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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CEBPE_CEBPD
Z-value: 1.50
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Transcription factors associated with CEBPE_CEBPD
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPD | hg19_v2_chr8_-_48651648_48651648 | 0.61 | 1.9e-23 | Click! |
| CEBPE | hg19_v2_chr14_-_23588816_23588836 | 0.07 | 3.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_7167980 Show fit | 26.84 |
ENST00000360817.5
ENST00000402681.3 |
complement component 1, s subcomponent |
|
| chr19_-_6720686 Show fit | 24.81 |
ENST00000245907.6
|
complement component 3 |
|
| chr9_-_94186131 Show fit | 24.43 |
ENST00000297689.3
|
nuclear factor, interleukin 3 regulated |
|
| chr4_-_185747188 Show fit | 16.44 |
ENST00000507295.1
ENST00000504900.1 ENST00000281455.2 ENST00000454703.2 |
acyl-CoA synthetase long-chain family member 1 |
|
| chr14_-_23285069 Show fit | 16.41 |
ENST00000554758.1
ENST00000397528.4 |
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 |
|
| chr14_-_23285011 Show fit | 16.20 |
ENST00000397532.3
|
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 |
|
| chr5_+_49963239 Show fit | 15.96 |
ENST00000505554.1
|
poly (ADP-ribose) polymerase family, member 8 |
|
| chr12_-_91573132 Show fit | 15.62 |
ENST00000550563.1
ENST00000546370.1 |
decorin |
|
| chr19_-_40971667 Show fit | 15.45 |
ENST00000263368.4
|
biliverdin reductase B (flavin reductase (NADPH)) |
|
| chr15_+_45926919 Show fit | 15.43 |
ENST00000561735.1
ENST00000260324.7 |
sulfide quinone reductase-like (yeast) |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPE_CEBPD
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 39.7 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 1.5 | 34.9 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 2.8 | 34.1 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
| 5.4 | 32.6 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822) |
| 2.0 | 29.5 | GO:0033015 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 1.9 | 27.2 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 5.1 | 25.5 | GO:0015855 | pyrimidine nucleobase transport(GO:0015855) urea transmembrane transport(GO:0071918) purine nucleobase transmembrane transport(GO:1904823) |
| 1.9 | 25.1 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 8.3 | 24.8 | GO:0002894 | positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894) |
| 0.5 | 24.4 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 106.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 51.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 46.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 2.6 | 36.7 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.3 | 28.9 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.3 | 21.9 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 19.9 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 1.3 | 17.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.2 | 17.4 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 1.0 | 16.7 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 74.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.7 | 51.5 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.5 | 49.9 | GO:0005518 | collagen binding(GO:0005518) |
| 0.8 | 37.0 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 3.0 | 32.6 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 7.4 | 29.5 | GO:0004074 | biliverdin reductase activity(GO:0004074) |
| 4.5 | 27.2 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 6.4 | 25.5 | GO:0015254 | glycerol channel activity(GO:0015254) urea channel activity(GO:0015265) |
| 0.2 | 23.1 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.7 | 21.9 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 52.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 41.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.7 | 36.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.6 | 30.2 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.7 | 29.8 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 1.1 | 24.8 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.4 | 23.2 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.6 | 18.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 15.7 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.3 | 15.1 | PID BMP PATHWAY | BMP receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 92.9 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 1.4 | 36.7 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.5 | 30.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.1 | 29.5 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.2 | 27.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 26.5 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 1.8 | 25.5 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.6 | 24.4 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.6 | 24.2 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.5 | 24.0 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |