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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ERG
Z-value: 1.69
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Transcription factors associated with ERG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ERG | hg19_v2_chr21_-_40033618_40033712, hg19_v2_chr21_-_39870339_39870443 | 0.30 | 4.6e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_-_46340770 Show fit | 33.98 |
ENST00000397854.3
|
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
|
| chr5_-_130970723 Show fit | 26.74 |
ENST00000308008.6
ENST00000296859.6 ENST00000507093.1 ENST00000510071.1 ENST00000509018.1 ENST00000307984.5 |
Rap guanine nucleotide exchange factor (GEF) 6 |
|
| chr1_+_153330322 Show fit | 26.04 |
ENST00000368738.3
|
S100 calcium binding protein A9 |
|
| chr11_+_1874200 Show fit | 25.88 |
ENST00000311604.3
|
lymphocyte-specific protein 1 |
|
| chr6_+_33048222 Show fit | 25.58 |
ENST00000428835.1
|
major histocompatibility complex, class II, DP beta 1 |
|
| chr3_-_121379739 Show fit | 25.17 |
ENST00000428394.2
ENST00000314583.3 |
hematopoietic cell-specific Lyn substrate 1 |
|
| chr21_-_46340884 Show fit | 25.14 |
ENST00000302347.5
ENST00000517819.1 |
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
|
| chr19_-_51875894 Show fit | 24.11 |
ENST00000600427.1
ENST00000595217.1 ENST00000221978.5 |
natural killer cell group 7 sequence |
|
| chr1_-_153518270 Show fit | 21.08 |
ENST00000354332.4
ENST00000368716.4 |
S100 calcium binding protein A4 |
|
| chr3_-_128879875 Show fit | 19.85 |
ENST00000418265.1
ENST00000393292.3 ENST00000273541.8 |
ISY1-RAB43 readthrough ISY1 splicing factor homolog (S. cerevisiae) |
Network of associatons between targets according to the STRING database.
First level regulatory network of ERG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 73.2 | GO:0032945 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 0.9 | 57.0 | GO:0032729 | positive regulation of interferon-gamma production(GO:0032729) |
| 18.3 | 55.0 | GO:1902365 | regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846) |
| 3.0 | 54.6 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.4 | 47.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 3.8 | 37.8 | GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291) |
| 2.3 | 36.2 | GO:0051531 | NFAT protein import into nucleus(GO:0051531) |
| 5.0 | 35.1 | GO:0045079 | negative regulation of chemokine biosynthetic process(GO:0045079) |
| 1.8 | 34.4 | GO:0060117 | auditory receptor cell development(GO:0060117) |
| 1.3 | 33.9 | GO:0071800 | podosome assembly(GO:0071800) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 669.1 | GO:0016021 | integral component of membrane(GO:0016021) |
| 1.2 | 96.3 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.1 | 86.4 | GO:0005615 | extracellular space(GO:0005615) |
| 14.1 | 84.5 | GO:0034687 | integrin alphaL-beta2 complex(GO:0034687) |
| 0.3 | 72.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 2.9 | 66.3 | GO:0001931 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 5.2 | 57.1 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.3 | 56.1 | GO:0030426 | growth cone(GO:0030426) |
| 18.3 | 55.0 | GO:0061673 | cortical microtubule(GO:0055028) mitotic spindle astral microtubule(GO:0061673) |
| 0.7 | 54.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 136.4 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 12.3 | 86.4 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 0.7 | 76.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.8 | 73.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.2 | 61.8 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 4.5 | 58.1 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.4 | 57.0 | GO:0005178 | integrin binding(GO:0005178) |
| 0.4 | 51.5 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.3 | 50.4 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 2.8 | 49.7 | GO:0005522 | profilin binding(GO:0005522) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 189.0 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 3.4 | 176.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.5 | 116.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.7 | 112.4 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 1.1 | 81.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.2 | 73.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.5 | 66.6 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.9 | 66.5 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.4 | 63.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.9 | 57.9 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 275.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.8 | 133.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 4.7 | 122.1 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 1.9 | 62.0 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.4 | 61.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 56.8 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.3 | 51.0 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 2.9 | 43.0 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.4 | 41.6 | REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE | Genes involved in MyD88:Mal cascade initiated on plasma membrane |
| 1.9 | 40.2 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |