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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for EZH2
Z-value: 2.30
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Transcription factors associated with EZH2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EZH2 | hg19_v2_chr7_-_148580563_148580601 | -0.55 | 9.0e-19 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_111781610 Show fit | 67.93 |
ENST00000525823.1
|
crystallin, alpha B |
|
| chr11_-_111781554 Show fit | 54.71 |
ENST00000526167.1
ENST00000528961.1 |
crystallin, alpha B |
|
| chr11_-_111781454 Show fit | 54.60 |
ENST00000533280.1
|
crystallin, alpha B |
|
| chr3_+_115342159 Show fit | 52.03 |
ENST00000305124.6
|
growth associated protein 43 |
|
| chr3_+_115342349 Show fit | 49.67 |
ENST00000393780.3
|
growth associated protein 43 |
|
| chr15_+_43885252 Show fit | 35.15 |
ENST00000453782.1
ENST00000300283.6 ENST00000437924.1 ENST00000450086.2 |
creatine kinase, mitochondrial 1B |
|
| chr14_-_60337684 Show fit | 32.23 |
ENST00000267484.5
|
reticulon 1 |
|
| chrX_+_103031421 Show fit | 31.50 |
ENST00000433491.1
ENST00000418604.1 ENST00000443502.1 |
proteolipid protein 1 |
|
| chr15_+_43985084 Show fit | 30.99 |
ENST00000434505.1
ENST00000411750.1 |
creatine kinase, mitochondrial 1A |
|
| chr14_-_21490958 Show fit | 28.99 |
ENST00000554104.1
|
NDRG family member 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of EZH2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.9 | 196.5 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 7.6 | 121.1 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.7 | 113.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 10.9 | 108.7 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 3.9 | 94.6 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 2.5 | 69.7 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 1.7 | 65.0 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 2.4 | 64.5 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 7.0 | 63.0 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 4.0 | 56.2 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 214.0 | GO:0030426 | growth cone(GO:0030426) |
| 13.1 | 210.0 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 15.5 | 108.8 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.4 | 91.1 | GO:0043209 | myelin sheath(GO:0043209) |
| 4.1 | 81.9 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.5 | 64.3 | GO:0043204 | perikaryon(GO:0043204) |
| 3.1 | 63.0 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.2 | 57.1 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 11.1 | 55.7 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 11.0 | 55.0 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 172.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 139.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 10.1 | 101.4 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 7.6 | 83.4 | GO:0030274 | LIM domain binding(GO:0030274) |
| 5.8 | 69.4 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 4.1 | 65.5 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.6 | 57.9 | GO:0001618 | virus receptor activity(GO:0001618) |
| 11.0 | 55.0 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.8 | 54.3 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 4.3 | 52.1 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 163.8 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 1.6 | 87.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.5 | 66.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 1.2 | 61.8 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.7 | 61.1 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 1.2 | 54.3 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.7 | 50.9 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.2 | 50.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.8 | 35.5 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.7 | 30.3 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 89.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.8 | 87.7 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 1.4 | 77.1 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 2.8 | 66.2 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 3.2 | 57.0 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.9 | 48.1 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 1.7 | 44.7 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 1.7 | 41.4 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.8 | 37.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.7 | 31.3 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |