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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CREB3L1_CREB3
Z-value: 1.52
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Transcription factors associated with CREB3L1_CREB3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREB3 | hg19_v2_chr9_+_35732312_35732332 | 0.35 | 8.8e-08 | Click! |
| CREB3L1 | hg19_v2_chr11_+_46316677_46316719 | -0.08 | 2.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB3L1_CREB3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.2 | 68.2 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.4 | 67.6 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 0.1 | 58.4 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 3.8 | 42.0 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 2.6 | 34.2 | GO:0006048 | UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 2.3 | 30.3 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 1.1 | 28.6 | GO:0061157 | mRNA destabilization(GO:0061157) |
| 0.9 | 23.6 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 3.4 | 20.7 | GO:0046985 | positive regulation of hemoglobin biosynthetic process(GO:0046985) |
| 0.4 | 20.3 | GO:0018208 | peptidyl-proline modification(GO:0018208) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 54.6 | GO:0030663 | COPI-coated vesicle membrane(GO:0030663) |
| 0.4 | 47.2 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.4 | 46.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 4.2 | 46.5 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.1 | 46.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 39.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.4 | 31.3 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 1.4 | 30.3 | GO:0042599 | lamellar body(GO:0042599) |
| 4.9 | 29.3 | GO:0071256 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.4 | 21.3 | GO:0005801 | cis-Golgi network(GO:0005801) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 80.4 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.2 | 50.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 42.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 2.4 | 30.6 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 6.1 | 30.3 | GO:0019798 | procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798) |
| 6.1 | 24.5 | GO:0005046 | KDEL sequence binding(GO:0005046) |
| 7.9 | 23.6 | GO:0047757 | chondroitin-glucuronate 5-epimerase activity(GO:0047757) |
| 0.2 | 23.0 | GO:0019905 | syntaxin binding(GO:0019905) |
| 3.4 | 20.7 | GO:0044020 | histone methyltransferase activity (H4-R3 specific)(GO:0044020) |
| 0.5 | 20.6 | GO:0003785 | actin monomer binding(GO:0003785) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 71.1 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.2 | 45.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 1.5 | 39.9 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.3 | 26.2 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 25.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 19.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.3 | 18.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.7 | 16.5 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.3 | 15.6 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.2 | 11.9 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 91.0 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.5 | 76.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.8 | 58.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 3.8 | 37.7 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.4 | 25.8 | REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |
| 1.1 | 19.9 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.7 | 18.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.3 | 14.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 13.6 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 1.1 | 12.3 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |