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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CEBPG
Z-value: 0.96
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Transcription factors associated with CEBPG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPG | hg19_v2_chr19_+_33865218_33865254 | -0.20 | 3.7e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_5248294 Show fit | 23.09 |
ENST00000335295.4
|
hemoglobin, beta |
|
| chr3_+_186435137 Show fit | 16.49 |
ENST00000447445.1
|
kininogen 1 |
|
| chr3_+_186435065 Show fit | 14.49 |
ENST00000287611.2
ENST00000265023.4 |
kininogen 1 |
|
| chr4_+_74269956 Show fit | 12.80 |
ENST00000295897.4
ENST00000415165.2 ENST00000503124.1 ENST00000509063.1 ENST00000401494.3 |
albumin |
|
| chr3_+_186330712 Show fit | 11.91 |
ENST00000411641.2
ENST00000273784.5 |
alpha-2-HS-glycoprotein |
|
| chr9_+_117085336 Show fit | 10.38 |
ENST00000259396.8
ENST00000538816.1 |
orosomucoid 1 |
|
| chr6_+_31895467 Show fit | 9.19 |
ENST00000556679.1
ENST00000456570.1 |
complement factor B Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B |
|
| chr9_+_117092149 Show fit | 9.17 |
ENST00000431067.2
ENST00000412657.1 |
orosomucoid 2 |
|
| chr9_+_130911770 Show fit | 8.97 |
ENST00000372998.1
|
lipocalin 2 |
|
| chr9_+_130911723 Show fit | 8.06 |
ENST00000277480.2
ENST00000373013.2 ENST00000540948.1 |
lipocalin 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 41.3 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 5.8 | 23.1 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 0.3 | 20.1 | GO:0006953 | acute-phase response(GO:0006953) |
| 2.4 | 19.6 | GO:1904469 | positive regulation of tumor necrosis factor secretion(GO:1904469) |
| 3.4 | 17.0 | GO:0015891 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 4.3 | 12.8 | GO:0019836 | hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331) |
| 0.5 | 11.9 | GO:0030502 | pinocytosis(GO:0006907) negative regulation of bone mineralization(GO:0030502) |
| 3.0 | 11.8 | GO:0003330 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 1.0 | 10.9 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.4 | 9.2 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 81.0 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 36.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 33.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 7.6 | 30.2 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.7 | 26.6 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.2 | 15.9 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 11.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 1.0 | 7.7 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.0 | 6.0 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 5.1 | GO:0043195 | terminal bouton(GO:0043195) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 40.0 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 5.0 | 30.2 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.1 | 21.4 | GO:0002020 | protease binding(GO:0002020) |
| 0.1 | 20.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 20.1 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.6 | 15.2 | GO:0001848 | complement binding(GO:0001848) |
| 0.5 | 15.0 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.8 | 12.8 | GO:0015643 | toxic substance binding(GO:0015643) |
| 1.9 | 7.7 | GO:0035473 | lipase binding(GO:0035473) |
| 1.8 | 7.3 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 37.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.3 | 19.3 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.5 | 15.2 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 14.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 12.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 11.9 | PID BMP PATHWAY | BMP receptor signaling |
| 0.4 | 10.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 5.8 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 4.6 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 2.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 34.9 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 1.3 | 26.8 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 23.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 1.0 | 15.9 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.3 | 10.4 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.4 | 7.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.4 | 6.5 | REACTOME DEFENSINS | Genes involved in Defensins |
| 0.2 | 6.0 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.2 | 5.8 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.2 | 4.8 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |