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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CXXC1
Z-value: 3.52
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Transcription factors associated with CXXC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CXXC1 | hg19_v2_chr18_-_47813940_47814021 | 0.18 | 7.2e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CXXC1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 301.4 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 3.1 | 220.6 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 1.7 | 217.8 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 19.4 | 155.0 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 3.9 | 137.6 | GO:0007094 | mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173) |
| 0.7 | 126.6 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 1.4 | 109.8 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 5.4 | 102.4 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 6.9 | 97.0 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.7 | 96.9 | GO:0000910 | cytokinesis(GO:0000910) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 299.8 | GO:0005730 | nucleolus(GO:0005730) |
| 7.4 | 200.4 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 2.6 | 186.3 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 1.0 | 179.4 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 1.4 | 146.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 3.5 | 146.3 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 1.3 | 105.0 | GO:0070469 | respiratory chain(GO:0070469) |
| 1.0 | 97.9 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 11.5 | 92.1 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 1.0 | 90.7 | GO:0005643 | nuclear pore(GO:0005643) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 661.4 | GO:0003723 | RNA binding(GO:0003723) |
| 2.5 | 217.9 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 12.8 | 140.9 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 3.2 | 134.5 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 16.7 | 133.4 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 1.8 | 121.6 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 1.1 | 121.1 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 3.9 | 116.4 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.7 | 107.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 3.5 | 102.4 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 277.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 2.9 | 224.7 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 1.8 | 111.9 | PID ATR PATHWAY | ATR signaling pathway |
| 1.8 | 91.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 1.2 | 89.1 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.6 | 75.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.6 | 60.1 | PID P73PATHWAY | p73 transcription factor network |
| 1.3 | 56.2 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 1.0 | 56.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.0 | 54.3 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 283.3 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 2.9 | 250.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.4 | 227.6 | REACTOME TRANSLATION | Genes involved in Translation |
| 3.1 | 178.9 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 1.7 | 171.8 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.8 | 134.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 2.7 | 118.0 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 1.9 | 116.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 2.9 | 111.6 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 6.2 | 99.5 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |