ISMARA results: FOXM1

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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for FOXM1_TBL1XR1

Z-value: 2.38

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Transcription factors associated with FOXM1_TBL1XR1

Gene Symbol	Gene ID	Gene Info
FOXM1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000111206.8	forkhead box M1
TBL1XR1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000177565.11	TBL1X receptor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXM1	hg19_v2_chr12_-_2986107_2986258	-0.27	5.8e-05	Click!
TBL1XR1	hg19_v2_chr3_-_176914238_176914277	-0.23	6.4e-04	Click!

Activity profile of FOXM1_TBL1XR1 motif

Sorted Z-values of FOXM1_TBL1XR1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_91574142 Show fit	70.20	ENST00000547937.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr12_-_91572278 Show fit	33.12	ENST00000425043.1 ENST00000420120.2 ENST00000441303.2 ENST00000456569.2	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr18_+_74240610 Show fit	32.61	ENST00000578092.1 ENST00000578613.1 ENST00000583578.1	LINC00908 Ensembl NCBI GeneCards UniProt NextProt Show fit	long intergenic non-protein coding RNA 908
chr12_-_10022735 Show fit	31.64	ENST00000228438.2	CLEC2B Ensembl NCBI GeneCards UniProt NextProt Show fit	C-type lectin domain family 2, member B
chr12_-_91573132 Show fit	31.40	ENST00000550563.1 ENST00000546370.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr16_-_30032610 Show fit	30.61	ENST00000574405.1	DOC2A Ensembl NCBI GeneCards UniProt NextProt Show fit	double C2-like domains, alpha
chr3_+_189507460 Show fit	28.70	ENST00000434928.1	TP63 Ensembl NCBI GeneCards UniProt NextProt Show fit	tumor protein p63
chr12_-_91576429 Show fit	27.41	ENST00000552145.1 ENST00000546745.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr12_-_91576561 Show fit	27.10	ENST00000547568.2 ENST00000552962.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr11_+_5710919 Show fit	25.85	ENST00000379965.3 ENST00000425490.1	TRIM22 Ensembl NCBI GeneCards UniProt NextProt Show fit	tripartite motif containing 22

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXM1_TBL1XR1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
23.9	286.4	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
1.9	222.3	GO:0060333	interferon-gamma-mediated signaling pathway(GO:0060333)
2.5	153.0	GO:0006910	phagocytosis, recognition(GO:0006910)
1.8	144.2	GO:0006958	complement activation, classical pathway(GO:0006958)
1.0	132.5	GO:0002377	immunoglobulin production(GO:0002377)
0.7	94.4	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
2.6	72.1	GO:0098743	cell aggregation(GO:0098743)
1.5	68.7	GO:0018149	peptide cross-linking(GO:0018149)
3.1	67.7	GO:0006957	complement activation, alternative pathway(GO:0006957)
5.5	65.9	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)

Showing 1 to 10 of 1,269 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	719.5	GO:0005615	extracellular space(GO:0005615)
23.1	323.2	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2	288.2	GO:0005887	integral component of plasma membrane(GO:0005887)
1.0	232.6	GO:0009897	external side of plasma membrane(GO:0009897)
8.2	171.6	GO:0042613	MHC class II protein complex(GO:0042613)
2.9	136.1	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
1.1	109.6	GO:0035578	azurophil granule lumen(GO:0035578)
0.8	103.9	GO:0072562	blood microparticle(GO:0072562)
0.9	103.2	GO:0005796	Golgi lumen(GO:0005796)
0.7	77.6	GO:0022626	cytosolic ribosome(GO:0022626)

Showing 1 to 10 of 287 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	371.9	GO:0003700	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
4.2	310.4	GO:0050840	extracellular matrix binding(GO:0050840)
1.8	240.4	GO:0003823	antigen binding(GO:0003823)
1.4	155.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
2.7	149.5	GO:0034987	immunoglobulin receptor binding(GO:0034987)
1.5	116.1	GO:0005201	extracellular matrix structural constituent(GO:0005201)
3.6	105.3	GO:0042605	peptide antigen binding(GO:0042605)
6.7	94.1	GO:0032395	MHC class II receptor activity(GO:0032395)
0.4	77.4	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.7	74.6	GO:0004222	metalloendopeptidase activity(GO:0004222)

Showing 1 to 10 of 721 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.2	349.1	NABA PROTEOGLYCANS	Genes encoding proteoglycans
1.0	265.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.3	224.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.6	181.1	NABA MATRISOME	Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins
0.7	146.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
1.3	124.6	PID IL12 2PATHWAY	IL12-mediated signaling events
2.3	121.4	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
1.0	89.1	PID BCR 5PATHWAY	BCR signaling pathway
0.9	83.3	PID CASPASE PATHWAY	Caspase cascade in apoptosis
1.5	70.3	NABA COLLAGENS	Genes encoding collagen proteins

Showing 1 to 10 of 101 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
11.1	300.9	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.8	286.6	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
2.1	162.2	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
5.9	136.5	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.8	129.8	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.9	111.9	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.8	106.3	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
1.0	78.7	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.7	75.1	REACTOME MUSCLE CONTRACTION	Genes involved in Muscle contraction
0.7	69.9	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation

Showing 1 to 10 of 174 entries

Results for FOXM1_TBL1XR1

Z-value: 2.38

Motif logo

Transcription factors associated with FOXM1_TBL1XR1

Activity-expression correlation:

Activity profile of FOXM1_TBL1XR1 motif

Sorted Z-values of FOXM1_TBL1XR1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXM1_TBL1XR1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: