ISMARA results: ETV6

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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ETV6

Z-value: 2.15

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Transcription factors associated with ETV6

Gene Symbol	Gene ID	Gene Info
ETV6 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000139083.6	ETS variant transcription factor 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ETV6	hg19_v2_chr12_+_11802753_11802834	-0.26	1.0e-04	Click!

Activity profile of ETV6 motif

Sorted Z-values of ETV6 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_167913450 Show fit	73.77	ENST00000231572.3 ENST00000538719.1	RARS Ensembl NCBI GeneCards UniProt NextProt Show fit	arginyl-tRNA synthetase
chr2_+_65454926 Show fit	43.13	ENST00000542850.1 ENST00000377982.4	ACTR2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ARP2 actin-related protein 2 homolog (yeast)
chr2_+_65454863 Show fit	41.84	ENST00000260641.5	ACTR2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ARP2 actin-related protein 2 homolog (yeast)
chr2_-_96971259 Show fit	40.94	ENST00000349783.5	SNRNP200 Ensembl NCBI GeneCards UniProt NextProt Show fit	small nuclear ribonucleoprotein 200kDa (U5)
chr11_+_65770227 Show fit	36.93	ENST00000527348.1	BANF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	barrier to autointegration factor 1
chr2_-_96971232 Show fit	33.85	ENST00000323853.5	SNRNP200 Ensembl NCBI GeneCards UniProt NextProt Show fit	small nuclear ribonucleoprotein 200kDa (U5)
chr1_+_203830703 Show fit	33.42	ENST00000414487.2	SNRPE Ensembl NCBI GeneCards UniProt NextProt Show fit	small nuclear ribonucleoprotein polypeptide E
chr20_-_49575058 Show fit	33.17	ENST00000371584.4 ENST00000371583.5 ENST00000413082.1	DPM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
chr11_+_65769550 Show fit	31.73	ENST00000312175.2 ENST00000445560.2 ENST00000530204.1	BANF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	barrier to autointegration factor 1
chr1_-_19811996 Show fit	31.71	ENST00000264203.3 ENST00000401084.2	CAPZB Ensembl NCBI GeneCards UniProt NextProt Show fit	capping protein (actin filament) muscle Z-line, beta

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ETV6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	183.3	GO:0006413	translational initiation(GO:0006413)
4.6	101.1	GO:0006465	signal peptide processing(GO:0006465)
8.1	97.0	GO:0015074	DNA integration(GO:0015074)
28.3	85.0	GO:0016344	meiotic chromosome movement towards spindle pole(GO:0016344)
1.8	83.9	GO:0000387	spliceosomal snRNP assembly(GO:0000387)
24.9	74.8	GO:0000354	cis assembly of pre-catalytic spliceosome(GO:0000354)
24.1	72.3	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
1.1	71.8	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
17.8	71.4	GO:0090579	transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.9	65.6	GO:0070125	mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)

Showing 1 to 10 of 203 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.8	122.4	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
4.3	120.3	GO:0046540	U4/U6 x U5 tri-snRNP complex(GO:0046540)
3.6	111.2	GO:0030687	preribosome, large subunit precursor(GO:0030687)
14.4	101.1	GO:0005787	signal peptidase complex(GO:0005787)
5.7	85.0	GO:0030478	actin cap(GO:0030478)
1.3	84.4	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
8.2	73.8	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
7.1	71.4	GO:0097255	R2TP complex(GO:0097255)
0.6	70.8	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
2.1	64.2	GO:0030140	trans-Golgi network transport vesicle(GO:0030140)

Showing 1 to 10 of 133 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	198.6	GO:0051015	actin filament binding(GO:0051015)
2.4	173.9	GO:0003743	translation initiation factor activity(GO:0003743)
0.6	139.6	GO:0003735	structural constituent of ribosome(GO:0003735)
0.7	112.2	GO:0047485	protein N-terminus binding(GO:0047485)
7.3	87.8	GO:0070990	snRNP binding(GO:0070990)
1.6	84.4	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.1	74.8	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
24.1	72.3	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
3.2	71.2	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
3.7	66.6	GO:1990381	ubiquitin-specific protease binding(GO:1990381)

Showing 1 to 10 of 152 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	103.6	PID MYC PATHWAY	C-MYC pathway
1.7	96.9	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
1.9	52.5	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.4	42.4	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.8	32.6	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.4	31.2	PID ILK PATHWAY	Integrin-linked kinase signaling
0.4	28.9	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.9	23.5	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.4	23.1	PID IL3 PATHWAY	IL3-mediated signaling events
0.7	19.5	PID ARF 3PATHWAY	Arf1 pathway

Showing 1 to 10 of 31 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	174.3	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
3.4	159.8	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
1.7	147.7	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
4.0	145.3	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
11.4	102.8	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
5.9	101.1	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.8	97.8	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
5.6	90.1	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
1.9	72.9	REACTOME EXTENSION OF TELOMERES	Genes involved in Extension of Telomeres
0.9	72.4	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport

Showing 1 to 10 of 74 entries

Results for ETV6

Z-value: 2.15

Motif logo

Transcription factors associated with ETV6

Activity-expression correlation:

Activity profile of ETV6 motif

Sorted Z-values of ETV6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ETV6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: