chrX_+_24483338 1.47 ENST00000379162.4
ENST00000441463.2
PDK3
pyruvate dehydrogenase kinase, isozyme 3
chr14_-_106573756 1.47 ENST00000390601.2
IGHV3-11
immunoglobulin heavy variable 3-11 (gene/pseudogene)
chr1_-_168698433 1.44 ENST00000367817.3
DPT
dermatopontin
chr6_-_31940065 1.43 ENST00000375349.3
ENST00000337523.5
DXO
decapping exoribonuclease
chr20_-_22566089 1.43 ENST00000377115.4
FOXA2
forkhead box A2
chr4_+_96012614 1.39 ENST00000264568.4
BMPR1B
bone morphogenetic protein receptor, type IB
chr20_-_34330129 1.32 ENST00000397370.3
ENST00000528062.3
ENST00000407261.4
ENST00000374038.3
ENST00000361162.6
RBM39
RNA binding motif protein 39
chr3_-_148939835 1.31 ENST00000264613.6
CP
ceruloplasmin (ferroxidase)
chr11_-_64510409 1.28 ENST00000394429.1
ENST00000394428.1
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr21_+_27011584 1.16 ENST00000400532.1
ENST00000480456.1
ENST00000312957.5
JAM2
junctional adhesion molecule 2
chr19_+_41497178 1.14 ENST00000324071.4
CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr1_-_149832704 1.13 ENST00000392933.1
ENST00000369157.2
ENST00000392932.4
HIST2H4B
histone cluster 2, H4b
chr4_+_78079450 1.06 ENST00000395640.1
ENST00000512918.1
CCNG2
cyclin G2
chr4_+_78079570 1.06 ENST00000509972.1
CCNG2
cyclin G2
chr1_-_228613026 1.06 ENST00000366696.1
HIST3H3
histone cluster 3, H3
chr1_+_245133278 1.05 ENST00000366522.2
EFCAB2
EF-hand calcium binding domain 2
chr18_+_21032781 1.03 ENST00000339486.3
RIOK3
RIO kinase 3
chr5_-_39364586 1.00 ENST00000263408.4
C9
complement component 9
chr1_-_45956822 0.95 ENST00000372086.3
ENST00000341771.6
TESK2
testis-specific kinase 2
chr2_+_113885138 0.94 ENST00000409930.3
IL1RN
interleukin 1 receptor antagonist
chr19_+_55014085 0.94 ENST00000351841.2
LAIR2
leukocyte-associated immunoglobulin-like receptor 2
chr1_+_161087873 0.93 ENST00000368009.2
ENST00000368007.4
ENST00000368008.1
ENST00000392190.5
NIT1
nitrilase 1
chr7_-_87936195 0.93 ENST00000414498.1
ENST00000301959.5
ENST00000380079.4
STEAP4
STEAP family member 4
chr1_+_149804218 0.86 ENST00000610125.1
HIST2H4A
histone cluster 2, H4a
chr2_+_135676381 0.84 ENST00000537343.1
ENST00000295238.6
ENST00000264157.5
CCNT2
cyclin T2
chr20_-_33732952 0.84 ENST00000541621.1
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr1_+_196743912 0.84 ENST00000367425.4
CFHR3
complement factor H-related 3
chr1_-_67519782 0.83 ENST00000235345.5
SLC35D1
solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
chr9_-_88356789 0.82 ENST00000357081.3
ENST00000376081.4
ENST00000337006.4
ENST00000376109.3
AGTPBP1
ATP/GTP binding protein 1
chr19_+_55014013 0.81 ENST00000301202.2
LAIR2
leukocyte-associated immunoglobulin-like receptor 2
chr14_+_64971292 0.78 ENST00000358738.3
ENST00000394712.2
ZBTB1
zinc finger and BTB domain containing 1
chr4_-_2935674 0.75 ENST00000514800.1
MFSD10
major facilitator superfamily domain containing 10
chr19_-_41945804 0.75 ENST00000221943.9
ENST00000597457.1
ENST00000589970.1
ENST00000595425.1
ENST00000438807.3
ENST00000589102.1
ENST00000592922.2
ATP5SL
ATP5S-like
chr7_+_150065278 0.74 ENST00000519397.1
ENST00000479668.1
ENST00000540729.1
REPIN1
replication initiator 1
chr2_-_191878162 0.73 ENST00000540176.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr16_-_30457048 0.73 ENST00000500504.2
ENST00000542752.1
SEPHS2
selenophosphate synthetase 2
chrX_-_105282712 0.70 ENST00000372563.1
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr2_-_167232484 0.70 ENST00000375387.4
ENST00000303354.6
ENST00000409672.1
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr17_+_27369918 0.70 ENST00000323372.4
PIPOX
pipecolic acid oxidase
chr5_-_58882219 0.66 ENST00000505453.1
ENST00000360047.5
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_-_191878681 0.63 ENST00000409465.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr9_-_77502636 0.59 ENST00000449912.2
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr12_+_110011571 0.52 ENST00000539696.1
ENST00000228510.3
ENST00000392727.3
MVK
mevalonate kinase
chr14_+_102276192 0.50 ENST00000557714.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr2_-_201936302 0.49 ENST00000453765.1
ENST00000452799.1
ENST00000446678.1
ENST00000418596.3
FAM126B
family with sequence similarity 126, member B
chr14_-_70263979 0.44 ENST00000216540.4
SLC10A1
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr4_-_119274121 0.36 ENST00000296498.3
PRSS12
protease, serine, 12 (neurotrypsin, motopsin)
chr12_-_110939870 0.36 ENST00000447578.2
ENST00000546588.1
ENST00000360579.7
ENST00000549970.1
ENST00000549578.1
VPS29
vacuolar protein sorting 29 homolog (S. cerevisiae)
chr14_-_80697396 0.35 ENST00000557010.1
DIO2
deiodinase, iodothyronine, type II
chr2_-_77749474 0.34 ENST00000409093.1
ENST00000409088.3
LRRTM4
leucine rich repeat transmembrane neuronal 4
chr6_+_31515337 0.28 ENST00000376148.4
ENST00000376145.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr3_-_122233723 0.27 ENST00000493510.1
ENST00000344337.6
ENST00000476916.1
ENST00000465882.1
KPNA1
karyopherin alpha 1 (importin alpha 5)
chr17_+_72427477 0.23 ENST00000342648.5
ENST00000481232.1
GPRC5C
G protein-coupled receptor, family C, group 5, member C

Network of associatons between targets according to the STRING database.

First level regulatory network of CEBPE_CEBPD

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
8.3 24.8 GO:0002894 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
7.2 21.5 GO:0019557 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
5.8 17.4 GO:0055073 cadmium ion homeostasis(GO:0055073)
5.4 32.6 GO:0000821 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
5.1 25.5 GO:0015855 pyrimidine nucleobase transport(GO:0015855) urea transmembrane transport(GO:0071918) purine nucleobase transmembrane transport(GO:1904823)
4.8 14.3 GO:0033214 iron assimilation(GO:0033212) iron assimilation by chelation and transport(GO:0033214) positive regulation of bone mineralization involved in bone maturation(GO:1900159) negative regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000308)
4.6 9.2 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
4.2 12.7 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
4.1 12.3 GO:0002384 hepatic immune response(GO:0002384)
3.4 10.1 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
3.3 39.7 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
3.1 9.3 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
2.9 11.6 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
2.8 34.1 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
2.8 16.7 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
2.7 8.2 GO:0072277 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
2.7 16.4 GO:0034201 response to oleic acid(GO:0034201)
2.7 8.1 GO:0046136 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
2.7 8.0 GO:2000439 negative regulation of eosinophil activation(GO:1902567) positive regulation of monocyte extravasation(GO:2000439)
2.6 10.4 GO:0071727 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
2.4 9.4 GO:0090362 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of platelet-derived growth factor production(GO:0090362) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
2.3 11.7 GO:0044793 negative regulation by host of viral process(GO:0044793) negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
2.2 9.0 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
2.2 8.7 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
2.0 21.9 GO:0090232 peripheral nervous system myelin maintenance(GO:0032287) positive regulation of spindle checkpoint(GO:0090232)
2.0 29.5 GO:0033015 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
1.9 27.2 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
1.9 25.1 GO:0001867 complement activation, lectin pathway(GO:0001867)
1.9 3.7 GO:0010746 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
1.7 8.3 GO:0002399 MHC class II protein complex assembly(GO:0002399)
1.6 6.2 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
1.5 34.9 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.5 4.5 GO:1901859 late nucleophagy(GO:0044805) negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859) single-organism membrane invagination(GO:1902534)
1.4 5.6 GO:0043387 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
1.4 9.6 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
1.3 14.3 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
1.3 5.2 GO:1904640 response to methionine(GO:1904640)
1.2 12.0 GO:0015939 pantothenate metabolic process(GO:0015939)
0.8 3.2 GO:0097368 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.8 16.6 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.8 1.5 GO:0006097 glyoxylate cycle(GO:0006097)
0.7 2.9 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697)
0.7 7.3 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.7 2.7 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of lipoprotein particle clearance(GO:0010986)
0.6 6.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.6 5.5 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.6 1.7 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.6 13.7 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.5 1.6 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.5 2.2 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.5 2.2 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
0.5 3.3 GO:0097527 Fas signaling pathway(GO:0036337) necroptotic signaling pathway(GO:0097527)
0.5 3.6 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.5 3.1 GO:0006741 NADP biosynthetic process(GO:0006741)
0.5 24.4 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.5 17.3 GO:0050832 defense response to fungus(GO:0050832)
0.5 1.5 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853) negative regulation of DNA catabolic process(GO:1903625) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.5 3.0 GO:0097460 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.5 1.4 GO:0045013 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.5 3.7 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.4 2.7 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.4 4.5 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.4 20.8 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.4 7.6 GO:0010623 programmed cell death involved in cell development(GO:0010623)
0.4 7.8 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.4 0.8 GO:0002572 pro-T cell differentiation(GO:0002572)
0.3 1.0 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.3 8.7 GO:0019731 antibacterial humoral response(GO:0019731)
0.3 0.8 GO:0036509 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.3 1.4 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.3 0.8 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.3 4.1 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249)
0.3 1.6 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.2 1.5 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.2 0.7 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.2 0.7 GO:0046440 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.2 3.7 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.2 12.9 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.2 0.8 GO:0019086 late viral transcription(GO:0019086)
0.2 3.8 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.2 2.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.2 2.1 GO:0072507 divalent inorganic cation homeostasis(GO:0072507)
0.2 0.9 GO:0097461 ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.2 0.5 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.2 0.9 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.2 3.2 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 1.2 GO:0007162 negative regulation of cell adhesion(GO:0007162)
0.1 1.8 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 6.0 GO:0006953 acute-phase response(GO:0006953)
0.1 0.8 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 10.5 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.1 2.7 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 1.4 GO:0071028 nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.1 2.9 GO:0006379 mRNA cleavage(GO:0006379)
0.1 0.2 GO:0060454 positive regulation of gastric acid secretion(GO:0060454)
0.1 0.7 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 0.2 GO:0003218 cardiac left ventricle formation(GO:0003218) cell migration involved in vasculogenesis(GO:0035441)
0.1 2.0 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 1.3 GO:0006825 copper ion transport(GO:0006825)
0.1 2.2 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.1 0.7 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.7 GO:0048266 behavioral response to pain(GO:0048266)
0.0 1.4 GO:0030199 collagen fibril organization(GO:0030199)
0.0 1.1 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.3 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.3 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 1.6 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.8 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 5.7 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 3.3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 6.7 GO:0010506 regulation of autophagy(GO:0010506)
0.0 0.1 GO:2000674 regulation of type B pancreatic cell apoptotic process(GO:2000674)
0.0 0.3 GO:0019054 modulation by virus of host process(GO:0019054)
0.0 1.6 GO:2000257 regulation of complement activation(GO:0030449) regulation of protein activation cascade(GO:2000257)
0.0 0.3 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 1.2 GO:0000075 cell cycle checkpoint(GO:0000075)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
2.6 36.7 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
2.3 9.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
2.1 10.4 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
2.0 14.3 GO:0097013 phagocytic vesicle lumen(GO:0097013)
1.3 17.4 GO:0005577 fibrinogen complex(GO:0005577)
1.2 6.2 GO:0097179 protease inhibitor complex(GO:0097179)
1.0 16.7 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.5 14.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.5 106.1 GO:0072562 blood microparticle(GO:0072562)
0.5 9.3 GO:0097225 sperm midpiece(GO:0097225)
0.4 8.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.3 28.9 GO:0043195 terminal bouton(GO:0043195)
0.3 21.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 17.4 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.2 15.2 GO:0035580 specific granule lumen(GO:0035580)
0.2 15.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.2 3.3 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.2 3.6 GO:0071437 invadopodium(GO:0071437)
0.2 4.5 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.2 1.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 2.9 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.1 2.0 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.1 46.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 8.2 GO:0005902 microvillus(GO:0005902)
0.1 14.3 GO:0005882 intermediate filament(GO:0005882)
0.1 1.0 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 0.4 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 9.4 GO:0005901 caveola(GO:0005901)
0.1 4.0 GO:0031526 brush border membrane(GO:0031526)
0.1 11.6 GO:0016605 PML body(GO:0016605)
0.1 0.8 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 1.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 6.2 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 8.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 8.1 GO:0005884 actin filament(GO:0005884)
0.1 9.2 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1 0.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.7 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 3.3 GO:0005844 polysome(GO:0005844)
0.1 2.7 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.8 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 6.3 GO:0043204 perikaryon(GO:0043204)
0.0 5.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 51.0 GO:0005615 extracellular space(GO:0005615)
0.0 2.1 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 2.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 2.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 16.7 GO:0030054 cell junction(GO:0030054)
0.0 6.9 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.8 GO:0072686 mitotic spindle(GO:0072686)
0.0 3.8 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.7 GO:0044438 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.0 3.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.5 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.1 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.3 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.2 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 19.9 GO:0005783 endoplasmic reticulum(GO:0005783)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
7.4 29.5 GO:0004074 biliverdin reductase activity(GO:0004074)
6.4 25.5 GO:0015254 glycerol channel activity(GO:0015254) urea channel activity(GO:0015265)
5.8 17.4 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
5.4 21.5 GO:0016841 ammonia-lyase activity(GO:0016841)
4.5 27.2 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
4.1 20.5 GO:0017159 pantetheine hydrolase activity(GO:0017159)
3.5 10.4 GO:0016019 peptidoglycan receptor activity(GO:0016019)
3.2 12.7 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
3.1 9.3 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
3.0 32.6 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
2.7 8.2 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
2.7 8.0 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
2.6 7.8 GO:0004915 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
2.4 14.3 GO:1990254 keratin filament binding(GO:1990254)
2.4 9.4 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473)
1.9 9.6 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
1.7 5.2 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
1.6 4.9 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
1.6 12.9 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
1.5 9.2 GO:0030492 hemoglobin binding(GO:0030492)
1.5 11.7 GO:0001849 complement component C1q binding(GO:0001849)
1.4 5.7 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
1.2 3.7 GO:0070052 collagen V binding(GO:0070052)
1.2 3.7 GO:0032427 GBD domain binding(GO:0032427)
1.1 5.5 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
1.0 3.0 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.9 16.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.8 16.7 GO:0051787 misfolded protein binding(GO:0051787)
0.8 37.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.8 4.5 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.7 4.5 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.7 4.5 GO:0042610 CD8 receptor binding(GO:0042610)
0.7 21.9 GO:0043015 gamma-tubulin binding(GO:0043015)
0.7 21.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.7 18.1 GO:0001848 complement binding(GO:0001848)
0.7 51.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.7 3.3 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.6 7.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.5 49.9 GO:0005518 collagen binding(GO:0005518)
0.5 9.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.5 1.5 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.5 1.4 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
0.5 2.7 GO:0004522 ribonuclease A activity(GO:0004522)
0.5 2.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.4 2.7 GO:0004630 phospholipase D activity(GO:0004630)
0.4 1.6 GO:0031716 calcitonin receptor binding(GO:0031716)
0.4 1.5 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.3 14.3 GO:0042056 chemoattractant activity(GO:0042056)
0.3 2.6 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.3 10.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.3 74.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 5.3 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.3 8.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 0.7 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.2 0.9 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.2 23.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 8.3 GO:0042605 peptide antigen binding(GO:0042605)
0.2 1.0 GO:0089720 caspase binding(GO:0089720)
0.2 2.6 GO:0050700 CARD domain binding(GO:0050700)
0.2 1.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 2.4 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.1 1.3 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 2.2 GO:0070513 death domain binding(GO:0070513)
0.1 0.8 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 7.6 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 1.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 5.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.7 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 0.4 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.8 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 9.0 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 9.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.8 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 1.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 1.6 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 3.2 GO:0004407 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.1 2.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.3 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.1 3.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.4 GO:0019534 toxin transporter activity(GO:0019534)
0.0 1.2 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 1.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.8 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 19.8 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 1.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 1.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.7 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 1.7 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 3.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.2 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 6.7 GO:0003779 actin binding(GO:0003779)
0.0 2.4 GO:0003735 structural constituent of ribosome(GO:0003735)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 24.8 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.7 29.8 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.7 36.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.6 12.3 ST STAT3 PATHWAY STAT3 Pathway
0.6 18.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.6 30.2 PID IL1 PATHWAY IL1-mediated signaling events
0.4 23.2 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.4 9.4 PID S1P S1P1 PATHWAY S1P1 pathway
0.4 2.9 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.4 52.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.3 8.2 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.3 15.1 PID BMP PATHWAY BMP receptor signaling
0.2 3.6 PID S1P S1P2 PATHWAY S1P2 pathway
0.2 7.8 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.2 3.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2 8.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.2 15.7 PID IL12 2PATHWAY IL12-mediated signaling events
0.2 3.7 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.2 14.3 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 2.3 PID IL23 PATHWAY IL23-mediated signaling events
0.1 3.0 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 41.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 3.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 6.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.7 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 1.2 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 1.3 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.8 PID PLK1 PATHWAY PLK1 signaling events
0.0 5.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.3 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.3 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 92.9 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
1.8 25.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
1.7 17.4 REACTOME BETA DEFENSINS Genes involved in Beta defensins
1.4 36.7 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
1.1 29.5 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.9 10.4 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.9 16.4 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.8 15.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.8 16.6 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.8 18.7 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.6 24.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.6 3.0 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.6 24.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.6 13.7 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.5 30.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.5 24.0 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.4 14.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.4 6.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.4 4.5 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.4 5.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.4 8.3 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.4 8.3 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.3 14.3 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.2 27.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 3.6 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.2 26.5 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.2 3.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.2 2.9 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 3.7 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 24.0 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 3.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 8.0 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 10.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.1 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.5 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 2.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 8.3 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.1 4.0 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.3 REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.0 0.8 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 3.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.5 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0 0.6 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 3.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.8 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions