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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for DMBX1

Z-value: 0.48

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Transcription factors associated with DMBX1

Gene Symbol Gene ID Gene Info
DMBX1
ENSG00000197587.6 diencephalon/mesencephalon homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMBX1hg19_v2_chr1_+_46972668_46972669-0.282.2e-05Click!

Activity profile of DMBX1 motif

Sorted Z-values of DMBX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_170679024 5.41 ENST00000393381.2
C4orf27
chromosome 4 open reading frame 27
chr12_+_53693812 5.39 ENST00000549488.1
C12orf10
chromosome 12 open reading frame 10
chr9_-_21995300 5.04 ENST00000498628.2
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr3_+_136649311 4.45 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr2_+_73461410 4.38 ENST00000399032.2
ENST00000398422.2
ENST00000537131.1
ENST00000538797.1
CCT7
chaperonin containing TCP1, subunit 7 (eta)
chr2_+_73461364 4.38 ENST00000540468.1
ENST00000539919.1
ENST00000258091.5
CCT7
chaperonin containing TCP1, subunit 7 (eta)
chr3_+_138340049 4.28 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chr2_+_223725652 4.24 ENST00000357430.3
ENST00000392066.3
ACSL3
acyl-CoA synthetase long-chain family member 3
chr3_+_49058444 4.03 ENST00000326925.6
ENST00000395458.2
NDUFAF3
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
chr3_+_49057876 3.93 ENST00000326912.4
NDUFAF3
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
chr9_-_21995249 3.75 ENST00000494262.1
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr3_+_138340067 3.62 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr9_-_21994344 3.45 ENST00000530628.2
ENST00000361570.3
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr9_-_21994597 2.89 ENST00000579755.1
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr17_-_19651668 2.51 ENST00000494157.2
ENST00000225740.6
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr3_-_149293990 2.40 ENST00000472417.1
WWTR1
WW domain containing transcription regulator 1
chr17_-_19651654 2.36 ENST00000395555.3
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr2_-_175711133 2.31 ENST00000409597.1
ENST00000413882.1
CHN1
chimerin 1
chr3_-_11685345 2.31 ENST00000430365.2
VGLL4
vestigial like 4 (Drosophila)
chr14_+_50234309 2.25 ENST00000298307.5
KLHDC2
kelch domain containing 2
chr6_-_111927062 2.19 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr4_+_41937131 1.95 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
TMEM33
transmembrane protein 33
chr2_+_37571845 1.93 ENST00000537448.1
QPCT
glutaminyl-peptide cyclotransferase
chr22_-_43411106 1.92 ENST00000453643.1
ENST00000263246.3
ENST00000337959.4
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr3_-_10362725 1.63 ENST00000397109.3
ENST00000428626.1
ENST00000445064.1
ENST00000431352.1
ENST00000397117.1
ENST00000337354.4
ENST00000383801.2
ENST00000432213.1
ENST00000350697.3
SEC13
SEC13 homolog (S. cerevisiae)
chr14_+_22919081 1.43 ENST00000390473.1
TRDJ1
T cell receptor delta joining 1
chr17_-_12921270 1.19 ENST00000578071.1
ENST00000426905.3
ENST00000395962.2
ENST00000583371.1
ENST00000338034.4
ELAC2
elaC ribonuclease Z 2
chr11_-_45940343 1.05 ENST00000532681.1
PEX16
peroxisomal biogenesis factor 16
chr1_+_109756523 0.93 ENST00000234677.2
ENST00000369923.4
SARS
seryl-tRNA synthetase
chr1_-_165414414 0.88 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr17_+_60536002 0.86 ENST00000582809.1
TLK2
tousled-like kinase 2
chr17_+_68100989 0.86 ENST00000585558.1
ENST00000392670.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr12_-_118628350 0.82 ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr15_-_60771280 0.80 ENST00000560072.1
ENST00000560406.1
ENST00000560520.1
ENST00000261520.4
ENST00000439632.1
NARG2
NMDA receptor regulated 2
chrX_-_64754611 0.75 ENST00000374807.5
ENST00000374811.3
ENST00000374804.5
ENST00000312391.8
LAS1L
LAS1-like (S. cerevisiae)
chr5_+_50678921 0.75 ENST00000230658.7
ISL1
ISL LIM homeobox 1
chr15_-_61521495 0.67 ENST00000335670.6
RORA
RAR-related orphan receptor A
chr15_-_85201779 0.61 ENST00000360476.3
ENST00000394588.3
NMB
neuromedin B
chr3_-_49058479 0.61 ENST00000440857.1
DALRD3
DALR anticodon binding domain containing 3
chr12_+_54718904 0.54 ENST00000262061.2
ENST00000549043.1
ENST00000552218.1
ENST00000553231.1
ENST00000552362.1
ENST00000455864.2
ENST00000416254.2
ENST00000549116.1
ENST00000551779.1
COPZ1
coatomer protein complex, subunit zeta 1
chr6_+_10585979 0.52 ENST00000265012.4
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr3_-_121468513 0.49 ENST00000494517.1
ENST00000393667.3
GOLGB1
golgin B1
chr19_-_51538148 0.41 ENST00000319590.4
ENST00000250351.4
KLK12
kallikrein-related peptidase 12
chr2_-_70780572 0.34 ENST00000450929.1
TGFA
transforming growth factor, alpha
chr1_-_94586651 0.30 ENST00000535735.1
ENST00000370225.3
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr12_-_10959892 0.30 ENST00000240615.2
TAS2R8
taste receptor, type 2, member 8
chr10_-_35104185 0.28 ENST00000374789.3
ENST00000374788.3
ENST00000346874.4
ENST00000374794.3
ENST00000350537.4
ENST00000374790.3
ENST00000374776.1
ENST00000374773.1
ENST00000545693.1
ENST00000545260.1
ENST00000340077.5
PARD3
par-3 family cell polarity regulator
chrX_-_48931648 0.23 ENST00000376386.3
ENST00000376390.4
PRAF2
PRA1 domain family, member 2
chr3_-_121468602 0.19 ENST00000340645.5
GOLGB1
golgin B1
chr16_-_31076332 0.15 ENST00000539836.3
ENST00000535577.1
ENST00000442862.2
ZNF668
zinc finger protein 668
chr1_-_47655686 0.14 ENST00000294338.2
PDZK1IP1
PDZK1 interacting protein 1
chr1_+_35734562 0.07 ENST00000314607.6
ENST00000373297.2
ZMYM4
zinc finger, MYM-type 4
chr19_-_51538118 0.07 ENST00000529888.1
KLK12
kallikrein-related peptidase 12
chr16_-_31076273 0.06 ENST00000426488.2
ZNF668
zinc finger protein 668
chr3_-_150920979 0.03 ENST00000309180.5
ENST00000480322.1
GPR171
G protein-coupled receptor 171
chr1_-_28384598 0.01 ENST00000373864.1
EYA3
eyes absent homolog 3 (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of DMBX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.4 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
1.4 4.2 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
1.4 15.1 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
0.7 8.8 GO:1904869 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.7 2.0 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.6 1.9 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.4 1.2 GO:0000965 mitochondrial RNA 3'-end processing(GO:0000965)
0.3 1.0 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.3 0.9 GO:0097056 seryl-tRNA aminoacylation(GO:0006434) selenocysteinyl-tRNA(Sec) biosynthetic process(GO:0097056)
0.3 5.4 GO:0035641 locomotory exploration behavior(GO:0035641)
0.2 0.7 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.2 2.4 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.2 0.6 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.2 1.9 GO:0070836 caveola assembly(GO:0070836)
0.1 8.0 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 0.9 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.1 2.2 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 1.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.5 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 2.3 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 0.8 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
0.1 4.9 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 0.7 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.8 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.9 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.9 GO:0010107 potassium ion import(GO:0010107)
0.0 0.6 GO:0050482 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0 0.5 GO:1901998 toxin transport(GO:1901998)
0.0 0.3 GO:0008356 asymmetric cell division(GO:0008356)
0.0 0.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.3 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 15.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.7 8.8 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.3 4.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 1.6 GO:0061700 GATOR2 complex(GO:0061700)
0.1 5.3 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 0.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 1.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.2 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 2.0 GO:0005643 nuclear pore(GO:0005643)
0.0 0.7 GO:0005801 cis-Golgi network(GO:0005801)
0.0 5.7 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.9 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.9 4.4 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.8 15.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.6 1.9 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.3 0.9 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.2 8.8 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.2 4.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.2 0.9 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 0.6 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.1 0.6 GO:0031705 bombesin receptor binding(GO:0031705)
0.1 0.7 GO:0008142 oxysterol binding(GO:0008142)
0.1 1.9 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 0.5 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 2.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 1.2 GO:0004549 tRNA-specific ribonuclease activity(GO:0004549)
0.0 2.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 15.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 4.4 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.1 7.9 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 2.3 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.9 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.8 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2 15.1 REACTOME G1 PHASE Genes involved in G1 Phase
0.2 4.2 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 4.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 2.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 0.5 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 1.6 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.7 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.9 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.9 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.7 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 2.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway