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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for EZH2

Z-value: 2.30

Motif logo

Transcription factors associated with EZH2

Gene Symbol Gene ID Gene Info
ENSG00000106462.6 enhancer of zeste 2 polycomb repressive complex 2 subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
EZH2hg19_v2_chr7_-_148580563_148580601-0.559.0e-19Click!

Activity profile of EZH2 motif

Sorted Z-values of EZH2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_111781610 67.93 ENST00000525823.1
crystallin, alpha B
chr11_-_111781554 54.71 ENST00000526167.1
ENST00000528961.1
crystallin, alpha B
chr11_-_111781454 54.60 ENST00000533280.1
crystallin, alpha B
chr3_+_115342159 52.03 ENST00000305124.6
growth associated protein 43
chr3_+_115342349 49.67 ENST00000393780.3
growth associated protein 43
chr15_+_43885252 35.15 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
creatine kinase, mitochondrial 1B
chr14_-_60337684 32.23 ENST00000267484.5
reticulon 1
chrX_+_103031421 31.50 ENST00000433491.1
ENST00000418604.1
ENST00000443502.1
proteolipid protein 1
chr15_+_43985084 30.99 ENST00000434505.1
ENST00000411750.1
creatine kinase, mitochondrial 1A
chr14_-_21490958 28.99 ENST00000554104.1
NDRG family member 2
chr12_+_79258444 28.79 ENST00000261205.4
synaptotagmin I
chr12_-_45269430 28.68 ENST00000395487.2
NEL-like 2 (chicken)
chr3_-_195310802 28.41 ENST00000421243.1
ENST00000453131.1
apolipoprotein D
chr1_+_160097462 27.51 ENST00000447527.1
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr14_-_21490653 26.71 ENST00000449431.2
NDRG family member 2
chr3_+_111717511 26.34 ENST00000478951.1
ENST00000393917.2
transgelin 3
chr12_+_79258547 26.19 ENST00000457153.2
synaptotagmin I
chr5_-_73937244 25.85 ENST00000302351.4
ENST00000510316.1
ENST00000508331.1
ectodermal-neural cortex 1 (with BTB domain)
chr4_-_16900242 25.40 ENST00000502640.1
ENST00000506732.1
LIM domain binding 2
chr12_+_66218212 25.04 ENST00000393578.3
ENST00000425208.2
ENST00000536545.1
ENST00000354636.3
high mobility group AT-hook 2
chr8_-_27115903 23.82 ENST00000350889.4
ENST00000519997.1
ENST00000519614.1
ENST00000522908.1
ENST00000265770.7
stathmin-like 4
chr14_-_21491305 23.77 ENST00000554531.1
NDRG family member 2
chr8_-_18666360 23.38 ENST00000286485.8
pleckstrin and Sec7 domain containing 3
chr11_-_111782484 22.93 ENST00000533971.1
crystallin, alpha B
chr2_-_55277654 22.84 ENST00000337526.6
ENST00000317610.7
ENST00000357732.4
reticulon 4
chr14_-_21490590 22.64 ENST00000557633.1
NDRG family member 2
chr15_+_43886057 22.30 ENST00000441322.1
ENST00000413657.2
ENST00000453733.1
creatine kinase, mitochondrial 1B
chr11_-_133402410 22.18 ENST00000524381.1
opioid binding protein/cell adhesion molecule-like
chr13_-_67804445 22.03 ENST00000456367.1
ENST00000377861.3
ENST00000544246.1
protocadherin 9
chr1_+_169077172 21.06 ENST00000499679.3
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr12_-_91576561 20.74 ENST00000547568.2
ENST00000552962.1
decorin
chr8_+_80523962 20.72 ENST00000518491.1
stathmin-like 2
chr5_+_92919043 20.63 ENST00000327111.3
nuclear receptor subfamily 2, group F, member 1
chrX_+_103031758 20.59 ENST00000303958.2
ENST00000361621.2
proteolipid protein 1
chr8_-_27468842 20.02 ENST00000523500.1
clusterin
chr4_-_16900410 19.92 ENST00000304523.5
LIM domain binding 2
chr4_-_153457197 19.89 ENST00000281708.4
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr16_-_29910853 19.87 ENST00000308713.5
seizure related 6 homolog (mouse)-like 2
chr15_+_43809797 19.51 ENST00000399453.1
ENST00000300231.5
microtubule-associated protein 1A
chr4_+_158141806 19.49 ENST00000393815.2
glutamate receptor, ionotropic, AMPA 2
chr4_-_16900184 19.47 ENST00000515064.1
LIM domain binding 2
chr14_-_21490417 18.99 ENST00000556366.1
NDRG family member 2
chr4_+_158141843 18.97 ENST00000509417.1
ENST00000296526.7
glutamate receptor, ionotropic, AMPA 2
chr1_-_177134024 18.92 ENST00000367654.3
astrotactin 1
chr2_-_55277692 18.83 ENST00000394611.2
reticulon 4
chr5_+_140749803 18.77 ENST00000576222.1
protocadherin gamma subfamily B, 3
chr4_-_16900217 18.57 ENST00000441778.2
LIM domain binding 2
chr6_-_74161977 18.36 ENST00000370318.1
ENST00000370315.3
Mab-21 domain containing 1
chr14_-_21270995 18.33 ENST00000555698.1
ENST00000397970.4
ENST00000340900.3
ribonuclease, RNase A family, 1 (pancreatic)
chr4_+_156588249 18.18 ENST00000393832.3
guanylate cyclase 1, soluble, alpha 3
chrX_-_13835461 18.03 ENST00000316715.4
ENST00000356942.5
glycoprotein M6B
chr17_-_7123021 17.92 ENST00000399510.2
discs, large homolog 4 (Drosophila)
chr5_-_146461027 17.86 ENST00000394410.2
ENST00000508267.1
ENST00000504198.1
protein phosphatase 2, regulatory subunit B, beta
chr1_-_57045228 17.68 ENST00000371250.3
phosphatidic acid phosphatase type 2B
chr7_-_124405681 17.38 ENST00000303921.2
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr4_+_158141899 17.27 ENST00000264426.9
ENST00000506284.1
glutamate receptor, ionotropic, AMPA 2
chr1_-_156399184 17.17 ENST00000368243.1
ENST00000357975.4
ENST00000310027.5
ENST00000400991.2
chromosome 1 open reading frame 61
chrX_+_69282303 17.10 ENST00000338352.2
OTU domain containing 6A
chr3_+_111717600 17.07 ENST00000273368.4
transgelin 3
chr12_+_175930 16.60 ENST00000538872.1
ENST00000326261.4
IQ motif and Sec7 domain 3
chr12_-_91576429 16.53 ENST00000552145.1
ENST00000546745.1
decorin
chr12_+_7167980 16.52 ENST00000360817.5
ENST00000402681.3
complement component 1, s subcomponent
chr15_+_78730622 16.51 ENST00000560440.1
iron-responsive element binding protein 2
chr3_+_147127142 16.48 ENST00000282928.4
Zic family member 1
chr14_-_45431091 16.48 ENST00000579157.1
ENST00000396128.4
ENST00000556500.1
kelch-like family member 28
chr1_+_50574585 16.47 ENST00000371824.1
ENST00000371823.4
ELAV like neuron-specific RNA binding protein 4
chr19_-_49149553 16.24 ENST00000084798.4
carbonic anhydrase XI
chr15_+_43985725 16.21 ENST00000413453.2
creatine kinase, mitochondrial 1A
chr1_-_177133818 16.13 ENST00000424564.2
ENST00000361833.2
astrotactin 1
chr16_-_21289627 16.01 ENST00000396023.2
ENST00000415987.2
crystallin, mu
chr16_-_31085514 15.80 ENST00000300849.4
zinc finger protein 668
chr1_-_145076186 15.55 ENST00000369348.3
phosphodiesterase 4D interacting protein
chr12_-_50294033 15.50 ENST00000552669.1
Fas apoptotic inhibitory molecule 2
chr5_-_35230434 15.43 ENST00000504500.1
prolactin receptor
chr7_-_38671098 15.20 ENST00000356264.2
amphiphysin
chr6_+_29624862 15.13 ENST00000376894.4
myelin oligodendrocyte glycoprotein
chr3_+_111718036 14.75 ENST00000455401.2
transgelin 3
chr6_+_29624898 14.62 ENST00000396704.3
ENST00000483013.1
ENST00000490427.1
ENST00000416766.2
ENST00000376891.4
ENST00000376898.3
ENST00000396701.2
ENST00000494692.1
ENST00000431798.2
myelin oligodendrocyte glycoprotein
chr9_+_87284622 14.60 ENST00000395882.1
neurotrophic tyrosine kinase, receptor, type 2
chr1_+_209859510 14.55 ENST00000367028.2
ENST00000261465.1
hydroxysteroid (11-beta) dehydrogenase 1
chr1_+_65775204 14.29 ENST00000371069.4
DnaJ (Hsp40) homolog, subfamily C, member 6
chr6_+_29624758 14.26 ENST00000376917.3
ENST00000376902.3
ENST00000533330.2
ENST00000376888.2
myelin oligodendrocyte glycoprotein
chr1_+_2005425 14.10 ENST00000461106.2
protein kinase C, zeta
chr1_-_182361327 14.08 ENST00000331872.6
ENST00000311223.5
glutamate-ammonia ligase
chr18_-_40695604 13.97 ENST00000590910.1
ENST00000326695.5
ENST00000589109.1
ENST00000282028.4
Ras-like without CAAX 2
chr12_-_45270151 13.96 ENST00000429094.2
NEL-like 2 (chicken)
chr14_+_45431379 13.90 ENST00000361577.3
ENST00000361462.2
ENST00000382233.2
family with sequence similarity 179, member B
chr11_+_27062272 13.89 ENST00000529202.1
ENST00000533566.1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr13_+_113633620 13.85 ENST00000421756.1
ENST00000375601.3
MCF.2 cell line derived transforming sequence-like
chr1_+_2036149 13.75 ENST00000482686.1
ENST00000400920.1
ENST00000486681.1
protein kinase C, zeta
chr8_-_27115931 13.64 ENST00000523048.1
stathmin-like 4
chr5_+_36608422 13.63 ENST00000381918.3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr19_-_42498231 13.62 ENST00000602133.1
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr12_-_45270077 13.56 ENST00000551601.1
ENST00000549027.1
ENST00000452445.2
NEL-like 2 (chicken)
chr1_+_2004901 13.52 ENST00000400921.2
protein kinase C, zeta
chr19_+_35630926 13.48 ENST00000588081.1
ENST00000589121.1
FXYD domain containing ion transport regulator 1
chr1_+_54519242 13.42 ENST00000234827.1
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr2_+_210288760 13.42 ENST00000199940.6
microtubule-associated protein 2
chr7_-_100844193 13.32 ENST00000440203.2
ENST00000379423.3
ENST00000223114.4
monoacylglycerol O-acyltransferase 3
chr1_-_182360918 13.30 ENST00000339526.4
glutamate-ammonia ligase
chr12_-_91576750 13.14 ENST00000228329.5
ENST00000303320.3
ENST00000052754.5
decorin
chr7_-_137028534 13.10 ENST00000348225.2
pleiotrophin
chr5_+_161275320 13.09 ENST00000437025.2
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr4_+_156588115 12.82 ENST00000455639.2
guanylate cyclase 1, soluble, alpha 3
chr18_-_53177984 12.82 ENST00000543082.1
transcription factor 4
chr1_-_163172625 12.68 ENST00000527988.1
ENST00000531476.1
ENST00000530507.1
regulator of G-protein signaling 5
chr7_-_22233442 12.65 ENST00000401957.2
Rap guanine nucleotide exchange factor (GEF) 5
chr22_-_50524298 12.48 ENST00000311597.5
megalencephalic leukoencephalopathy with subcortical cysts 1
chr9_+_124062071 12.39 ENST00000373818.4
gelsolin
chr12_+_101988627 12.38 ENST00000547405.1
ENST00000452455.2
ENST00000441232.1
ENST00000360610.2
ENST00000392934.3
ENST00000547509.1
ENST00000361685.2
ENST00000549145.1
ENST00000553190.1
myosin binding protein C, slow type
chr7_+_86273700 12.18 ENST00000546348.1
glutamate receptor, metabotropic 3
chr6_+_19837592 12.07 ENST00000378700.3
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr13_-_80915059 11.98 ENST00000377104.3
sprouty homolog 2 (Drosophila)
chr2_-_68384603 11.97 ENST00000406245.2
ENST00000409164.1
ENST00000295121.6
WD repeat domain 92
chr16_-_1020954 11.89 ENST00000543238.1
ENST00000539379.1
ENST00000399843.2
ENST00000262301.11
lipase maturation factor 1
chr1_+_156589051 11.81 ENST00000255039.1
hyaluronan and proteoglycan link protein 2
chr7_-_31380502 11.77 ENST00000297142.3
neuronal differentiation 6
chr13_-_53422640 11.71 ENST00000338862.4
ENST00000377942.3
protocadherin 8
chr4_-_46911223 11.69 ENST00000396533.1
cytochrome c oxidase subunit VIIb2
chr4_+_71587669 11.42 ENST00000381006.3
ENST00000226328.4
RUN and FYVE domain containing 3
chr19_+_35783047 11.39 ENST00000595791.1
ENST00000597035.1
ENST00000537831.2
myelin associated glycoprotein
chr5_-_11588907 11.21 ENST00000513598.1
ENST00000503622.1
catenin (cadherin-associated protein), delta 2
chr20_-_62130474 11.09 ENST00000217182.3
eukaryotic translation elongation factor 1 alpha 2
chr1_+_151043070 11.05 ENST00000368918.3
ENST00000368917.1
GA binding protein transcription factor, beta subunit 2
chr10_+_18629628 11.04 ENST00000377329.4
calcium channel, voltage-dependent, beta 2 subunit
chr2_-_55277436 10.99 ENST00000354474.6
reticulon 4
chr20_-_52687059 10.87 ENST00000371435.2
ENST00000395961.3
breast carcinoma amplified sequence 1
chr6_-_167276033 10.67 ENST00000503859.1
ENST00000506565.1
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr16_+_29911864 10.66 ENST00000308748.5
aspartate beta-hydroxylase domain containing 1
chr11_-_132813566 10.65 ENST00000331898.7
opioid binding protein/cell adhesion molecule-like
chr16_+_66914264 10.64 ENST00000311765.2
ENST00000568869.1
ENST00000561704.1
ENST00000568398.1
ENST00000566776.1
pyruvate dehyrogenase phosphatase catalytic subunit 2
chr16_+_7382745 10.64 ENST00000436368.2
ENST00000311745.5
ENST00000355637.4
ENST00000340209.4
RNA binding protein, fox-1 homolog (C. elegans) 1
chr2_-_50574856 10.61 ENST00000342183.5
neurexin 1
chrX_+_102631248 10.57 ENST00000361298.4
ENST00000372645.3
ENST00000372635.1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr5_-_20575959 10.56 ENST00000507958.1
cadherin 18, type 2
chr7_-_137028498 10.56 ENST00000393083.2
pleiotrophin
chr16_+_31085714 10.53 ENST00000300850.5
ENST00000564189.1
ENST00000428260.1
zinc finger protein 646
chr17_+_26684604 10.52 ENST00000292114.3
ENST00000509083.1
transmembrane protein 199
chr15_-_90892669 10.51 ENST00000412799.2
GABA(A) receptors associated protein like 3, pseudogene
chr1_+_154193325 10.48 ENST00000428931.1
ENST00000441890.1
ENST00000271877.7
ENST00000412596.1
ENST00000368504.1
ENST00000437652.1
ubiquitin associated protein 2-like
chr6_+_31982539 10.42 ENST00000435363.2
ENST00000425700.2
complement component 4B (Chido blood group)
chr15_-_88799948 10.41 ENST00000394480.2
neurotrophic tyrosine kinase, receptor, type 3
chr12_+_6930813 10.38 ENST00000428545.2
G protein-coupled receptor 162
chr18_+_29171689 10.37 ENST00000237014.3
transthyretin
chr11_-_115630900 10.33 ENST00000537070.1
ENST00000499809.1
ENST00000514294.2
ENST00000535683.1
long intergenic non-protein coding RNA 900
chr2_-_55277512 10.29 ENST00000402434.2
reticulon 4
chrX_-_34675391 10.27 ENST00000275954.3
transmembrane protein 47
chr7_-_143059780 10.23 ENST00000409578.1
ENST00000409346.1
family with sequence similarity 131, member B
chr10_-_81205373 10.18 ENST00000372336.3
zinc finger, CCHC domain containing 24
chr6_+_126240442 10.17 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
nuclear receptor coactivator 7
chr7_+_129251531 10.16 ENST00000393232.1
ENST00000353868.4
ENST00000539636.1
ENST00000454688.1
ENST00000223190.4
ENST00000311967.2
nuclear respiratory factor 1
chr1_+_233749739 10.02 ENST00000366621.3
potassium channel, subfamily K, member 1
chr8_+_21916680 9.96 ENST00000358242.3
ENST00000415253.1
dematin actin binding protein
chr6_+_123100620 9.96 ENST00000368444.3
fatty acid binding protein 7, brain
chr5_-_24645078 9.86 ENST00000264463.4
cadherin 10, type 2 (T2-cadherin)
chr8_+_21916710 9.82 ENST00000523266.1
ENST00000519907.1
dematin actin binding protein
chr2_-_69870835 9.79 ENST00000409085.4
ENST00000406297.3
AP2 associated kinase 1
chr16_-_1020849 9.74 ENST00000568897.1
lipase maturation factor 1
chr4_+_24797085 9.73 ENST00000382120.3
superoxide dismutase 3, extracellular
chr6_-_110501200 9.71 ENST00000392586.1
ENST00000419252.1
ENST00000392589.1
ENST00000392588.1
ENST00000359451.2
WAS protein family, member 1
chr10_-_73848764 9.66 ENST00000317376.4
ENST00000412663.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr7_-_143059845 9.64 ENST00000443739.2
family with sequence similarity 131, member B
chr5_-_11589131 9.61 ENST00000511377.1
catenin (cadherin-associated protein), delta 2
chr3_-_194991876 9.54 ENST00000310380.6
xyloside xylosyltransferase 1
chr12_+_113376249 9.50 ENST00000551007.1
ENST00000548514.1
2'-5'-oligoadenylate synthetase 3, 100kDa
chr10_-_73848086 9.50 ENST00000536168.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr2_+_210517895 9.37 ENST00000447185.1
microtubule-associated protein 2
chr19_-_10333842 9.34 ENST00000317726.4
CTD-2369P2.2
chr12_+_101988774 9.34 ENST00000545503.2
ENST00000536007.1
ENST00000541119.1
ENST00000361466.2
ENST00000551300.1
ENST00000550270.1
myosin binding protein C, slow type
chr3_-_9291063 9.27 ENST00000383836.3
SLIT-ROBO Rho GTPase activating protein 3
chr2_-_69870747 9.25 ENST00000409068.1
AP2 associated kinase 1
chr17_-_36956155 9.23 ENST00000269554.3
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr6_-_116601044 9.22 ENST00000368608.3
TSPY-like 1
chr2_+_45168875 9.21 ENST00000260653.3
SIX homeobox 3
chr2_-_241737128 9.14 ENST00000404283.3
kinesin family member 1A
chr22_-_36236623 9.12 ENST00000405409.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr11_-_66496430 9.07 ENST00000533211.1
spectrin, beta, non-erythrocytic 2
chr11_+_131240373 8.99 ENST00000374791.3
ENST00000436745.1
neurotrimin
chr6_+_43543864 8.90 ENST00000372236.4
ENST00000535400.1
polymerase (DNA directed), eta
chr6_-_110500905 8.79 ENST00000392587.2
WAS protein family, member 1
chr18_-_52989525 8.78 ENST00000457482.3
transcription factor 4
chr1_-_72748417 8.78 ENST00000357731.5
neuronal growth regulator 1
chr5_+_140345820 8.76 ENST00000289269.5
protocadherin alpha subfamily C, 2
chr11_-_5255696 8.68 ENST00000292901.3
ENST00000417377.1
hemoglobin, delta
chr17_+_57232690 8.66 ENST00000262293.4
proline rich 11
chr12_+_121088291 8.54 ENST00000351200.2
calcium binding protein 1
chr2_+_173686303 8.49 ENST00000397087.3
Rap guanine nucleotide exchange factor (GEF) 4
chr3_-_47619623 8.43 ENST00000456150.1
chondroitin sulfate proteoglycan 5 (neuroglycan C)
chr1_+_17906970 8.42 ENST00000375415.1
Rho guanine nucleotide exchange factor (GEF) 10-like
chr11_+_76092353 8.42 ENST00000530460.1
ENST00000321844.4
Homo sapiens putative uncharacterized protein FLJ37770-like (LOC100506127), mRNA.
chr11_-_117166276 8.37 ENST00000510630.1
ENST00000392937.6
beta-site APP-cleaving enzyme 1
chr12_+_6930703 8.36 ENST00000311268.3
G protein-coupled receptor 162
chrX_+_70316005 8.36 ENST00000374259.3
forkhead box O4
chr18_-_52969844 8.34 ENST00000561831.3
transcription factor 4
chr5_-_146258291 8.28 ENST00000394411.4
ENST00000453001.1
protein phosphatase 2, regulatory subunit B, beta
chr19_-_51920952 8.10 ENST00000356298.5
ENST00000339313.5
ENST00000529627.1
ENST00000439889.2
ENST00000353836.5
ENST00000432469.2
sialic acid binding Ig-like lectin 10
chr20_+_17207665 8.08 ENST00000536609.1
proprotein convertase subtilisin/kexin type 2
chr4_-_87028478 8.04 ENST00000515400.1
ENST00000395157.3
mitogen-activated protein kinase 10
chr5_+_112227311 8.03 ENST00000391338.1
zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1
chr2_-_122407007 7.95 ENST00000263710.4
ENST00000455322.2
ENST00000397587.3
ENST00000541377.1
cytoplasmic linker associated protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of EZH2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
18.3 55.0 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
10.9 196.5 GO:0007021 tubulin complex assembly(GO:0007021)
10.9 108.7 GO:0016198 axon choice point recognition(GO:0016198)
8.4 25.1 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
7.9 23.7 GO:1904395 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
7.6 121.1 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
7.3 44.1 GO:0052565 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
7.3 51.2 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
7.0 63.0 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
6.9 41.4 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
6.8 27.4 GO:0006542 glutamine biosynthetic process(GO:0006542)
5.7 17.1 GO:1990168 protein K33-linked deubiquitination(GO:1990168)
5.3 26.7 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
5.2 20.7 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
4.5 53.7 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
4.5 26.7 GO:0038161 prolactin signaling pathway(GO:0038161)
4.4 13.3 GO:2000685 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
4.3 47.2 GO:0006600 creatine metabolic process(GO:0006600)
4.0 56.2 GO:0070050 neuron cellular homeostasis(GO:0070050)
4.0 12.0 GO:0060437 lung growth(GO:0060437)
3.9 94.6 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
3.5 7.0 GO:0007497 posterior midgut development(GO:0007497)
3.5 10.4 GO:0048687 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
3.4 23.6 GO:0060075 regulation of resting membrane potential(GO:0060075)
3.3 19.8 GO:0070560 protein secretion by platelet(GO:0070560)
3.3 26.3 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
3.2 22.5 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
3.2 6.4 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
3.1 15.4 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
3.1 24.6 GO:0033578 protein glycosylation in Golgi(GO:0033578)
3.1 9.2 GO:0021798 neuroblast differentiation(GO:0014016) forebrain dorsal/ventral pattern formation(GO:0021798) regulation of neural retina development(GO:0061074) regulation of retina development in camera-type eye(GO:1902866)
2.9 14.6 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
2.9 25.9 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
2.8 8.4 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
2.8 30.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
2.7 35.4 GO:0070327 thyroid hormone transport(GO:0070327)
2.7 10.6 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
2.6 2.6 GO:0010463 positive regulation of mesenchymal cell proliferation(GO:0002053) mesenchymal cell proliferation(GO:0010463) regulation of mesenchymal cell proliferation(GO:0010464)
2.5 5.0 GO:0072275 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
2.5 69.7 GO:0010669 epithelial structure maintenance(GO:0010669)
2.5 12.4 GO:1903906 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
2.4 9.6 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
2.4 64.5 GO:0007158 neuron cell-cell adhesion(GO:0007158)
2.4 11.8 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
2.4 16.5 GO:0006537 glutamate biosynthetic process(GO:0006537)
2.3 6.9 GO:0021888 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
2.3 6.8 GO:1905072 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm development(GO:0048389) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) pattern specification involved in mesonephros development(GO:0061227) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in kidney development(GO:0072098) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter urothelium development(GO:0072190) ureter epithelial cell differentiation(GO:0072192) ureter morphogenesis(GO:0072197) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
2.3 11.3 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
2.2 13.5 GO:1903278 regulation of sodium ion export(GO:1903273) positive regulation of sodium ion export(GO:1903275) regulation of sodium ion export from cell(GO:1903276) positive regulation of sodium ion export from cell(GO:1903278)
2.2 6.6 GO:0071557 histone H3-K27 demethylation(GO:0071557)
2.1 8.6 GO:0048807 ectoderm and mesoderm interaction(GO:0007499) female genitalia morphogenesis(GO:0048807)
2.1 21.2 GO:0045329 carnitine biosynthetic process(GO:0045329)
2.1 10.5 GO:0007042 lysosomal lumen acidification(GO:0007042)
2.1 8.4 GO:0097676 histone H3-K36 dimethylation(GO:0097676)
2.0 15.7 GO:0015671 oxygen transport(GO:0015671)
1.9 36.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
1.9 28.7 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
1.9 5.7 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
1.9 5.6 GO:0070634 transepithelial ammonium transport(GO:0070634)
1.9 5.6 GO:1901624 negative regulation of lymphocyte chemotaxis(GO:1901624)
1.8 11.0 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
1.8 12.8 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
1.8 18.0 GO:0051610 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.8 10.8 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
1.8 5.3 GO:0001172 transcription, RNA-templated(GO:0001172)
1.7 10.5 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
1.7 7.0 GO:0007525 somatic muscle development(GO:0007525)
1.7 17.4 GO:0045915 positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
1.7 6.9 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
1.7 65.0 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.7 6.7 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
1.6 24.7 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
1.6 8.1 GO:0030070 insulin processing(GO:0030070)
1.6 14.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
1.6 11.0 GO:1903689 regulation of wound healing, spreading of epidermal cells(GO:1903689) negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
1.6 3.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
1.5 1.5 GO:0003018 vascular process in circulatory system(GO:0003018) regulation of tube size(GO:0035150) regulation of blood vessel size(GO:0050880)
1.5 4.5 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
1.5 4.5 GO:0090035 regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035)
1.5 4.4 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
1.5 1.5 GO:0010818 T cell chemotaxis(GO:0010818)
1.5 5.8 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
1.4 4.2 GO:0051097 negative regulation of helicase activity(GO:0051097)
1.4 12.5 GO:0032490 detection of molecule of bacterial origin(GO:0032490)
1.4 4.2 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
1.4 12.5 GO:0047484 regulation of response to osmotic stress(GO:0047484)
1.4 2.8 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
1.3 6.7 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
1.3 16.0 GO:0006290 pyrimidine dimer repair(GO:0006290)
1.3 2.6 GO:0035962 response to interleukin-13(GO:0035962)
1.3 1.3 GO:0002763 positive regulation of myeloid leukocyte differentiation(GO:0002763)
1.2 6.2 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
1.2 2.5 GO:0015793 glycerol transport(GO:0015793)
1.2 8.5 GO:0042308 negative regulation of protein import into nucleus(GO:0042308) negative regulation of protein import(GO:1904590)
1.2 4.9 GO:0019086 late viral transcription(GO:0019086)
1.2 15.8 GO:0001867 complement activation, lectin pathway(GO:0001867)
1.2 4.8 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
1.2 38.0 GO:0008038 neuron recognition(GO:0008038)
1.2 7.1 GO:0052055 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
1.2 19.8 GO:0071360 cellular response to exogenous dsRNA(GO:0071360)
1.1 4.6 GO:0019805 quinolinate biosynthetic process(GO:0019805)
1.1 4.5 GO:1903597 negative regulation of gap junction assembly(GO:1903597)
1.1 4.5 GO:0006114 glycerol biosynthetic process(GO:0006114) response to methionine(GO:1904640)
1.1 11.3 GO:0060700 regulation of ribonuclease activity(GO:0060700)
1.1 14.4 GO:0006071 glycerol metabolic process(GO:0006071)
1.1 2.2 GO:0048867 stem cell fate determination(GO:0048867)
1.1 3.3 GO:0098528 skeletal muscle fiber differentiation(GO:0098528) regulation of skeletal muscle fiber differentiation(GO:1902809)
1.1 2.1 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
1.1 4.2 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
1.0 36.6 GO:0007019 microtubule depolymerization(GO:0007019)
1.0 4.1 GO:0001519 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
1.0 9.2 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
1.0 8.0 GO:0007258 JUN phosphorylation(GO:0007258)
1.0 8.0 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
1.0 7.0 GO:0021999 neural plate anterior/posterior regionalization(GO:0021999)
1.0 4.8 GO:0030997 regulation of centriole-centriole cohesion(GO:0030997)
1.0 2.9 GO:0006014 D-ribose metabolic process(GO:0006014)
0.9 4.7 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.9 5.6 GO:0051012 microtubule sliding(GO:0051012)
0.9 5.6 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.9 3.7 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.9 2.8 GO:0015888 thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
0.9 6.3 GO:0045007 depurination(GO:0045007)
0.9 3.5 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.9 2.6 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.9 3.5 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.9 2.6 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.9 6.0 GO:0060684 epithelial-mesenchymal cell signaling(GO:0060684)
0.9 3.4 GO:0035425 autocrine signaling(GO:0035425)
0.8 5.9 GO:0036438 maintenance of lens transparency(GO:0036438)
0.8 5.0 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.8 4.2 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.8 4.2 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.8 1.7 GO:0060168 positive regulation of adenosine receptor signaling pathway(GO:0060168)
0.8 19.0 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.8 2.5 GO:2001303 lipoxin biosynthetic process(GO:2001301) lipoxin A4 metabolic process(GO:2001302) lipoxin A4 biosynthetic process(GO:2001303)
0.8 5.7 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.8 7.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.8 0.8 GO:0014734 skeletal muscle hypertrophy(GO:0014734)
0.8 4.0 GO:0071918 urea transmembrane transport(GO:0071918)
0.8 3.9 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.8 5.5 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.8 10.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.8 3.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.8 4.5 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.7 6.0 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.7 2.2 GO:0071812 regulation of fever generation by regulation of prostaglandin secretion(GO:0071810) positive regulation of fever generation by positive regulation of prostaglandin secretion(GO:0071812) positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling(GO:0071848) regulation of fever generation by prostaglandin secretion(GO:0100009)
0.7 3.6 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.7 10.1 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.7 5.7 GO:0071363 cellular response to growth factor stimulus(GO:0071363)
0.7 113.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.7 2.1 GO:1901994 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.7 3.5 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.7 4.9 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.7 6.2 GO:0008090 retrograde axonal transport(GO:0008090)
0.7 16.5 GO:0007628 adult walking behavior(GO:0007628)
0.7 2.7 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.7 9.4 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.7 3.3 GO:1904073 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.7 9.3 GO:0060134 prepulse inhibition(GO:0060134)
0.7 3.3 GO:0036376 sodium ion export from cell(GO:0036376)
0.7 2.0 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.7 10.5 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.7 13.1 GO:0071420 cellular response to histamine(GO:0071420)
0.6 3.8 GO:0035799 ureter maturation(GO:0035799)
0.6 1.9 GO:0060042 retina morphogenesis in camera-type eye(GO:0060042)
0.6 7.4 GO:0035641 locomotory exploration behavior(GO:0035641)
0.6 1.2 GO:0035441 cell migration involved in vasculogenesis(GO:0035441)
0.6 3.0 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.6 1.8 GO:0045212 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.6 14.2 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.6 4.0 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.6 3.4 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.6 2.3 GO:0015811 L-cystine transport(GO:0015811)
0.6 1.7 GO:0045726 regulation of integrin biosynthetic process(GO:0045113) positive regulation of integrin biosynthetic process(GO:0045726)
0.6 12.9 GO:0046688 response to copper ion(GO:0046688)
0.6 5.6 GO:0021895 cerebral cortex neuron differentiation(GO:0021895)
0.6 1.1 GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902548)
0.5 10.7 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.5 4.2 GO:0002051 osteoblast fate commitment(GO:0002051)
0.5 1.6 GO:1901490 regulation of lymphangiogenesis(GO:1901490)
0.5 10.1 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.5 3.0 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.5 11.4 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.5 8.3 GO:0005513 detection of calcium ion(GO:0005513)
0.5 1.5 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.5 3.9 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.5 20.8 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.5 2.3 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.5 1.4 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.4 10.7 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.4 2.7 GO:0042048 olfactory behavior(GO:0042048)
0.4 5.8 GO:0060736 prostate gland growth(GO:0060736)
0.4 8.4 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.4 2.2 GO:0021759 globus pallidus development(GO:0021759)
0.4 2.6 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.4 15.8 GO:0097484 dendrite extension(GO:0097484)
0.4 1.3 GO:0050720 interleukin-1 beta biosynthetic process(GO:0050720)
0.4 3.4 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.4 6.9 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.4 2.4 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.4 1.2 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.4 5.5 GO:0045793 positive regulation of cell size(GO:0045793)
0.4 4.3 GO:0043586 tongue development(GO:0043586)
0.4 4.3 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.4 9.1 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.4 3.4 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.4 0.7 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.4 2.6 GO:0006489 dolichyl diphosphate biosynthetic process(GO:0006489) dolichyl diphosphate metabolic process(GO:0046465)
0.4 1.8 GO:0001555 oocyte growth(GO:0001555)
0.4 7.9 GO:0006833 water transport(GO:0006833)
0.4 1.8 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.4 9.2 GO:0010107 potassium ion import(GO:0010107)
0.4 4.9 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.3 17.5 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.3 3.1 GO:0051552 flavone metabolic process(GO:0051552)
0.3 5.5 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.3 2.4 GO:0048681 negative regulation of myelination(GO:0031642) negative regulation of axon regeneration(GO:0048681)
0.3 2.4 GO:0006776 vitamin A metabolic process(GO:0006776)
0.3 4.7 GO:0030308 negative regulation of cell growth(GO:0030308)
0.3 1.6 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.3 43.4 GO:0046718 viral entry into host cell(GO:0046718)
0.3 1.0 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.3 2.6 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.3 3.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.3 2.7 GO:0031018 endocrine pancreas development(GO:0031018)
0.3 0.9 GO:0000965 mitochondrial RNA 3'-end processing(GO:0000965)
0.3 1.5 GO:0038170 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.3 0.3 GO:0090325 regulation of locomotion involved in locomotory behavior(GO:0090325)
0.3 3.3 GO:0019216 regulation of lipid metabolic process(GO:0019216)
0.3 2.7 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.3 4.4 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.3 2.6 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.3 0.9 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.3 1.9 GO:0072520 seminiferous tubule development(GO:0072520)
0.3 4.7 GO:0010927 cellular component assembly involved in morphogenesis(GO:0010927)
0.3 1.1 GO:0006203 dGTP catabolic process(GO:0006203)
0.3 2.7 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.3 1.1 GO:0003335 corneocyte development(GO:0003335)
0.3 6.2 GO:0001502 cartilage condensation(GO:0001502)
0.3 14.8 GO:0021954 central nervous system neuron development(GO:0021954)
0.3 0.8 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.3 4.0 GO:0000338 protein deneddylation(GO:0000338)
0.3 5.6 GO:0048665 neuron fate specification(GO:0048665)
0.3 6.6 GO:0038084 vascular endothelial growth factor signaling pathway(GO:0038084)
0.3 4.8 GO:0044804 nucleophagy(GO:0044804)
0.3 1.6 GO:1903506 regulation of nucleic acid-templated transcription(GO:1903506) regulation of RNA biosynthetic process(GO:2001141)
0.3 0.5 GO:0018879 biphenyl metabolic process(GO:0018879)
0.3 3.4 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.3 5.1 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.3 4.3 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.3 1.0 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.3 4.0 GO:0001976 neurological system process involved in regulation of systemic arterial blood pressure(GO:0001976)
0.3 0.8 GO:0051941 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935) regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.3 6.3 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.2 35.0 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.2 1.0 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.2 2.2 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.2 0.9 GO:0021590 cerebellum maturation(GO:0021590) cerebellar Purkinje cell layer maturation(GO:0021691) cerebellar cortex maturation(GO:0021699)
0.2 2.6 GO:0016576 histone dephosphorylation(GO:0016576)
0.2 2.3 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.2 3.6 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.2 10.6 GO:0007050 cell cycle arrest(GO:0007050)
0.2 1.8 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.2 1.6 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.2 1.8 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.2 0.4 GO:0061743 motor learning(GO:0061743)
0.2 11.1 GO:0016266 O-glycan processing(GO:0016266)
0.2 5.0 GO:0006884 cell volume homeostasis(GO:0006884)
0.2 12.3 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.2 2.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.2 5.8 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 3.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 5.0 GO:0009083 branched-chain amino acid metabolic process(GO:0009081) branched-chain amino acid catabolic process(GO:0009083)
0.2 5.4 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.2 0.8 GO:0060671 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.2 6.2 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.2 6.3 GO:0016486 peptide hormone processing(GO:0016486)
0.2 3.3 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.2 8.4 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.2 3.1 GO:0021542 dentate gyrus development(GO:0021542)
0.2 0.5 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.2 0.4 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.2 3.0 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.2 12.9 GO:0006826 iron ion transport(GO:0006826)
0.2 3.1 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.2 5.8 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.2 1.1 GO:0072592 oxygen metabolic process(GO:0072592)
0.2 8.5 GO:0007517 muscle organ development(GO:0007517)
0.2 0.6 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.1 9.5 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 4.1 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 4.2 GO:0008089 anterograde axonal transport(GO:0008089)
0.1 3.4 GO:0010762 regulation of fibroblast migration(GO:0010762)
0.1 1.2 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.1 0.8 GO:0003360 brainstem development(GO:0003360)
0.1 4.5 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 16.4 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.1 3.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 0.4 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 3.3 GO:0014887 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.1 1.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 1.8 GO:0051497 negative regulation of actin filament bundle assembly(GO:0032232) negative regulation of stress fiber assembly(GO:0051497)
0.1 0.3 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.1 2.4 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.1 4.1 GO:0005980 glycogen catabolic process(GO:0005980)
0.1 2.2 GO:0050919 negative chemotaxis(GO:0050919)
0.1 0.6 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.1 0.3 GO:0045900 negative regulation of translational elongation(GO:0045900)
0.1 0.7 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 0.3 GO:0090259 regulation of retinal ganglion cell axon guidance(GO:0090259)
0.1 1.5 GO:0060732 regulation of inositol phosphate biosynthetic process(GO:0010919) positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.1 0.4 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.1 4.1 GO:0006458 'de novo' protein folding(GO:0006458)
0.1 0.7 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.1 0.2 GO:0005988 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.1 2.6 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.1 3.9 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 1.8 GO:0007340 acrosome reaction(GO:0007340)
0.1 1.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 2.5 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 1.2 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.1 1.1 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.1 0.6 GO:0051775 response to redox state(GO:0051775)
0.1 0.3 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.1 0.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.3 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1 1.5 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 2.1 GO:0061512 protein localization to cilium(GO:0061512)
0.1 0.6 GO:0008544 epidermis development(GO:0008544)
0.0 4.9 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 0.7 GO:0048593 camera-type eye morphogenesis(GO:0048593)
0.0 1.4 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 1.3 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)
0.0 0.7 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 2.2 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.1 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 1.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.6 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.0 0.1 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.0 0.4 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.9 GO:0046710 GDP metabolic process(GO:0046710)
0.0 0.7 GO:0003417 growth plate cartilage development(GO:0003417)
0.0 0.5 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.2 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 7.2 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.9 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.4 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.0 1.3 GO:0007422 peripheral nervous system development(GO:0007422)
0.0 0.5 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.2 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 0.3 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.1 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.7 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 0.1 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.0 0.1 GO:0042428 serotonin metabolic process(GO:0042428)
0.0 0.5 GO:0060711 labyrinthine layer development(GO:0060711)
0.0 0.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.7 GO:0032006 regulation of TOR signaling(GO:0032006)
0.0 0.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
15.5 108.8 GO:0032584 growth cone membrane(GO:0032584)
13.1 210.0 GO:0097512 cardiac myofibril(GO:0097512)
11.1 55.7 GO:0098843 postsynaptic endocytic zone(GO:0098843)
11.0 55.0 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
5.2 41.4 GO:0045179 apical cortex(GO:0045179)
4.7 14.0 GO:0097447 dendritic tree(GO:0097447)
4.4 26.4 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
4.1 81.9 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
3.8 26.7 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
3.8 11.4 GO:1990015 mesaxon(GO:0097453) ensheathing process(GO:1990015)
3.6 50.4 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
3.2 12.8 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
3.1 63.0 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
2.5 22.8 GO:0098839 postsynaptic density membrane(GO:0098839)
2.4 7.1 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
2.0 10.0 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
1.8 11.0 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
1.8 34.3 GO:0097386 glial cell projection(GO:0097386)
1.8 43.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
1.8 21.0 GO:0060077 inhibitory synapse(GO:0060077)
1.7 3.3 GO:0044308 axonal spine(GO:0044308)
1.6 8.0 GO:0089701 U2AF(GO:0089701)
1.6 6.2 GO:0031673 H zone(GO:0031673)
1.5 3.0 GO:0045298 tubulin complex(GO:0045298)
1.4 30.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
1.4 20.0 GO:0042583 chromaffin granule(GO:0042583)
1.3 12.5 GO:0031209 SCAR complex(GO:0031209)
1.2 13.3 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
1.1 11.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
1.1 214.0 GO:0030426 growth cone(GO:0030426)
1.0 5.0 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.9 20.8 GO:0032982 myosin filament(GO:0032982)
0.9 11.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.8 12.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.8 3.1 GO:0036449 microtubule minus-end(GO:0036449)
0.8 2.3 GO:0005873 plus-end kinesin complex(GO:0005873)
0.8 10.5 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.7 3.0 GO:0005797 Golgi medial cisterna(GO:0005797)
0.7 4.3 GO:0030893 meiotic cohesin complex(GO:0030893)
0.7 10.7 GO:0030478 actin cap(GO:0030478)
0.7 2.7 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.6 6.3 GO:0044297 cell body(GO:0044297)
0.6 8.7 GO:0005833 hemoglobin complex(GO:0005833)
0.6 1.8 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.6 5.4 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.6 3.6 GO:1990769 proximal neuron projection(GO:1990769)
0.6 4.2 GO:0070852 cell body fiber(GO:0070852)
0.6 40.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.6 12.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.6 10.5 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.5 4.8 GO:0071439 clathrin complex(GO:0071439)
0.5 2.7 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.5 2.5 GO:0005594 collagen type IX trimer(GO:0005594)
0.5 64.3 GO:0043204 perikaryon(GO:0043204)
0.5 8.9 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.5 4.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.5 7.7 GO:0045277 respiratory chain complex IV(GO:0045277)
0.4 4.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.4 2.2 GO:0035253 ciliary rootlet(GO:0035253)
0.4 2.6 GO:0070545 PeBoW complex(GO:0070545)
0.4 1.3 GO:0016013 syntrophin complex(GO:0016013)
0.4 14.0 GO:0060076 excitatory synapse(GO:0060076)
0.4 3.8 GO:0005579 membrane attack complex(GO:0005579)
0.4 29.3 GO:0042734 presynaptic membrane(GO:0042734)
0.4 91.1 GO:0043209 myelin sheath(GO:0043209)
0.4 5.3 GO:0000974 Prp19 complex(GO:0000974)
0.4 1.8 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.4 17.6 GO:0031594 neuromuscular junction(GO:0031594)
0.3 51.5 GO:0031225 anchored component of membrane(GO:0031225)
0.3 4.1 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.3 1.7 GO:0071438 invadopodium membrane(GO:0071438)
0.3 4.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.3 2.0 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.3 3.3 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.3 2.5 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.3 10.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.3 5.3 GO:0005922 connexon complex(GO:0005922)
0.3 8.4 GO:0035861 site of double-strand break(GO:0035861)
0.3 11.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 3.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.3 6.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.3 8.4 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.3 4.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.3 9.9 GO:0000421 autophagosome membrane(GO:0000421)
0.3 2.6 GO:0005614 interstitial matrix(GO:0005614)
0.3 2.8 GO:0033268 node of Ranvier(GO:0033268)
0.2 1.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 6.4 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.2 4.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 57.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 19.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.2 12.1 GO:0031904 endosome lumen(GO:0031904)
0.2 2.4 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.2 19.0 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 2.8 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.2 9.2 GO:0005776 autophagosome(GO:0005776)
0.2 1.9 GO:0001739 sex chromatin(GO:0001739)
0.2 6.8 GO:0016592 mediator complex(GO:0016592)
0.2 10.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 9.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 10.8 GO:0005796 Golgi lumen(GO:0005796)
0.2 1.8 GO:0044666 MLL3/4 complex(GO:0044666)
0.2 4.0 GO:0008180 COP9 signalosome(GO:0008180)
0.1 6.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 5.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 7.7 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 1.5 GO:0016600 flotillin complex(GO:0016600)
0.1 3.5 GO:0002080 acrosomal membrane(GO:0002080)
0.1 2.5 GO:0005861 troponin complex(GO:0005861)
0.1 20.0 GO:0005875 microtubule associated complex(GO:0005875)
0.1 2.7 GO:0030315 T-tubule(GO:0030315)
0.1 3.6 GO:0005771 multivesicular body(GO:0005771)
0.1 6.7 GO:0005901 caveola(GO:0005901)
0.1 1.4 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 2.5 GO:0001533 cornified envelope(GO:0001533)
0.1 0.7 GO:0031931 TORC1 complex(GO:0031931)
0.1 5.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 2.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.8 GO:0005921 gap junction(GO:0005921)
0.1 1.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 6.7 GO:0005802 trans-Golgi network(GO:0005802)
0.1 0.8 GO:0034451 centriolar satellite(GO:0034451)
0.1 0.4 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 0.3 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.9 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 1.3 GO:0009925 basal plasma membrane(GO:0009925)
0.1 18.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 6.5 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 2.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 2.2 GO:0098794 postsynapse(GO:0098794)
0.0 1.2 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.2 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 32.2 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 3.6 GO:0005814 centriole(GO:0005814)
0.0 2.9 GO:0045202 synapse(GO:0045202)
0.0 0.2 GO:0042629 mast cell granule(GO:0042629)
0.0 7.9 GO:0031252 cell leading edge(GO:0031252)
0.0 1.2 GO:0005811 lipid particle(GO:0005811)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.5 GO:0044439 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.0 0.6 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.5 GO:0097546 ciliary base(GO:0097546)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.3 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.1 GO:0048786 presynaptic active zone(GO:0048786)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
11.0 55.0 GO:0030348 syntaxin-3 binding(GO:0030348)
10.1 101.4 GO:0035727 lysophosphatidic acid binding(GO:0035727)
7.7 23.1 GO:0030350 iron-responsive element binding(GO:0030350)
7.6 83.4 GO:0030274 LIM domain binding(GO:0030274)
7.5 22.5 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
6.8 27.4 GO:0004356 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
5.9 23.7 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
5.9 47.2 GO:0004111 creatine kinase activity(GO:0004111)
5.8 69.4 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
5.6 172.6 GO:0005212 structural constituent of eye lens(GO:0005212)
5.3 26.7 GO:0004925 prolactin receptor activity(GO:0004925)
5.3 21.2 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
4.9 14.6 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
4.7 18.8 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
4.4 13.3 GO:0035501 MH1 domain binding(GO:0035501)
4.4 13.3 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
4.3 52.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
4.1 65.5 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
3.3 26.7 GO:0050816 phosphothreonine binding(GO:0050816)
3.1 9.2 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
3.1 18.3 GO:0004522 ribonuclease A activity(GO:0004522)
2.9 14.6 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
2.8 8.4 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
2.8 11.0 GO:0043515 kinetochore binding(GO:0043515)
2.6 13.1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
2.6 12.8 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
2.5 20.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
2.4 12.2 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
2.3 7.0 GO:0004962 endothelin receptor activity(GO:0004962)
2.3 29.9 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
2.3 29.4 GO:0097109 neuroligin family protein binding(GO:0097109)
2.2 6.6 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
2.1 27.3 GO:0031432 titin binding(GO:0031432)
2.0 8.0 GO:0030305 heparanase activity(GO:0030305)
2.0 41.4 GO:0043560 insulin receptor substrate binding(GO:0043560)
1.9 13.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.9 9.5 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
1.9 5.6 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
1.8 10.6 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
1.8 7.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
1.8 43.9 GO:0004383 guanylate cyclase activity(GO:0004383)
1.8 12.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
1.8 5.3 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
1.7 17.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
1.7 5.0 GO:0003863 alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
1.7 21.7 GO:0005344 oxygen transporter activity(GO:0005344)
1.7 5.0 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
1.6 8.0 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
1.6 6.3 GO:0032406 MutLbeta complex binding(GO:0032406) MutSbeta complex binding(GO:0032408)
1.6 4.7 GO:0051373 FATZ binding(GO:0051373)
1.5 12.4 GO:0030172 troponin C binding(GO:0030172)
1.5 4.5 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
1.4 5.7 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
1.4 8.4 GO:0044547 DNA topoisomerase binding(GO:0044547)
1.4 36.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.4 11.0 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
1.3 6.7 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
1.3 8.0 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
1.3 5.3 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
1.3 10.4 GO:0005030 neurotrophin receptor activity(GO:0005030)
1.3 10.4 GO:0070324 thyroid hormone binding(GO:0070324)
1.3 10.3 GO:0004565 beta-galactosidase activity(GO:0004565)
1.2 2.5 GO:0015254 glycerol channel activity(GO:0015254)
1.2 24.5 GO:0051787 misfolded protein binding(GO:0051787)
1.2 30.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
1.2 26.7 GO:0002162 dystroglycan binding(GO:0002162)
1.2 10.7 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
1.1 3.4 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
1.1 9.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
1.1 11.3 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
1.1 3.4 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
1.1 6.7 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
1.1 3.3 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
1.1 9.7 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
1.1 14.0 GO:0030215 semaphorin receptor binding(GO:0030215)
1.1 7.5 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
1.1 4.3 GO:0004351 glutamate decarboxylase activity(GO:0004351)
1.0 4.1 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
1.0 7.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
1.0 5.0 GO:0004974 leukotriene receptor activity(GO:0004974)
1.0 16.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.9 2.8 GO:0015234 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
0.9 5.5 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.9 11.4 GO:0033691 sialic acid binding(GO:0033691)
0.9 18.0 GO:0005112 Notch binding(GO:0005112)
0.9 8.6 GO:0009374 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.8 15.6 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.8 2.5 GO:0047977 hepoxilin-epoxide hydrolase activity(GO:0047977)
0.8 2.4 GO:0005148 prolactin receptor binding(GO:0005148)
0.8 54.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.8 4.0 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.8 7.0 GO:0051425 PTB domain binding(GO:0051425)
0.8 10.6 GO:0003680 AT DNA binding(GO:0003680)
0.8 4.5 GO:0008240 tripeptidyl-peptidase activity(GO:0008240) peptidyl-dipeptidase activity(GO:0008241)
0.8 3.0 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.7 5.0 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.7 4.1 GO:0004447 iodide peroxidase activity(GO:0004447)
0.7 4.8 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.7 8.6 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.7 7.9 GO:0015250 water transmembrane transporter activity(GO:0005372) water channel activity(GO:0015250)
0.6 5.7 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.6 8.6 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.6 6.0 GO:0015386 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.6 2.4 GO:0005502 11-cis retinal binding(GO:0005502)
0.6 57.9 GO:0001618 virus receptor activity(GO:0001618)
0.6 9.2 GO:0001222 transcription corepressor binding(GO:0001222)
0.6 5.1 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.6 5.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.6 16.4 GO:0034061 DNA polymerase activity(GO:0034061)
0.5 4.4 GO:0097322 7SK snRNA binding(GO:0097322)
0.5 2.7 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.5 1.6 GO:0047783 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
0.5 17.8 GO:0017091 AU-rich element binding(GO:0017091)
0.5 2.5 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.5 4.5 GO:0005000 vasopressin receptor activity(GO:0005000)
0.5 3.0 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.5 6.5 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.5 6.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.5 3.3 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.5 4.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.4 4.4 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.4 3.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.4 5.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.4 2.5 GO:0005499 vitamin D binding(GO:0005499)
0.4 4.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.4 11.1 GO:0003746 translation elongation factor activity(GO:0003746)
0.4 4.5 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.4 10.6 GO:0030506 ankyrin binding(GO:0030506)
0.4 0.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.4 6.3 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.4 20.7 GO:0015485 cholesterol binding(GO:0015485)
0.4 3.0 GO:0038132 neuregulin binding(GO:0038132)
0.4 2.3 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.4 2.5 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.4 1.8 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.3 17.5 GO:0004984 olfactory receptor activity(GO:0004984)
0.3 3.8 GO:0016918 retinal binding(GO:0016918)
0.3 6.9 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.3 5.4 GO:0017166 vinculin binding(GO:0017166)
0.3 2.7 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.3 7.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.3 7.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 1.0 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.3 3.5 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.3 6.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 0.9 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.3 1.5 GO:0004994 somatostatin receptor activity(GO:0004994)
0.3 7.9 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.3 15.4 GO:0048365 Rac GTPase binding(GO:0048365)
0.3 0.9 GO:0042289 MHC class II protein binding(GO:0042289)
0.3 6.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.3 1.7 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.3 3.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.3 2.9 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.3 10.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.3 2.9 GO:0070330 aromatase activity(GO:0070330)
0.3 4.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.3 6.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 1.0 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.3 20.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.3 3.0 GO:0045159 myosin II binding(GO:0045159)
0.3 2.8 GO:0043274 phospholipase binding(GO:0043274)
0.2 2.7 GO:0019215 intermediate filament binding(GO:0019215)
0.2 2.6 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.2 4.3 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.2 4.5 GO:0008066 glutamate receptor activity(GO:0008066)
0.2 23.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 8.8 GO:0030552 cAMP binding(GO:0030552)
0.2 2.4 GO:0008430 selenium binding(GO:0008430)
0.2 1.1 GO:0034056 estrogen response element binding(GO:0034056)
0.2 1.3 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.2 5.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.2 1.7 GO:0004000 adenosine deaminase activity(GO:0004000)
0.2 9.4 GO:0030507 spectrin binding(GO:0030507)
0.2 1.8 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.2 7.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 2.2 GO:0038191 neuropilin binding(GO:0038191)
0.2 3.0 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.2 1.4 GO:0000146 microfilament motor activity(GO:0000146)
0.2 11.2 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.2 3.6 GO:0016805 dipeptidase activity(GO:0016805)
0.2 3.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.2 5.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.2 1.1 GO:0032554 purine deoxyribonucleotide binding(GO:0032554)
0.2 2.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 139.1 GO:0005509 calcium ion binding(GO:0005509)
0.2 2.7 GO:0005243 gap junction channel activity(GO:0005243)
0.2 3.0 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.2 1.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 17.1 GO:0044325 ion channel binding(GO:0044325)
0.2 0.5 GO:0005174 CD40 receptor binding(GO:0005174)
0.2 1.6 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.2 1.5 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.2 2.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.2 1.7 GO:0039706 co-receptor binding(GO:0039706)
0.1 4.1 GO:0001972 retinoic acid binding(GO:0001972)
0.1 10.7 GO:0051213 dioxygenase activity(GO:0051213)
0.1 0.8 GO:0032027 myosin light chain binding(GO:0032027)
0.1 1.8 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 5.0 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 12.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 3.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 2.4 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 0.6 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 1.1 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.1 0.7 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.1 19.6 GO:0051015 actin filament binding(GO:0051015)
0.1 2.2 GO:0001848 complement binding(GO:0001848)
0.1 2.8 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 33.3 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 0.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 6.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 1.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 22.2 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.1 7.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 6.3 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 2.9 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 2.2 GO:0019894 kinesin binding(GO:0019894)
0.1 6.9 GO:0043130 ubiquitin binding(GO:0043130)
0.1 22.7 GO:0015631 tubulin binding(GO:0015631)
0.1 7.2 GO:0008565 protein transporter activity(GO:0008565)
0.1 5.6 GO:0008013 beta-catenin binding(GO:0008013)
0.1 5.3 GO:0051087 chaperone binding(GO:0051087)
0.1 0.5 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 2.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.0 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.1 0.2 GO:0071566 UFM1 activating enzyme activity(GO:0071566)
0.1 12.0 GO:0000287 magnesium ion binding(GO:0000287)
0.1 3.3 GO:0019902 phosphatase binding(GO:0019902)
0.1 6.2 GO:0005178 integrin binding(GO:0005178)
0.1 0.8 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.1 1.2 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.9 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 15.0 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.5 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467) fatty acid ligase activity(GO:0015645) decanoate--CoA ligase activity(GO:0102391)
0.0 1.0 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.0 1.5 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.6 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 1.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 2.0 GO:0005506 iron ion binding(GO:0005506)
0.0 1.2 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.6 GO:0008301 DNA binding, bending(GO:0008301)
0.0 1.8 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 1.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 1.0 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 2.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.6 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.4 GO:0005109 frizzled binding(GO:0005109)
0.0 1.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.3 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.6 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 163.8 PID NCADHERIN PATHWAY N-cadherin signaling events
1.6 87.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
1.5 1.5 PID CXCR3 PATHWAY CXCR3-mediated signaling events
1.2 61.8 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
1.2 54.3 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.8 23.7 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.8 35.5 ST GA13 PATHWAY G alpha 13 Pathway
0.7 61.1 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.7 7.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.7 30.3 PID MYC PATHWAY C-MYC pathway
0.7 50.9 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.6 27.2 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.5 24.1 PID ERBB4 PATHWAY ErbB4 signaling events
0.5 66.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.5 14.9 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.4 7.9 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.4 11.9 PID FAS PATHWAY FAS (CD95) signaling pathway
0.4 9.4 PID ARF 3PATHWAY Arf1 pathway
0.4 7.3 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.4 19.8 PID ATR PATHWAY ATR signaling pathway
0.4 27.3 PID LKB1 PATHWAY LKB1 signaling events
0.4 5.0 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.4 10.6 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.3 20.7 PID RAC1 PATHWAY RAC1 signaling pathway
0.3 3.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.3 14.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.3 14.0 PID ENDOTHELIN PATHWAY Endothelins
0.2 1.0 PID IL5 PATHWAY IL5-mediated signaling events
0.2 50.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 2.9 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.2 3.4 PID RHOA PATHWAY RhoA signaling pathway
0.2 2.6 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.2 4.8 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 3.5 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 8.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 13.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 5.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 2.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 3.8 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 3.0 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 1.8 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 9.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 3.3 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 3.5 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 24.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 1.2 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 3.0 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 0.8 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.0 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 3.5 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 1.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.3 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.0 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.8 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.5 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 57.0 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
2.8 66.2 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
2.5 17.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
1.7 41.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
1.7 44.7 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
1.6 28.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.6 17.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
1.4 77.1 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
1.0 26.4 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
1.0 31.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.9 29.3 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.9 48.1 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.9 15.6 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.8 17.9 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.8 8.0 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.8 87.7 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.8 37.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.7 12.0 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.7 10.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.7 31.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.7 6.5 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.7 18.4 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.6 14.1 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.6 10.0 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.5 17.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.5 12.2 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.5 20.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.5 9.9 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.4 7.0 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.4 7.9 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.4 15.0 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.4 12.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.4 4.6 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.4 4.5 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.4 89.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.4 6.3 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.3 1.0 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.3 4.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.3 16.2 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.3 5.0 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.3 12.6 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.3 6.0 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.3 5.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.3 6.0 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.3 8.1 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.3 7.0 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.3 8.0 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.3 5.4 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 4.4 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.2 2.3 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.2 6.7 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 3.5 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.2 3.6 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.2 8.5 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.2 19.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 5.6 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.2 7.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 14.9 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 4.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 4.0 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.2 3.0 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2 4.5 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 14.0 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 2.0 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.2 2.4 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.1 4.1 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 6.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.5 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 3.8 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 2.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 7.1 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.1 9.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 14.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 3.7 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.1 2.9 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 5.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 2.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 1.1 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.1 2.2 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.1 2.9 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.8 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 0.6 REACTOME ION CHANNEL TRANSPORT Genes involved in Ion channel transport
0.1 1.9 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 8.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.1 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 1.4 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.5 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.3 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.8 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.3 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint
0.0 0.4 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.6 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 2.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling