Project
averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for EBF1
Z-value: 3.50
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Transcription factors associated with EBF1
Network of associatons between targets according to the STRING database.
First level regulatory network of EBF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 338.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 8.7 | 156.5 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 1.9 | 126.7 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 4.6 | 105.5 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 9.8 | 78.7 | GO:0002606 | positive regulation of dendritic cell antigen processing and presentation(GO:0002606) |
| 23.8 | 71.4 | GO:0071139 | resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140) |
| 11.8 | 70.6 | GO:0010732 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 0.7 | 65.2 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 2.1 | 60.1 | GO:1903861 | regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861) |
| 7.8 | 54.4 | GO:0045007 | depurination(GO:0045007) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 396.4 | GO:0016021 | integral component of membrane(GO:0016021) |
| 10.8 | 172.5 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 1.0 | 159.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 2.7 | 127.4 | GO:0019814 | immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571) |
| 0.5 | 117.7 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 5.2 | 103.3 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 4.3 | 90.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 1.9 | 88.6 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.7 | 76.5 | GO:0043679 | axon terminus(GO:0043679) |
| 0.7 | 63.2 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 320.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 192.9 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.5 | 187.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 3.0 | 165.7 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 5.3 | 163.3 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 1.4 | 147.4 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 2.1 | 105.1 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 1.6 | 80.5 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.8 | 79.3 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.7 | 72.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 127.6 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 1.9 | 91.8 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.6 | 85.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 1.8 | 64.5 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 1.4 | 61.5 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.3 | 54.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.9 | 49.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.6 | 44.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 1.4 | 41.6 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.7 | 36.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 88.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 1.7 | 87.4 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 1.6 | 84.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 1.7 | 82.5 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 1.4 | 79.4 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 2.6 | 69.9 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 3.3 | 69.2 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.8 | 66.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.7 | 65.5 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 3.0 | 54.4 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |