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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for FUBP1

Z-value: 0.66

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Transcription factors associated with FUBP1

Gene Symbol Gene ID Gene Info
FUBP1
ENSG00000162613.12 far upstream element binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FUBP1hg19_v2_chr1_-_78444776_78444800-0.237.1e-04Click!

Activity profile of FUBP1 motif

Sorted Z-values of FUBP1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_91576429 12.25 ENST00000552145.1
ENST00000546745.1
DCN
decorin
chr12_-_91576561 11.57 ENST00000547568.2
ENST00000552962.1
DCN
decorin
chr1_-_182360918 10.09 ENST00000339526.4
GLUL
glutamate-ammonia ligase
chr1_-_182360498 9.32 ENST00000417584.2
GLUL
glutamate-ammonia ligase
chr11_-_33891362 8.74 ENST00000395833.3
LMO2
LIM domain only 2 (rhombotin-like 1)
chr9_-_110251836 6.56 ENST00000374672.4
KLF4
Kruppel-like factor 4 (gut)
chr3_-_112127981 5.50 ENST00000486726.2
RP11-231E6.1
RP11-231E6.1
chr2_+_113033164 4.74 ENST00000409871.1
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr18_-_53255766 4.49 ENST00000566286.1
ENST00000564999.1
ENST00000566279.1
ENST00000354452.3
ENST00000356073.4
TCF4
transcription factor 4
chr12_+_57522258 4.21 ENST00000553277.1
ENST00000243077.3
LRP1
low density lipoprotein receptor-related protein 1
chr8_-_120685608 4.06 ENST00000427067.2
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr2_-_216300784 3.50 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
FN1
fibronectin 1
chr11_-_10590238 3.24 ENST00000256178.3
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr6_+_121756809 3.21 ENST00000282561.3
GJA1
gap junction protein, alpha 1, 43kDa
chr3_-_187454281 2.94 ENST00000232014.4
BCL6
B-cell CLL/lymphoma 6
chr11_-_10590118 2.94 ENST00000529598.1
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr1_+_202317815 2.70 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr7_+_139529040 2.69 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr16_+_67381263 2.60 ENST00000541146.1
ENST00000563189.1
ENST00000290940.7
LRRC36
leucine rich repeat containing 36
chr7_+_139528952 2.57 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr9_+_82186682 2.48 ENST00000376552.2
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr14_+_61654271 2.42 ENST00000555185.1
ENST00000557294.1
ENST00000556778.1
PRKCH
protein kinase C, eta
chr1_-_150738261 2.35 ENST00000448301.2
ENST00000368985.3
CTSS
cathepsin S
chr12_+_10365404 2.28 ENST00000266458.5
ENST00000421801.2
ENST00000544284.1
ENST00000545047.1
ENST00000543602.1
ENST00000545887.1
GABARAPL1
GABA(A) receptor-associated protein like 1
chr9_+_82186872 2.28 ENST00000376544.3
ENST00000376520.4
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chrX_-_65259900 2.26 ENST00000412866.2
VSIG4
V-set and immunoglobulin domain containing 4
chrX_-_65259914 2.22 ENST00000374737.4
ENST00000455586.2
VSIG4
V-set and immunoglobulin domain containing 4
chr4_-_16900242 2.21 ENST00000502640.1
ENST00000506732.1
LDB2
LIM domain binding 2
chr9_-_113761720 2.20 ENST00000541779.1
ENST00000374430.2
LPAR1
lysophosphatidic acid receptor 1
chr1_+_198608146 2.06 ENST00000367376.2
ENST00000352140.3
ENST00000594404.1
ENST00000598951.1
ENST00000530727.1
ENST00000442510.2
ENST00000367367.4
ENST00000348564.6
ENST00000367364.1
ENST00000413409.2
PTPRC
protein tyrosine phosphatase, receptor type, C
chr12_-_46766577 2.06 ENST00000256689.5
SLC38A2
solute carrier family 38, member 2
chr17_-_76713100 2.03 ENST00000585509.1
CYTH1
cytohesin 1
chr10_-_70092671 1.99 ENST00000358769.2
ENST00000432941.1
ENST00000495025.2
PBLD
phenazine biosynthesis-like protein domain containing
chr4_-_100242549 1.94 ENST00000305046.8
ENST00000394887.3
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chr19_+_18682661 1.86 ENST00000596273.1
ENST00000442744.2
ENST00000595683.1
ENST00000599256.1
ENST00000595158.1
ENST00000598780.1
UBA52
ubiquitin A-52 residue ribosomal protein fusion product 1
chr4_-_16900410 1.82 ENST00000304523.5
LDB2
LIM domain binding 2
chr7_+_116166331 1.77 ENST00000393468.1
ENST00000393467.1
CAV1
caveolin 1, caveolae protein, 22kDa
chr15_-_34628951 1.70 ENST00000397707.2
ENST00000560611.1
SLC12A6
solute carrier family 12 (potassium/chloride transporter), member 6
chr10_+_114710516 1.70 ENST00000542695.1
ENST00000346198.4
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr14_-_24711865 1.69 ENST00000399423.4
ENST00000267415.7
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr14_-_24711806 1.69 ENST00000540705.1
ENST00000538777.1
ENST00000558566.1
ENST00000559019.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr16_+_28565230 1.64 ENST00000317058.3
CCDC101
coiled-coil domain containing 101
chr5_+_54320078 1.63 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chr4_-_16900217 1.62 ENST00000441778.2
LDB2
LIM domain binding 2
chr2_+_33359687 1.59 ENST00000402934.1
ENST00000404525.1
ENST00000407925.1
LTBP1
latent transforming growth factor beta binding protein 1
chr4_-_16900184 1.57 ENST00000515064.1
LDB2
LIM domain binding 2
chr2_+_33359646 1.57 ENST00000390003.4
ENST00000418533.2
LTBP1
latent transforming growth factor beta binding protein 1
chr1_+_43766642 1.54 ENST00000372476.3
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr2_+_162087577 1.49 ENST00000439442.1
TANK
TRAF family member-associated NFKB activator
chr2_+_201980827 1.43 ENST00000309955.3
ENST00000443227.1
ENST00000341222.6
ENST00000355558.4
ENST00000340870.5
ENST00000341582.6
CFLAR
CASP8 and FADD-like apoptosis regulator
chr19_-_19302931 1.37 ENST00000444486.3
ENST00000514819.3
ENST00000585679.1
ENST00000162023.5
MEF2BNB-MEF2B
MEF2BNB
MEF2B
MEF2BNB-MEF2B readthrough
MEF2B neighbor
myocyte enhancer factor 2B
chr5_-_88179017 1.37 ENST00000514028.1
ENST00000514015.1
ENST00000503075.1
ENST00000437473.2
MEF2C
myocyte enhancer factor 2C
chr4_-_89152474 1.34 ENST00000515655.1
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr7_+_74508372 1.32 ENST00000356115.5
ENST00000430511.2
ENST00000312575.7
GTF2IRD2B
GTF2I repeat domain containing 2B
chrX_+_12924732 1.27 ENST00000218032.6
ENST00000311912.5
TLR8
toll-like receptor 8
chr7_-_74267836 1.21 ENST00000361071.5
ENST00000453619.2
ENST00000417115.2
ENST00000405086.2
GTF2IRD2
GTF2I repeat domain containing 2
chr5_-_88178964 1.18 ENST00000513252.1
ENST00000508569.1
ENST00000510942.1
ENST00000506554.1
MEF2C
myocyte enhancer factor 2C
chr1_-_27701307 1.14 ENST00000270879.4
ENST00000354982.2
FCN3
ficolin (collagen/fibrinogen domain containing) 3
chr17_-_10421853 1.13 ENST00000226207.5
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr4_-_25865159 1.11 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr12_+_14572070 1.09 ENST00000545769.1
ENST00000428217.2
ENST00000396279.2
ENST00000542514.1
ENST00000536279.1
ATF7IP
activating transcription factor 7 interacting protein
chr17_-_8151353 1.00 ENST00000315684.8
CTC1
CTS telomere maintenance complex component 1
chr1_+_43855560 1.00 ENST00000562955.1
SZT2
seizure threshold 2 homolog (mouse)
chr10_-_105845674 0.99 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr5_-_160973649 0.98 ENST00000393959.1
ENST00000517547.1
GABRB2
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr9_-_123812542 0.95 ENST00000223642.1
C5
complement component 5
chr12_+_56324756 0.93 ENST00000331886.5
ENST00000555090.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr5_-_1882858 0.93 ENST00000511126.1
ENST00000231357.2
IRX4
iroquois homeobox 4
chr7_+_96634850 0.90 ENST00000518156.2
DLX6
distal-less homeobox 6
chr3_-_170303845 0.88 ENST00000231706.5
SLC7A14
solute carrier family 7, member 14
chr13_-_26795840 0.83 ENST00000381570.3
ENST00000399762.2
ENST00000346166.3
RNF6
ring finger protein (C3H2C3 type) 6
chr1_-_216978709 0.83 ENST00000360012.3
ESRRG
estrogen-related receptor gamma
chr5_+_137225158 0.82 ENST00000290431.5
PKD2L2
polycystic kidney disease 2-like 2
chr13_+_49551020 0.82 ENST00000541916.1
FNDC3A
fibronectin type III domain containing 3A
chr6_+_167525277 0.82 ENST00000400926.2
CCR6
chemokine (C-C motif) receptor 6
chr11_+_64004888 0.81 ENST00000541681.1
VEGFB
vascular endothelial growth factor B
chrX_-_55020511 0.80 ENST00000375006.3
ENST00000374992.2
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr19_+_10765003 0.78 ENST00000407004.3
ENST00000589998.1
ENST00000589600.1
ILF3
interleukin enhancer binding factor 3, 90kDa
chr14_+_75761099 0.77 ENST00000561000.1
ENST00000558575.1
RP11-293M10.5
RP11-293M10.5
chr15_-_88799948 0.74 ENST00000394480.2
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr2_-_183291741 0.72 ENST00000351439.5
ENST00000409365.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr5_-_115872142 0.68 ENST00000510263.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chrX_+_49644470 0.67 ENST00000508866.2
USP27X
ubiquitin specific peptidase 27, X-linked
chrX_+_22056165 0.66 ENST00000535894.1
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr18_-_60986613 0.63 ENST00000444484.1
BCL2
B-cell CLL/lymphoma 2
chr12_-_57522813 0.61 ENST00000556155.1
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr1_-_115238207 0.59 ENST00000520113.2
ENST00000369538.3
ENST00000353928.6
AMPD1
adenosine monophosphate deaminase 1
chr19_-_45996465 0.59 ENST00000430715.2
RTN2
reticulon 2
chr18_-_60985914 0.59 ENST00000589955.1
BCL2
B-cell CLL/lymphoma 2
chr13_+_49684445 0.55 ENST00000398316.3
FNDC3A
fibronectin type III domain containing 3A
chr1_-_161208013 0.54 ENST00000515452.1
ENST00000367983.4
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr7_-_144533074 0.54 ENST00000360057.3
ENST00000378099.3
TPK1
thiamin pyrophosphokinase 1
chr10_-_65028817 0.51 ENST00000542921.1
JMJD1C
jumonji domain containing 1C
chr7_-_144435985 0.50 ENST00000549981.1
TPK1
thiamin pyrophosphokinase 1
chr17_-_41739283 0.50 ENST00000393661.2
ENST00000318579.4
MEOX1
mesenchyme homeobox 1
chrX_-_33146477 0.49 ENST00000378677.2
DMD
dystrophin
chr12_+_54366894 0.46 ENST00000546378.1
ENST00000243082.4
HOXC11
homeobox C11
chr4_-_101439242 0.46 ENST00000296420.4
EMCN
endomucin
chr2_+_27435734 0.45 ENST00000419744.1
ATRAID
all-trans retinoic acid-induced differentiation factor
chr7_-_124405681 0.45 ENST00000303921.2
GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr10_+_32856764 0.43 ENST00000375030.2
ENST00000375028.3
C10orf68
Homo sapiens coiled-coil domain containing 7 (CCDC7), transcript variant 5, mRNA.
chr11_-_66964638 0.43 ENST00000444002.2
AP001885.1
AP001885.1
chr3_+_19988566 0.40 ENST00000273047.4
RAB5A
RAB5A, member RAS oncogene family
chr11_+_111473108 0.39 ENST00000304987.3
SIK2
salt-inducible kinase 2
chr11_-_62752162 0.39 ENST00000458333.2
ENST00000421062.2
SLC22A6
solute carrier family 22 (organic anion transporter), member 6
chr4_+_170581213 0.38 ENST00000507875.1
CLCN3
chloride channel, voltage-sensitive 3
chr11_-_107590383 0.35 ENST00000525934.1
ENST00000531293.1
SLN
sarcolipin
chr19_+_48969094 0.34 ENST00000595676.1
CTC-273B12.7
Uncharacterized protein
chr11_+_112832090 0.33 ENST00000533760.1
NCAM1
neural cell adhesion molecule 1
chr8_-_20040638 0.32 ENST00000519026.1
ENST00000276373.5
ENST00000440926.1
ENST00000437980.1
SLC18A1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr17_-_41738931 0.30 ENST00000329168.3
ENST00000549132.1
MEOX1
mesenchyme homeobox 1
chr1_+_171107241 0.29 ENST00000236166.3
FMO6P
flavin containing monooxygenase 6 pseudogene
chr15_-_55657428 0.29 ENST00000568543.1
CCPG1
cell cycle progression 1
chr2_+_202122703 0.29 ENST00000447616.1
ENST00000358485.4
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr2_-_228497888 0.28 ENST00000264387.4
ENST00000409066.1
C2orf83
chromosome 2 open reading frame 83
chr4_-_48082192 0.28 ENST00000507351.1
TXK
TXK tyrosine kinase
chr1_-_161207986 0.27 ENST00000506209.1
ENST00000367980.2
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr12_+_120740119 0.25 ENST00000536460.1
ENST00000202967.4
SIRT4
sirtuin 4
chrX_+_22050546 0.22 ENST00000379374.4
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr11_-_62752455 0.22 ENST00000360421.4
SLC22A6
solute carrier family 22 (organic anion transporter), member 6
chr12_+_56324933 0.19 ENST00000549629.1
ENST00000555218.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr12_-_26986076 0.18 ENST00000381340.3
ITPR2
inositol 1,4,5-trisphosphate receptor, type 2
chr7_-_22233442 0.16 ENST00000401957.2
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr18_-_25616519 0.15 ENST00000399380.3
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr5_+_156607829 0.12 ENST00000422843.3
ITK
IL2-inducible T-cell kinase
chr11_-_62752429 0.11 ENST00000377871.3
SLC22A6
solute carrier family 22 (organic anion transporter), member 6
chr7_-_15601595 0.10 ENST00000342526.3
AGMO
alkylglycerol monooxygenase
chr1_+_41157361 0.10 ENST00000427410.2
ENST00000447388.3
ENST00000425457.2
ENST00000453631.1
ENST00000456393.2
NFYC
nuclear transcription factor Y, gamma
chr12_-_91451758 0.08 ENST00000266719.3
KERA
keratocan
chr15_-_89764929 0.08 ENST00000268125.5
RLBP1
retinaldehyde binding protein 1
chr4_-_168155730 0.07 ENST00000502330.1
ENST00000357154.3
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr4_-_48136217 0.06 ENST00000264316.4
TXK
TXK tyrosine kinase
chr5_+_140027355 0.06 ENST00000417647.2
ENST00000507593.1
ENST00000508301.1
IK
IK cytokine, down-regulator of HLA II
chr1_-_244006528 0.06 ENST00000336199.5
ENST00000263826.5
AKT3
v-akt murine thymoma viral oncogene homolog 3
chr1_-_45140074 0.05 ENST00000420706.1
ENST00000372235.3
ENST00000372242.3
ENST00000372243.3
ENST00000372244.3
TMEM53
transmembrane protein 53
chr3_-_169587621 0.05 ENST00000523069.1
ENST00000316428.5
ENST00000264676.5
LRRC31
leucine rich repeat containing 31
chr17_-_77005860 0.04 ENST00000591773.1
ENST00000588611.1
ENST00000586916.2
ENST00000592033.1
ENST00000588075.1
ENST00000302345.2
ENST00000591811.1
CANT1
calcium activated nucleotidase 1
chr8_+_94929969 0.04 ENST00000517764.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr11_+_120207787 0.03 ENST00000397843.2
ENST00000356641.3
ARHGEF12
Rho guanine nucleotide exchange factor (GEF) 12
chr14_+_65878565 0.03 ENST00000556518.1
ENST00000557164.1
FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr17_-_77005801 0.01 ENST00000392446.5
CANT1
calcium activated nucleotidase 1
chr19_+_11546093 0.00 ENST00000591462.1
PRKCSH
protein kinase C substrate 80K-H

Network of associatons between targets according to the STRING database.

First level regulatory network of FUBP1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 19.4 GO:0006542 glutamine biosynthetic process(GO:0006542)
2.2 6.6 GO:0071409 negative regulation of muscle hyperplasia(GO:0014740) cellular response to cycloheximide(GO:0071409)
2.0 23.8 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
1.4 4.2 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
1.2 3.5 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
1.0 2.9 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.8 3.2 GO:0010645 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.6 2.5 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.6 3.1 GO:0048539 bone marrow development(GO:0048539)
0.6 1.8 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.6 3.4 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.5 2.2 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.5 2.0 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.4 11.1 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.4 3.2 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.3 2.4 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.3 2.1 GO:0032328 alanine transport(GO:0032328)
0.3 1.7 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.3 1.3 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.3 0.9 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.3 4.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.3 1.2 GO:0043375 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.3 5.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.3 1.7 GO:0044334 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.3 7.2 GO:0010669 epithelial structure maintenance(GO:0010669)
0.3 0.8 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.3 0.8 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.3 1.0 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.2 1.5 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.2 0.7 GO:0052026 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.2 0.7 GO:0097254 renal tubular secretion(GO:0097254)
0.2 1.1 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.2 6.2 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.2 0.8 GO:0061056 somite specification(GO:0001757) sclerotome development(GO:0061056)
0.2 4.5 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.2 1.9 GO:0006069 ethanol oxidation(GO:0006069)
0.2 0.9 GO:1904383 response to sodium phosphate(GO:1904383)
0.2 0.3 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.2 1.0 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.2 0.6 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.1 1.4 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 2.3 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 1.3 GO:0015886 heme transport(GO:0015886)
0.1 0.8 GO:1903301 fructose 2,6-bisphosphate metabolic process(GO:0006003) positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.1 0.4 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.1 1.9 GO:0017085 response to insecticide(GO:0017085)
0.1 0.3 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.1 2.0 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 0.4 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.1 4.8 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.1 0.3 GO:0052148 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
0.1 0.3 GO:0015888 thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
0.1 0.8 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.1 0.4 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 1.4 GO:0060009 Sertoli cell development(GO:0060009)
0.1 0.5 GO:0045964 positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.1 0.3 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.1 0.6 GO:0032264 IMP salvage(GO:0032264)
0.1 0.3 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 1.0 GO:0071420 cellular response to histamine(GO:0071420)
0.0 1.1 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 0.5 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 1.5 GO:0045026 plasma membrane fusion(GO:0045026)
0.0 1.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 1.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.5 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.0 0.7 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.5 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.0 0.1 GO:0070444 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 0.5 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.8 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.0 0.1 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.1 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 3.1 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.9 GO:0009798 axis specification(GO:0009798)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 23.8 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
1.0 19.4 GO:0097386 glial cell projection(GO:0097386)
0.7 3.4 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.3 2.3 GO:0036021 endolysosome lumen(GO:0036021)
0.3 1.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 3.5 GO:0005577 fibrinogen complex(GO:0005577)
0.3 3.4 GO:0005916 fascia adherens(GO:0005916)
0.2 6.6 GO:0005719 nuclear euchromatin(GO:0005719)
0.2 1.0 GO:1990130 Iml1 complex(GO:1990130)
0.1 3.2 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.1 1.8 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.9 GO:0005579 membrane attack complex(GO:0005579)
0.1 1.7 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.1 1.2 GO:0046930 pore complex(GO:0046930)
0.1 0.6 GO:0014802 terminal cisterna(GO:0014802)
0.1 2.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 1.3 GO:0036020 endolysosome membrane(GO:0036020)
0.1 1.0 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 0.8 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 1.0 GO:0030056 hemidesmosome(GO:0030056)
0.1 1.9 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 0.5 GO:0016013 syntrophin complex(GO:0016013)
0.1 22.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.4 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.0 4.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 3.4 GO:0031672 A band(GO:0031672)
0.0 2.9 GO:0005657 replication fork(GO:0005657)
0.0 0.3 GO:0070083 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 1.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.0 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.1 GO:0005581 collagen trimer(GO:0005581)
0.0 1.7 GO:0005903 brush border(GO:0005903)
0.0 0.2 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 3.4 GO:0045121 membrane raft(GO:0045121)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 19.4 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
1.8 5.3 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
1.3 6.6 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
1.1 4.2 GO:0042954 apolipoprotein receptor activity(GO:0030226) lipoprotein transporter activity(GO:0042954)
1.0 4.1 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.7 7.2 GO:0030274 LIM domain binding(GO:0030274)
0.6 3.2 GO:0050436 microfibril binding(GO:0050436)
0.6 1.8 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.5 3.2 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.5 2.4 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.4 26.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 4.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.3 1.9 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.3 0.8 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.2 1.5 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.2 2.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.2 6.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 2.9 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.2 8.7 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 3.3 GO:0071837 HMG box domain binding(GO:0071837)
0.2 1.3 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.2 2.3 GO:0030957 Tat protein binding(GO:0030957)
0.2 0.8 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.2 1.7 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 1.0 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.1 0.8 GO:0004882 androgen receptor activity(GO:0004882)
0.1 1.0 GO:0016778 diphosphotransferase activity(GO:0016778)
0.1 0.8 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 1.2 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.3 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.1 0.7 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 1.8 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 0.3 GO:0015234 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
0.1 1.0 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 3.4 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 2.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 3.5 GO:0016504 peptidase activator activity(GO:0016504)
0.1 0.7 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.7 GO:1990380 Lys63-specific deubiquitinase activity(GO:0061578) Lys48-specific deubiquitinase activity(GO:1990380)
0.1 0.6 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.4 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.8 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.3 GO:0047708 biotinidase activity(GO:0047708)
0.1 1.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 1.6 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 1.7 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 0.7 GO:0005030 GPI-linked ephrin receptor activity(GO:0005004) neurotrophin receptor activity(GO:0005030)
0.0 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.3 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.5 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 2.2 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 3.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.5 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.9 GO:0008009 chemokine activity(GO:0008009)
0.0 2.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.1 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.0 0.1 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.9 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.1 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.8 GO:0050681 androgen receptor binding(GO:0050681)
0.0 2.0 GO:0016853 isomerase activity(GO:0016853)
0.0 2.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 24.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 7.7 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 17.5 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.9 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 4.8 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 3.2 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 1.8 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.8 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 2.3 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 2.2 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.4 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 2.4 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 2.1 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 1.3 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.0 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.6 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 1.1 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 3.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.7 PID SHP2 PATHWAY SHP2 signaling
0.0 0.5 PID FGF PATHWAY FGF signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 23.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.7 19.4 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.4 6.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.4 6.6 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.3 3.6 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.2 1.9 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 1.9 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.2 3.2 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 8.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 3.5 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 1.3 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 2.1 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 3.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 5.2 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 0.8 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.1 2.1 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 3.4 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 4.3 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.7 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.8 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.1 1.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.7 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.8 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.0 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.7 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.6 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.8 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.9 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.6 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction