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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ETV6

Z-value: 2.15

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Transcription factors associated with ETV6

Gene Symbol Gene ID Gene Info
ETV6
ENSG00000139083.6 ETS variant transcription factor 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ETV6hg19_v2_chr12_+_11802753_11802834-0.261.0e-04Click!

Activity profile of ETV6 motif

Sorted Z-values of ETV6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_167913450 73.77 ENST00000231572.3
ENST00000538719.1
RARS
arginyl-tRNA synthetase
chr2_+_65454926 43.13 ENST00000542850.1
ENST00000377982.4
ACTR2
ARP2 actin-related protein 2 homolog (yeast)
chr2_+_65454863 41.84 ENST00000260641.5
ACTR2
ARP2 actin-related protein 2 homolog (yeast)
chr2_-_96971259 40.94 ENST00000349783.5
SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr11_+_65770227 36.93 ENST00000527348.1
BANF1
barrier to autointegration factor 1
chr2_-_96971232 33.85 ENST00000323853.5
SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr1_+_203830703 33.42 ENST00000414487.2
SNRPE
small nuclear ribonucleoprotein polypeptide E
chr20_-_49575058 33.17 ENST00000371584.4
ENST00000371583.5
ENST00000413082.1
DPM1
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
chr11_+_65769550 31.73 ENST00000312175.2
ENST00000445560.2
ENST00000530204.1
BANF1
barrier to autointegration factor 1
chr1_-_19811996 31.71 ENST00000264203.3
ENST00000401084.2
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr3_+_52740094 31.29 ENST00000602728.1
SPCS1
signal peptidase complex subunit 1 homolog (S. cerevisiae)
chr1_-_149900122 30.42 ENST00000271628.8
SF3B4
splicing factor 3b, subunit 4, 49kDa
chr12_+_108079664 30.15 ENST00000541166.1
PWP1
PWP1 homolog (S. cerevisiae)
chr7_+_99006550 30.03 ENST00000222969.5
BUD31
BUD31 homolog (S. cerevisiae)
chr11_+_65769946 29.10 ENST00000533166.1
BANF1
barrier to autointegration factor 1
chr2_+_201936707 28.46 ENST00000433898.1
ENST00000454214.1
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr19_+_49497121 27.98 ENST00000413176.2
RUVBL2
RuvB-like AAA ATPase 2
chr12_+_10658201 26.93 ENST00000322446.3
EIF2S3L
Putative eukaryotic translation initiation factor 2 subunit 3-like protein
chr7_-_54826920 26.42 ENST00000395535.3
ENST00000352861.4
SEC61G
Sec61 gamma subunit
chr20_-_33872518 26.25 ENST00000374436.3
EIF6
eukaryotic translation initiation factor 6
chr22_+_40742497 26.22 ENST00000216194.7
ADSL
adenylosuccinate lyase
chr1_+_84944926 25.83 ENST00000370656.1
ENST00000370654.5
RPF1
ribosome production factor 1 homolog (S. cerevisiae)
chr20_-_33872548 25.80 ENST00000374443.3
EIF6
eukaryotic translation initiation factor 6
chr1_+_32687971 25.41 ENST00000373586.1
EIF3I
eukaryotic translation initiation factor 3, subunit I
chr15_-_65809581 25.39 ENST00000341861.5
DPP8
dipeptidyl-peptidase 8
chr3_+_127771212 24.99 ENST00000243253.3
ENST00000481210.1
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr2_+_122494676 24.76 ENST00000455432.1
TSN
translin
chr19_+_49496705 24.53 ENST00000595090.1
RUVBL2
RuvB-like AAA ATPase 2
chr8_-_121457332 24.52 ENST00000518918.1
MRPL13
mitochondrial ribosomal protein L13
chr7_+_99006232 24.52 ENST00000403633.2
BUD31
BUD31 homolog (S. cerevisiae)
chr20_+_16710606 24.00 ENST00000377943.5
ENST00000246071.6
SNRPB2
small nuclear ribonucleoprotein polypeptide B
chr14_-_24616426 23.97 ENST00000216802.5
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr22_+_40742512 23.65 ENST00000454266.2
ENST00000342312.6
ADSL
adenylosuccinate lyase
chr15_-_65282232 23.35 ENST00000416889.2
SPG21
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr8_-_117768023 23.30 ENST00000518949.1
ENST00000522453.1
ENST00000521861.1
ENST00000518995.1
EIF3H
eukaryotic translation initiation factor 3, subunit H
chr3_-_49142178 23.18 ENST00000452739.1
ENST00000414533.1
ENST00000417025.1
QARS
glutaminyl-tRNA synthetase
chr15_-_65810042 23.06 ENST00000321147.6
DPP8
dipeptidyl-peptidase 8
chr11_+_47600562 23.06 ENST00000263774.4
ENST00000529276.1
ENST00000528192.1
ENST00000530295.1
ENST00000534208.1
ENST00000534716.2
NDUFS3
NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
chr11_-_6633799 22.95 ENST00000299424.4
TAF10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr15_-_65809991 22.80 ENST00000559526.1
ENST00000358939.4
ENST00000560665.1
ENST00000321118.7
ENST00000339244.5
ENST00000300141.6
DPP8
dipeptidyl-peptidase 8
chr3_-_10362725 22.63 ENST00000397109.3
ENST00000428626.1
ENST00000445064.1
ENST00000431352.1
ENST00000397117.1
ENST00000337354.4
ENST00000383801.2
ENST00000432213.1
ENST00000350697.3
SEC13
SEC13 homolog (S. cerevisiae)
chr3_+_23847394 22.25 ENST00000306627.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr15_-_65282274 21.76 ENST00000204566.2
SPG21
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr1_+_151372010 21.48 ENST00000290541.6
PSMB4
proteasome (prosome, macropain) subunit, beta type, 4
chr1_-_165738072 21.25 ENST00000481278.1
TMCO1
transmembrane and coiled-coil domains 1
chr8_-_124054362 21.03 ENST00000405944.3
DERL1
derlin 1
chr13_+_28194873 21.02 ENST00000302979.3
POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chr17_+_49337881 20.86 ENST00000225298.7
UTP18
UTP18 small subunit (SSU) processome component homolog (yeast)
chr14_+_35452104 20.69 ENST00000216774.6
ENST00000546080.1
SRP54
signal recognition particle 54kDa
chr16_+_74330673 20.61 ENST00000219313.4
ENST00000540379.1
ENST00000567958.1
ENST00000568615.2
PSMD7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr1_-_150207017 20.27 ENST00000369119.3
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr7_+_100482595 20.08 ENST00000448764.1
SRRT
serrate RNA effector molecule homolog (Arabidopsis)
chr15_-_85259294 20.08 ENST00000558217.1
ENST00000558196.1
ENST00000558134.1
SEC11A
SEC11 homolog A (S. cerevisiae)
chrX_+_69509927 20.08 ENST00000374403.3
KIF4A
kinesin family member 4A
chr8_-_124054484 19.92 ENST00000419562.2
DERL1
derlin 1
chr4_+_1723197 19.91 ENST00000485989.2
ENST00000313288.4
TACC3
transforming, acidic coiled-coil containing protein 3
chr6_-_13814663 19.71 ENST00000359495.2
ENST00000379170.4
MCUR1
mitochondrial calcium uniporter regulator 1
chr1_-_19811962 19.62 ENST00000375142.1
ENST00000264202.6
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr9_-_2844058 19.44 ENST00000397885.2
KIAA0020
KIAA0020
chr10_+_43278217 19.39 ENST00000374518.5
BMS1
BMS1 ribosome biogenesis factor
chr3_-_49142504 19.39 ENST00000306125.6
ENST00000420147.2
QARS
glutaminyl-tRNA synthetase
chr13_+_29233218 19.38 ENST00000380842.4
POMP
proteasome maturation protein
chr19_-_40336969 19.21 ENST00000599134.1
ENST00000597634.1
ENST00000598417.1
ENST00000601274.1
ENST00000594309.1
ENST00000221801.3
FBL
fibrillarin
chr15_-_65281775 19.12 ENST00000433215.2
ENST00000558415.1
ENST00000557795.1
SPG21
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr19_+_49496782 18.88 ENST00000601968.1
ENST00000596837.1
RUVBL2
RuvB-like AAA ATPase 2
chr19_-_59066327 18.85 ENST00000596708.1
ENST00000601220.1
ENST00000597848.1
CHMP2A
charged multivesicular body protein 2A
chr15_-_85259330 18.81 ENST00000560266.1
SEC11A
SEC11 homolog A (S. cerevisiae)
chr14_+_21458127 18.80 ENST00000382985.4
ENST00000556670.2
ENST00000553564.1
ENST00000554751.1
ENST00000554283.1
ENST00000555670.1
METTL17
methyltransferase like 17
chr19_+_9938562 18.79 ENST00000586895.1
ENST00000358666.3
ENST00000590068.1
ENST00000593087.1
UBL5
ubiquitin-like 5
chr9_+_127631399 18.32 ENST00000259477.6
ARPC5L
actin related protein 2/3 complex, subunit 5-like
chrX_+_24072833 18.30 ENST00000253039.4
EIF2S3
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr3_+_23847432 18.23 ENST00000346855.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr11_-_18548426 18.19 ENST00000357193.3
ENST00000536719.1
TSG101
tumor susceptibility 101
chr17_+_61904766 18.15 ENST00000581842.1
ENST00000582130.1
ENST00000584320.1
ENST00000585123.1
ENST00000580864.1
PSMC5
proteasome (prosome, macropain) 26S subunit, ATPase, 5
chr11_+_58910201 18.13 ENST00000528737.1
FAM111A
family with sequence similarity 111, member A
chr12_-_120907374 18.13 ENST00000550458.1
SRSF9
serine/arginine-rich splicing factor 9
chr1_-_43855444 18.12 ENST00000372455.4
MED8
mediator complex subunit 8
chr19_-_9546177 17.83 ENST00000592292.1
ENST00000588221.1
ZNF266
zinc finger protein 266
chr6_-_170862322 17.82 ENST00000262193.6
PSMB1
proteasome (prosome, macropain) subunit, beta type, 1
chr19_-_10230562 17.73 ENST00000587146.1
ENST00000588709.1
ENST00000253108.4
EIF3G
eukaryotic translation initiation factor 3, subunit G
chr14_+_35452169 17.64 ENST00000555557.1
SRP54
signal recognition particle 54kDa
chr6_+_31633902 17.48 ENST00000375865.2
ENST00000375866.2
CSNK2B
casein kinase 2, beta polypeptide
chr15_-_85259384 17.41 ENST00000455959.3
SEC11A
SEC11 homolog A (S. cerevisiae)
chr20_-_49575081 17.40 ENST00000371588.5
ENST00000371582.4
DPM1
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
chr14_-_67826486 17.31 ENST00000555431.1
ENST00000554236.1
ENST00000555474.1
ATP6V1D
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
chr11_-_60674037 17.29 ENST00000541371.1
ENST00000227524.4
PRPF19
pre-mRNA processing factor 19
chr19_-_59066452 17.21 ENST00000312547.2
CHMP2A
charged multivesicular body protein 2A
chr2_+_201936458 17.19 ENST00000237889.4
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr4_-_10118348 17.14 ENST00000502702.1
WDR1
WD repeat domain 1
chr21_-_46340884 16.95 ENST00000302347.5
ENST00000517819.1
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr6_-_75953484 16.88 ENST00000472311.2
ENST00000460985.1
ENST00000377978.3
ENST00000509698.1
ENST00000230459.4
ENST00000370089.2
COX7A2
cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
chr12_-_9102549 16.84 ENST00000000412.3
M6PR
mannose-6-phosphate receptor (cation dependent)
chr14_+_55518349 16.81 ENST00000395468.4
MAPK1IP1L
mitogen-activated protein kinase 1 interacting protein 1-like
chr2_+_201981527 16.68 ENST00000441224.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr19_-_10514184 16.67 ENST00000589629.1
ENST00000222005.2
CDC37
cell division cycle 37
chr22_+_24951436 16.63 ENST00000215829.3
SNRPD3
small nuclear ribonucleoprotein D3 polypeptide 18kDa
chr4_-_10118573 16.38 ENST00000382452.2
ENST00000382451.2
WDR1
WD repeat domain 1
chr19_-_10230540 16.36 ENST00000589454.1
EIF3G
eukaryotic translation initiation factor 3, subunit G
chr16_-_69373396 16.32 ENST00000562595.1
ENST00000562081.1
ENST00000306875.4
COG8
component of oligomeric golgi complex 8
chr8_-_101962777 16.23 ENST00000395951.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr20_+_60962143 16.23 ENST00000343986.4
RPS21
ribosomal protein S21
chr17_-_38574169 16.10 ENST00000423485.1
TOP2A
topoisomerase (DNA) II alpha 170kDa
chr11_+_58910295 16.02 ENST00000420244.1
FAM111A
family with sequence similarity 111, member A
chr1_-_43638168 15.99 ENST00000431635.2
EBNA1BP2
EBNA1 binding protein 2
chr8_-_121457608 15.96 ENST00000306185.3
MRPL13
mitochondrial ribosomal protein L13
chr20_-_524415 15.95 ENST00000400217.2
CSNK2A1
casein kinase 2, alpha 1 polypeptide
chr5_-_31532160 15.90 ENST00000511367.2
ENST00000513349.1
DROSHA
drosha, ribonuclease type III
chr19_-_9546227 15.79 ENST00000361451.2
ENST00000361151.1
ZNF266
zinc finger protein 266
chr3_-_196669248 15.71 ENST00000447325.1
NCBP2
nuclear cap binding protein subunit 2, 20kDa
chr7_+_44240520 15.70 ENST00000496112.1
ENST00000223369.2
YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr21_-_46340770 15.70 ENST00000397854.3
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr5_+_36152091 15.63 ENST00000274254.5
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr8_-_48872686 15.37 ENST00000314191.2
ENST00000338368.3
PRKDC
protein kinase, DNA-activated, catalytic polypeptide
chr19_+_55897699 15.28 ENST00000558131.1
ENST00000558752.1
ENST00000458349.2
RPL28
ribosomal protein L28
chr5_+_96079240 15.20 ENST00000515663.1
CAST
calpastatin
chr19_+_19303008 14.86 ENST00000353145.1
ENST00000421262.3
ENST00000303088.4
ENST00000456252.3
ENST00000593273.1
RFXANK
regulatory factor X-associated ankyrin-containing protein
chr19_-_13044494 14.85 ENST00000593021.1
ENST00000587981.1
ENST00000423140.2
ENST00000314606.4
FARSA
phenylalanyl-tRNA synthetase, alpha subunit
chr1_+_15736359 14.84 ENST00000375980.4
EFHD2
EF-hand domain family, member D2
chr6_-_144416737 14.81 ENST00000367569.2
SF3B5
splicing factor 3b, subunit 5, 10kDa
chr6_-_31620149 14.57 ENST00000435080.1
ENST00000375976.4
ENST00000441054.1
BAG6
BCL2-associated athanogene 6
chr12_-_120907459 14.37 ENST00000229390.3
SRSF9
serine/arginine-rich splicing factor 9
chr2_+_96931834 14.31 ENST00000488633.1
CIAO1
cytosolic iron-sulfur protein assembly 1
chr6_+_31633833 14.25 ENST00000375882.2
ENST00000375880.2
CSNK2B
CSNK2B-LY6G5B-1181
casein kinase 2, beta polypeptide
Uncharacterized protein
chr19_-_16770915 14.22 ENST00000593459.1
ENST00000358726.6
ENST00000597711.1
ENST00000487416.2
CTC-429P9.4
SMIM7
Small integral membrane protein 7; Uncharacterized protein
small integral membrane protein 7
chr8_+_145137489 14.21 ENST00000355091.4
ENST00000525087.1
ENST00000361036.6
ENST00000524418.1
GPAA1
glycosylphosphatidylinositol anchor attachment 1
chr8_-_117778494 14.20 ENST00000276682.4
EIF3H
eukaryotic translation initiation factor 3, subunit H
chr3_-_16555150 14.06 ENST00000334133.4
RFTN1
raftlin, lipid raft linker 1
chr19_-_46195029 13.80 ENST00000588599.1
ENST00000585392.1
ENST00000590212.1
ENST00000587367.1
ENST00000391932.3
SNRPD2
small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
chr19_+_54619125 13.75 ENST00000445811.1
ENST00000419967.1
ENST00000445124.1
ENST00000447810.1
PRPF31
pre-mRNA processing factor 31
chr1_+_26644441 13.67 ENST00000374213.2
CD52
CD52 molecule
chr22_+_32871224 13.63 ENST00000452138.1
ENST00000382058.3
ENST00000397426.1
FBXO7
F-box protein 7
chr3_-_196669298 13.60 ENST00000411704.1
ENST00000452404.2
NCBP2
nuclear cap binding protein subunit 2, 20kDa
chr15_-_85259360 13.48 ENST00000559729.1
SEC11A
SEC11 homolog A (S. cerevisiae)
chr19_+_49375649 13.46 ENST00000200453.5
PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr16_+_30075783 13.35 ENST00000412304.2
ALDOA
aldolase A, fructose-bisphosphate
chr14_+_75348592 13.32 ENST00000334220.4
DLST
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
chr6_-_31697255 13.30 ENST00000436437.1
DDAH2
dimethylarginine dimethylaminohydrolase 2
chr6_-_108395907 13.18 ENST00000193322.3
OSTM1
osteopetrosis associated transmembrane protein 1
chr16_+_30075463 13.11 ENST00000562168.1
ENST00000569545.1
ALDOA
aldolase A, fructose-bisphosphate
chr20_+_3190006 13.06 ENST00000380113.3
ENST00000455664.2
ENST00000399838.3
ITPA
inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
chr9_+_36190853 12.95 ENST00000433436.2
ENST00000538225.1
ENST00000540080.1
CLTA
clathrin, light chain A
chr1_-_43637915 12.93 ENST00000236051.2
EBNA1BP2
EBNA1 binding protein 2
chr17_-_30228678 12.87 ENST00000261708.4
UTP6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr10_+_22605374 12.85 ENST00000448361.1
COMMD3
COMM domain containing 3
chr3_-_33481835 12.79 ENST00000283629.3
UBP1
upstream binding protein 1 (LBP-1a)
chr17_+_79650962 12.72 ENST00000329138.4
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chrX_+_148622513 12.58 ENST00000393985.3
ENST00000423421.1
ENST00000423540.2
ENST00000434353.2
ENST00000514208.1
CXorf40A
chromosome X open reading frame 40A
chr19_+_39109735 12.52 ENST00000593149.1
ENST00000248342.4
ENST00000538434.1
ENST00000588934.1
ENST00000545173.2
ENST00000589307.1
ENST00000586513.1
ENST00000591409.1
ENST00000592558.1
EIF3K
eukaryotic translation initiation factor 3, subunit K
chr5_+_31532373 12.51 ENST00000325366.9
ENST00000355907.3
ENST00000507818.2
C5orf22
chromosome 5 open reading frame 22
chr16_+_30075595 12.47 ENST00000563060.2
ALDOA
aldolase A, fructose-bisphosphate
chrX_-_100872911 12.38 ENST00000361910.4
ENST00000539247.1
ENST00000538627.1
ARMCX6
armadillo repeat containing, X-linked 6
chr8_-_131028869 12.38 ENST00000518283.1
ENST00000519110.1
FAM49B
family with sequence similarity 49, member B
chr9_+_36190905 12.36 ENST00000345519.5
ENST00000470744.1
ENST00000242285.6
ENST00000466396.1
ENST00000396603.2
CLTA
clathrin, light chain A
chr14_-_75179774 12.25 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
AREL1
AC007956.1
apoptosis resistant E3 ubiquitin protein ligase 1
Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr12_+_53693812 12.21 ENST00000549488.1
C12orf10
chromosome 12 open reading frame 10
chr15_+_41624892 12.08 ENST00000260359.6
ENST00000450318.1
ENST00000450592.2
ENST00000559596.1
ENST00000414849.2
ENST00000560747.1
ENST00000560177.1
NUSAP1
nucleolar and spindle associated protein 1
chr10_-_5855350 11.92 ENST00000456041.1
ENST00000380181.3
ENST00000418688.1
ENST00000380132.4
ENST00000609712.1
ENST00000380191.4
GDI2
GDP dissociation inhibitor 2
chr1_-_235324530 11.90 ENST00000447801.1
ENST00000366606.3
ENST00000429912.1
RBM34
RNA binding motif protein 34
chr19_+_50919056 11.85 ENST00000599632.1
CTD-2545M3.6
CTD-2545M3.6
chr1_-_20987889 11.77 ENST00000415136.2
DDOST
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
chr1_-_20987851 11.77 ENST00000464364.1
ENST00000602624.2
DDOST
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
chr14_+_23340822 11.76 ENST00000359591.4
LRP10
low density lipoprotein receptor-related protein 10
chr22_-_18111499 11.64 ENST00000413576.1
ENST00000399796.2
ENST00000399798.2
ENST00000253413.5
ATP6V1E1
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
chr11_+_60681346 11.53 ENST00000227525.3
TMEM109
transmembrane protein 109
chr6_+_30539153 11.22 ENST00000326195.8
ENST00000376545.3
ENST00000396515.4
ENST00000441867.1
ENST00000468958.1
ABCF1
ATP-binding cassette, sub-family F (GCN20), member 1
chr10_+_7830125 11.12 ENST00000335698.4
ENST00000541227.1
ATP5C1
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
chr6_+_133135580 11.09 ENST00000230050.3
RPS12
ribosomal protein S12
chr4_-_10118469 11.05 ENST00000499869.2
WDR1
WD repeat domain 1
chr17_-_79876010 10.99 ENST00000328666.6
SIRT7
sirtuin 7
chr6_-_149969829 10.93 ENST00000367411.2
KATNA1
katanin p60 (ATPase containing) subunit A 1
chr11_+_8008867 10.92 ENST00000309828.4
ENST00000449102.2
EIF3F
eukaryotic translation initiation factor 3, subunit F
chr3_+_101292939 10.90 ENST00000265260.3
ENST00000469941.1
ENST00000296024.5
PCNP
PEST proteolytic signal containing nuclear protein
chr12_+_27863706 10.88 ENST00000081029.3
ENST00000538315.1
ENST00000542791.1
MRPS35
mitochondrial ribosomal protein S35
chr18_-_45456930 10.87 ENST00000262160.6
ENST00000587269.1
SMAD2
SMAD family member 2
chr8_-_104427313 10.82 ENST00000297578.4
SLC25A32
solute carrier family 25 (mitochondrial folate carrier), member 32
chr12_+_120875910 10.77 ENST00000551806.1
AL021546.6
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial
chr3_-_196669371 10.70 ENST00000427641.2
ENST00000321256.5
NCBP2
nuclear cap binding protein subunit 2, 20kDa
chr2_+_64069459 10.68 ENST00000445915.2
ENST00000475462.1
UGP2
UDP-glucose pyrophosphorylase 2
chr5_+_36152163 10.60 ENST00000274255.6
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr6_-_127664736 10.57 ENST00000368291.2
ENST00000309620.9
ENST00000454859.3
ECHDC1
enoyl CoA hydratase domain containing 1
chrX_+_100646190 10.56 ENST00000471855.1
RPL36A
ribosomal protein L36a
chrX_+_100645812 10.48 ENST00000427805.2
ENST00000553110.3
ENST00000392994.3
ENST00000409338.1
ENST00000409170.3
RPL36A
RPL36A-HNRNPH2
ribosomal protein L36a
RPL36A-HNRNPH2 readthrough
chr15_+_75074385 10.39 ENST00000220003.9
CSK
c-src tyrosine kinase
chr15_+_75074410 10.32 ENST00000439220.2
CSK
c-src tyrosine kinase
chr1_+_150293921 10.30 ENST00000324862.6
PRPF3
pre-mRNA processing factor 3
chr14_+_96000930 10.29 ENST00000331334.4
GLRX5
glutaredoxin 5
chr8_-_124054587 10.29 ENST00000259512.4
DERL1
derlin 1
chr16_-_67694129 10.22 ENST00000602320.1
ACD
adrenocortical dysplasia homolog (mouse)
chr2_-_27632390 10.19 ENST00000350803.4
ENST00000344034.4
PPM1G
protein phosphatase, Mg2+/Mn2+ dependent, 1G
chr6_-_127664683 10.14 ENST00000528402.1
ENST00000454591.2
ECHDC1
enoyl CoA hydratase domain containing 1
chr6_-_31697563 10.05 ENST00000375789.2
ENST00000416410.1
DDAH2
dimethylarginine dimethylaminohydrolase 2
chr11_-_67205538 10.04 ENST00000326294.3
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr9_+_33264861 10.04 ENST00000223500.8
CHMP5
charged multivesicular body protein 5
chr19_-_50143452 10.04 ENST00000246792.3
RRAS
related RAS viral (r-ras) oncogene homolog
chr13_-_31736027 9.90 ENST00000380406.5
ENST00000320027.5
ENST00000380405.4
HSPH1
heat shock 105kDa/110kDa protein 1
chr10_+_22605304 9.88 ENST00000475460.2
ENST00000602390.1
ENST00000489125.2
ENST00000456711.1
ENST00000444869.1
COMMD3-BMI1
COMMD3
COMMD3-BMI1 readthrough
COMM domain containing 3
chr20_-_524455 9.88 ENST00000349736.5
ENST00000217244.3
CSNK2A1
casein kinase 2, alpha 1 polypeptide
chr18_+_21032781 9.87 ENST00000339486.3
RIOK3
RIO kinase 3
chr1_+_150293973 9.78 ENST00000414970.2
ENST00000543398.1
PRPF3
pre-mRNA processing factor 3
chr12_+_53693466 9.76 ENST00000267103.5
ENST00000548632.1
C12orf10
chromosome 12 open reading frame 10

Network of associatons between targets according to the STRING database.

First level regulatory network of ETV6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
28.3 85.0 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
24.9 74.8 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
24.1 72.3 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
17.8 71.4 GO:0090579 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
16.6 49.9 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
14.2 42.6 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
13.2 39.5 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
13.0 52.0 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
12.8 38.3 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
12.0 36.1 GO:1903722 regulation of centriole elongation(GO:1903722)
11.1 44.6 GO:0016334 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
10.3 51.3 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
10.1 50.6 GO:0019348 dolichol metabolic process(GO:0019348)
10.0 40.0 GO:0046833 snRNA export from nucleus(GO:0006408) positive regulation of RNA export from nucleus(GO:0046833)
8.5 51.2 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
8.1 97.0 GO:0015074 DNA integration(GO:0015074)
7.2 7.2 GO:1903094 regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
7.1 21.4 GO:0060380 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381) positive regulation of telomeric DNA binding(GO:1904744)
6.8 54.6 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
6.1 18.2 GO:2000397 ubiquitin-dependent endocytosis(GO:0070086) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
5.6 16.8 GO:0070902 mitochondrial tRNA pseudouridine synthesis(GO:0070902)
5.5 33.0 GO:0048254 snoRNA localization(GO:0048254)
5.1 40.5 GO:0032020 ISG15-protein conjugation(GO:0032020)
5.0 25.0 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
4.6 101.1 GO:0006465 signal peptide processing(GO:0006465)
4.5 13.5 GO:1902310 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
4.4 13.3 GO:0019474 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
4.3 34.1 GO:0075525 viral translational termination-reinitiation(GO:0075525)
4.1 20.7 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
4.1 8.3 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
4.0 15.9 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
4.0 31.7 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
3.8 15.3 GO:1904379 maintenance of unfolded protein(GO:0036506) protein localization to cytosolic proteasome complex(GO:1904327) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
3.7 18.7 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
3.7 18.6 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
3.7 14.9 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
3.7 11.0 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
3.6 10.8 GO:0015883 FAD transport(GO:0015883) FAD transmembrane transport(GO:0035350)
3.3 19.7 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
3.1 18.9 GO:0000393 spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
3.1 40.7 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
2.7 8.2 GO:0002588 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
2.6 7.9 GO:1901355 response to rapamycin(GO:1901355)
2.5 10.0 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
2.5 7.4 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
2.4 14.7 GO:0051013 microtubule severing(GO:0051013)
2.4 23.5 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
2.3 6.9 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
2.2 44.4 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
2.2 28.9 GO:0031053 primary miRNA processing(GO:0031053)
2.2 28.5 GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479)
2.2 17.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
2.2 38.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
2.1 12.4 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
2.0 6.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
2.0 14.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
2.0 31.4 GO:0006527 arginine catabolic process(GO:0006527)
1.9 15.4 GO:0002326 B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152) ectopic germ cell programmed cell death(GO:0035234)
1.9 7.7 GO:0043128 regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128)
1.9 7.6 GO:0071492 cellular response to UV-A(GO:0071492)
1.9 5.6 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
1.9 13.1 GO:0009146 purine nucleoside triphosphate catabolic process(GO:0009146)
1.9 5.6 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
1.8 19.8 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
1.8 83.9 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
1.8 22.9 GO:0070365 hepatocyte differentiation(GO:0070365)
1.7 17.2 GO:0045047 protein targeting to ER(GO:0045047)
1.7 16.8 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
1.7 21.5 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
1.6 8.1 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
1.6 16.1 GO:0030263 resolution of meiotic recombination intermediates(GO:0000712) apoptotic chromosome condensation(GO:0030263)
1.6 4.8 GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
1.6 30.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
1.6 9.4 GO:1903750 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
1.6 32.6 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
1.5 18.1 GO:0090261 positive regulation of inclusion body assembly(GO:0090261)
1.5 6.0 GO:0015746 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
1.4 5.7 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
1.4 25.3 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
1.4 12.6 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
1.4 16.7 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
1.3 20.1 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
1.3 5.2 GO:1904502 regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
1.3 16.6 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
1.3 5.1 GO:0035879 plasma membrane lactate transport(GO:0035879)
1.3 13.9 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
1.3 29.0 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
1.2 22.5 GO:1903204 negative regulation of oxidative stress-induced neuron death(GO:1903204)
1.2 3.7 GO:0034184 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
1.2 22.0 GO:0035641 locomotory exploration behavior(GO:0035641)
1.2 19.4 GO:0043248 proteasome assembly(GO:0043248)
1.2 3.6 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
1.1 8.0 GO:0000710 meiotic mismatch repair(GO:0000710)
1.1 10.3 GO:0009249 protein lipoylation(GO:0009249)
1.1 71.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
1.1 7.7 GO:0048318 axial mesoderm development(GO:0048318)
1.1 15.2 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
1.1 32.5 GO:0006376 mRNA splice site selection(GO:0006376)
1.1 16.2 GO:0090168 Golgi reassembly(GO:0090168)
1.0 3.9 GO:0090234 regulation of kinetochore assembly(GO:0090234)
1.0 12.7 GO:1903543 positive regulation of exosomal secretion(GO:1903543)
1.0 4.9 GO:2000574 regulation of microtubule motor activity(GO:2000574)
1.0 4.8 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.9 20.7 GO:1904886 beta-catenin destruction complex disassembly(GO:1904886)
0.9 65.6 GO:0070125 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.9 7.1 GO:0070475 rRNA base methylation(GO:0070475)
0.9 33.4 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.9 9.5 GO:2000210 positive regulation of anoikis(GO:2000210)
0.9 27.4 GO:0090383 phagosome acidification(GO:0090383)
0.9 23.0 GO:0006491 N-glycan processing(GO:0006491)
0.8 10.9 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.8 5.0 GO:0044800 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.8 6.6 GO:0006983 ER overload response(GO:0006983)
0.8 8.0 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) positive regulation of translational elongation(GO:0045901)
0.8 17.5 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.8 11.8 GO:0048839 inner ear development(GO:0048839)
0.7 62.4 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.7 6.3 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.7 183.3 GO:0006413 translational initiation(GO:0006413)
0.6 10.2 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.6 5.7 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.6 15.1 GO:0043101 purine-containing compound salvage(GO:0043101)
0.6 8.4 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.6 1.8 GO:1903028 positive regulation of opsonization(GO:1903028)
0.6 7.0 GO:0045116 protein neddylation(GO:0045116)
0.6 18.6 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.6 3.5 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.6 16.5 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.6 1.1 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.6 6.6 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.5 16.7 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.5 7.9 GO:0009086 methionine biosynthetic process(GO:0009086)
0.5 9.0 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.5 10.5 GO:0007289 spermatid nucleus differentiation(GO:0007289)
0.5 8.7 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.5 25.3 GO:0007091 metaphase/anaphase transition of mitotic cell cycle(GO:0007091)
0.5 1.5 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.5 1.5 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.5 34.1 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.5 5.2 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.5 7.9 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.5 21.3 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.5 1.8 GO:0034398 telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.4 13.7 GO:0045730 respiratory burst(GO:0045730)
0.4 1.3 GO:0048213 Golgi vesicle prefusion complex stabilization(GO:0048213)
0.4 1.7 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.4 4.6 GO:0006105 succinate metabolic process(GO:0006105)
0.4 4.6 GO:0042074 cell migration involved in gastrulation(GO:0042074)
0.4 2.4 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.4 8.0 GO:0009226 nucleotide-sugar biosynthetic process(GO:0009226)
0.4 4.7 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.4 2.3 GO:0061635 regulation of protein complex stability(GO:0061635)
0.4 29.0 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.4 11.8 GO:0060325 face morphogenesis(GO:0060325)
0.3 19.6 GO:0019079 viral genome replication(GO:0019079)
0.3 8.3 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.3 6.7 GO:0017004 cytochrome complex assembly(GO:0017004)
0.3 4.6 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.3 4.8 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.3 19.2 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.3 15.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.3 1.1 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.3 1.4 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.3 15.1 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.3 2.2 GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128)
0.3 3.8 GO:0034447 very-low-density lipoprotein particle clearance(GO:0034447)
0.3 5.5 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.2 20.3 GO:0000271 polysaccharide biosynthetic process(GO:0000271)
0.2 8.4 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.2 4.4 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.2 1.4 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.2 0.6 GO:0030205 dermatan sulfate metabolic process(GO:0030205)
0.2 9.1 GO:0006270 DNA replication initiation(GO:0006270)
0.2 3.4 GO:0006020 inositol metabolic process(GO:0006020)
0.2 4.0 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.2 0.7 GO:0030242 pexophagy(GO:0030242)
0.2 2.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.2 2.1 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.1 8.7 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.1 40.9 GO:0050851 antigen receptor-mediated signaling pathway(GO:0050851)
0.1 2.0 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)
0.1 1.0 GO:0070236 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 13.2 GO:0030316 osteoclast differentiation(GO:0030316)
0.1 6.6 GO:0046686 response to cadmium ion(GO:0046686)
0.1 5.9 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.1 1.3 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 0.7 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 2.2 GO:0006337 nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986)
0.1 3.5 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.1 5.5 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.1 20.2 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.1 0.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 18.8 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.1 GO:1903599 positive regulation of mitophagy(GO:1903599)
0.0 3.1 GO:0042113 B cell activation(GO:0042113)
0.0 0.9 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 14.0 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 1.6 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.7 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 1.3 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 1.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.5 GO:0090398 cellular senescence(GO:0090398)
0.0 0.1 GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
16.9 50.6 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
14.4 101.1 GO:0005787 signal peptidase complex(GO:0005787)
12.8 51.2 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
10.0 40.0 GO:0005846 nuclear cap binding complex(GO:0005846)
8.9 44.6 GO:0042643 actomyosin, actin portion(GO:0042643)
8.9 26.6 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
8.2 73.8 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
8.0 63.9 GO:0034715 pICln-Sm protein complex(GO:0034715)
7.3 51.3 GO:0071203 WASH complex(GO:0071203)
7.1 71.4 GO:0097255 R2TP complex(GO:0097255)
6.7 33.7 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
6.5 32.6 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
6.4 19.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
5.8 122.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
5.7 85.0 GO:0030478 actin cap(GO:0030478)
5.4 16.1 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
5.3 37.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
5.2 15.7 GO:0097441 basilar dendrite(GO:0097441)
4.8 38.3 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
4.7 14.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
4.3 120.3 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
4.2 12.7 GO:0033565 ESCRT-0 complex(GO:0033565)
4.0 24.0 GO:0008537 proteasome activator complex(GO:0008537)
4.0 15.9 GO:0044611 nuclear pore inner ring(GO:0044611)
3.9 46.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
3.8 15.3 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
3.7 22.5 GO:1990037 Lewy body core(GO:1990037)
3.6 18.2 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
3.6 111.2 GO:0030687 preribosome, large subunit precursor(GO:0030687)
3.0 9.1 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
3.0 38.8 GO:0005686 U2 snRNP(GO:0005686)
2.9 8.8 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
2.9 46.6 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
2.9 40.1 GO:0005689 U12-type spliceosomal complex(GO:0005689)
2.8 25.3 GO:0071439 clathrin complex(GO:0071439)
2.8 36.1 GO:0000815 ESCRT III complex(GO:0000815)
2.7 18.6 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
2.6 18.2 GO:0000813 ESCRT I complex(GO:0000813)
2.6 15.4 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
2.5 22.9 GO:0000125 PCAF complex(GO:0000125)
2.5 15.1 GO:1902560 GMP reductase complex(GO:1902560)
2.5 39.3 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
2.4 14.3 GO:0071817 MMXD complex(GO:0071817)
2.3 6.9 GO:0005674 transcription factor TFIIF complex(GO:0005674)
2.1 64.2 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
2.0 8.0 GO:0032301 MutSalpha complex(GO:0032301)
1.9 13.3 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
1.7 12.0 GO:0061700 GATOR2 complex(GO:0061700)
1.7 10.0 GO:0030688 preribosome, small subunit precursor(GO:0030688)
1.6 6.6 GO:0032044 DSIF complex(GO:0032044)
1.5 18.1 GO:0031595 nuclear proteasome complex(GO:0031595)
1.5 11.8 GO:0005905 clathrin-coated pit(GO:0005905)
1.4 25.7 GO:0097342 ripoptosome(GO:0097342)
1.4 1.4 GO:0048500 signal recognition particle(GO:0048500)
1.4 8.2 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
1.3 5.2 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
1.3 51.4 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
1.3 84.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
1.3 17.6 GO:0017119 Golgi transport complex(GO:0017119)
1.2 7.4 GO:0032444 activin responsive factor complex(GO:0032444)
1.2 19.4 GO:0030686 90S preribosome(GO:0030686)
1.2 21.0 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
1.2 4.6 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
1.0 20.6 GO:0022624 proteasome regulatory particle(GO:0005838) proteasome accessory complex(GO:0022624)
0.9 3.7 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.8 15.8 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)
0.8 42.4 GO:0031430 M band(GO:0031430)
0.8 13.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.7 11.0 GO:0000812 Swr1 complex(GO:0000812)
0.7 11.6 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.7 7.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.7 16.8 GO:0030904 retromer complex(GO:0030904)
0.7 15.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.7 19.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.6 70.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.6 34.9 GO:0045171 intercellular bridge(GO:0045171)
0.6 10.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.6 8.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.6 5.7 GO:0030897 HOPS complex(GO:0030897)
0.6 14.2 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.6 19.2 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.5 57.3 GO:0005840 ribosome(GO:0005840)
0.4 1.3 GO:0031251 PAN complex(GO:0031251)
0.4 12.1 GO:0005876 spindle microtubule(GO:0005876)
0.4 21.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.4 11.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.4 9.6 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.4 4.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.3 9.4 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.3 23.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.3 3.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.3 3.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.3 47.4 GO:0005681 spliceosomal complex(GO:0005681)
0.3 58.2 GO:0000793 condensed chromosome(GO:0000793)
0.3 40.2 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.3 3.0 GO:0044754 autolysosome(GO:0044754)
0.2 1.5 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2 1.5 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.2 3.6 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.2 2.0 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 3.8 GO:0042627 chylomicron(GO:0042627)
0.2 9.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 4.8 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.2 1.8 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 22.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 7.7 GO:0001772 immunological synapse(GO:0001772)
0.1 3.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 3.9 GO:0000776 kinetochore(GO:0000776)
0.1 4.8 GO:0016592 mediator complex(GO:0016592)
0.1 0.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 12.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 2.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 8.4 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 7.9 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 0.5 GO:0019815 B cell receptor complex(GO:0019815)
0.1 2.2 GO:0071564 npBAF complex(GO:0071564)
0.1 13.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 15.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 30.3 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 1.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 10.1 GO:0000922 spindle pole(GO:0000922)
0.1 5.5 GO:0005643 nuclear pore(GO:0005643)
0.1 19.9 GO:0019866 organelle inner membrane(GO:0019866)
0.1 4.6 GO:0035579 specific granule membrane(GO:0035579)
0.0 0.9 GO:0016363 nuclear matrix(GO:0016363)
0.0 2.1 GO:0005769 early endosome(GO:0005769)
0.0 1.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 35.7 GO:0005739 mitochondrion(GO:0005739)
0.0 5.7 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 1.8 GO:0042641 actomyosin(GO:0042641)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
24.1 72.3 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
16.9 50.6 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
14.2 42.6 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
10.6 63.8 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
10.4 52.0 GO:0043023 ribosomal large subunit binding(GO:0043023)
8.8 26.3 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
8.6 25.8 GO:0042134 rRNA primary transcript binding(GO:0042134)
7.7 38.3 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
7.3 87.8 GO:0070990 snRNP binding(GO:0070990)
6.7 40.5 GO:0042296 ISG15 transferase activity(GO:0042296)
6.3 31.4 GO:0016403 dimethylargininase activity(GO:0016403)
6.2 18.7 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
5.6 16.8 GO:0004730 pseudouridylate synthase activity(GO:0004730)
5.4 16.1 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
5.0 40.0 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
4.9 39.6 GO:0016842 amidine-lyase activity(GO:0016842)
4.7 14.2 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
4.7 32.6 GO:0030369 ICAM-3 receptor activity(GO:0030369)
4.4 13.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
3.7 14.9 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
3.7 66.6 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
3.7 11.0 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
3.6 10.8 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
3.5 38.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
3.4 24.0 GO:0061133 endopeptidase activator activity(GO:0061133)
3.3 13.3 GO:0016748 succinyltransferase activity(GO:0016748)
3.2 71.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
3.2 19.4 GO:0034511 U3 snoRNA binding(GO:0034511)
3.2 15.9 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
3.2 9.5 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
3.1 30.8 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
2.9 8.8 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
2.9 64.2 GO:0042609 CD4 receptor binding(GO:0042609)
2.8 8.4 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
2.7 8.2 GO:0032090 Pyrin domain binding(GO:0032090)
2.6 26.4 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
2.6 15.4 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
2.5 15.2 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
2.5 15.1 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
2.4 14.7 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
2.4 173.9 GO:0003743 translation initiation factor activity(GO:0003743)
2.4 7.2 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
2.3 23.2 GO:0046790 virion binding(GO:0046790)
2.3 6.9 GO:0004914 interleukin-5 receptor activity(GO:0004914)
2.1 12.4 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
2.0 8.0 GO:0032143 single thymine insertion binding(GO:0032143)
1.9 5.8 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
1.9 11.6 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
1.9 19.2 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
1.7 5.2 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
1.7 5.0 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
1.6 18.1 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
1.6 8.1 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
1.6 4.8 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
1.6 84.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.6 6.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
1.6 18.8 GO:0031386 protein tag(GO:0031386)
1.6 6.2 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
1.5 4.6 GO:0051538 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
1.5 18.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
1.5 6.0 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
1.4 5.5 GO:0052827 inositol pentakisphosphate phosphatase activity(GO:0052827)
1.4 5.4 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
1.3 8.0 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
1.3 39.3 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
1.2 36.1 GO:0031210 phosphatidylcholine binding(GO:0031210)
1.2 6.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
1.2 16.7 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
1.2 21.0 GO:0001054 RNA polymerase I activity(GO:0001054)
1.1 14.4 GO:0016018 cyclosporin A binding(GO:0016018)
1.1 33.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
1.1 74.8 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
1.0 13.9 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
1.0 7.9 GO:0008172 S-methyltransferase activity(GO:0008172)
1.0 16.8 GO:0005537 mannose binding(GO:0005537)
0.8 6.7 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.8 23.5 GO:0005123 death receptor binding(GO:0005123)
0.8 10.0 GO:0089720 caspase binding(GO:0089720)
0.8 20.7 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.8 198.6 GO:0051015 actin filament binding(GO:0051015)
0.8 8.8 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.8 22.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.8 21.4 GO:0070182 DNA polymerase binding(GO:0070182)
0.8 3.8 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.7 11.8 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.7 112.2 GO:0047485 protein N-terminus binding(GO:0047485)
0.7 7.8 GO:0019211 phosphatase activator activity(GO:0019211)
0.7 56.7 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.7 18.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.7 10.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.7 19.2 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.7 3.4 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.7 12.9 GO:0030515 snoRNA binding(GO:0030515)
0.7 7.4 GO:0070878 primary miRNA binding(GO:0070878)
0.7 8.0 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.6 7.7 GO:1990459 transferrin receptor binding(GO:1990459)
0.6 139.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.6 33.5 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.6 7.9 GO:0003680 AT DNA binding(GO:0003680)
0.6 2.4 GO:0015140 malate transmembrane transporter activity(GO:0015140)
0.6 3.5 GO:0015266 protein channel activity(GO:0015266)
0.6 5.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.6 25.3 GO:0005080 protein kinase C binding(GO:0005080)
0.6 1.1 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.5 9.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.5 11.2 GO:0008135 translation factor activity, RNA binding(GO:0008135)
0.5 11.9 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.4 4.8 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.4 9.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.4 1.1 GO:0000403 Y-form DNA binding(GO:0000403)
0.4 19.6 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.3 1.7 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.3 5.9 GO:0051400 BH domain binding(GO:0051400)
0.3 29.0 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 6.9 GO:0000149 SNARE binding(GO:0000149)
0.2 9.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 1.6 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.2 17.4 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.2 7.6 GO:0030331 estrogen receptor binding(GO:0030331)
0.2 12.6 GO:0035064 methylated histone binding(GO:0035064)
0.2 3.3 GO:0043274 phospholipase binding(GO:0043274)
0.2 14.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 2.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 1.0 GO:0043426 MRF binding(GO:0043426)
0.2 15.2 GO:0043130 ubiquitin binding(GO:0043130)
0.2 4.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 1.4 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.1 0.7 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 16.6 GO:0005262 calcium channel activity(GO:0005262)
0.1 10.0 GO:0019003 GDP binding(GO:0019003)
0.1 37.8 GO:0008236 serine-type peptidase activity(GO:0008236)
0.1 8.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 16.2 GO:0044325 ion channel binding(GO:0044325)
0.1 0.3 GO:0032089 NACHT domain binding(GO:0032089)
0.1 10.1 GO:0015405 primary active transmembrane transporter activity(GO:0015399) P-P-bond-hydrolysis-driven transmembrane transporter activity(GO:0015405) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 6.6 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 11.5 GO:0022832 voltage-gated ion channel activity(GO:0005244) voltage-gated channel activity(GO:0022832)
0.1 5.9 GO:0051087 chaperone binding(GO:0051087)
0.1 1.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 4.8 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 2.5 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 0.5 GO:0035325 Toll-like receptor binding(GO:0035325)
0.0 0.5 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.8 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 2.2 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 2.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 18.4 GO:0003723 RNA binding(GO:0003723)
0.0 0.7 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 103.6 PID MYC PATHWAY C-MYC pathway
1.9 52.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
1.7 96.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
1.0 13.5 PID BMP PATHWAY BMP receptor signaling
0.9 23.5 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.8 32.6 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.7 19.5 PID ARF 3PATHWAY Arf1 pathway
0.4 23.1 PID IL3 PATHWAY IL3-mediated signaling events
0.4 28.9 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.4 10.5 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.4 31.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.4 42.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.4 7.0 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.3 7.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3 14.9 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.3 5.1 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 10.0 PID RAS PATHWAY Regulation of Ras family activation
0.2 13.5 PID FOXO PATHWAY FoxO family signaling
0.2 16.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 12.7 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 8.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.5 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 4.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 3.3 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 4.5 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.6 PID ATM PATHWAY ATM pathway
0.0 2.6 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 1.1 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.8 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
11.4 102.8 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
5.9 101.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
5.6 90.1 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
4.0 145.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
3.4 159.8 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
2.9 49.9 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
2.7 66.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
2.6 41.7 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
2.3 174.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
2.0 37.8 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
2.0 15.9 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
1.9 72.9 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
1.8 40.5 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
1.7 53.8 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
1.7 18.6 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
1.7 147.7 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
1.4 25.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
1.3 6.6 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
1.0 27.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
1.0 22.9 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.9 72.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.8 97.8 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.8 23.5 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.8 18.6 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.8 20.1 REACTOME KINESINS Genes involved in Kinesins
0.8 20.7 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.8 9.1 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.7 19.4 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.7 13.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.7 47.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.7 18.7 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.7 21.0 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.7 37.2 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.6 18.2 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.6 15.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.6 16.7 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.5 8.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.5 34.0 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.5 15.9 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.5 40.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.5 7.9 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.5 4.6 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.5 16.8 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.4 10.0 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.3 7.6 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.3 9.9 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.3 5.1 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.3 12.3 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.3 44.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.3 6.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.3 8.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.3 19.6 REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA Genes involved in Processing of Capped Intron-Containing Pre-mRNA
0.2 7.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 2.2 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.2 2.3 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.2 6.9 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.2 8.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.2 12.2 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 4.6 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.2 5.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.6 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 4.8 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 10.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 0.7 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 5.7 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 0.6 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 1.8 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 3.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 0.5 REACTOME IL 2 SIGNALING Genes involved in Interleukin-2 signaling
0.1 1.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 4.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.1 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.1 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 4.7 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production