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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GCAGCAU

Z-value: 0.79

Motif logo

logo of

miRNA associated with seed GCAGCAU

NamemiRBASE accession
hsa-miR-103a-3p
MIMAT0000101
hsa-miR-107
MIMAT0000104

Activity profile of GCAGCAU motif

Sorted Z-values of GCAGCAU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_152017181 10.41 ENST00000498502.1
ENST00000324196.5
ENST00000545754.1
ENST00000357472.3
MBNL1
muscleblind-like splicing regulator 1
chr4_+_174089904 10.34 ENST00000265000.4
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr12_+_104359576 8.38 ENST00000392872.3
ENST00000436021.2
TDG
thymine-DNA glycosylase
chr12_-_31479045 8.30 ENST00000539409.1
ENST00000395766.1
FAM60A
family with sequence similarity 60, member A
chr5_-_98262240 7.90 ENST00000284049.3
CHD1
chromodomain helicase DNA binding protein 1
chrX_-_109561294 7.74 ENST00000372059.2
ENST00000262844.5
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr12_-_102513843 7.39 ENST00000551744.2
ENST00000552283.1
NUP37
nucleoporin 37kDa
chr5_+_65440032 7.09 ENST00000334121.6
SREK1
splicing regulatory glutamine/lysine-rich protein 1
chr1_-_11120057 6.86 ENST00000376957.2
SRM
spermidine synthase
chrX_-_20284958 6.55 ENST00000379565.3
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr8_-_66546439 6.32 ENST00000276569.3
ARMC1
armadillo repeat containing 1
chr15_-_41624685 5.94 ENST00000560640.1
ENST00000220514.3
OIP5
Opa interacting protein 5
chr18_+_158513 5.89 ENST00000400266.3
ENST00000580410.1
ENST00000383589.2
ENST00000261601.7
USP14
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr9_-_127952032 5.81 ENST00000456642.1
ENST00000373546.3
ENST00000373547.4
PPP6C
protein phosphatase 6, catalytic subunit
chr22_-_36784035 5.74 ENST00000216181.5
MYH9
myosin, heavy chain 9, non-muscle
chr11_+_118230287 5.58 ENST00000252108.3
ENST00000431736.2
UBE4A
ubiquitination factor E4A
chr4_+_140222609 5.40 ENST00000296543.5
ENST00000398947.1
NAA15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr2_+_120517174 5.34 ENST00000263708.2
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr17_+_30264014 5.31 ENST00000322652.5
ENST00000580398.1
SUZ12
SUZ12 polycomb repressive complex 2 subunit
chr7_-_26240357 5.22 ENST00000354667.4
ENST00000356674.7
HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr16_-_88851618 5.18 ENST00000301015.9
PIEZO1
piezo-type mechanosensitive ion channel component 1
chrX_+_21958674 5.16 ENST00000404933.2
SMS
spermine synthase
chr1_+_26798955 5.01 ENST00000361427.5
HMGN2
high mobility group nucleosomal binding domain 2
chr12_-_120884175 4.98 ENST00000546954.1
TRIAP1
TP53 regulated inhibitor of apoptosis 1
chr6_+_135502466 4.82 ENST00000367814.4
MYB
v-myb avian myeloblastosis viral oncogene homolog
chrX_+_70752917 4.81 ENST00000373719.3
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
chr12_+_66217911 4.78 ENST00000403681.2
HMGA2
high mobility group AT-hook 2
chr3_-_167452614 4.78 ENST00000392750.2
ENST00000464360.1
ENST00000492139.1
ENST00000471885.1
ENST00000470131.1
PDCD10
programmed cell death 10
chr9_+_112810878 4.64 ENST00000434623.2
ENST00000374525.1
AKAP2
A kinase (PRKA) anchor protein 2
chr17_-_38804061 4.64 ENST00000474246.1
ENST00000377808.4
ENST00000578044.1
ENST00000580419.1
ENST00000400122.3
ENST00000580654.1
ENST00000577721.1
ENST00000478349.2
ENST00000431889.2
SMARCE1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr2_-_200322723 4.58 ENST00000417098.1
SATB2
SATB homeobox 2
chr7_-_55640176 4.48 ENST00000285279.5
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr9_+_112542572 4.43 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr4_-_69215699 4.41 ENST00000510746.1
ENST00000344157.4
ENST00000355665.3
YTHDC1
YTH domain containing 1
chr1_-_70671216 4.41 ENST00000370952.3
LRRC40
leucine rich repeat containing 40
chr1_+_90286562 4.40 ENST00000525774.1
ENST00000337338.5
LRRC8D
leucine rich repeat containing 8 family, member D
chr2_+_231577532 4.39 ENST00000258418.5
CAB39
calcium binding protein 39
chr1_+_11072696 4.37 ENST00000240185.3
ENST00000476201.1
TARDBP
TAR DNA binding protein
chr15_-_49447835 4.35 ENST00000388901.5
ENST00000299259.6
COPS2
COP9 signalosome subunit 2
chr22_-_39096661 4.33 ENST00000216039.5
JOSD1
Josephin domain containing 1
chr5_+_5422778 4.28 ENST00000296564.7
KIAA0947
KIAA0947
chr6_-_90062543 4.20 ENST00000435041.2
UBE2J1
ubiquitin-conjugating enzyme E2, J1
chr19_+_1941117 4.03 ENST00000255641.8
CSNK1G2
casein kinase 1, gamma 2
chr6_+_34204642 3.99 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr17_-_28618948 3.91 ENST00000261714.6
BLMH
bleomycin hydrolase
chr12_+_68042495 3.90 ENST00000344096.3
DYRK2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr10_-_119134918 3.88 ENST00000334464.5
PDZD8
PDZ domain containing 8
chr6_-_43596899 3.62 ENST00000307126.5
ENST00000452781.1
GTPBP2
GTP binding protein 2
chr9_-_36400213 3.53 ENST00000259605.6
ENST00000353739.4
RNF38
ring finger protein 38
chr3_-_72496035 3.51 ENST00000477973.2
RYBP
RING1 and YY1 binding protein
chr4_-_111119804 3.37 ENST00000394607.3
ENST00000302274.3
ELOVL6
ELOVL fatty acid elongase 6
chr13_-_50367057 3.35 ENST00000261667.3
KPNA3
karyopherin alpha 3 (importin alpha 4)
chr4_-_76598296 3.34 ENST00000395719.3
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr6_+_155054459 3.30 ENST00000367178.3
ENST00000417268.1
ENST00000367186.4
SCAF8
SR-related CTD-associated factor 8
chr4_-_25864581 3.29 ENST00000399878.3
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr15_+_69706585 3.27 ENST00000559279.1
ENST00000395392.2
KIF23
kinesin family member 23
chr1_+_110091189 3.23 ENST00000369851.4
GNAI3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
chr9_-_95055956 3.21 ENST00000375629.3
ENST00000447699.2
ENST00000375643.3
ENST00000395554.3
IARS
isoleucyl-tRNA synthetase
chr7_+_116502527 3.06 ENST00000361183.3
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr22_+_32340481 2.96 ENST00000397492.1
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr21_-_16437255 2.91 ENST00000400199.1
ENST00000400202.1
NRIP1
nuclear receptor interacting protein 1
chr8_-_67525473 2.89 ENST00000522677.3
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr14_+_70078303 2.84 ENST00000342745.4
KIAA0247
KIAA0247
chr14_+_57046500 2.81 ENST00000261556.6
TMEM260
transmembrane protein 260
chr17_-_65241281 2.81 ENST00000358691.5
ENST00000580168.1
HELZ
helicase with zinc finger
chr3_-_176914238 2.77 ENST00000430069.1
ENST00000428970.1
TBL1XR1
transducin (beta)-like 1 X-linked receptor 1
chr22_+_40573921 2.76 ENST00000454349.2
ENST00000335727.9
TNRC6B
trinucleotide repeat containing 6B
chr5_-_111093406 2.73 ENST00000379671.3
NREP
neuronal regeneration related protein
chr20_-_13765526 2.71 ENST00000202816.1
ESF1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr9_+_127624387 2.67 ENST00000353214.2
ARPC5L
actin related protein 2/3 complex, subunit 5-like
chr6_-_24721054 2.63 ENST00000378119.4
C6orf62
chromosome 6 open reading frame 62
chr2_+_85198216 2.55 ENST00000456682.1
ENST00000409785.4
KCMF1
potassium channel modulatory factor 1
chr8_-_81083731 2.54 ENST00000379096.5
TPD52
tumor protein D52
chrX_-_41782249 2.52 ENST00000442742.2
ENST00000421587.2
ENST00000378166.4
ENST00000318588.9
ENST00000361962.4
CASK
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
chr14_+_55518349 2.51 ENST00000395468.4
MAPK1IP1L
mitogen-activated protein kinase 1 interacting protein 1-like
chr6_-_91006461 2.49 ENST00000257749.4
ENST00000343122.3
ENST00000406998.2
ENST00000453877.1
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr12_+_122242597 2.48 ENST00000267197.5
SETD1B
SET domain containing 1B
chr3_+_43328004 2.48 ENST00000454177.1
ENST00000429705.2
ENST00000296088.7
ENST00000437827.1
SNRK
SNF related kinase
chr12_-_22697343 2.42 ENST00000446597.1
ENST00000536386.1
ENST00000396028.2
ENST00000545552.1
ENST00000544930.1
ENST00000333957.4
C2CD5
C2 calcium-dependent domain containing 5
chr15_-_65809581 2.42 ENST00000341861.5
DPP8
dipeptidyl-peptidase 8
chr19_+_30302805 2.40 ENST00000262643.3
ENST00000575243.1
ENST00000357943.5
CCNE1
cyclin E1
chr2_-_172017343 2.30 ENST00000431350.2
ENST00000360843.3
TLK1
tousled-like kinase 1
chrX_-_131352152 2.24 ENST00000342983.2
RAP2C
RAP2C, member of RAS oncogene family
chr1_-_108507631 2.22 ENST00000527011.1
ENST00000370056.4
VAV3
vav 3 guanine nucleotide exchange factor
chr3_+_30648066 2.20 ENST00000359013.4
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr14_+_103243813 2.20 ENST00000560371.1
ENST00000347662.4
ENST00000392745.2
ENST00000539721.1
ENST00000560463.1
TRAF3
TNF receptor-associated factor 3
chr1_+_36348790 2.17 ENST00000373204.4
AGO1
argonaute RISC catalytic component 1
chr12_+_104850740 2.06 ENST00000547956.1
ENST00000549260.1
ENST00000303694.5
CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr8_+_96145974 2.05 ENST00000315367.3
PLEKHF2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr2_-_33824336 2.04 ENST00000431950.1
ENST00000403368.1
ENST00000441530.2
FAM98A
family with sequence similarity 98, member A
chr12_-_118797475 2.04 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr2_+_85804614 2.03 ENST00000263864.5
ENST00000409760.1
VAMP8
vesicle-associated membrane protein 8
chr18_+_60190226 2.02 ENST00000269499.5
ZCCHC2
zinc finger, CCHC domain containing 2
chr12_-_9913489 1.99 ENST00000228434.3
ENST00000536709.1
CD69
CD69 molecule
chr12_+_105501487 1.98 ENST00000332180.5
KIAA1033
KIAA1033
chr6_+_138188551 1.97 ENST00000237289.4
ENST00000433680.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr10_+_11206925 1.93 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CELF2
CUGBP, Elav-like family member 2
chr22_-_41252962 1.90 ENST00000216218.3
ST13
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
chr5_+_67511524 1.90 ENST00000521381.1
ENST00000521657.1
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr3_-_160283348 1.89 ENST00000334256.4
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr16_+_69345243 1.88 ENST00000254950.11
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr3_+_137906109 1.86 ENST00000481646.1
ENST00000469044.1
ENST00000491704.1
ENST00000461600.1
ARMC8
armadillo repeat containing 8
chr18_+_2655692 1.86 ENST00000320876.6
SMCHD1
structural maintenance of chromosomes flexible hinge domain containing 1
chr18_+_29598335 1.85 ENST00000217740.3
RNF125
ring finger protein 125, E3 ubiquitin protein ligase
chr14_+_39644387 1.82 ENST00000553331.1
ENST00000216832.4
PNN
pinin, desmosome associated protein
chr3_+_152879985 1.81 ENST00000323534.2
RAP2B
RAP2B, member of RAS oncogene family
chr3_+_9439400 1.80 ENST00000450326.1
ENST00000402198.1
ENST00000402466.1
SETD5
SET domain containing 5
chr8_+_87354945 1.75 ENST00000517970.1
WWP1
WW domain containing E3 ubiquitin protein ligase 1
chr15_-_61521495 1.74 ENST00000335670.6
RORA
RAR-related orphan receptor A
chr2_-_24149977 1.68 ENST00000238789.5
ATAD2B
ATPase family, AAA domain containing 2B
chr10_+_89622870 1.68 ENST00000371953.3
PTEN
phosphatase and tensin homolog
chr3_-_196159268 1.65 ENST00000381887.3
ENST00000535858.1
ENST00000428095.1
ENST00000296328.4
UBXN7
UBX domain protein 7
chr5_-_137368708 1.60 ENST00000033079.3
FAM13B
family with sequence similarity 13, member B
chr1_-_78444776 1.59 ENST00000370767.1
ENST00000421641.1
FUBP1
far upstream element (FUSE) binding protein 1
chr3_+_133293278 1.57 ENST00000508481.1
ENST00000420115.2
ENST00000504867.1
ENST00000507408.1
ENST00000511392.1
ENST00000515421.1
CDV3
CDV3 homolog (mouse)
chr8_-_57123815 1.52 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chr3_-_58419537 1.48 ENST00000474765.1
ENST00000485460.1
ENST00000302746.6
ENST00000383714.4
PDHB
pyruvate dehydrogenase (lipoamide) beta
chr7_+_32535060 1.48 ENST00000318709.4
ENST00000409301.1
ENST00000404479.1
AVL9
AVL9 homolog (S. cerevisiase)
chr5_+_102455853 1.46 ENST00000515845.1
ENST00000321521.9
ENST00000507921.1
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr1_-_33502441 1.44 ENST00000548033.1
ENST00000487289.1
ENST00000373449.2
ENST00000480134.1
ENST00000467905.1
AK2
adenylate kinase 2
chr2_-_131850951 1.41 ENST00000409185.1
ENST00000389915.3
FAM168B
family with sequence similarity 168, member B
chr6_+_134274322 1.41 ENST00000367871.1
ENST00000237264.4
TBPL1
TBP-like 1
chr12_+_53399942 1.40 ENST00000262056.9
EIF4B
eukaryotic translation initiation factor 4B
chr6_+_30539153 1.39 ENST00000326195.8
ENST00000376545.3
ENST00000396515.4
ENST00000441867.1
ENST00000468958.1
ABCF1
ATP-binding cassette, sub-family F (GCN20), member 1
chr19_-_46476791 1.38 ENST00000263257.5
NOVA2
neuro-oncological ventral antigen 2
chr14_+_102228123 1.38 ENST00000422945.2
ENST00000554442.1
ENST00000556260.2
ENST00000328724.5
ENST00000557268.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr2_-_40679186 1.37 ENST00000406785.2
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr5_-_137878887 1.34 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
ETF1
eukaryotic translation termination factor 1
chr4_+_26585538 1.30 ENST00000264866.4
TBC1D19
TBC1 domain family, member 19
chrX_-_118827333 1.30 ENST00000360156.7
ENST00000354228.4
ENST00000489216.1
ENST00000354416.3
ENST00000394610.1
ENST00000343984.5
SEPT6
septin 6
chr13_-_76056250 1.28 ENST00000377636.3
ENST00000431480.2
ENST00000377625.2
ENST00000425511.1
TBC1D4
TBC1 domain family, member 4
chrX_-_102757802 1.25 ENST00000372633.1
RAB40A
RAB40A, member RAS oncogene family
chr16_-_48644061 1.25 ENST00000262384.3
N4BP1
NEDD4 binding protein 1
chr10_-_88854518 1.23 ENST00000277865.4
GLUD1
glutamate dehydrogenase 1
chr16_-_20911641 1.23 ENST00000564349.1
ENST00000324344.4
ERI2
DCUN1D3
ERI1 exoribonuclease family member 2
DCN1, defective in cullin neddylation 1, domain containing 3
chr1_-_38325256 1.22 ENST00000373036.4
MTF1
metal-regulatory transcription factor 1
chr17_+_45727204 1.22 ENST00000290158.4
KPNB1
karyopherin (importin) beta 1
chr2_+_228336849 1.21 ENST00000409979.2
ENST00000310078.8
AGFG1
ArfGAP with FG repeats 1
chr17_-_45266542 1.20 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
CDC27
cell division cycle 27
chr12_+_22778009 1.20 ENST00000266517.4
ENST00000335148.3
ETNK1
ethanolamine kinase 1
chr8_+_23386305 1.19 ENST00000519973.1
SLC25A37
solute carrier family 25 (mitochondrial iron transporter), member 37
chr3_-_98620500 1.18 ENST00000326840.6
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr1_-_155224751 1.18 ENST00000350210.2
ENST00000368368.3
FAM189B
family with sequence similarity 189, member B
chr4_+_57774042 1.18 ENST00000309042.7
REST
RE1-silencing transcription factor
chr12_-_80084862 1.13 ENST00000328827.4
PAWR
PRKC, apoptosis, WT1, regulator
chr10_-_15210666 1.13 ENST00000378165.4
NMT2
N-myristoyltransferase 2
chr22_+_21771656 1.13 ENST00000407464.2
HIC2
hypermethylated in cancer 2
chr16_-_74700737 1.08 ENST00000576652.1
ENST00000572337.1
ENST00000571750.1
ENST00000572990.1
ENST00000361070.4
RFWD3
ring finger and WD repeat domain 3
chr15_+_49715293 1.04 ENST00000267843.4
ENST00000560270.1
FGF7
fibroblast growth factor 7
chr4_+_47033345 1.03 ENST00000295454.3
GABRB1
gamma-aminobutyric acid (GABA) A receptor, beta 1
chr3_+_88188254 1.01 ENST00000309495.5
ZNF654
zinc finger protein 654
chr6_+_158733692 0.93 ENST00000367094.2
ENST00000367097.3
TULP4
tubby like protein 4
chr7_-_92463210 0.92 ENST00000265734.4
CDK6
cyclin-dependent kinase 6
chr10_+_52751010 0.91 ENST00000373985.1
PRKG1
protein kinase, cGMP-dependent, type I
chr8_+_38614807 0.89 ENST00000330691.6
ENST00000348567.4
TACC1
transforming, acidic coiled-coil containing protein 1
chr8_+_59465728 0.87 ENST00000260130.4
ENST00000422546.2
ENST00000447182.2
ENST00000413219.2
ENST00000424270.2
ENST00000523483.1
ENST00000520168.1
SDCBP
syndecan binding protein (syntenin)
chr3_-_122233723 0.85 ENST00000493510.1
ENST00000344337.6
ENST00000476916.1
ENST00000465882.1
KPNA1
karyopherin alpha 1 (importin alpha 5)
chr10_+_54074033 0.85 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr15_-_28567298 0.84 ENST00000261609.7
HERC2
HECT and RLD domain containing E3 ubiquitin protein ligase 2
chr5_+_179159813 0.83 ENST00000292599.3
MAML1
mastermind-like 1 (Drosophila)
chr17_-_27224621 0.83 ENST00000394906.2
ENST00000585169.1
ENST00000394908.4
FLOT2
flotillin 2
chr2_-_68479614 0.81 ENST00000234310.3
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha
chr16_-_25026641 0.78 ENST00000289968.6
ENST00000303665.5
ENST00000455311.2
ENST00000441763.2
ARHGAP17
Rho GTPase activating protein 17
chr6_-_116381918 0.77 ENST00000606080.1
FRK
fyn-related kinase
chr1_-_39325431 0.76 ENST00000373001.3
RRAGC
Ras-related GTP binding C
chr4_+_52709229 0.74 ENST00000334635.5
ENST00000381441.3
ENST00000381437.4
DCUN1D4
DCN1, defective in cullin neddylation 1, domain containing 4
chr19_+_10982189 0.73 ENST00000327064.4
ENST00000588947.1
CARM1
coactivator-associated arginine methyltransferase 1
chr1_+_109234907 0.72 ENST00000370025.4
ENST00000370022.5
ENST00000370021.1
PRPF38B
pre-mRNA processing factor 38B
chr3_+_48956249 0.71 ENST00000452882.1
ENST00000430423.1
ENST00000356401.4
ENST00000449376.1
ENST00000420814.1
ENST00000449729.1
ENST00000433170.1
ARIH2
ariadne RBR E3 ubiquitin protein ligase 2
chr17_-_56595196 0.71 ENST00000579921.1
ENST00000579925.1
ENST00000323456.5
MTMR4
myotubularin related protein 4
chr10_+_72164135 0.69 ENST00000373218.4
EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr1_-_154842741 0.69 ENST00000271915.4
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr11_-_64546202 0.67 ENST00000377390.3
ENST00000227503.9
ENST00000377394.3
ENST00000422298.2
ENST00000334944.5
SF1
splicing factor 1
chr17_-_35969409 0.66 ENST00000394378.2
ENST00000585472.1
ENST00000591288.1
ENST00000502449.2
ENST00000345615.4
ENST00000346661.4
ENST00000585689.1
ENST00000339208.6
SYNRG
synergin, gamma
chr22_+_45559722 0.58 ENST00000347635.4
ENST00000407019.2
ENST00000424634.1
ENST00000417702.1
ENST00000425733.2
ENST00000430547.1
NUP50
nucleoporin 50kDa
chr1_+_36396677 0.58 ENST00000373191.4
ENST00000397828.2
AGO3
argonaute RISC catalytic component 3
chr1_+_100435315 0.58 ENST00000370155.3
ENST00000465289.1
SLC35A3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
chr15_+_72766651 0.57 ENST00000379887.4
ARIH1
ariadne RBR E3 ubiquitin protein ligase 1
chr5_+_82767284 0.57 ENST00000265077.3
VCAN
versican
chr8_-_23315190 0.56 ENST00000356206.6
ENST00000358689.4
ENST00000417069.2
ENTPD4
ectonucleoside triphosphate diphosphohydrolase 4
chr2_+_170440844 0.55 ENST00000260970.3
ENST00000433207.1
ENST00000409714.3
ENST00000462903.1
PPIG
peptidylprolyl isomerase G (cyclophilin G)
chr16_+_87636474 0.55 ENST00000284262.2
JPH3
junctophilin 3
chr12_-_65146636 0.54 ENST00000418919.2
GNS
glucosamine (N-acetyl)-6-sulfatase
chr17_-_46623441 0.54 ENST00000330070.4
HOXB2
homeobox B2
chr8_-_74791051 0.54 ENST00000453587.2
ENST00000602969.1
ENST00000602593.1
ENST00000419880.3
ENST00000517608.1
UBE2W
ubiquitin-conjugating enzyme E2W (putative)
chr10_-_119806085 0.54 ENST00000355624.3
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr3_-_53381539 0.53 ENST00000606822.1
ENST00000294241.6
ENST00000607628.1
DCP1A
decapping mRNA 1A
chr14_-_57735528 0.52 ENST00000340918.7
ENST00000413566.2
EXOC5
exocyst complex component 5
chr2_+_181845298 0.52 ENST00000410062.4
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr10_+_97803151 0.49 ENST00000403870.3
ENST00000265992.5
ENST00000465148.2
ENST00000534974.1
CCNJ
cyclin J
chr5_-_147162078 0.49 ENST00000507386.1
JAKMIP2
janus kinase and microtubule interacting protein 2
chr5_-_126366500 0.48 ENST00000308660.5
MARCH3
membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
chr8_+_23430157 0.48 ENST00000399967.3
FP15737
FP15737
chr12_+_862089 0.47 ENST00000315939.6
ENST00000537687.1
ENST00000447667.2
WNK1
WNK lysine deficient protein kinase 1
chr1_-_22469459 0.47 ENST00000290167.6
WNT4
wingless-type MMTV integration site family, member 4
chr12_+_50451331 0.46 ENST00000228468.4
ASIC1
acid-sensing (proton-gated) ion channel 1
chr20_+_1099233 0.45 ENST00000246015.4
ENST00000335877.6
ENST00000438768.2
PSMF1
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr2_-_165697920 0.40 ENST00000342193.4
ENST00000375458.2
COBLL1
cordon-bleu WH2 repeat protein-like 1
chr2_+_235860616 0.38 ENST00000392011.2
SH3BP4
SH3-domain binding protein 4
chr3_-_45017609 0.38 ENST00000342790.4
ENST00000424952.2
ENST00000296127.3
ENST00000455235.1
ZDHHC3
zinc finger, DHHC-type containing 3

Network of associatons between targets according to the STRING database.

First level regulatory network of GCAGCAU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.8 GO:0090402 oncogene-induced cell senescence(GO:0090402)
2.1 8.4 GO:1902544 oxidative DNA demethylation(GO:0035511) regulation of DNA N-glycosylase activity(GO:1902544)
2.0 5.9 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
1.9 5.7 GO:0051295 establishment of meiotic spindle localization(GO:0051295)
1.7 5.2 GO:0006597 spermine biosynthetic process(GO:0006597)
1.6 4.8 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
1.6 4.8 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
1.5 4.4 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
1.3 5.2 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
1.1 6.9 GO:0008295 spermidine biosynthetic process(GO:0008295)
1.1 3.2 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
1.0 5.2 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
1.0 4.8 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.9 1.9 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.9 5.4 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.8 3.3 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.8 3.9 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.7 2.2 GO:0002663 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.7 4.2 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.7 2.0 GO:1903595 positive regulation of histamine secretion by mast cell(GO:1903595)
0.7 2.0 GO:0034146 B-1 B cell homeostasis(GO:0001922) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) negative regulation of osteoclast proliferation(GO:0090291)
0.7 3.9 GO:0043418 homocysteine catabolic process(GO:0043418)
0.6 3.4 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.6 5.0 GO:2001138 regulation of phospholipid transport(GO:2001138) positive regulation of phospholipid transport(GO:2001140)
0.5 2.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.5 1.4 GO:0006172 ADP biosynthetic process(GO:0006172)
0.5 2.8 GO:0060613 fat pad development(GO:0060613)
0.5 4.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 4.4 GO:0071763 nuclear membrane organization(GO:0071763)
0.4 1.7 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.4 2.0 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795)
0.4 1.2 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.4 1.2 GO:0061110 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.4 1.1 GO:0018201 N-terminal peptidyl-glycine N-myristoylation(GO:0018008) peptidyl-glycine modification(GO:0018201)
0.4 7.9 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.4 1.4 GO:0009212 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.3 1.4 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.3 1.0 GO:0060437 lung growth(GO:0060437)
0.3 1.3 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.3 1.9 GO:0061083 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.3 1.2 GO:0031291 Ran protein signal transduction(GO:0031291)
0.3 4.4 GO:0000338 protein deneddylation(GO:0000338)
0.3 1.1 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.3 0.8 GO:0003308 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) negative regulation of cell fate specification(GO:0009996) Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.3 0.8 GO:0060926 atrioventricular node development(GO:0003162) cardiac pacemaker cell differentiation(GO:0060920) cardiac pacemaker cell development(GO:0060926)
0.3 2.4 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.3 2.3 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.2 6.5 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.2 0.5 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.2 0.5 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.2 4.6 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498)
0.2 5.3 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.2 2.8 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.2 1.7 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.2 0.9 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.2 4.0 GO:0032486 Rap protein signal transduction(GO:0032486)
0.2 6.1 GO:0019054 modulation by virus of host process(GO:0019054)
0.2 3.3 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.2 5.9 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.2 2.9 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.2 7.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.2 1.7 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.2 1.9 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.2 3.0 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.2 3.5 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.2 0.5 GO:0021569 rhombomere 3 development(GO:0021569)
0.2 10.2 GO:0016266 O-glycan processing(GO:0016266)
0.2 1.2 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.2 2.1 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.2 8.0 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.2 1.8 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.2 1.5 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.2 1.9 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.2 0.9 GO:1904628 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.2 1.2 GO:0001675 acrosome assembly(GO:0001675)
0.1 0.7 GO:0034971 regulation of growth plate cartilage chondrocyte proliferation(GO:0003420) histone H3-R17 methylation(GO:0034971)
0.1 2.1 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.1 0.8 GO:1903903 regulation of establishment of T cell polarity(GO:1903903)
0.1 7.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 1.7 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.1 2.0 GO:0045116 protein neddylation(GO:0045116)
0.1 3.3 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.1 1.5 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.1 10.4 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 1.3 GO:0006449 regulation of translational termination(GO:0006449)
0.1 0.3 GO:0032900 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) negative regulation of neurotrophin production(GO:0032900) negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1 2.0 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 0.6 GO:0009191 ribonucleoside diphosphate catabolic process(GO:0009191)
0.1 5.0 GO:0031640 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.1 0.6 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 0.3 GO:0048073 regulation of eye pigmentation(GO:0048073)
0.1 1.4 GO:0006020 inositol metabolic process(GO:0006020)
0.1 3.4 GO:0046039 GTP metabolic process(GO:0046039)
0.1 0.5 GO:0071218 cellular response to misfolded protein(GO:0071218)
0.1 0.5 GO:0031087 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) protein localization to cytoplasmic stress granule(GO:1903608)
0.1 2.4 GO:0007129 synapsis(GO:0007129)
0.1 0.7 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 0.9 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.1 0.5 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 1.1 GO:0031297 replication fork processing(GO:0031297)
0.1 4.3 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.1 0.2 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 1.2 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 0.1 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.1 2.2 GO:0030890 positive regulation of B cell proliferation(GO:0030890)
0.1 1.0 GO:0071420 cellular response to histamine(GO:0071420)
0.1 4.9 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.1 GO:1904647 response to rotenone(GO:1904647)
0.0 0.4 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 1.7 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.1 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.0 4.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.8 GO:1903432 regulation of TORC1 signaling(GO:1903432)
0.0 0.3 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.2 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0 0.5 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 1.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 1.2 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.4 GO:0051639 actin filament network formation(GO:0051639)
0.0 1.2 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 2.0 GO:0035690 cellular response to drug(GO:0035690)
0.0 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.3 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.9 GO:0061512 protein localization to cilium(GO:0061512)
0.0 0.5 GO:0048278 vesicle docking(GO:0048278)
0.0 0.6 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.2 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.0 0.7 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 3.8 GO:0002576 platelet degranulation(GO:0002576)
0.0 1.3 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435)
0.0 1.1 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.0 0.3 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.4 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 4.4 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 5.1 GO:0008380 RNA splicing(GO:0008380)
0.0 0.8 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.4 GO:0061462 protein localization to lysosome(GO:0061462)
0.0 0.7 GO:0035065 regulation of histone acetylation(GO:0035065)
0.0 1.4 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.1 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 2.2 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.7 GO:0051703 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.0 0.3 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.4 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 1.2 GO:0046546 male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.0 0.5 GO:0003091 renal water homeostasis(GO:0003091)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 GO:0005826 actomyosin contractile ring(GO:0005826)
0.9 4.4 GO:0005726 perichromatin fibrils(GO:0005726) interchromatin granule(GO:0035061)
0.8 2.4 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.8 8.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.8 5.4 GO:0031415 NatA complex(GO:0031415)
0.7 3.3 GO:0097149 centralspindlin complex(GO:0097149)
0.5 5.3 GO:0001739 sex chromatin(GO:0001739)
0.5 1.9 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.5 1.9 GO:0001740 Barr body(GO:0001740)
0.5 7.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.3 8.3 GO:0016580 Sin3 complex(GO:0016580)
0.3 2.0 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.3 5.9 GO:0010369 chromocenter(GO:0010369)
0.3 2.0 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.2 2.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2 3.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.2 0.2 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) intrinsic component of mitochondrial membrane(GO:0098573)
0.2 4.6 GO:0071564 npBAF complex(GO:0071564)
0.2 2.5 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.2 1.9 GO:0090543 Flemming body(GO:0090543)
0.2 1.8 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 1.4 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.2 0.8 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2 3.4 GO:0042588 zymogen granule(GO:0042588)
0.2 10.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 10.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 2.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 2.5 GO:0005652 nuclear lamina(GO:0005652)
0.2 2.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.2 3.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 1.5 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 2.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.6 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.1 1.7 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.1 0.5 GO:0030314 junctional membrane complex(GO:0030314)
0.1 0.8 GO:0034448 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 0.4 GO:0005873 plus-end kinesin complex(GO:0005873)
0.1 9.0 GO:0043657 host(GO:0018995) host cell(GO:0043657)
0.1 0.7 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 1.3 GO:0097227 sperm annulus(GO:0097227)
0.1 0.7 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.4 GO:1990425 ryanodine receptor complex(GO:1990425)
0.1 0.8 GO:0005955 calcineurin complex(GO:0005955)
0.1 5.8 GO:0015030 Cajal body(GO:0015030)
0.1 1.8 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 1.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 6.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 3.1 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.8 GO:0016600 flotillin complex(GO:0016600)
0.1 7.3 GO:0016363 nuclear matrix(GO:0016363)
0.1 5.3 GO:0000502 proteasome complex(GO:0000502)
0.1 3.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 4.5 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 4.3 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.3 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 1.1 GO:0035861 site of double-strand break(GO:0035861)
0.0 12.6 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 3.3 GO:0036126 sperm flagellum(GO:0036126)
0.0 4.7 GO:1902554 serine/threonine protein kinase complex(GO:1902554)
0.0 6.6 GO:0005681 spliceosomal complex(GO:0005681)
0.0 3.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 3.6 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.5 GO:0000145 exocyst(GO:0000145)
0.0 2.5 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.3 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 2.9 GO:0016605 PML body(GO:0016605)
0.0 1.5 GO:0005643 nuclear pore(GO:0005643)
0.0 0.9 GO:0030496 midbody(GO:0030496)
0.0 0.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 2.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.2 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.0 2.2 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 1.2 GO:0055037 recycling endosome(GO:0055037)
0.0 4.2 GO:0016607 nuclear speck(GO:0016607)
0.0 4.4 GO:0031301 integral component of organelle membrane(GO:0031301)
0.0 10.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 1.4 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 1.5 GO:0001650 fibrillar center(GO:0001650)
0.0 0.8 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 2.5 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.1 GO:0005796 Golgi lumen(GO:0005796)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.4 GO:0001069 regulatory region RNA binding(GO:0001069)
2.8 8.4 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
2.3 6.9 GO:0004766 spermidine synthase activity(GO:0004766)
2.0 5.9 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
1.6 4.8 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
1.6 4.8 GO:0035501 MH1 domain binding(GO:0035501)
1.1 3.2 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.9 5.2 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.7 9.6 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.7 7.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.7 10.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.6 5.3 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.6 3.4 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.6 1.7 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.6 2.2 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.5 2.1 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.5 1.4 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.4 4.4 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.4 5.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.4 5.3 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.4 1.1 GO:0019107 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
0.4 5.6 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.4 1.5 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.3 1.4 GO:0034057 RNA strand-exchange activity(GO:0034057)
0.3 1.9 GO:0032564 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.3 1.2 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.3 0.9 GO:0098770 FBXO family protein binding(GO:0098770)
0.3 1.5 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.3 0.9 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.3 4.0 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.3 5.0 GO:0043495 protein anchor(GO:0043495)
0.2 1.7 GO:0008142 oxysterol binding(GO:0008142)
0.2 1.9 GO:0043559 insulin binding(GO:0043559)
0.2 5.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 2.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.2 9.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 1.3 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.2 7.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 2.0 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 7.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.2 0.9 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 2.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.2 2.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 6.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 2.2 GO:0031996 thioesterase binding(GO:0031996)
0.1 0.7 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 5.4 GO:0043175 RNA polymerase core enzyme binding(GO:0043175)
0.1 1.2 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.1 1.4 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 2.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.6 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 2.0 GO:0097602 cullin family protein binding(GO:0097602)
0.1 7.5 GO:0002039 p53 binding(GO:0002039)
0.1 1.4 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 4.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.4 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 0.5 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 2.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 3.9 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 2.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 4.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 1.2 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 1.0 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.1 0.8 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.6 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 1.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 2.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 4.8 GO:0019003 GDP binding(GO:0019003)
0.1 4.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 2.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 2.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 5.2 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 5.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 2.6 GO:0030145 manganese ion binding(GO:0030145)
0.1 0.7 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.8 GO:0032183 SUMO binding(GO:0032183)
0.0 2.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 1.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.5 GO:0070628 proteasome binding(GO:0070628)
0.0 0.3 GO:0005113 patched binding(GO:0005113)
0.0 0.5 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 1.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.5 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 1.2 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.3 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 1.2 GO:0050699 WW domain binding(GO:0050699)
0.0 3.2 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 1.8 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.2 GO:0050733 RS domain binding(GO:0050733)
0.0 0.5 GO:0099604 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 2.8 GO:0004386 helicase activity(GO:0004386)
0.0 0.8 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.5 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.2 GO:0050542 icosanoid binding(GO:0050542) arachidonic acid binding(GO:0050544) fatty acid derivative binding(GO:1901567)
0.0 0.2 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 3.8 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.8 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 6.0 GO:0016887 ATPase activity(GO:0016887)
0.0 1.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 2.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 4.7 GO:0005525 GTP binding(GO:0005525)
0.0 0.4 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 14.4 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.2 4.5 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 13.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 2.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 0.9 PID IL5 PATHWAY IL5-mediated signaling events
0.1 4.2 PID CD40 PATHWAY CD40/CD40L signaling
0.1 2.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 2.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 7.6 PID P53 REGULATION PATHWAY p53 pathway
0.1 2.9 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 2.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 2.1 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.1 4.2 PID AURORA B PATHWAY Aurora B signaling
0.0 0.9 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 4.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 3.5 PID E2F PATHWAY E2F transcription factor network
0.0 1.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 2.4 PID LKB1 PATHWAY LKB1 signaling events
0.0 2.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.6 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 1.1 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 3.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.4 PID RHOA PATHWAY RhoA signaling pathway
0.0 1.5 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 1.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.8 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.8 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.8 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 PID INSULIN PATHWAY Insulin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 12.0 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.5 8.4 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.4 4.0 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2 10.0 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.2 10.2 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.2 3.2 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.2 1.7 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.2 3.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 6.6 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.1 3.8 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 2.2 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 5.7 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 3.3 REACTOME KINESINS Genes involved in Kinesins
0.1 2.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 3.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 2.5 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.4 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 3.1 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 1.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 4.1 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.1 1.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 5.8 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 2.5 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 2.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 5.9 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 3.2 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 2.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.7 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 1.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 1.2 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.1 1.4 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.1 1.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.8 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.5 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 8.4 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 4.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.0 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 5.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 5.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.9 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.7 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.9 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.4 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.5 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.6 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity