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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CUACAGU

Z-value: 0.17

Motif logo

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miRNA associated with seed CUACAGU

NamemiRBASE accession
hsa-miR-139-5p
MIMAT0000250

Activity profile of CUACAGU motif

Sorted Z-values of CUACAGU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_136834982 1.54 ENST00000510689.1
ENST00000394945.1
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr16_+_58497567 1.24 ENST00000258187.5
NDRG4
NDRG family member 4
chr3_-_114790179 0.83 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr3_-_123603137 0.78 ENST00000360304.3
ENST00000359169.1
ENST00000346322.5
ENST00000360772.3
MYLK
myosin light chain kinase
chr3_+_158991025 0.68 ENST00000337808.6
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr3_+_159557637 0.63 ENST00000445224.2
SCHIP1
schwannomin interacting protein 1
chr1_-_225840747 0.55 ENST00000366843.2
ENST00000366844.3
ENAH
enabled homolog (Drosophila)
chr15_+_39873268 0.48 ENST00000397591.2
ENST00000260356.5
THBS1
thrombospondin 1
chr19_+_10527449 0.45 ENST00000592685.1
ENST00000380702.2
PDE4A
phosphodiesterase 4A, cAMP-specific
chr9_-_14314066 0.39 ENST00000397575.3
NFIB
nuclear factor I/B
chr2_+_113033164 0.39 ENST00000409871.1
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr9_-_101471479 0.38 ENST00000259455.2
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr11_-_95657231 0.33 ENST00000409459.1
ENST00000352297.7
ENST00000393223.3
ENST00000346299.5
MTMR2
myotubularin related protein 2
chr17_-_78450398 0.33 ENST00000306773.4
NPTX1
neuronal pentraxin I
chr10_-_735553 0.29 ENST00000280886.6
ENST00000423550.1
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr3_-_124774802 0.29 ENST00000311127.4
HEG1
heart development protein with EGF-like domains 1
chrX_-_33146477 0.28 ENST00000378677.2
DMD
dystrophin
chr2_-_38604398 0.27 ENST00000443098.1
ENST00000449130.1
ENST00000378954.4
ENST00000539122.1
ENST00000419554.2
ENST00000451483.1
ENST00000406122.1
ATL2
atlastin GTPase 2
chr15_-_77363513 0.25 ENST00000267970.4
TSPAN3
tetraspanin 3
chr4_+_113970772 0.25 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
ANK2
ankyrin 2, neuronal
chr3_-_98620500 0.25 ENST00000326840.6
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr8_-_67525473 0.23 ENST00000522677.3
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr16_-_10674528 0.22 ENST00000359543.3
EMP2
epithelial membrane protein 2
chr2_-_11484710 0.22 ENST00000315872.6
ROCK2
Rho-associated, coiled-coil containing protein kinase 2
chr1_+_29563011 0.21 ENST00000345512.3
ENST00000373779.3
ENST00000356870.3
ENST00000323874.8
ENST00000428026.2
ENST00000460170.2
PTPRU
protein tyrosine phosphatase, receptor type, U
chr1_-_175712829 0.20 ENST00000367674.2
TNR
tenascin R
chr20_-_48099182 0.19 ENST00000371741.4
KCNB1
potassium voltage-gated channel, Shab-related subfamily, member 1
chr10_-_99393242 0.17 ENST00000370635.3
ENST00000478953.1
ENST00000335628.3
MORN4
MORN repeat containing 4
chr15_-_37390482 0.15 ENST00000559085.1
ENST00000397624.3
MEIS2
Meis homeobox 2
chr5_+_149109825 0.14 ENST00000360453.4
ENST00000394320.3
ENST00000309241.5
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr1_+_87794150 0.14 ENST00000370544.5
LMO4
LIM domain only 4
chr17_+_64298944 0.13 ENST00000413366.3
PRKCA
protein kinase C, alpha
chr11_+_92085262 0.13 ENST00000298047.6
ENST00000409404.2
ENST00000541502.1
FAT3
FAT atypical cadherin 3
chr3_-_129407535 0.13 ENST00000432054.2
TMCC1
transmembrane and coiled-coil domain family 1
chrX_+_146993449 0.13 ENST00000218200.8
ENST00000370471.3
ENST00000370477.1
FMR1
fragile X mental retardation 1
chr10_-_11653753 0.12 ENST00000609104.1
USP6NL
USP6 N-terminal like
chr5_-_132073210 0.12 ENST00000378735.1
ENST00000378746.4
KIF3A
kinesin family member 3A
chr18_+_3451646 0.11 ENST00000345133.5
ENST00000330513.5
ENST00000549546.1
TGIF1
TGFB-induced factor homeobox 1
chr10_-_70287231 0.11 ENST00000609923.1
SLC25A16
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
chr5_+_15500280 0.11 ENST00000504595.1
FBXL7
F-box and leucine-rich repeat protein 7
chr5_-_114598548 0.11 ENST00000379615.3
ENST00000419445.1
PGGT1B
protein geranylgeranyltransferase type I, beta subunit
chr6_+_37787262 0.10 ENST00000287218.4
ZFAND3
zinc finger, AN1-type domain 3
chr1_-_72748417 0.10 ENST00000357731.5
NEGR1
neuronal growth regulator 1
chr7_+_77325738 0.08 ENST00000334955.8
RSBN1L
round spermatid basic protein 1-like
chr2_-_166930131 0.08 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr7_-_56119238 0.08 ENST00000275605.3
ENST00000395471.3
PSPH
phosphoserine phosphatase
chr15_-_79383102 0.08 ENST00000558480.2
ENST00000419573.3
RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr18_+_55018044 0.08 ENST00000324000.3
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chrX_+_16804544 0.07 ENST00000380122.5
ENST00000398155.4
TXLNG
taxilin gamma
chr8_+_61591337 0.07 ENST00000423902.2
CHD7
chromodomain helicase DNA binding protein 7
chr5_-_59189545 0.07 ENST00000340635.6
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_-_85156216 0.06 ENST00000342203.3
ENST00000370612.4
SSX2IP
synovial sarcoma, X breakpoint 2 interacting protein
chr5_-_114961858 0.06 ENST00000282382.4
ENST00000456936.3
ENST00000408996.4
TMED7-TICAM2
TMED7
TICAM2
TMED7-TICAM2 readthrough
transmembrane emp24 protein transport domain containing 7
toll-like receptor adaptor molecule 2
chr1_-_21671968 0.06 ENST00000415912.2
ECE1
endothelin converting enzyme 1
chr2_-_69870835 0.06 ENST00000409085.4
ENST00000406297.3
AAK1
AP2 associated kinase 1
chr4_+_77870856 0.05 ENST00000264893.6
ENST00000502584.1
ENST00000510641.1
SEPT11
septin 11
chr11_+_86748863 0.05 ENST00000340353.7
TMEM135
transmembrane protein 135
chr12_+_26348429 0.05 ENST00000242729.2
SSPN
sarcospan
chr2_+_27070964 0.05 ENST00000288699.6
DPYSL5
dihydropyrimidinase-like 5
chr3_-_160283348 0.05 ENST00000334256.4
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr6_-_8064567 0.04 ENST00000543936.1
ENST00000397457.2
BLOC1S5
biogenesis of lysosomal organelles complex-1, subunit 5, muted
chr21_-_36260980 0.04 ENST00000344691.4
ENST00000358356.5
RUNX1
runt-related transcription factor 1
chr1_-_155532484 0.04 ENST00000368346.3
ENST00000548830.1
ASH1L
ash1 (absent, small, or homeotic)-like (Drosophila)
chr8_-_105601134 0.04 ENST00000276654.5
ENST00000424843.2
LRP12
low density lipoprotein receptor-related protein 12
chr10_+_31608054 0.03 ENST00000320985.10
ENST00000361642.5
ENST00000560721.2
ENST00000558440.1
ENST00000424869.1
ENST00000542815.3
ZEB1
zinc finger E-box binding homeobox 1
chr7_-_138666053 0.03 ENST00000440172.1
ENST00000422774.1
KIAA1549
KIAA1549
chr4_-_99579733 0.03 ENST00000305798.3
TSPAN5
tetraspanin 5
chr11_+_129939779 0.03 ENST00000533195.1
ENST00000533713.1
ENST00000528499.1
ENST00000539648.1
ENST00000263574.5
APLP2
amyloid beta (A4) precursor-like protein 2
chr9_+_77112244 0.02 ENST00000376896.3
RORB
RAR-related orphan receptor B
chr1_+_37940153 0.02 ENST00000373087.6
ZC3H12A
zinc finger CCCH-type containing 12A
chr18_-_53255766 0.02 ENST00000566286.1
ENST00000564999.1
ENST00000566279.1
ENST00000354452.3
ENST00000356073.4
TCF4
transcription factor 4
chr20_-_4982132 0.01 ENST00000338244.1
ENST00000424750.2
SLC23A2
solute carrier family 23 (ascorbic acid transporter), member 2
chr6_-_16761678 0.01 ENST00000244769.4
ENST00000436367.1
ATXN1
ataxin 1
chr13_-_21476900 0.01 ENST00000400602.2
ENST00000255305.6
XPO4
exportin 4
chr12_+_123868320 0.01 ENST00000402868.3
ENST00000330479.4
SETD8
SET domain containing (lysine methyltransferase) 8
chr3_-_116164306 0.01 ENST00000490035.2
LSAMP
limbic system-associated membrane protein
chr12_+_57998595 0.01 ENST00000337737.3
ENST00000548198.1
ENST00000551632.1
DTX3
deltex homolog 3 (Drosophila)
chr18_+_49866496 0.00 ENST00000442544.2
DCC
deleted in colorectal carcinoma
chr5_-_133561752 0.00 ENST00000519718.1
ENST00000481195.1
CTD-2410N18.5
PPP2CA
S-phase kinase-associated protein 1
protein phosphatase 2, catalytic subunit, alpha isozyme

Network of associatons between targets according to the STRING database.

First level regulatory network of CUACAGU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0002605 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) negative regulation of dendritic cell antigen processing and presentation(GO:0002605)
0.1 0.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 1.2 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.1 0.3 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.1 0.2 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 0.4 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.2 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.1 GO:2000705 histone H3-T6 phosphorylation(GO:0035408) dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.0 0.3 GO:0090270 fibroblast growth factor production(GO:0090269) regulation of fibroblast growth factor production(GO:0090270)
0.0 0.2 GO:0048690 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.0 0.2 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0021553 olfactory nerve development(GO:0021553)
0.0 0.3 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.0 0.1 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.3 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:2000301 regulation of intracellular transport of viral material(GO:1901252) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.2 GO:0070836 caveola assembly(GO:0070836)
0.0 0.1 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.0 1.5 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.0 0.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.1 GO:0042659 regulation of cell fate specification(GO:0042659)
0.0 0.1 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.5 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)
0.0 0.1 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.0 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.1 GO:0010265 SCF complex assembly(GO:0010265)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.2 GO:0072534 perineuronal net(GO:0072534)
0.1 1.6 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0019034 viral replication complex(GO:0019034)
0.0 0.5 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.0 0.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.3 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.1 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.1 GO:0031302 intrinsic component of endosome membrane(GO:0031302)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0070052 collagen V binding(GO:0070052)
0.2 0.8 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.4 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 1.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.0 0.1 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.6 GO:0050699 WW domain binding(GO:0050699)
0.0 0.3 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.4 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor