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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ESRRB_ESRRG
Z-value: 2.74
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Transcription factors associated with ESRRB_ESRRG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESRRG | hg19_v2_chr1_-_217250231_217250349 | -0.40 | 5.3e-10 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_176046391 Show fit | 81.19 |
ENST00000392541.3
ENST00000409194.1 |
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) |
|
| chr1_+_169077172 Show fit | 60.52 |
ENST00000499679.3
|
ATPase, Na+/K+ transporting, beta 1 polypeptide |
|
| chr20_-_62130474 Show fit | 59.51 |
ENST00000217182.3
|
eukaryotic translation elongation factor 1 alpha 2 |
|
| chr8_+_145149930 Show fit | 52.60 |
ENST00000318911.4
|
cytochrome c-1 |
|
| chr14_-_103987679 Show fit | 48.19 |
ENST00000553610.1
|
creatine kinase, brain |
|
| chr10_+_81107271 Show fit | 45.45 |
ENST00000448165.1
|
peptidylprolyl isomerase F |
|
| chr1_+_165600436 Show fit | 38.68 |
ENST00000367888.4
ENST00000367885.1 ENST00000367884.2 |
microsomal glutathione S-transferase 3 |
|
| chr1_-_149889382 Show fit | 38.26 |
ENST00000369145.1
ENST00000369146.3 |
synaptic vesicle glycoprotein 2A |
|
| chr12_+_120875910 Show fit | 37.06 |
ENST00000551806.1
|
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial |
|
| chr7_-_30029367 Show fit | 34.60 |
ENST00000242059.5
|
secernin 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESRRB_ESRRG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.1 | 322.9 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 4.4 | 301.0 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 7.2 | 143.5 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 1.4 | 101.2 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 6.0 | 95.9 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 22.1 | 88.6 | GO:1903288 | protein transport into plasma membrane raft(GO:0044861) positive regulation of potassium ion import(GO:1903288) |
| 3.7 | 85.0 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 26.2 | 78.7 | GO:2000276 | regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276) |
| 22.6 | 67.9 | GO:0006106 | fumarate metabolic process(GO:0006106) |
| 6.4 | 63.6 | GO:0006600 | creatine metabolic process(GO:0006600) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 350.0 | GO:0043209 | myelin sheath(GO:0043209) |
| 4.0 | 240.6 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 11.0 | 197.2 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 10.3 | 144.8 | GO:0005753 | mitochondrial proton-transporting ATP synthase complex(GO:0005753) |
| 0.5 | 143.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 10.0 | 139.8 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 3.2 | 128.6 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 2.1 | 109.8 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 4.7 | 93.4 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.4 | 79.6 | GO:0030426 | growth cone(GO:0030426) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 262.7 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 5.8 | 167.1 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 6.0 | 138.7 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 14.0 | 111.8 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 7.0 | 97.9 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.9 | 96.0 | GO:0051087 | chaperone binding(GO:0051087) |
| 5.5 | 88.6 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 1.5 | 87.6 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 0.4 | 83.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.5 | 70.7 | GO:0004364 | glutathione transferase activity(GO:0004364) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 113.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 1.3 | 106.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.8 | 101.0 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.7 | 81.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.1 | 41.1 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 2.9 | 41.0 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 26.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.9 | 26.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.9 | 22.0 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.3 | 19.2 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.7 | 570.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 3.2 | 208.1 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 7.3 | 168.5 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.6 | 155.2 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 3.2 | 132.3 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 1.8 | 83.4 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 2.0 | 63.5 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.3 | 56.0 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 3.0 | 54.7 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 1.6 | 54.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |