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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CUX1

Z-value: 2.04

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Transcription factors associated with CUX1

Gene Symbol Gene ID Gene Info
CUX1
ENSG00000257923.5 cut like homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CUX1hg19_v2_chr7_+_101917407_1019174450.533.8e-17Click!

Activity profile of CUX1 motif

Sorted Z-values of CUX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_23241661 29.22 ENST00000390322.2
IGLJ2
immunoglobulin lambda joining 2
chr6_-_32557610 28.88 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr17_+_1665345 26.72 ENST00000576406.1
ENST00000571149.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr14_-_106092403 25.22 ENST00000390543.2
IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr6_-_32498046 24.60 ENST00000374975.3
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr22_+_23243156 21.72 ENST00000390323.2
IGLC2
immunoglobulin lambda constant 2 (Kern-Oz- marker)
chr2_+_90139056 19.29 ENST00000492446.1
IGKV1D-16
immunoglobulin kappa variable 1D-16
chr14_+_75745477 18.55 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chrX_+_129473859 18.54 ENST00000424447.1
SLC25A14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr6_-_33048483 18.34 ENST00000419277.1
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chrX_-_153059811 17.79 ENST00000427365.2
ENST00000444450.1
ENST00000370093.1
IDH3G
isocitrate dehydrogenase 3 (NAD+) gamma
chr15_-_22448819 17.74 ENST00000604066.1
IGHV1OR15-1
immunoglobulin heavy variable 1/OR15-1 (non-functional)
chr5_-_176057518 17.68 ENST00000393693.2
SNCB
synuclein, beta
chr6_+_31554826 17.36 ENST00000376089.2
ENST00000396112.2
LST1
leukocyte specific transcript 1
chr5_-_176057365 16.66 ENST00000310112.3
SNCB
synuclein, beta
chr6_+_31554962 16.56 ENST00000376092.3
ENST00000376086.3
ENST00000303757.8
ENST00000376093.2
ENST00000376102.3
LST1
leukocyte specific transcript 1
chrX_-_107019181 15.78 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
TSC22D3
TSC22 domain family, member 3
chr12_-_91574142 15.77 ENST00000547937.1
DCN
decorin
chr1_-_183560011 15.19 ENST00000367536.1
NCF2
neutrophil cytosolic factor 2
chr11_-_111175739 14.94 ENST00000532918.1
COLCA1
colorectal cancer associated 1
chr19_+_41509851 14.79 ENST00000593831.1
ENST00000330446.5
CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr12_-_105478339 14.66 ENST00000424857.2
ENST00000258494.9
ALDH1L2
aldehyde dehydrogenase 1 family, member L2
chr7_-_150038704 14.63 ENST00000466675.1
ENST00000482669.1
ENST00000467793.1
ENST00000223271.3
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chrX_-_153059958 14.30 ENST00000370092.3
ENST00000217901.5
IDH3G
isocitrate dehydrogenase 3 (NAD+) gamma
chr3_+_49507674 14.30 ENST00000431960.1
ENST00000452317.1
ENST00000435508.2
ENST00000452060.1
ENST00000428779.1
ENST00000419218.1
ENST00000430636.1
DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr12_+_112204691 14.19 ENST00000416293.3
ENST00000261733.2
ALDH2
aldehyde dehydrogenase 2 family (mitochondrial)
chr15_+_74908147 13.96 ENST00000568139.1
ENST00000563297.1
ENST00000568488.1
ENST00000352989.5
ENST00000348245.3
CLK3
CDC-like kinase 3
chr22_-_17680472 13.93 ENST00000330232.4
CECR1
cat eye syndrome chromosome region, candidate 1
chr14_-_106322288 13.89 ENST00000390559.2
IGHM
immunoglobulin heavy constant mu
chr3_+_169491171 13.73 ENST00000356716.4
MYNN
myoneurin
chr17_+_1665253 13.69 ENST00000254722.4
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr22_+_23040274 13.20 ENST00000390306.2
IGLV2-23
immunoglobulin lambda variable 2-23
chr15_+_75118888 13.20 ENST00000395018.4
CPLX3
complexin 3
chr8_-_56685859 13.13 ENST00000523423.1
ENST00000523073.1
ENST00000519784.1
ENST00000434581.2
ENST00000519780.1
ENST00000521229.1
ENST00000522576.1
ENST00000523180.1
ENST00000522090.1
TMEM68
transmembrane protein 68
chr1_-_67142710 12.73 ENST00000502413.2
AL139147.1
Uncharacterized protein
chr8_-_56685966 12.70 ENST00000334667.2
TMEM68
transmembrane protein 68
chr1_+_22962948 12.68 ENST00000374642.3
C1QA
complement component 1, q subcomponent, A chain
chr19_+_5681011 12.64 ENST00000581893.1
ENST00000411793.2
ENST00000301382.4
ENST00000581773.1
ENST00000423665.2
ENST00000583928.1
ENST00000342970.2
ENST00000422535.2
ENST00000581521.1
ENST00000339423.2
HSD11B1L
hydroxysteroid (11-beta) dehydrogenase 1-like
chrX_-_70331298 12.44 ENST00000456850.2
ENST00000473378.1
ENST00000487883.1
ENST00000374202.2
IL2RG
interleukin 2 receptor, gamma
chr8_+_27168988 12.39 ENST00000397501.1
ENST00000338238.4
ENST00000544172.1
PTK2B
protein tyrosine kinase 2 beta
chr1_+_11866270 12.31 ENST00000376497.3
ENST00000376487.3
ENST00000376496.3
CLCN6
chloride channel, voltage-sensitive 6
chr1_+_161185032 12.25 ENST00000367992.3
ENST00000289902.1
FCER1G
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr1_+_160085501 12.25 ENST00000361216.3
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr5_-_131826457 12.16 ENST00000437654.1
ENST00000245414.4
IRF1
interferon regulatory factor 1
chr9_-_115983641 12.07 ENST00000238256.3
FKBP15
FK506 binding protein 15, 133kDa
chrX_+_70316005 11.91 ENST00000374259.3
FOXO4
forkhead box O4
chr19_+_56652686 11.84 ENST00000592949.1
ZNF444
zinc finger protein 444
chr14_-_21270995 11.70 ENST00000555698.1
ENST00000397970.4
ENST00000340900.3
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr1_+_168148273 11.68 ENST00000367830.3
TIPRL
TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
chr22_+_23077065 11.63 ENST00000390310.2
IGLV2-18
immunoglobulin lambda variable 2-18
chr2_-_96811170 11.61 ENST00000288943.4
DUSP2
dual specificity phosphatase 2
chr12_-_53601000 11.59 ENST00000338737.4
ENST00000549086.2
ITGB7
integrin, beta 7
chr22_+_22786288 11.56 ENST00000390301.2
IGLV1-36
immunoglobulin lambda variable 1-36
chr17_-_74137374 11.56 ENST00000322957.6
FOXJ1
forkhead box J1
chr1_-_112281875 11.53 ENST00000527621.1
ENST00000534365.1
ENST00000357260.5
FAM212B
family with sequence similarity 212, member B
chr11_-_66725837 11.46 ENST00000393958.2
ENST00000393960.1
ENST00000524491.1
ENST00000355677.3
PC
pyruvate carboxylase
chr1_+_156119798 11.39 ENST00000355014.2
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr1_-_27952741 11.38 ENST00000399173.1
FGR
feline Gardner-Rasheed sarcoma viral oncogene homolog
chr22_-_36903069 11.37 ENST00000216187.6
ENST00000423980.1
FOXRED2
FAD-dependent oxidoreductase domain containing 2
chr22_+_23165153 11.29 ENST00000390317.2
IGLV2-8
immunoglobulin lambda variable 2-8
chr22_-_37545972 11.23 ENST00000216223.5
IL2RB
interleukin 2 receptor, beta
chr22_+_22712087 11.22 ENST00000390294.2
IGLV1-47
immunoglobulin lambda variable 1-47
chr17_+_41006095 11.00 ENST00000591562.1
ENST00000588033.1
AOC3
amine oxidase, copper containing 3
chr20_-_43883197 10.84 ENST00000338380.2
SLPI
secretory leukocyte peptidase inhibitor
chr2_-_89278535 10.68 ENST00000390247.2
IGKV3-7
immunoglobulin kappa variable 3-7 (non-functional)
chr14_-_21490417 10.63 ENST00000556366.1
NDRG2
NDRG family member 2
chr17_+_47865917 10.59 ENST00000259021.4
ENST00000454930.2
ENST00000509773.1
ENST00000510819.1
ENST00000424009.2
KAT7
K(lysine) acetyltransferase 7
chr7_-_37024665 10.59 ENST00000396040.2
ELMO1
engulfment and cell motility 1
chr19_-_36523709 10.54 ENST00000592017.1
ENST00000360535.4
CLIP3
CAP-GLY domain containing linker protein 3
chr19_+_56652556 10.51 ENST00000337080.3
ZNF444
zinc finger protein 444
chr5_+_178368186 10.45 ENST00000320129.3
ENST00000519564.1
ZNF454
zinc finger protein 454
chr5_-_149535421 10.38 ENST00000261799.4
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr1_+_89829610 10.37 ENST00000370456.4
ENST00000535065.1
GBP6
guanylate binding protein family, member 6
chr1_-_212208842 10.36 ENST00000366992.3
ENST00000366993.3
ENST00000440600.2
ENST00000366994.3
INTS7
integrator complex subunit 7
chr3_+_169490606 10.35 ENST00000349841.5
MYNN
myoneurin
chr8_-_22089845 10.22 ENST00000454243.2
PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr19_+_45417812 10.21 ENST00000592535.1
APOC1
apolipoprotein C-I
chr22_-_37213045 10.12 ENST00000406910.2
ENST00000417718.2
PVALB
parvalbumin
chr17_-_47755338 10.08 ENST00000508805.1
ENST00000515508.2
ENST00000451526.2
ENST00000507970.1
SPOP
speckle-type POZ protein
chr14_-_21490590 10.08 ENST00000557633.1
NDRG2
NDRG family member 2
chrX_+_23352133 10.06 ENST00000379361.4
PTCHD1
patched domain containing 1
chr1_+_46668994 10.05 ENST00000371980.3
LURAP1
leucine rich adaptor protein 1
chr21_+_34144411 10.05 ENST00000382375.4
ENST00000453404.1
ENST00000382378.1
ENST00000477513.1
C21orf49
chromosome 21 open reading frame 49
chr20_-_18774614 10.04 ENST00000412553.1
LINC00652
long intergenic non-protein coding RNA 652
chr12_-_52715179 10.02 ENST00000293670.3
KRT83
keratin 83
chr13_-_28674693 9.94 ENST00000537084.1
ENST00000241453.7
ENST00000380982.4
FLT3
fms-related tyrosine kinase 3
chr3_-_15106747 9.93 ENST00000449354.2
ENST00000444840.2
ENST00000253686.2
MRPS25
mitochondrial ribosomal protein S25
chr8_-_110620284 9.93 ENST00000529690.1
SYBU
syntabulin (syntaxin-interacting)
chr7_+_6522922 9.85 ENST00000601673.1
FLJ20306
CDNA FLJ20306 fis, clone HEP06881; Putative uncharacterized protein FLJ20306; Uncharacterized protein
chr17_+_7942335 9.73 ENST00000380183.4
ENST00000572022.1
ENST00000380173.2
ALOX15B
arachidonate 15-lipoxygenase, type B
chr3_+_111717600 9.69 ENST00000273368.4
TAGLN3
transgelin 3
chr11_-_118213360 9.67 ENST00000529594.1
CD3D
CD3d molecule, delta (CD3-TCR complex)
chr4_+_123844225 9.64 ENST00000274008.4
SPATA5
spermatogenesis associated 5
chr1_-_203274418 9.61 ENST00000457348.1
RP11-134P9.1
long intergenic non-protein coding RNA 1136
chr7_-_76829125 9.60 ENST00000248598.5
FGL2
fibrinogen-like 2
chr14_-_25045446 9.56 ENST00000216336.2
CTSG
cathepsin G
chr13_-_50018241 9.43 ENST00000409308.1
CAB39L
calcium binding protein 39-like
chr12_-_71182695 9.39 ENST00000342084.4
PTPRR
protein tyrosine phosphatase, receptor type, R
chr1_+_158801095 9.37 ENST00000368141.4
MNDA
myeloid cell nuclear differentiation antigen
chr7_+_65579799 9.34 ENST00000431089.2
ENST00000398684.2
ENST00000338592.5
CRCP
CGRP receptor component
chr4_-_48018580 9.28 ENST00000514170.1
CNGA1
cyclic nucleotide gated channel alpha 1
chr6_+_72926145 9.18 ENST00000425662.2
ENST00000453976.2
RIMS1
regulating synaptic membrane exocytosis 1
chr17_-_2415169 9.12 ENST00000263092.6
ENST00000538844.1
ENST00000576976.1
METTL16
methyltransferase like 16
chr1_+_156123359 9.12 ENST00000368284.1
ENST00000368286.2
ENST00000438830.1
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr1_+_11866207 9.08 ENST00000312413.6
ENST00000346436.6
CLCN6
chloride channel, voltage-sensitive 6
chr1_+_160097462 9.07 ENST00000447527.1
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr19_-_49945617 9.01 ENST00000600601.1
ENST00000543531.1
SLC17A7
solute carrier family 17 (vesicular glutamate transporter), member 7
chr17_+_7452336 9.00 ENST00000293826.4
TNFSF12-TNFSF13
TNFSF12-TNFSF13 readthrough
chr11_-_72385437 8.94 ENST00000418754.2
ENST00000542969.2
ENST00000334456.5
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr1_+_156123318 8.81 ENST00000368285.3
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr11_+_118175596 8.64 ENST00000528600.1
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr2_-_73869508 8.64 ENST00000272425.3
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr17_-_18218270 8.64 ENST00000321105.5
TOP3A
topoisomerase (DNA) III alpha
chr6_+_26204825 8.63 ENST00000360441.4
HIST1H4E
histone cluster 1, H4e
chr6_-_34113856 8.39 ENST00000538487.2
GRM4
glutamate receptor, metabotropic 4
chr13_-_50018140 8.39 ENST00000410043.1
ENST00000347776.5
CAB39L
calcium binding protein 39-like
chr6_+_31554636 8.36 ENST00000433492.1
LST1
leukocyte specific transcript 1
chr3_-_170303845 8.26 ENST00000231706.5
SLC7A14
solute carrier family 7, member 14
chr11_+_126225529 8.25 ENST00000227495.6
ENST00000444328.2
ENST00000356132.4
ST3GAL4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr1_-_15911510 8.25 ENST00000375826.3
AGMAT
agmatine ureohydrolase (agmatinase)
chr8_+_11561660 8.24 ENST00000526716.1
ENST00000335135.4
ENST00000528027.1
GATA4
GATA binding protein 4
chr11_+_117070037 8.23 ENST00000392951.4
ENST00000525531.1
ENST00000278968.6
TAGLN
transgelin
chr2_+_60983361 8.22 ENST00000238714.3
PAPOLG
poly(A) polymerase gamma
chr2_+_64751433 8.21 ENST00000238856.4
ENST00000422803.1
ENST00000238855.7
AFTPH
aftiphilin
chr19_+_55084438 8.16 ENST00000439534.1
LILRA2
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
chr16_-_89768097 8.11 ENST00000289805.5
ENST00000335360.7
SPATA2L
spermatogenesis associated 2-like
chr12_+_7055631 8.09 ENST00000543115.1
ENST00000399448.1
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr7_-_152373216 8.09 ENST00000359321.1
XRCC2
X-ray repair complementing defective repair in Chinese hamster cells 2
chr19_+_44556158 8.07 ENST00000434772.3
ENST00000585552.1
ZNF223
zinc finger protein 223
chr16_+_69166418 8.06 ENST00000314423.7
ENST00000562237.1
ENST00000567460.1
ENST00000566227.1
ENST00000352319.4
ENST00000563094.1
CIRH1A
cirrhosis, autosomal recessive 1A (cirhin)
chr22_+_41763274 8.01 ENST00000406644.3
TEF
thyrotrophic embryonic factor
chr14_-_106330458 8.01 ENST00000461719.1
IGHJ4
immunoglobulin heavy joining 4
chr1_+_158901329 8.00 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
PYHIN1
pyrin and HIN domain family, member 1
chr19_-_51530916 8.00 ENST00000594768.1
KLK11
kallikrein-related peptidase 11
chr14_-_23285069 7.96 ENST00000554758.1
ENST00000397528.4
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr20_+_18269121 7.90 ENST00000377671.3
ENST00000360010.5
ENST00000396026.3
ENST00000402618.2
ENST00000401790.1
ENST00000434018.1
ENST00000538547.1
ENST00000535822.1
ZNF133
zinc finger protein 133
chr17_-_18950310 7.82 ENST00000573099.1
GRAP
GRB2-related adaptor protein
chrX_+_46937745 7.82 ENST00000397180.1
ENST00000457380.1
ENST00000352078.4
RGN
regucalcin
chr6_-_22297730 7.82 ENST00000306482.1
PRL
prolactin
chr15_-_64648273 7.78 ENST00000607537.1
ENST00000303052.7
ENST00000303032.6
CSNK1G1
casein kinase 1, gamma 1
chr19_-_42133420 7.77 ENST00000221954.2
ENST00000600925.1
CEACAM4
carcinoembryonic antigen-related cell adhesion molecule 4
chr6_-_46459675 7.71 ENST00000306764.7
RCAN2
regulator of calcineurin 2
chr6_-_29600832 7.69 ENST00000377016.4
ENST00000376977.3
ENST00000377034.4
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr19_-_5680499 7.67 ENST00000587589.1
C19orf70
chromosome 19 open reading frame 70
chr14_-_107283278 7.59 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr19_-_54784353 7.57 ENST00000391746.1
LILRB2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
chrY_+_16168097 7.57 ENST00000250823.4
VCY1B
variable charge, Y-linked 1B
chr19_+_36266433 7.57 ENST00000314737.5
ARHGAP33
Rho GTPase activating protein 33
chr1_+_119957554 7.56 ENST00000543831.1
ENST00000433745.1
ENST00000369416.3
HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr11_-_14993819 7.52 ENST00000396372.2
ENST00000361010.3
ENST00000359642.3
ENST00000331587.4
CALCA
calcitonin-related polypeptide alpha
chr6_-_31514333 7.51 ENST00000376151.4
ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr1_+_204797749 7.49 ENST00000367172.4
ENST00000367171.4
ENST00000367170.4
ENST00000338515.6
ENST00000339876.6
ENST00000338586.6
ENST00000539706.1
ENST00000360049.4
ENST00000367169.4
ENST00000446412.1
ENST00000403080.1
NFASC
neurofascin
chr7_-_102252038 7.49 ENST00000461209.1
RASA4
RAS p21 protein activator 4
chr2_-_50574856 7.43 ENST00000342183.5
NRXN1
neurexin 1
chr6_-_90025011 7.42 ENST00000402938.3
GABRR2
gamma-aminobutyric acid (GABA) A receptor, rho 2
chr13_-_25496926 7.39 ENST00000545981.1
ENST00000381884.4
CENPJ
centromere protein J
chr15_+_58702742 7.38 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr12_-_11508520 7.27 ENST00000545626.1
ENST00000500254.2
PRB1
proline-rich protein BstNI subfamily 1
chrX_+_153059608 7.25 ENST00000370087.1
SSR4
signal sequence receptor, delta
chr17_+_73043301 7.21 ENST00000322444.6
KCTD2
potassium channel tetramerization domain containing 2
chr19_+_50380682 7.20 ENST00000221543.5
TBC1D17
TBC1 domain family, member 17
chr14_-_25103388 7.20 ENST00000526004.1
ENST00000415355.3
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr14_-_106963409 7.17 ENST00000390621.2
IGHV1-45
immunoglobulin heavy variable 1-45
chr14_-_23285011 7.15 ENST00000397532.3
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr6_-_167797887 7.12 ENST00000476779.2
ENST00000460930.2
ENST00000397829.4
ENST00000366827.2
TCP10
t-complex 10
chr1_-_36948879 7.11 ENST00000373106.1
ENST00000373104.1
ENST00000373103.1
CSF3R
colony stimulating factor 3 receptor (granulocyte)
chr13_+_111365602 7.07 ENST00000333219.7
ING1
inhibitor of growth family, member 1
chr6_-_31514516 7.06 ENST00000303892.5
ENST00000483251.1
ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr8_-_110656995 7.02 ENST00000276646.9
ENST00000533065.1
SYBU
syntabulin (syntaxin-interacting)
chr14_+_74416989 7.02 ENST00000334571.2
ENST00000554920.1
COQ6
coenzyme Q6 monooxygenase
chr9_-_115983568 7.01 ENST00000446284.1
ENST00000414250.1
FKBP15
FK506 binding protein 15, 133kDa
chrX_-_130037198 7.01 ENST00000370935.1
ENST00000338144.3
ENST00000394363.1
ENOX2
ecto-NOX disulfide-thiol exchanger 2
chr5_+_35617940 6.93 ENST00000282469.6
ENST00000509059.1
ENST00000356031.3
ENST00000510777.1
SPEF2
sperm flagellar 2
chr6_+_31554456 6.92 ENST00000339530.4
LST1
leukocyte specific transcript 1
chr9_-_35665165 6.92 ENST00000343259.3
ENST00000378387.3
ARHGEF39
Rho guanine nucleotide exchange factor (GEF) 39
chr15_-_88799384 6.87 ENST00000540489.2
ENST00000557856.1
ENST00000558676.1
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr15_-_88799661 6.86 ENST00000360948.2
ENST00000357724.2
ENST00000355254.2
ENST00000317501.3
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr12_+_57522258 6.86 ENST00000553277.1
ENST00000243077.3
LRP1
low density lipoprotein receptor-related protein 1
chr1_-_212588157 6.84 ENST00000261455.4
ENST00000535273.1
TMEM206
transmembrane protein 206
chr2_+_103035102 6.84 ENST00000264260.2
IL18RAP
interleukin 18 receptor accessory protein
chr7_-_142176790 6.82 ENST00000390369.2
TRBV7-4
T cell receptor beta variable 7-4 (gene/pseudogene)
chr2_-_152118352 6.81 ENST00000331426.5
RBM43
RNA binding motif protein 43
chr9_+_35605274 6.80 ENST00000336395.5
TESK1
testis-specific kinase 1
chr10_+_75545391 6.78 ENST00000604524.1
ENST00000605216.1
ENST00000398706.2
ZSWIM8
zinc finger, SWIM-type containing 8
chr6_+_31554612 6.75 ENST00000211921.7
LST1
leukocyte specific transcript 1
chr12_+_7060432 6.74 ENST00000318974.9
ENST00000456013.1
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr12_+_79258444 6.73 ENST00000261205.4
SYT1
synaptotagmin I
chr10_+_74927875 6.68 ENST00000242505.6
FAM149B1
family with sequence similarity 149, member B1
chr2_+_90153696 6.68 ENST00000417279.2
IGKV3D-15
immunoglobulin kappa variable 3D-15 (gene/pseudogene)
chr11_-_59950519 6.67 ENST00000528851.1
MS4A6A
membrane-spanning 4-domains, subfamily A, member 6A
chr12_+_79258547 6.66 ENST00000457153.2
SYT1
synaptotagmin I
chrX_-_78622805 6.62 ENST00000373298.2
ITM2A
integral membrane protein 2A
chr8_+_38585704 6.59 ENST00000519416.1
ENST00000520615.1
TACC1
transforming, acidic coiled-coil containing protein 1
chr5_+_140186647 6.55 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
PCDHA4
protocadherin alpha 4
chr1_-_52870059 6.53 ENST00000371566.1
ORC1
origin recognition complex, subunit 1
chrX_+_102469997 6.52 ENST00000372695.5
ENST00000372691.3
BEX4
brain expressed, X-linked 4
chr11_-_62783303 6.51 ENST00000336232.2
ENST00000430500.2
SLC22A8
solute carrier family 22 (organic anion transporter), member 8
chr16_+_23765948 6.50 ENST00000300113.2
CHP2
calcineurin-like EF-hand protein 2
chr1_-_168698433 6.50 ENST00000367817.3
DPT
dermatopontin
chr6_-_90024967 6.47 ENST00000602399.1
GABRR2
gamma-aminobutyric acid (GABA) A receptor, rho 2

Network of associatons between targets according to the STRING database.

First level regulatory network of CUX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
8.1 40.4 GO:0071279 cellular response to cobalt ion(GO:0071279)
5.8 28.9 GO:0002399 MHC class II protein complex assembly(GO:0002399)
4.9 14.7 GO:0009258 10-formyltetrahydrofolate catabolic process(GO:0009258)
4.9 14.6 GO:0061760 antifungal innate immune response(GO:0061760)
4.6 32.1 GO:0006102 isocitrate metabolic process(GO:0006102)
4.6 13.7 GO:0019056 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
4.5 9.0 GO:0048690 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
4.5 13.4 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
4.3 4.3 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
4.3 13.0 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
4.3 21.3 GO:1900920 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
4.3 12.8 GO:0060437 lung growth(GO:0060437)
4.1 12.3 GO:0001812 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type I hypersensitivity(GO:0001812) positive regulation of type II hypersensitivity(GO:0002894) positive regulation of mast cell cytokine production(GO:0032765) mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
4.1 12.2 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
3.9 11.6 GO:0002663 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
3.7 11.2 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
3.7 14.8 GO:0033277 abortive mitotic cell cycle(GO:0033277)
3.4 23.7 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
3.1 12.4 GO:2000537 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
3.0 12.1 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
3.0 9.0 GO:0042137 sequestering of neurotransmitter(GO:0042137)
3.0 15.0 GO:0002913 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
3.0 8.9 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
3.0 11.9 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
2.9 11.6 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
2.9 14.3 GO:0016476 regulation of embryonic cell shape(GO:0016476)
2.7 8.2 GO:0003285 septum secundum development(GO:0003285)
2.6 10.6 GO:0043983 histone H4-K12 acetylation(GO:0043983)
2.6 7.8 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853) negative regulation of DNA catabolic process(GO:1903625) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
2.6 10.2 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
2.5 7.6 GO:0097254 renal tubular secretion(GO:0097254)
2.5 5.1 GO:0001810 type IIa hypersensitivity(GO:0001794) regulation of type IIa hypersensitivity(GO:0001796) regulation of type I hypersensitivity(GO:0001810) type II hypersensitivity(GO:0002445) regulation of type II hypersensitivity(GO:0002892) type I hypersensitivity(GO:0016068)
2.5 15.1 GO:0000821 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
2.3 18.5 GO:0001661 conditioned taste aversion(GO:0001661)
2.3 6.9 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
2.1 10.5 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
2.1 6.2 GO:0060018 astrocyte fate commitment(GO:0060018)
2.1 8.3 GO:1901162 primary amino compound biosynthetic process(GO:1901162)
2.1 10.3 GO:0019805 quinolinate biosynthetic process(GO:0019805)
2.0 15.8 GO:0070236 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
1.9 5.8 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
1.9 9.4 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
1.9 5.6 GO:0002625 regulation of T cell antigen processing and presentation(GO:0002625)
1.9 7.4 GO:0002408 myeloid dendritic cell chemotaxis(GO:0002408)
1.8 14.8 GO:0070944 neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943) neutrophil mediated killing of bacterium(GO:0070944)
1.8 9.1 GO:0080009 mRNA methylation(GO:0080009)
1.7 5.2 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.7 17.3 GO:0006069 ethanol oxidation(GO:0006069)
1.7 5.2 GO:2000584 regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
1.7 5.1 GO:0001694 histamine biosynthetic process(GO:0001694)
1.7 5.1 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
1.7 6.7 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
1.7 5.0 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
1.7 6.6 GO:0002317 plasma cell differentiation(GO:0002317)
1.6 4.9 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
1.6 9.7 GO:0051121 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
1.6 4.7 GO:0021678 midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592) third ventricle development(GO:0021678)
1.6 4.7 GO:0045082 interleukin-4 biosynthetic process(GO:0042097) positive regulation of interleukin-10 biosynthetic process(GO:0045082) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
1.5 4.6 GO:0002125 maternal aggressive behavior(GO:0002125) positive regulation of female receptivity(GO:0045925)
1.5 7.6 GO:0002578 negative regulation of antigen processing and presentation(GO:0002578)
1.5 8.9 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
1.5 7.4 GO:0061511 centriole elongation(GO:0061511)
1.5 5.8 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
1.5 8.7 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
1.4 17.0 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
1.4 5.6 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
1.4 8.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.4 4.1 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
1.3 8.1 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
1.3 20.7 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
1.3 3.8 GO:0018874 benzoate metabolic process(GO:0018874) butyrate metabolic process(GO:0019605)
1.3 6.3 GO:0032455 nerve growth factor processing(GO:0032455)
1.2 88.6 GO:0006910 phagocytosis, recognition(GO:0006910)
1.2 7.2 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
1.2 6.0 GO:0030382 sperm mitochondrion organization(GO:0030382)
1.2 10.6 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
1.2 8.2 GO:0048014 Tie signaling pathway(GO:0048014)
1.2 2.3 GO:1904589 regulation of protein import(GO:1904589)
1.2 9.3 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
1.1 9.7 GO:0045059 positive thymic T cell selection(GO:0045059)
1.1 14.9 GO:0042738 exogenous drug catabolic process(GO:0042738)
1.1 7.4 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
1.0 3.1 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
1.0 2.0 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
1.0 2.9 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.9 7.4 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.9 6.5 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.9 3.6 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.9 4.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.9 2.7 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.9 12.5 GO:0008212 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.9 2.7 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.9 7.9 GO:0032966 negative regulation of collagen biosynthetic process(GO:0032966)
0.9 3.5 GO:1990262 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.9 2.6 GO:2000317 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.9 10.4 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.8 10.1 GO:0021794 thalamus development(GO:0021794)
0.8 1.7 GO:0002331 pre-B cell differentiation(GO:0002329) pre-B cell allelic exclusion(GO:0002331)
0.8 29.3 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.8 0.8 GO:0086100 endothelin receptor signaling pathway(GO:0086100)
0.8 4.0 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.8 3.9 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.8 2.3 GO:0019557 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.8 2.3 GO:0007418 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.8 11.7 GO:0043306 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.8 3.1 GO:2001193 gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) negative regulation of CD8-positive, alpha-beta T cell activation(GO:2001186) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)
0.8 6.2 GO:0070995 NADPH oxidation(GO:0070995)
0.8 5.4 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.8 3.1 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.8 3.8 GO:2000035 regulation of stem cell division(GO:2000035)
0.7 21.4 GO:0006884 cell volume homeostasis(GO:0006884)
0.7 2.9 GO:0060406 positive regulation of penile erection(GO:0060406)
0.7 24.2 GO:0045730 respiratory burst(GO:0045730)
0.7 71.9 GO:0006958 complement activation, classical pathway(GO:0006958)
0.7 2.9 GO:0034959 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.7 2.9 GO:0046967 cytosol to ER transport(GO:0046967)
0.7 2.8 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.7 9.8 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.7 8.1 GO:0036158 outer dynein arm assembly(GO:0036158)
0.7 2.0 GO:0035634 response to stilbenoid(GO:0035634)
0.6 6.5 GO:0010265 SCF complex assembly(GO:0010265)
0.6 1.9 GO:0009080 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080)
0.6 2.5 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.6 4.4 GO:0007341 penetration of zona pellucida(GO:0007341)
0.6 57.5 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.6 34.3 GO:0042417 dopamine metabolic process(GO:0042417)
0.6 26.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.6 1.8 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.6 2.4 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.6 4.8 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.6 1.8 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.6 2.9 GO:1904382 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.6 20.7 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.6 4.6 GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128)
0.6 8.6 GO:0016576 histone dephosphorylation(GO:0016576)
0.6 4.0 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.6 4.5 GO:0010165 response to X-ray(GO:0010165)
0.6 6.2 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.6 8.4 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.6 6.1 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.5 3.8 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.5 4.9 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.5 41.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.5 1.6 GO:0090427 activation of meiosis(GO:0090427)
0.5 17.3 GO:0090383 phagosome acidification(GO:0090383)
0.5 8.6 GO:0006265 DNA topological change(GO:0006265)
0.5 7.0 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.5 5.5 GO:0071600 otic vesicle formation(GO:0030916) otic vesicle morphogenesis(GO:0071600)
0.5 4.3 GO:0006957 complement activation, alternative pathway(GO:0006957) protein O-linked fucosylation(GO:0036066)
0.5 5.7 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.5 5.2 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.5 4.2 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.5 1.4 GO:0036343 psychomotor behavior(GO:0036343)
0.5 4.6 GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371)
0.5 8.2 GO:0030575 nuclear body organization(GO:0030575)
0.5 1.8 GO:0003335 corneocyte development(GO:0003335)
0.5 2.7 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.4 3.6 GO:0006013 mannose metabolic process(GO:0006013)
0.4 3.1 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.4 17.2 GO:0010107 potassium ion import(GO:0010107)
0.4 3.1 GO:0007000 nucleolus organization(GO:0007000)
0.4 11.3 GO:0009235 cobalamin metabolic process(GO:0009235)
0.4 11.0 GO:0051354 negative regulation of oxidoreductase activity(GO:0051354)
0.4 0.8 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.4 3.3 GO:0099563 modification of synaptic structure(GO:0099563)
0.4 6.5 GO:0005513 detection of calcium ion(GO:0005513)
0.4 2.0 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.4 1.2 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.4 10.8 GO:0019731 antibacterial humoral response(GO:0019731)
0.4 2.4 GO:0010761 fibroblast migration(GO:0010761)
0.4 5.3 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.4 2.6 GO:0089700 protein kinase D signaling(GO:0089700)
0.4 35.6 GO:0031295 T cell costimulation(GO:0031295)
0.4 1.5 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.4 3.0 GO:0006600 creatine metabolic process(GO:0006600)
0.4 1.1 GO:0072709 cellular response to sorbitol(GO:0072709)
0.4 12.3 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.4 6.8 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.4 7.1 GO:0097186 amelogenesis(GO:0097186)
0.3 9.5 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.3 2.7 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.3 4.0 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.3 1.7 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
0.3 8.3 GO:0097503 sialylation(GO:0097503)
0.3 1.8 GO:0009804 coumarin metabolic process(GO:0009804)
0.3 0.6 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.3 11.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.3 11.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.3 0.8 GO:0030223 neutrophil differentiation(GO:0030223)
0.3 1.9 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.3 1.1 GO:0015793 glycerol transport(GO:0015793)
0.3 37.2 GO:0002377 immunoglobulin production(GO:0002377)
0.3 19.4 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.3 3.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.3 2.1 GO:0072205 metanephric collecting duct development(GO:0072205)
0.3 5.7 GO:0015813 L-glutamate transport(GO:0015813)
0.3 10.9 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.3 0.3 GO:0070459 prolactin secretion(GO:0070459)
0.2 3.2 GO:1903817 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.2 2.2 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.2 0.5 GO:0032242 regulation of nucleoside transport(GO:0032242) negative regulation of neurotrophin production(GO:0032900)
0.2 0.2 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.2 3.3 GO:0060326 cell chemotaxis(GO:0060326)
0.2 4.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 4.9 GO:0019430 removal of superoxide radicals(GO:0019430)
0.2 5.8 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.2 4.3 GO:0006828 manganese ion transport(GO:0006828)
0.2 1.1 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.2 8.8 GO:0000266 mitochondrial fission(GO:0000266)
0.2 8.5 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.2 2.5 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.2 1.2 GO:0014004 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.2 5.5 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.2 2.6 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.2 2.5 GO:0015671 oxygen transport(GO:0015671)
0.2 9.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.2 3.2 GO:0042136 neurotransmitter biosynthetic process(GO:0042136)
0.2 1.5 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.2 1.3 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.2 1.3 GO:0045779 negative regulation of bone resorption(GO:0045779)
0.2 3.9 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.2 5.3 GO:0048536 spleen development(GO:0048536)
0.2 2.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 3.8 GO:0006337 nucleosome disassembly(GO:0006337)
0.2 4.3 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.2 10.0 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.2 1.9 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.2 3.9 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.2 0.5 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.2 6.5 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.2 4.2 GO:0001895 retina homeostasis(GO:0001895)
0.2 1.3 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.2 7.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 1.9 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.2 3.8 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.2 1.4 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.2 7.5 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.2 3.0 GO:0035640 exploration behavior(GO:0035640)
0.2 6.4 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.2 0.6 GO:0032667 interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) positive regulation of interleukin-23 production(GO:0032747)
0.2 4.2 GO:0030101 natural killer cell activation(GO:0030101)
0.2 7.1 GO:0015701 bicarbonate transport(GO:0015701)
0.2 8.3 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.1 1.3 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.1 0.7 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 8.2 GO:0006378 mRNA polyadenylation(GO:0006378)
0.1 0.9 GO:0009100 glycoprotein metabolic process(GO:0009100)
0.1 2.2 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 3.7 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.1 4.0 GO:0031018 endocrine pancreas development(GO:0031018)
0.1 1.2 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 5.5 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 2.1 GO:0060850 regulation of transcription involved in cell fate commitment(GO:0060850)
0.1 2.1 GO:0051639 actin filament network formation(GO:0051639)
0.1 2.1 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.1 0.4 GO:0035932 mineralocorticoid secretion(GO:0035931) aldosterone secretion(GO:0035932) regulation of mineralocorticoid secretion(GO:2000855) positive regulation of mineralocorticoid secretion(GO:2000857) regulation of aldosterone secretion(GO:2000858) positive regulation of aldosterone secretion(GO:2000860)
0.1 3.3 GO:0032094 response to food(GO:0032094)
0.1 4.2 GO:0030199 collagen fibril organization(GO:0030199)
0.1 3.3 GO:0002449 lymphocyte mediated immunity(GO:0002449)
0.1 1.8 GO:0006020 inositol metabolic process(GO:0006020)
0.1 5.6 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.1 1.6 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.1 25.8 GO:0002250 adaptive immune response(GO:0002250)
0.1 1.6 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 3.5 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.1 1.2 GO:0015074 DNA integration(GO:0015074)
0.1 17.0 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 1.5 GO:0032495 response to muramyl dipeptide(GO:0032495)
0.1 2.5 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.1 3.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 1.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 5.6 GO:0009060 aerobic respiration(GO:0009060)
0.1 1.2 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.1 1.9 GO:0003016 respiratory system process(GO:0003016)
0.1 6.8 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.1 6.2 GO:0007045 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041)
0.1 2.1 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.1 3.1 GO:0007565 female pregnancy(GO:0007565)
0.1 24.3 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.1 7.1 GO:0042742 defense response to bacterium(GO:0042742)
0.1 1.2 GO:0048665 neuron fate specification(GO:0048665)
0.1 0.4 GO:0042118 endothelial cell activation(GO:0042118)
0.1 2.3 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.1 0.3 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.1 3.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 4.6 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 3.8 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 8.4 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 2.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 4.9 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 16.5 GO:0007050 cell cycle arrest(GO:0007050)
0.1 0.5 GO:0051552 flavone metabolic process(GO:0051552)
0.1 4.0 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 14.0 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.1 2.9 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.1 1.8 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.1 2.2 GO:0006968 cellular defense response(GO:0006968)
0.1 1.5 GO:0016486 peptide hormone processing(GO:0016486)
0.1 10.0 GO:0007568 aging(GO:0007568)
0.1 2.5 GO:0015914 phospholipid transport(GO:0015914)
0.1 0.3 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 2.0 GO:0031124 mRNA 3'-end processing(GO:0031124)
0.0 1.9 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 2.6 GO:0045995 regulation of embryonic development(GO:0045995)
0.0 1.3 GO:0046324 regulation of glucose import(GO:0046324)
0.0 1.7 GO:0018149 peptide cross-linking(GO:0018149)
0.0 3.7 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 1.8 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 1.7 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.3 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.3 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.6 GO:0002223 innate immune response activating cell surface receptor signaling pathway(GO:0002220) stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.0 2.4 GO:0001525 angiogenesis(GO:0001525)
0.0 0.5 GO:0046626 regulation of insulin receptor signaling pathway(GO:0046626)
0.0 3.5 GO:0060047 heart contraction(GO:0060047)
0.0 1.2 GO:0031668 cellular response to extracellular stimulus(GO:0031668)
0.0 2.2 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 0.8 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 1.8 GO:0007030 Golgi organization(GO:0007030)
0.0 0.8 GO:0045087 innate immune response(GO:0045087)
0.0 0.7 GO:0070268 cornification(GO:0070268)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 39.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
3.4 71.8 GO:0042613 MHC class II protein complex(GO:0042613)
3.4 40.4 GO:0043203 axon hillock(GO:0043203)
3.0 9.0 GO:0072534 perineuronal net(GO:0072534)
2.9 11.6 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
2.8 22.4 GO:0060199 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
2.6 7.7 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
2.5 20.4 GO:0032010 phagolysosome(GO:0032010)
2.5 12.7 GO:0005602 complement component C1 complex(GO:0005602)
2.3 18.5 GO:0035976 AP1 complex(GO:0035976)
1.9 11.6 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
1.9 7.5 GO:0097454 Schwann cell microvillus(GO:0097454)
1.6 81.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
1.6 15.6 GO:0016011 dystroglycan complex(GO:0016011)
1.5 7.4 GO:0008275 gamma-tubulin small complex(GO:0008275)
1.5 4.4 GO:0043159 acrosomal matrix(GO:0043159)
1.5 2.9 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
1.4 9.5 GO:0097452 GAIT complex(GO:0097452)
1.3 8.1 GO:0033061 DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
1.3 17.0 GO:0097433 dense body(GO:0097433)
1.2 25.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
1.2 8.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
1.2 5.8 GO:0000408 EKC/KEOPS complex(GO:0000408)
1.2 10.4 GO:0032039 integrator complex(GO:0032039)
1.1 15.8 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
1.1 4.3 GO:0055087 Ski complex(GO:0055087)
0.9 10.6 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.8 7.6 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.7 2.9 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.7 17.3 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.7 10.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.7 5.5 GO:0036157 outer dynein arm(GO:0036157)
0.7 9.3 GO:0042575 DNA polymerase complex(GO:0042575)
0.7 11.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.6 9.6 GO:0097512 cardiac myofibril(GO:0097512)
0.6 10.4 GO:0031089 platelet dense granule lumen(GO:0031089)
0.5 7.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.5 5.9 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.5 3.1 GO:0014802 terminal cisterna(GO:0014802)
0.5 3.6 GO:0097209 epidermal lamellar body(GO:0097209)
0.5 4.6 GO:0071439 clathrin complex(GO:0071439)
0.5 2.5 GO:0042643 actomyosin, actin portion(GO:0042643)
0.5 6.5 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.5 2.9 GO:0042824 MHC class I peptide loading complex(GO:0042824) TAP complex(GO:0042825)
0.5 4.8 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.5 3.2 GO:1990635 proximal dendrite(GO:1990635)
0.5 4.6 GO:0071953 elastic fiber(GO:0071953)
0.4 7.1 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.4 6.0 GO:0097227 sperm annulus(GO:0097227)
0.4 9.2 GO:0042627 chylomicron(GO:0042627)
0.4 4.5 GO:0000109 nucleotide-excision repair complex(GO:0000109)
0.4 13.9 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.4 7.8 GO:0031904 endosome lumen(GO:0031904)
0.4 5.5 GO:0036038 MKS complex(GO:0036038)
0.4 1.1 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.4 34.6 GO:0042734 presynaptic membrane(GO:0042734)
0.4 33.8 GO:0043195 terminal bouton(GO:0043195)
0.3 11.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 4.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.3 1.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.3 14.6 GO:0001917 photoreceptor inner segment(GO:0001917)
0.3 1.8 GO:1990769 proximal neuron projection(GO:1990769)
0.3 22.8 GO:0005902 microvillus(GO:0005902)
0.3 18.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 29.0 GO:0016234 inclusion body(GO:0016234)
0.3 1.8 GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.3 10.9 GO:0045095 keratin filament(GO:0045095)
0.3 33.0 GO:0072562 blood microparticle(GO:0072562)
0.3 8.0 GO:0016460 myosin II complex(GO:0016460)
0.2 5.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.2 1.5 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.2 25.6 GO:0035578 azurophil granule lumen(GO:0035578)
0.2 39.8 GO:0030426 growth cone(GO:0030426)
0.2 55.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 8.0 GO:0034707 chloride channel complex(GO:0034707)
0.2 2.6 GO:0005577 fibrinogen complex(GO:0005577)
0.2 4.6 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.2 7.2 GO:0001772 immunological synapse(GO:0001772)
0.2 7.6 GO:0031430 M band(GO:0031430)
0.2 12.2 GO:0035580 specific granule lumen(GO:0035580)
0.2 3.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.2 5.7 GO:0031201 SNARE complex(GO:0031201)
0.2 12.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 0.5 GO:0071159 NF-kappaB complex(GO:0071159)
0.2 3.7 GO:0098636 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.2 2.1 GO:0001891 phagocytic cup(GO:0001891)
0.2 11.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 2.2 GO:0000346 transcription export complex(GO:0000346)
0.2 40.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 4.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.2 5.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 2.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.2 12.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 12.7 GO:0005776 autophagosome(GO:0005776)
0.1 4.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 1.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 1.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 1.6 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 1.4 GO:0033268 node of Ranvier(GO:0033268)
0.1 10.3 GO:0005796 Golgi lumen(GO:0005796)
0.1 17.2 GO:0098793 presynapse(GO:0098793)
0.1 1.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.2 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 2.5 GO:0071564 npBAF complex(GO:0071564)
0.1 2.9 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 2.5 GO:0002102 podosome(GO:0002102)
0.1 6.6 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 1.7 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.1 3.7 GO:0005901 caveola(GO:0005901)
0.1 2.8 GO:0016592 mediator complex(GO:0016592)
0.1 5.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 5.3 GO:0035579 specific granule membrane(GO:0035579)
0.1 2.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 2.6 GO:0001533 cornified envelope(GO:0001533)
0.1 0.6 GO:0031672 A band(GO:0031672)
0.1 1.9 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 53.9 GO:0005615 extracellular space(GO:0005615)
0.0 2.9 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 161.4 GO:0016021 integral component of membrane(GO:0016021)
0.0 0.2 GO:0030057 desmosome(GO:0030057)
0.0 2.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.4 GO:0043679 axon terminus(GO:0043679)
0.0 0.8 GO:0005795 Golgi stack(GO:0005795)
0.0 1.0 GO:0097542 ciliary tip(GO:0097542)
0.0 0.3 GO:0001739 sex chromatin(GO:0001739)
0.0 2.6 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 8.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
8.0 32.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
5.9 23.7 GO:0019976 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
4.9 14.7 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
4.1 12.4 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
3.9 11.6 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
3.7 11.0 GO:0052594 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
3.5 10.4 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
3.2 9.6 GO:0042806 fucose binding(GO:0042806)
3.0 9.1 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
3.0 15.1 GO:0047820 D-glutamate cyclase activity(GO:0047820)
3.0 12.1 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
2.8 11.4 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
2.7 13.4 GO:0030348 syntaxin-3 binding(GO:0030348)
2.6 10.5 GO:0097001 ceramide binding(GO:0097001)
2.6 7.8 GO:0005148 prolactin receptor binding(GO:0005148)
2.6 7.7 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
2.5 7.6 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) steroid delta-isomerase activity(GO:0004769)
2.5 34.3 GO:1903136 cuprous ion binding(GO:1903136)
2.4 9.7 GO:0050473 arachidonate 15-lipoxygenase activity(GO:0050473)
2.4 14.3 GO:0043237 laminin-1 binding(GO:0043237)
2.3 9.1 GO:0031716 calcitonin receptor binding(GO:0031716)
2.3 9.0 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
2.2 17.3 GO:0019763 immunoglobulin receptor activity(GO:0019763)
2.1 8.3 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
2.0 20.4 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
1.9 11.7 GO:0004522 ribonuclease A activity(GO:0004522)
1.9 5.8 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
1.9 69.7 GO:0042605 peptide antigen binding(GO:0042605)
1.8 7.1 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
1.8 15.8 GO:0043426 MRF binding(GO:0043426)
1.7 8.6 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
1.7 29.3 GO:0038191 neuropilin binding(GO:0038191)
1.7 6.9 GO:0042954 lipoprotein transporter activity(GO:0042954)
1.7 6.7 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
1.7 8.3 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
1.6 81.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
1.6 12.6 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
1.6 25.0 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
1.5 3.1 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
1.5 8.9 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
1.5 4.4 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
1.4 8.6 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
1.4 4.2 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
1.4 4.1 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
1.4 15.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
1.3 10.7 GO:0032396 inhibitory MHC class I receptor activity(GO:0032396)
1.3 9.3 GO:0097642 calcitonin family receptor activity(GO:0097642)
1.3 3.9 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
1.3 14.2 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
1.3 7.7 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
1.3 10.2 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
1.2 15.0 GO:0042608 T cell receptor binding(GO:0042608)
1.2 4.9 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) aspartic-type endopeptidase inhibitor activity(GO:0019828) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
1.2 3.5 GO:0004507 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
1.1 11.2 GO:0009374 biotin binding(GO:0009374)
1.1 13.7 GO:0005030 GPI-linked ephrin receptor activity(GO:0005004) neurotrophin receptor activity(GO:0005030)
1.0 8.2 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
1.0 8.2 GO:0097322 7SK snRNA binding(GO:0097322)
1.0 21.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.9 17.4 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.9 9.9 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.9 3.5 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.8 3.4 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.8 3.2 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.8 5.6 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.8 3.2 GO:0004102 choline O-acetyltransferase activity(GO:0004102)
0.8 3.1 GO:0035276 aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
0.8 7.6 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.7 8.2 GO:0051525 NFAT protein binding(GO:0051525)
0.7 4.5 GO:0003796 lysozyme activity(GO:0003796)
0.7 8.1 GO:0000150 recombinase activity(GO:0000150)
0.7 10.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.7 2.9 GO:0031685 adenosine receptor binding(GO:0031685)
0.7 12.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.7 9.5 GO:0005351 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.7 5.8 GO:0030172 troponin C binding(GO:0030172)
0.7 18.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.7 9.3 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.7 4.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.7 6.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.7 10.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.7 18.5 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.7 2.7 GO:0001632 leukotriene B4 receptor activity(GO:0001632)
0.7 5.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.7 3.3 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.6 4.5 GO:0003678 DNA helicase activity(GO:0003678)
0.6 89.7 GO:0003823 antigen binding(GO:0003823)
0.6 3.8 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.6 10.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.6 6.1 GO:0008061 chitinase activity(GO:0004568) chitin binding(GO:0008061)
0.6 5.5 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.6 4.7 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.6 2.3 GO:0016841 ammonia-lyase activity(GO:0016841)
0.5 9.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.5 4.9 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.5 2.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.5 6.9 GO:0019957 C-C chemokine binding(GO:0019957)
0.5 6.8 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.5 18.4 GO:0004890 GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
0.5 13.2 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.5 2.5 GO:0001594 trace-amine receptor activity(GO:0001594)
0.5 2.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.5 10.6 GO:0035497 cAMP response element binding(GO:0035497)
0.5 7.9 GO:0097109 neuroligin family protein binding(GO:0097109)
0.5 52.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.5 24.2 GO:0070412 R-SMAD binding(GO:0070412)
0.5 3.4 GO:0050733 RS domain binding(GO:0050733)
0.5 2.4 GO:0004771 sterol esterase activity(GO:0004771)
0.5 13.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.5 5.9 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.5 2.3 GO:0051373 FATZ binding(GO:0051373)
0.4 8.0 GO:0044548 S100 protein binding(GO:0044548)
0.4 8.4 GO:0097602 cullin family protein binding(GO:0097602)
0.4 3.8 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.4 5.5 GO:0051011 microtubule minus-end binding(GO:0051011)
0.4 2.4 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.4 11.7 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.4 5.1 GO:0019841 retinol binding(GO:0019841)
0.4 6.5 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.4 1.9 GO:0016882 cyclo-ligase activity(GO:0016882)
0.4 4.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.4 3.0 GO:0004111 creatine kinase activity(GO:0004111)
0.4 1.8 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.4 4.0 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.4 2.9 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.4 13.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.4 11.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 2.1 GO:0005499 vitamin D binding(GO:0005499)
0.3 2.7 GO:0004000 adenosine deaminase activity(GO:0004000)
0.3 5.4 GO:0043274 phospholipase binding(GO:0043274)
0.3 3.4 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.3 2.1 GO:0008142 oxysterol binding(GO:0008142)
0.3 1.8 GO:0017018 myosin phosphatase activity(GO:0017018)
0.3 7.9 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.3 7.0 GO:0071949 FAD binding(GO:0071949)
0.3 5.5 GO:0034185 apolipoprotein binding(GO:0034185)
0.3 20.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.3 7.0 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.3 3.1 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.3 0.8 GO:0004962 endothelin receptor activity(GO:0004962)
0.3 1.3 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237) extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.3 1.1 GO:0015254 glycerol channel activity(GO:0015254)
0.3 7.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 2.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.3 1.8 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.3 1.3 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.2 5.0 GO:0071837 HMG box domain binding(GO:0071837)
0.2 11.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 53.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 1.0 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.2 4.9 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.2 2.6 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.2 3.8 GO:0032036 myosin heavy chain binding(GO:0032036)
0.2 15.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 12.2 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.2 2.3 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.2 4.6 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.2 7.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 3.9 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.2 8.4 GO:0008066 glutamate receptor activity(GO:0008066)
0.2 1.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 6.2 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.2 9.3 GO:0008200 ion channel inhibitor activity(GO:0008200)
0.2 1.7 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.2 1.2 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.2 2.8 GO:0042809 vitamin D receptor binding(GO:0042809)
0.2 4.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 2.5 GO:0005344 oxygen transporter activity(GO:0005344)
0.2 9.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.2 6.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 3.7 GO:0005112 Notch binding(GO:0005112)
0.2 2.2 GO:0019864 IgG binding(GO:0019864)
0.2 11.4 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.2 3.1 GO:0030553 cGMP binding(GO:0030553)
0.2 7.0 GO:0030544 Hsp70 protein binding(GO:0030544)
0.2 0.5 GO:0071532 ankyrin repeat binding(GO:0071532)
0.2 0.8 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.2 7.1 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.2 5.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 1.6 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.2 1.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.2 1.1 GO:0001849 complement component C1q binding(GO:0001849)
0.2 8.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.2 2.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.2 1.4 GO:0039706 co-receptor binding(GO:0039706)
0.2 1.4 GO:0032027 fibronectin binding(GO:0001968) myosin light chain binding(GO:0032027)
0.2 11.6 GO:0001618 virus receptor activity(GO:0001618)
0.1 0.4 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.1 10.0 GO:0030276 clathrin binding(GO:0030276)
0.1 1.3 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 6.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 3.2 GO:0070402 NADPH binding(GO:0070402)
0.1 3.4 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 5.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 10.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.8 GO:0008430 selenium binding(GO:0008430)
0.1 2.6 GO:0004697 protein kinase C activity(GO:0004697)
0.1 1.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 3.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 4.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 2.7 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.1 2.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 2.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 2.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 7.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 5.8 GO:0004601 peroxidase activity(GO:0004601)
0.1 14.5 GO:0044325 ion channel binding(GO:0044325)
0.1 2.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 7.1 GO:0035064 methylated histone binding(GO:0035064)
0.1 14.0 GO:0017124 SH3 domain binding(GO:0017124)
0.1 0.5 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.1 2.7 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 9.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 9.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 33.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 95.7 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1 1.5 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.1 0.3 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.1 2.1 GO:0005254 chloride channel activity(GO:0005254)
0.1 0.2 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1 1.0 GO:0004065 arylsulfatase activity(GO:0004065)
0.1 3.1 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 1.6 GO:0005521 lamin binding(GO:0005521)
0.1 11.1 GO:0016746 transferase activity, transferring acyl groups(GO:0016746)
0.1 4.8 GO:0005179 hormone activity(GO:0005179)
0.1 1.8 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 4.8 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820)
0.0 0.3 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 1.8 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 14.4 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 3.0 GO:0002020 protease binding(GO:0002020)
0.0 1.6 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.0 1.3 GO:0043621 protein self-association(GO:0043621)
0.0 0.4 GO:0005518 collagen binding(GO:0005518)
0.0 0.3 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.5 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.3 GO:0017022 myosin binding(GO:0017022)
0.0 2.1 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.2 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 2.1 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.5 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 86.6 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
1.6 17.6 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.7 13.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.6 26.8 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.6 16.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.5 13.4 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.5 4.5 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.5 26.9 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.4 16.8 PID EPO PATHWAY EPO signaling pathway
0.4 14.9 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.4 5.8 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4 8.2 PID SHP2 PATHWAY SHP2 signaling
0.4 8.8 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.4 21.3 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.4 10.6 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.3 3.8 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.3 16.5 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.3 7.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3 46.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 19.7 PID FOXO PATHWAY FoxO family signaling
0.2 7.0 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.2 7.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.2 7.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 13.7 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.2 7.5 PID RAS PATHWAY Regulation of Ras family activation
0.2 3.5 PID ALK2 PATHWAY ALK2 signaling events
0.2 12.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 6.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 51.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 4.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.2 23.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.2 9.4 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 8.6 PID ATM PATHWAY ATM pathway
0.2 4.5 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.2 3.1 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.2 6.0 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 11.1 PID NOTCH PATHWAY Notch signaling pathway
0.2 1.5 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.2 10.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.2 6.4 PID FGF PATHWAY FGF signaling pathway
0.2 0.3 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 4.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 7.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 9.0 PID E2F PATHWAY E2F transcription factor network
0.1 2.7 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 2.0 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 4.1 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 3.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 2.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 2.7 NABA COLLAGENS Genes encoding collagen proteins
0.1 1.4 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 2.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 4.0 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.4 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 1.4 PID BMP PATHWAY BMP receptor signaling
0.0 1.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.7 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.4 PID AP1 PATHWAY AP-1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 96.5 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
2.2 17.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
1.3 32.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
1.3 34.2 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
1.2 29.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
1.0 9.0 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
1.0 20.1 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.9 18.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.9 16.6 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.9 16.1 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.8 12.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.7 17.8 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.7 32.5 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.7 10.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.7 10.8 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.7 7.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.6 9.0 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.6 16.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.6 9.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.6 12.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.6 6.5 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.6 8.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.6 22.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.6 11.4 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.6 4.5 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.6 23.0 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.5 6.5 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.5 3.2 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.5 13.2 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.5 23.6 REACTOME IL 2 SIGNALING Genes involved in Interleukin-2 signaling
0.5 25.0 REACTOME ION CHANNEL TRANSPORT Genes involved in Ion channel transport
0.5 8.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.5 9.5 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.4 4.9 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.4 2.4 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.4 15.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.4 4.5 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.4 5.6 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.4 8.1 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.4 31.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.4 14.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.4 7.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.3 5.8 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.3 29.4 REACTOME AMYLOIDS Genes involved in Amyloids
0.3 10.6 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.3 3.4 REACTOME OPSINS Genes involved in Opsins
0.3 4.0 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.3 19.7 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.3 10.1 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.3 11.9 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.3 14.1 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.3 5.2 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.3 6.8 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 4.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 5.4 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2 13.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 2.6 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.2 3.9 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 2.9 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.2 2.7 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.2 1.6 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2 5.1 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 2.9 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 1.4 REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.2 3.5 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.2 6.5 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 2.5 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.1 2.9 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 3.8 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 4.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 3.3 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.1 6.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 1.6 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 10.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 6.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 4.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 0.5 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 2.8 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 1.8 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 3.9 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 3.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 1.1 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 9.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.5 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 0.5 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 2.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 4.0 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 6.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.7 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.2 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 1.2 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.3 REACTOME GPCR LIGAND BINDING Genes involved in GPCR ligand binding
0.0 0.3 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 1.7 REACTOME SIGNALLING BY NGF Genes involved in Signalling by NGF
0.0 0.5 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.3 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors