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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GAUAUGU

Z-value: 0.22

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miRNA associated with seed GAUAUGU

NamemiRBASE accession
hsa-miR-190a-5p
MIMAT0000458
hsa-miR-190b
MIMAT0004929

Activity profile of GAUAUGU motif

Sorted Z-values of GAUAUGU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_24612935 1.35 ENST00000222644.5
MPP6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr5_+_61602055 1.26 ENST00000381103.2
KIF2A
kinesin heavy chain member 2A
chr3_-_160283348 0.99 ENST00000334256.4
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr2_+_114647504 0.98 ENST00000263238.2
ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr19_-_1652575 0.95 ENST00000587235.1
ENST00000262965.5
TCF3
transcription factor 3
chr8_+_61591337 0.95 ENST00000423902.2
CHD7
chromodomain helicase DNA binding protein 7
chr2_+_228336849 0.74 ENST00000409979.2
ENST00000310078.8
AGFG1
ArfGAP with FG repeats 1
chr12_-_118797475 0.69 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr8_-_122653630 0.68 ENST00000303924.4
HAS2
hyaluronan synthase 2
chr1_-_33283754 0.61 ENST00000373477.4
YARS
tyrosyl-tRNA synthetase
chr22_+_40573921 0.58 ENST00000454349.2
ENST00000335727.9
TNRC6B
trinucleotide repeat containing 6B
chr13_-_103053946 0.57 ENST00000376131.4
FGF14
fibroblast growth factor 14
chr7_+_5085452 0.55 ENST00000353796.3
ENST00000396912.1
ENST00000396904.2
RBAK
RBAK-RBAKDN
RB-associated KRAB zinc finger
RBAK-RBAKDN readthrough
chr15_-_68498376 0.53 ENST00000540479.1
ENST00000395465.3
CALML4
calmodulin-like 4
chr14_+_55034599 0.51 ENST00000392067.3
ENST00000357634.3
SAMD4A
sterile alpha motif domain containing 4A
chr4_+_128703295 0.48 ENST00000296464.4
ENST00000508549.1
HSPA4L
heat shock 70kDa protein 4-like
chr2_+_208394616 0.47 ENST00000432329.2
ENST00000353267.3
ENST00000445803.1
CREB1
cAMP responsive element binding protein 1
chr1_-_212004090 0.41 ENST00000366997.4
LPGAT1
lysophosphatidylglycerol acyltransferase 1
chr11_-_31839488 0.38 ENST00000419022.1
ENST00000379132.3
ENST00000379129.2
PAX6
paired box 6
chr2_-_61765315 0.31 ENST00000406957.1
ENST00000401558.2
XPO1
exportin 1 (CRM1 homolog, yeast)
chr12_-_31744031 0.29 ENST00000389082.5
DENND5B
DENN/MADD domain containing 5B
chr2_-_182545603 0.29 ENST00000295108.3
NEUROD1
neuronal differentiation 1
chr4_+_99916765 0.29 ENST00000296411.6
METAP1
methionyl aminopeptidase 1
chr6_-_91006461 0.27 ENST00000257749.4
ENST00000343122.3
ENST00000406998.2
ENST00000453877.1
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr18_-_53255766 0.25 ENST00000566286.1
ENST00000564999.1
ENST00000566279.1
ENST00000354452.3
ENST00000356073.4
TCF4
transcription factor 4
chr3_+_187930719 0.24 ENST00000312675.4
LPP
LIM domain containing preferred translocation partner in lipoma
chrX_-_109561294 0.22 ENST00000372059.2
ENST00000262844.5
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr8_-_23712312 0.22 ENST00000290271.2
STC1
stanniocalcin 1
chr7_-_26240357 0.20 ENST00000354667.4
ENST00000356674.7
HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr3_+_173116225 0.18 ENST00000457714.1
NLGN1
neuroligin 1
chr14_+_79745746 0.18 ENST00000281127.7
NRXN3
neurexin 3
chr11_-_70507901 0.17 ENST00000449833.2
ENST00000357171.3
ENST00000449116.2
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr3_+_11314099 0.14 ENST00000446450.2
ENST00000354956.5
ENST00000354449.3
ENST00000419112.1
ATG7
autophagy related 7
chr18_+_60382672 0.14 ENST00000400316.4
ENST00000262719.5
PHLPP1
PH domain and leucine rich repeat protein phosphatase 1
chr15_-_52821247 0.10 ENST00000399231.3
ENST00000399233.2
MYO5A
myosin VA (heavy chain 12, myoxin)
chr21_-_39870339 0.05 ENST00000429727.2
ENST00000398905.1
ENST00000398907.1
ENST00000453032.2
ENST00000288319.7
ERG
v-ets avian erythroblastosis virus E26 oncogene homolog
chr8_+_64081118 0.05 ENST00000539294.1
YTHDF3
YTH domain family, member 3
chr11_-_30038490 0.03 ENST00000328224.6
KCNA4
potassium voltage-gated channel, shaker-related subfamily, member 4
chr8_-_93115445 0.02 ENST00000523629.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr12_-_28124903 0.01 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone

Network of associatons between targets according to the STRING database.

First level regulatory network of GAUAUGU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.3 0.9 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 0.7 GO:0070295 renal water absorption(GO:0070295)
0.1 1.0 GO:0002326 B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152)
0.1 0.7 GO:0001675 acrosome assembly(GO:0001675)
0.1 0.5 GO:1904550 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.1 0.4 GO:0003322 pancreatic A cell development(GO:0003322)
0.1 0.6 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.1 0.2 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.1 0.3 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.0 0.1 GO:1901859 late nucleophagy(GO:0044805) negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859) single-organism membrane invagination(GO:1902534)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.2 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.0 0.6 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.0 1.0 GO:0019054 modulation by virus of host process(GO:0019054)
0.0 0.7 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.4 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.0 0.3 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.2 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.1 GO:0051643 regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031585) secretory granule localization(GO:0032252) endoplasmic reticulum localization(GO:0051643)
0.0 0.1 GO:0002249 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.0 1.3 GO:0090307 mitotic spindle assembly(GO:0090307)
0.0 0.5 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.2 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.1 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.0 0.6 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.1 0.5 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 1.0 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.3 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.3 GO:0005642 annulate lamellae(GO:0005642)
0.0 1.7 GO:0005643 nuclear pore(GO:0005643)
0.0 0.3 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:0005883 neurofilament(GO:0005883)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 1.0 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.5 GO:1990763 arrestin family protein binding(GO:1990763)
0.1 0.4 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.0 0.6 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 1.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.2 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.2 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.0 0.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.5 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 1.3 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.4 GO:0035035 histone acetyltransferase binding(GO:0035035)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.9 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.3 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.7 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.7 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME KINESINS Genes involved in Kinesins
0.0 0.7 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.6 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 1.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.5 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.6 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition