Project
averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CUX2
Z-value: 2.37
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Transcription factors associated with CUX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CUX2 | hg19_v2_chr12_+_111471828_111471975 | 0.49 | 1.2e-14 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CUX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.6 | 91.1 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 4.0 | 56.2 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 6.3 | 50.7 | GO:0035608 | protein deglutamylation(GO:0035608) |
| 0.9 | 46.2 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 4.6 | 45.5 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 1.5 | 45.1 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 14.0 | 42.1 | GO:1902995 | regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) |
| 2.4 | 36.5 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 2.8 | 36.2 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 9.0 | 36.1 | GO:1904749 | regulation of protein localization to nucleolus(GO:1904749) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 91.1 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 83.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.4 | 79.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.4 | 55.5 | GO:0043204 | perikaryon(GO:0043204) |
| 1.0 | 54.6 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.2 | 52.7 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.2 | 49.4 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.6 | 48.5 | GO:0005811 | lipid particle(GO:0005811) |
| 14.0 | 42.1 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 1.3 | 37.2 | GO:0034451 | centriolar satellite(GO:0034451) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 75.3 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 1.0 | 62.2 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.1 | 59.4 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.4 | 47.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.9 | 46.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 1.0 | 43.8 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 43.7 | GO:0008270 | zinc ion binding(GO:0008270) |
| 14.0 | 42.1 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 2.0 | 41.0 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 3.1 | 37.5 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 99.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.4 | 94.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 87.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 39.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 38.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 37.0 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.8 | 34.1 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.2 | 31.2 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.2 | 24.4 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.3 | 24.0 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 91.1 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 2.9 | 73.4 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.9 | 47.6 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 1.6 | 43.8 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 3.8 | 41.5 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 1.0 | 40.5 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 1.7 | 33.2 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.5 | 31.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.8 | 25.6 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.6 | 24.6 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |