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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GCM1

Z-value: 1.31

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Transcription factors associated with GCM1

Gene Symbol Gene ID Gene Info
GCM1
ENSG00000137270.10 glial cells missing transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GCM1hg19_v2_chr6_-_53013620_530136440.101.4e-01Click!

Activity profile of GCM1 motif

Sorted Z-values of GCM1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_90108504 32.22 ENST00000390271.2
IGKV6D-41
immunoglobulin kappa variable 6D-41 (non-functional)
chr2_-_89459813 27.17 ENST00000390256.2
IGKV6-21
immunoglobulin kappa variable 6-21 (non-functional)
chr2_+_90060377 26.35 ENST00000436451.2
IGKV6D-21
immunoglobulin kappa variable 6D-21 (non-functional)
chr3_+_10206545 26.14 ENST00000256458.4
IRAK2
interleukin-1 receptor-associated kinase 2
chr22_+_23165153 24.57 ENST00000390317.2
IGLV2-8
immunoglobulin lambda variable 2-8
chr22_+_22930626 24.03 ENST00000390302.2
IGLV2-33
immunoglobulin lambda variable 2-33 (non-functional)
chr22_+_23077065 23.10 ENST00000390310.2
IGLV2-18
immunoglobulin lambda variable 2-18
chr22_+_22786288 22.10 ENST00000390301.2
IGLV1-36
immunoglobulin lambda variable 1-36
chr2_-_89385283 21.00 ENST00000390252.2
IGKV3-15
immunoglobulin kappa variable 3-15
chr22_+_23040274 19.93 ENST00000390306.2
IGLV2-23
immunoglobulin lambda variable 2-23
chr22_+_23101182 19.81 ENST00000390312.2
IGLV2-14
immunoglobulin lambda variable 2-14
chr2_-_89630186 19.06 ENST00000390264.2
IGKV2-40
immunoglobulin kappa variable 2-40
chr22_+_22712087 18.85 ENST00000390294.2
IGLV1-47
immunoglobulin lambda variable 1-47
chr2_-_136875712 17.49 ENST00000241393.3
CXCR4
chemokine (C-X-C motif) receptor 4
chr22_+_22936998 12.28 ENST00000390303.2
IGLV3-32
immunoglobulin lambda variable 3-32 (non-functional)
chr8_+_141521386 12.12 ENST00000220913.5
ENST00000519533.1
CHRAC1
chromatin accessibility complex 1
chr22_+_22676808 10.65 ENST00000390290.2
IGLV1-51
immunoglobulin lambda variable 1-51
chr3_-_46506563 9.98 ENST00000231751.4
LTF
lactotransferrin
chr22_+_23154239 9.97 ENST00000390315.2
IGLV3-10
immunoglobulin lambda variable 3-10
chr22_+_22764088 9.94 ENST00000390299.2
IGLV1-40
immunoglobulin lambda variable 1-40
chr17_-_15903002 9.70 ENST00000399277.1
ZSWIM7
zinc finger, SWIM-type containing 7
chr3_-_46506358 9.25 ENST00000417439.1
ENST00000431944.1
LTF
lactotransferrin
chr20_+_30639991 8.91 ENST00000534862.1
ENST00000538448.1
ENST00000375862.2
HCK
hemopoietic cell kinase
chr17_-_3599327 8.34 ENST00000551178.1
ENST00000552276.1
ENST00000547178.1
P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr17_-_3599492 8.22 ENST00000435558.1
ENST00000345901.3
P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr16_+_3115611 7.96 ENST00000530890.1
ENST00000444393.3
ENST00000533097.2
ENST00000008180.9
ENST00000396890.2
ENST00000525228.1
ENST00000548652.1
ENST00000525377.2
ENST00000530538.2
ENST00000549213.1
ENST00000552936.1
ENST00000548476.1
ENST00000552664.1
ENST00000552356.1
ENST00000551513.1
ENST00000382213.3
ENST00000548246.1
IL32
interleukin 32
chr14_-_23285069 7.15 ENST00000554758.1
ENST00000397528.4
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr19_+_12902289 7.11 ENST00000302754.4
JUNB
jun B proto-oncogene
chr16_+_3115378 7.06 ENST00000529550.1
ENST00000551122.1
ENST00000525643.2
ENST00000548807.1
ENST00000528163.2
IL32
interleukin 32
chr17_-_42580738 6.94 ENST00000585614.1
ENST00000591680.1
ENST00000434000.1
ENST00000588554.1
ENST00000592154.1
GPATCH8
G patch domain containing 8
chr11_-_64511575 6.84 ENST00000431822.1
ENST00000377486.3
ENST00000394432.3
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr9_-_116102562 6.82 ENST00000374193.4
ENST00000465979.1
WDR31
WD repeat domain 31
chr1_+_161185032 6.79 ENST00000367992.3
ENST00000289902.1
FCER1G
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr16_+_19729586 6.52 ENST00000564186.1
ENST00000541926.1
ENST00000433597.2
IQCK
IQ motif containing K
chr9_-_116102530 6.50 ENST00000374195.3
ENST00000341761.4
WDR31
WD repeat domain 31
chr15_-_60884706 6.44 ENST00000449337.2
RORA
RAR-related orphan receptor A
chr16_+_2034183 6.42 ENST00000569451.1
ENST00000248114.6
ENST00000561710.1
GFER
growth factor, augmenter of liver regeneration
chr14_+_39736582 6.12 ENST00000556148.1
ENST00000348007.3
CTAGE5
CTAGE family, member 5
chr6_+_42018251 6.07 ENST00000372978.3
ENST00000494547.1
ENST00000456846.2
ENST00000372982.4
ENST00000472818.1
ENST00000372977.3
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr9_-_35650900 5.71 ENST00000259608.3
SIT1
signaling threshold regulating transmembrane adaptor 1
chr16_+_53468332 5.50 ENST00000262133.6
RBL2
retinoblastoma-like 2 (p130)
chr10_+_104678102 5.13 ENST00000433628.2
CNNM2
cyclin M2
chr2_-_24583168 5.06 ENST00000361999.3
ITSN2
intersectin 2
chr19_+_54705025 5.05 ENST00000441429.1
RPS9
ribosomal protein S9
chr12_-_6665200 5.00 ENST00000336604.4
ENST00000396840.2
ENST00000356896.4
IFFO1
intermediate filament family orphan 1
chr5_-_79287060 4.95 ENST00000512560.1
ENST00000509852.1
ENST00000512528.1
MTX3
metaxin 3
chr4_+_76649797 4.94 ENST00000538159.1
ENST00000514213.2
USO1
USO1 vesicle transport factor
chr11_-_64511789 4.84 ENST00000419843.1
ENST00000394430.1
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr10_+_104678032 4.68 ENST00000369878.4
ENST00000369875.3
CNNM2
cyclin M2
chr16_+_67063262 4.56 ENST00000565389.1
CBFB
core-binding factor, beta subunit
chr3_+_38080691 4.49 ENST00000308059.6
ENST00000346219.3
ENST00000452631.2
DLEC1
deleted in lung and esophageal cancer 1
chr19_+_11658655 4.47 ENST00000588935.1
CNN1
calponin 1, basic, smooth muscle
chr20_+_34043085 4.46 ENST00000397527.1
ENST00000342580.4
CEP250
centrosomal protein 250kDa
chr4_-_57547870 4.42 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
HOPX
HOP homeobox
chr12_+_69864129 4.41 ENST00000547219.1
ENST00000299293.2
ENST00000549921.1
ENST00000550316.1
ENST00000548154.1
ENST00000547414.1
ENST00000550389.1
ENST00000550937.1
ENST00000549092.1
ENST00000550169.1
FRS2
fibroblast growth factor receptor substrate 2
chr5_-_169725231 4.29 ENST00000046794.5
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr19_+_54704718 4.28 ENST00000391752.1
ENST00000402367.1
ENST00000391751.3
RPS9
ribosomal protein S9
chr7_-_152373216 4.19 ENST00000359321.1
XRCC2
X-ray repair complementing defective repair in Chinese hamster cells 2
chr2_+_111878483 4.14 ENST00000308659.8
ENST00000357757.2
ENST00000393253.2
ENST00000337565.5
ENST00000393256.3
BCL2L11
BCL2-like 11 (apoptosis facilitator)
chr19_+_54704990 4.14 ENST00000391753.2
RPS9
ribosomal protein S9
chr9_+_4985016 4.07 ENST00000539801.1
JAK2
Janus kinase 2
chr11_+_17756279 3.71 ENST00000265969.6
KCNC1
potassium voltage-gated channel, Shaw-related subfamily, member 1
chr2_+_946543 3.56 ENST00000308624.5
ENST00000407292.1
SNTG2
syntrophin, gamma 2
chr16_-_21170762 3.48 ENST00000261383.3
ENST00000415178.1
DNAH3
dynein, axonemal, heavy chain 3
chr2_+_234959376 3.46 ENST00000425558.1
SPP2
secreted phosphoprotein 2, 24kDa
chr12_+_11802753 3.45 ENST00000396373.4
ETV6
ets variant 6
chr19_+_48867652 3.40 ENST00000344846.2
SYNGR4
synaptogyrin 4
chr7_-_143966381 3.27 ENST00000487179.1
CTAGE8
CTAGE family, member 8
chr9_-_99540328 3.26 ENST00000223428.4
ENST00000375231.1
ENST00000374641.3
ZNF510
zinc finger protein 510
chr10_+_131265443 3.24 ENST00000306010.7
MGMT
O-6-methylguanine-DNA methyltransferase
chr21_-_45660723 3.24 ENST00000344330.4
ENST00000407780.3
ENST00000400379.3
ICOSLG
inducible T-cell co-stimulator ligand
chr1_-_40237020 3.23 ENST00000327582.5
OXCT2
3-oxoacid CoA transferase 2
chr15_+_83776324 3.17 ENST00000379390.6
ENST00000379386.4
ENST00000565774.1
ENST00000565982.1
TM6SF1
transmembrane 6 superfamily member 1
chr10_-_105677427 3.15 ENST00000369764.1
OBFC1
oligonucleotide/oligosaccharide-binding fold containing 1
chr9_-_99381660 3.14 ENST00000375240.3
ENST00000463569.1
CDC14B
cell division cycle 14B
chr11_-_8190534 3.11 ENST00000309737.6
ENST00000425599.2
ENST00000539720.1
ENST00000531450.1
ENST00000419822.2
ENST00000335425.7
ENST00000343202.4
RIC3
RIC3 acetylcholine receptor chaperone
chr4_-_57547454 3.09 ENST00000556376.2
HOPX
HOP homeobox
chr1_+_27719148 3.07 ENST00000374024.3
GPR3
G protein-coupled receptor 3
chr10_-_105677886 3.04 ENST00000224950.3
OBFC1
oligonucleotide/oligosaccharide-binding fold containing 1
chr5_+_178322893 3.03 ENST00000361362.2
ENST00000520660.1
ENST00000520805.1
ZFP2
ZFP2 zinc finger protein
chr20_+_36946029 2.97 ENST00000417318.1
BPI
bactericidal/permeability-increasing protein
chr8_+_142138799 2.96 ENST00000518668.1
DENND3
DENN/MADD domain containing 3
chr4_-_5894777 2.94 ENST00000324989.7
CRMP1
collapsin response mediator protein 1
chr1_-_11907829 2.83 ENST00000376480.3
NPPA
natriuretic peptide A
chr21_+_35747773 2.82 ENST00000399292.3
ENST00000399299.1
ENST00000399295.2
SMIM11
small integral membrane protein 11
chr19_-_12886327 2.79 ENST00000397668.3
ENST00000587178.1
ENST00000264827.5
HOOK2
hook microtubule-tethering protein 2
chr7_-_50132860 2.79 ENST00000046087.2
ZPBP
zona pellucida binding protein
chr19_-_38806560 2.72 ENST00000591755.1
ENST00000337679.8
ENST00000339413.6
YIF1B
Yip1 interacting factor homolog B (S. cerevisiae)
chr7_-_50132801 2.71 ENST00000419417.1
ZPBP
zona pellucida binding protein
chr4_-_119274121 2.68 ENST00000296498.3
PRSS12
protease, serine, 12 (neurotrypsin, motopsin)
chr7_-_100253993 2.67 ENST00000461605.1
ENST00000160382.5
ACTL6B
actin-like 6B
chr12_-_4554780 2.64 ENST00000228837.2
FGF6
fibroblast growth factor 6
chr19_-_1021113 2.63 ENST00000333175.5
ENST00000356663.3
TMEM259
transmembrane protein 259
chr9_+_102668915 2.60 ENST00000259400.6
ENST00000531035.1
ENST00000525640.1
ENST00000534052.1
ENST00000526607.1
STX17
syntaxin 17
chr6_+_42928485 2.58 ENST00000372808.3
GNMT
glycine N-methyltransferase
chr7_+_143880559 2.57 ENST00000486333.1
CTAGE4
CTAGE family, member 4
chr1_+_158975744 2.56 ENST00000426592.2
IFI16
interferon, gamma-inducible protein 16
chr1_+_67773044 2.53 ENST00000262345.1
ENST00000371000.1
IL12RB2
interleukin 12 receptor, beta 2
chr2_+_88469835 2.52 ENST00000358591.2
ENST00000377254.3
ENST00000402102.1
ENST00000419759.1
ENST00000449349.1
ENST00000343544.4
THNSL2
threonine synthase-like 2 (S. cerevisiae)
chr10_-_134756030 2.49 ENST00000368586.5
ENST00000368582.2
TTC40
tetratricopeptide repeat domain 40
chr6_-_30043539 2.47 ENST00000376751.3
ENST00000244360.6
RNF39
ring finger protein 39
chr10_-_51371321 2.40 ENST00000602930.1
AGAP8
ArfGAP with GTPase domain, ankyrin repeat and PH domain 8
chr1_+_45805342 2.39 ENST00000372090.5
TOE1
target of EGR1, member 1 (nuclear)
chr10_+_73975742 2.38 ENST00000299381.4
ANAPC16
anaphase promoting complex subunit 16
chr16_-_90096309 2.34 ENST00000408886.2
C16orf3
chromosome 16 open reading frame 3
chr7_-_44180673 2.32 ENST00000457314.1
ENST00000447951.1
ENST00000431007.1
MYL7
myosin, light chain 7, regulatory
chr14_+_39736299 2.30 ENST00000341502.5
ENST00000396158.2
ENST00000280083.3
CTAGE5
CTAGE family, member 5
chr7_-_4901625 2.28 ENST00000404991.1
PAPOLB
poly(A) polymerase beta (testis specific)
chr20_-_3996036 2.26 ENST00000336095.6
RNF24
ring finger protein 24
chr11_-_18656028 2.25 ENST00000336349.5
SPTY2D1
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr19_+_50321528 2.21 ENST00000312865.6
ENST00000595185.1
ENST00000538643.1
MED25
mediator complex subunit 25
chr7_-_44179972 2.21 ENST00000446581.1
MYL7
myosin, light chain 7, regulatory
chr9_-_111619239 2.19 ENST00000374667.3
ACTL7B
actin-like 7B
chr17_+_40913264 2.16 ENST00000587142.1
ENST00000588576.1
RAMP2
receptor (G protein-coupled) activity modifying protein 2
chr1_-_228613026 2.13 ENST00000366696.1
HIST3H3
histone cluster 3, H3
chr11_-_47470591 2.08 ENST00000524487.1
RAPSN
receptor-associated protein of the synapse
chr19_+_50936142 2.06 ENST00000357701.5
MYBPC2
myosin binding protein C, fast type
chr16_-_57513657 2.04 ENST00000566936.1
ENST00000568617.1
ENST00000567276.1
ENST00000569548.1
ENST00000569250.1
ENST00000564378.1
DOK4
docking protein 4
chr16_+_2285817 2.01 ENST00000564065.1
DNASE1L2
deoxyribonuclease I-like 2
chr6_+_110012462 1.96 ENST00000441478.2
ENST00000230124.3
FIG4
FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
chr2_+_26915584 1.95 ENST00000302909.3
KCNK3
potassium channel, subfamily K, member 3
chr17_+_40913210 1.94 ENST00000253796.5
RAMP2
receptor (G protein-coupled) activity modifying protein 2
chr1_+_24069952 1.93 ENST00000609199.1
TCEB3
transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
chr12_+_52345448 1.92 ENST00000257963.4
ENST00000541224.1
ENST00000426655.2
ENST00000536420.1
ENST00000415850.2
ACVR1B
activin A receptor, type IB
chr2_+_234959323 1.90 ENST00000373368.1
ENST00000168148.3
SPP2
secreted phosphoprotein 2, 24kDa
chr17_-_7493390 1.90 ENST00000538513.2
ENST00000570788.1
ENST00000250055.2
SOX15
SRY (sex determining region Y)-box 15
chr5_-_218251 1.88 ENST00000296824.3
CCDC127
coiled-coil domain containing 127
chr4_+_56212270 1.85 ENST00000264228.4
SRD5A3
steroid 5 alpha-reductase 3
chr22_+_19705928 1.84 ENST00000383045.3
ENST00000438754.2
SEPT5
septin 5
chr11_+_20385666 1.81 ENST00000532081.1
ENST00000531058.1
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr1_-_148347506 1.80 ENST00000369189.3
NBPF20
neuroblastoma breakpoint family, member 20
chr15_-_71407833 1.75 ENST00000449977.2
CT62
cancer/testis antigen 62
chr5_-_133702761 1.72 ENST00000521118.1
ENST00000265334.4
ENST00000435211.1
CDKL3
cyclin-dependent kinase-like 3
chr19_-_6379069 1.64 ENST00000597721.1
PSPN
persephin
chr12_-_71533055 1.64 ENST00000552128.1
TSPAN8
tetraspanin 8
chr1_+_17634689 1.63 ENST00000375453.1
ENST00000375448.4
PADI4
peptidyl arginine deiminase, type IV
chr9_-_136004782 1.63 ENST00000393157.3
RALGDS
ral guanine nucleotide dissociation stimulator
chr11_-_75201791 1.62 ENST00000529721.1
GDPD5
glycerophosphodiester phosphodiesterase domain containing 5
chr9_+_117373486 1.60 ENST00000288502.4
ENST00000374049.4
C9orf91
chromosome 9 open reading frame 91
chr11_-_47470703 1.58 ENST00000298854.2
RAPSN
receptor-associated protein of the synapse
chr17_-_40913275 1.58 ENST00000589716.1
ENST00000360166.3
RAMP2-AS1
RAMP2 antisense RNA 1
chr1_+_1215816 1.53 ENST00000379116.5
SCNN1D
sodium channel, non-voltage-gated 1, delta subunit
chr15_+_45422178 1.53 ENST00000389037.3
ENST00000558322.1
DUOX1
dual oxidase 1
chr6_-_74363803 1.52 ENST00000355773.5
SLC17A5
solute carrier family 17 (acidic sugar transporter), member 5
chr19_+_49977818 1.51 ENST00000594009.1
ENST00000595510.1
FLT3LG
fms-related tyrosine kinase 3 ligand
chr15_+_45422131 1.50 ENST00000321429.4
DUOX1
dual oxidase 1
chr1_-_2145620 1.50 ENST00000545087.1
AL590822.1
Uncharacterized protein
chr7_-_26904317 1.49 ENST00000345317.2
SKAP2
src kinase associated phosphoprotein 2
chr16_+_67062996 1.44 ENST00000561924.2
CBFB
core-binding factor, beta subunit
chr11_-_47470682 1.40 ENST00000529341.1
ENST00000352508.3
RAPSN
receptor-associated protein of the synapse
chr1_-_8483723 1.39 ENST00000476556.1
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr9_-_104145795 1.38 ENST00000259407.2
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr15_-_78933567 1.35 ENST00000261751.3
ENST00000412074.2
CHRNB4
cholinergic receptor, nicotinic, beta 4 (neuronal)
chr11_-_62783303 1.34 ENST00000336232.2
ENST00000430500.2
SLC22A8
solute carrier family 22 (organic anion transporter), member 8
chr19_+_641178 1.34 ENST00000166133.3
FGF22
fibroblast growth factor 22
chrX_-_63615297 1.30 ENST00000374852.3
ENST00000453546.1
MTMR8
myotubularin related protein 8
chr6_-_132032206 1.23 ENST00000314099.8
CTAGE9
CTAGE family, member 9
chr9_+_100263912 1.20 ENST00000259365.4
TMOD1
tropomodulin 1
chr16_+_8715536 1.16 ENST00000563958.1
ENST00000381920.3
ENST00000564554.1
METTL22
methyltransferase like 22
chr7_-_31380502 1.14 ENST00000297142.3
NEUROD6
neuronal differentiation 6
chr19_-_52227221 1.07 ENST00000222115.1
ENST00000540069.2
HAS1
hyaluronan synthase 1
chr3_+_192958914 1.04 ENST00000264735.2
ENST00000602513.1
HRASLS
HRAS-like suppressor
chr17_+_41006095 1.03 ENST00000591562.1
ENST00000588033.1
AOC3
amine oxidase, copper containing 3
chr11_-_62783276 1.02 ENST00000535878.1
ENST00000545207.1
SLC22A8
solute carrier family 22 (organic anion transporter), member 8
chr5_+_69321074 1.01 ENST00000380751.5
ENST00000380750.3
ENST00000503931.1
ENST00000506542.1
SERF1B
small EDRK-rich factor 1B (centromeric)
chr14_+_50779071 0.98 ENST00000426751.2
ATP5S
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
chr16_+_8715574 0.97 ENST00000561758.1
METTL22
methyltransferase like 22
chr17_+_4675175 0.92 ENST00000270560.3
TM4SF5
transmembrane 4 L six family member 5
chr4_+_15704679 0.92 ENST00000382346.3
BST1
bone marrow stromal cell antigen 1
chr9_+_34958254 0.91 ENST00000242315.3
KIAA1045
KIAA1045
chr10_+_96162242 0.88 ENST00000225235.4
TBC1D12
TBC1 domain family, member 12
chr15_+_78632666 0.86 ENST00000299529.6
CRABP1
cellular retinoic acid binding protein 1
chr11_+_20691195 0.85 ENST00000532434.1
NELL1
NEL-like 1 (chicken)
chr6_-_97285336 0.83 ENST00000229955.3
ENST00000417980.1
GPR63
G protein-coupled receptor 63
chr2_-_113993020 0.81 ENST00000465084.1
PAX8
paired box 8
chr19_-_40596828 0.80 ENST00000414720.2
ENST00000455521.1
ENST00000340963.5
ENST00000595773.1
ZNF780A
zinc finger protein 780A
chr18_+_10526008 0.79 ENST00000542979.1
ENST00000322897.6
NAPG
N-ethylmaleimide-sensitive factor attachment protein, gamma
chr10_+_120789223 0.78 ENST00000425699.1
NANOS1
nanos homolog 1 (Drosophila)
chr20_+_2854066 0.78 ENST00000455631.1
ENST00000216877.6
ENST00000399903.2
ENST00000358719.4
ENST00000431048.1
ENST00000425918.2
ENST00000430705.1
ENST00000318266.5
PTPRA
protein tyrosine phosphatase, receptor type, A
chr16_+_72142195 0.76 ENST00000563819.1
ENST00000567142.2
DHX38
DEAH (Asp-Glu-Ala-His) box polypeptide 38
chr1_+_44399466 0.74 ENST00000498139.2
ENST00000491846.1
ARTN
artemin
chr7_+_148936732 0.73 ENST00000335870.2
ZNF212
zinc finger protein 212
chr11_+_124735282 0.73 ENST00000397801.1
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr19_-_18717627 0.71 ENST00000392386.3
CRLF1
cytokine receptor-like factor 1
chr14_-_24732368 0.59 ENST00000544573.1
TGM1
transglutaminase 1
chr5_+_176784837 0.58 ENST00000408923.3
RGS14
regulator of G-protein signaling 14
chr4_+_110749143 0.57 ENST00000317735.4
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr7_-_152133059 0.55 ENST00000262189.6
ENST00000355193.2
KMT2C
lysine (K)-specific methyltransferase 2C
chr19_-_40596767 0.55 ENST00000599972.1
ENST00000450241.2
ENST00000595687.2
ZNF780A
zinc finger protein 780A
chr17_-_7218631 0.55 ENST00000577040.2
ENST00000389167.5
ENST00000391950.3
GPS2
G protein pathway suppressor 2
chr20_-_45061695 0.52 ENST00000445496.2
ELMO2
engulfment and cell motility 2
chr12_+_106696581 0.51 ENST00000547153.1
ENST00000299045.3
ENST00000546625.1
ENST00000553098.1
TCP11L2
t-complex 11, testis-specific-like 2
chr20_-_44991813 0.50 ENST00000372227.1
SLC35C2
solute carrier family 35 (GDP-fucose transporter), member C2
chr11_-_100999775 0.49 ENST00000263463.5
PGR
progesterone receptor
chr16_+_10971037 0.36 ENST00000324288.8
ENST00000381835.5
CIITA
class II, major histocompatibility complex, transactivator
chr1_-_202897724 0.34 ENST00000435533.3
ENST00000367258.1
KLHL12
kelch-like family member 12
chr8_-_6914251 0.33 ENST00000330590.2
DEFA5
defensin, alpha 5, Paneth cell-specific
chr19_-_41945804 0.32 ENST00000221943.9
ENST00000597457.1
ENST00000589970.1
ENST00000595425.1
ENST00000438807.3
ENST00000589102.1
ENST00000592922.2
ATP5SL
ATP5S-like
chr14_+_65878565 0.31 ENST00000556518.1
ENST00000557164.1
FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr16_+_333152 0.30 ENST00000219406.6
ENST00000404312.1
ENST00000456379.1
PDIA2
protein disulfide isomerase family A, member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of GCM1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 19.2 GO:0033212 iron assimilation(GO:0033212) iron assimilation by chelation and transport(GO:0033214) positive regulation of bone mineralization involved in bone maturation(GO:1900159) negative regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000308)
3.0 8.9 GO:0002522 leukocyte migration involved in immune response(GO:0002522)
2.5 17.5 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
2.3 6.8 GO:0001812 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type I hypersensitivity(GO:0001812) positive regulation of type II hypersensitivity(GO:0002894) positive regulation of mast cell cytokine production(GO:0032765) mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
2.2 13.5 GO:0045903 positive regulation of translational fidelity(GO:0045903)
1.7 5.1 GO:1900073 regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075)
1.5 4.4 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
1.4 4.1 GO:1902263 apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
1.4 4.1 GO:0060398 regulation of growth hormone receptor signaling pathway(GO:0060398)
1.2 7.1 GO:0000821 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
1.2 26.1 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
1.2 7.1 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
1.0 174.7 GO:0002377 immunoglobulin production(GO:0002377)
1.0 2.9 GO:1904617 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.9 6.5 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.9 124.8 GO:0030449 regulation of complement activation(GO:0030449)
0.9 4.5 GO:0030997 regulation of centriole-centriole cohesion(GO:0030997)
0.8 8.4 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.8 2.5 GO:0006566 threonine metabolic process(GO:0006566)
0.8 3.0 GO:0042335 cuticle development(GO:0042335)
0.7 4.9 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.7 4.2 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.7 9.8 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.6 1.9 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.6 1.9 GO:0070318 myoblast development(GO:0048627) positive regulation of G0 to G1 transition(GO:0070318)
0.6 1.8 GO:0016095 polyprenol catabolic process(GO:0016095)
0.6 6.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.6 3.4 GO:0007296 vitellogenesis(GO:0007296)
0.5 16.6 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.5 2.6 GO:0016240 autophagosome docking(GO:0016240)
0.5 2.0 GO:0003335 corneocyte development(GO:0003335)
0.5 1.5 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.5 4.1 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.4 6.4 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.4 7.5 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.3 1.4 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.3 1.6 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.3 3.2 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.3 3.5 GO:0036159 inner dynein arm assembly(GO:0036159)
0.3 3.0 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.3 0.9 GO:0008300 isoprenoid catabolic process(GO:0008300) diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.3 2.3 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.3 2.0 GO:0031642 negative regulation of myelination(GO:0031642)
0.3 0.8 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460) regulation of thyroid-stimulating hormone secretion(GO:2000612)
0.2 4.5 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.2 3.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.2 1.8 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.2 1.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.2 0.6 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.2 5.1 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.2 0.7 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.2 1.4 GO:0019530 taurine metabolic process(GO:0019530)
0.2 1.6 GO:0048505 regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505)
0.1 0.7 GO:0048537 mucosal-associated lymphoid tissue development(GO:0048537) Peyer's patch development(GO:0048541) Peyer's patch morphogenesis(GO:0061146) lymphocyte migration into lymphoid organs(GO:0097021)
0.1 2.1 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 5.7 GO:0043029 T cell homeostasis(GO:0043029)
0.1 5.5 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.1 2.6 GO:1904294 positive regulation of ERAD pathway(GO:1904294)
0.1 0.5 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.1 5.7 GO:0008333 endosome to lysosome transport(GO:0008333)
0.1 3.2 GO:0006972 hyperosmotic response(GO:0006972)
0.1 1.4 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.1 2.6 GO:0001502 cartilage condensation(GO:0001502)
0.1 0.7 GO:0016199 axon midline choice point recognition(GO:0016199)
0.1 2.6 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.1 2.2 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)
0.1 2.0 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.1 0.6 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 3.1 GO:0040020 regulation of meiotic nuclear division(GO:0040020)
0.1 1.1 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
0.1 0.4 GO:0045348 positive regulation of MHC class II biosynthetic process(GO:0045348)
0.1 2.1 GO:0051290 protein heterotetramerization(GO:0051290)
0.1 5.5 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.1 0.1 GO:0002837 regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839) negative regulation of endothelial cell chemotaxis(GO:2001027)
0.1 2.5 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
0.1 3.1 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.1 0.8 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.1 0.9 GO:0030890 positive regulation of B cell proliferation(GO:0030890)
0.1 2.6 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.3 GO:1903116 positive regulation of actin filament-based movement(GO:1903116) positive regulation of cardiac conduction(GO:1903781) positive regulation of atrial cardiac muscle cell action potential(GO:1903949) positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736)
0.1 5.4 GO:0046849 bone remodeling(GO:0046849)
0.1 5.2 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 2.4 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 0.5 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.1 4.8 GO:0000724 double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.1 1.1 GO:0021542 dentate gyrus development(GO:0021542)
0.0 2.3 GO:0043631 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.0 1.7 GO:0030517 negative regulation of axon extension(GO:0030517)
0.0 0.1 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.0 9.0 GO:0071897 DNA biosynthetic process(GO:0071897)
0.0 15.7 GO:0002250 adaptive immune response(GO:0002250)
0.0 6.4 GO:0001889 liver development(GO:0001889)
0.0 0.8 GO:1900153 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.0 0.6 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 1.2 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 1.0 GO:0051354 negative regulation of oxidoreductase activity(GO:0051354)
0.0 1.6 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 2.7 GO:0021510 spinal cord development(GO:0021510)
0.0 4.3 GO:0050663 cytokine secretion(GO:0050663)
0.0 0.9 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.0 2.7 GO:0018022 peptidyl-lysine methylation(GO:0018022)
0.0 1.2 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.2 GO:0060346 sequestering of TGFbeta in extracellular matrix(GO:0035583) bone trabecula formation(GO:0060346)
0.0 0.3 GO:0014029 neural crest formation(GO:0014029)
0.0 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 2.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.5 GO:0042113 B cell activation(GO:0042113)
0.0 0.1 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0006021 inositol biosynthetic process(GO:0006021)
0.0 0.1 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 1.4 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.1 GO:0002922 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) positive regulation of humoral immune response(GO:0002922)
0.0 0.9 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.9 GO:1901264 carbohydrate derivative transport(GO:1901264)
0.0 0.8 GO:0031124 mRNA 3'-end processing(GO:0031124)
0.0 0.3 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.2 GO:0006298 mismatch repair(GO:0006298)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 19.2 GO:0097013 phagocytic vesicle lumen(GO:0097013)
2.4 12.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.9 7.1 GO:0035976 AP1 complex(GO:0035976)
0.9 4.3 GO:0036398 TCR signalosome(GO:0036398)
0.8 16.6 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.7 4.2 GO:0033063 DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.7 2.8 GO:0070695 FHF complex(GO:0070695)
0.6 4.1 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.4 5.1 GO:0099634 postsynaptic specialization membrane(GO:0099634)
0.4 3.6 GO:0016013 syntrophin complex(GO:0016013)
0.4 2.6 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.3 4.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.3 8.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.3 5.4 GO:0031089 platelet dense granule lumen(GO:0031089)
0.2 3.5 GO:0005858 axonemal dynein complex(GO:0005858)
0.2 0.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.2 5.5 GO:0002080 acrosomal membrane(GO:0002080)
0.2 2.7 GO:0043083 synaptic cleft(GO:0043083)
0.2 9.9 GO:1990391 DNA repair complex(GO:1990391)
0.2 13.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 39.9 GO:0072562 blood microparticle(GO:0072562)
0.2 1.9 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.2 2.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 6.1 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 4.1 GO:0031904 endosome lumen(GO:0031904)
0.1 3.7 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1 2.7 GO:0071565 nBAF complex(GO:0071565)
0.1 192.1 GO:0005615 extracellular space(GO:0005615)
0.1 4.5 GO:0031672 A band(GO:0031672)
0.1 1.0 GO:0005902 microvillus(GO:0005902)
0.1 1.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 8.1 GO:0070821 tertiary granule membrane(GO:0070821)
0.1 19.4 GO:0005770 late endosome(GO:0005770)
0.1 8.9 GO:0005901 caveola(GO:0005901)
0.1 2.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 2.1 GO:0032982 myosin filament(GO:0032982)
0.1 0.9 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 4.9 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 3.0 GO:0035580 specific granule lumen(GO:0035580)
0.1 21.9 GO:0010008 endosome membrane(GO:0010008)
0.1 1.2 GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 5.0 GO:0005882 intermediate filament(GO:0005882)
0.1 1.0 GO:0005903 brush border(GO:0005903)
0.1 0.6 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 11.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 4.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.3 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 1.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.8 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 3.2 GO:0031514 motile cilium(GO:0031514)
0.0 3.0 GO:0005814 centriole(GO:0005814)
0.0 1.5 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.8 GO:0031201 SNARE complex(GO:0031201)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.2 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 2.5 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.1 GO:0030673 axolemma(GO:0030673)
0.0 1.9 GO:1902554 serine/threonine protein kinase complex(GO:1902554)
0.0 0.6 GO:0001533 cornified envelope(GO:0001533)
0.0 0.9 GO:0005776 autophagosome(GO:0005776)
0.0 0.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.3 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.7 GO:0009897 external side of plasma membrane(GO:0009897)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 13.5 GO:1990932 5.8S rRNA binding(GO:1990932)
1.6 6.4 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971) thiol oxidase activity(GO:0016972)
1.6 17.5 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
1.5 16.6 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
1.1 6.8 GO:0019763 immunoglobulin receptor activity(GO:0019763)
1.0 242.0 GO:0003823 antigen binding(GO:0003823)
0.9 6.4 GO:0008142 oxysterol binding(GO:0008142)
0.8 2.5 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.7 22.2 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.6 11.7 GO:0019992 diacylglycerol binding(GO:0019992)
0.6 12.2 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.6 1.8 GO:0033765 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751)
0.6 4.1 GO:0097643 amylin receptor activity(GO:0097643)
0.5 7.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.5 3.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.5 2.0 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.5 1.9 GO:0016361 activin receptor activity, type I(GO:0016361)
0.5 1.4 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.4 4.7 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.4 12.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.4 3.2 GO:0008172 S-methyltransferase activity(GO:0008172) DNA-methyltransferase activity(GO:0009008)
0.4 1.6 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.4 4.4 GO:0019211 phosphatase activator activity(GO:0019211)
0.4 4.2 GO:0000150 recombinase activity(GO:0000150)
0.4 1.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.3 1.0 GO:0052594 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.3 1.6 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.3 2.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.3 0.9 GO:0003953 NAD+ nucleosidase activity(GO:0003953) NAD(P)+ nucleosidase activity(GO:0050135)
0.2 6.3 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.2 2.3 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.2 3.0 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.2 2.6 GO:0016594 glycine binding(GO:0016594)
0.1 5.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 8.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 4.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 3.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.7 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 2.9 GO:0031005 filamin binding(GO:0031005)
0.1 5.7 GO:0042169 SH2 domain binding(GO:0042169)
0.1 2.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 1.8 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.1 1.4 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 4.1 GO:0070840 dynein complex binding(GO:0070840)
0.1 0.8 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.1 2.3 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 2.0 GO:0044548 S100 protein binding(GO:0044548)
0.1 2.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 1.5 GO:0005351 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.1 2.2 GO:0046965 retinoid X receptor binding(GO:0046965)
0.1 0.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 3.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 2.4 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.1 16.5 GO:0005125 cytokine activity(GO:0005125)
0.1 6.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 2.0 GO:0005158 insulin receptor binding(GO:0005158)
0.1 0.9 GO:0016918 retinal binding(GO:0016918)
0.1 3.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 2.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 1.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.6 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 2.7 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 2.7 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0 28.0 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 1.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.8 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.6 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.3 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 1.7 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.8 GO:0030371 translation repressor activity(GO:0030371)
0.0 2.4 GO:0008083 growth factor activity(GO:0008083)
0.0 0.3 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438) phosphatidylinositol monophosphate phosphatase activity(GO:0052744)
0.0 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 3.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.1 GO:0052832 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 4.5 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.6 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 2.6 GO:0001047 core promoter binding(GO:0001047)
0.0 9.3 GO:0008047 enzyme activator activity(GO:0008047)
0.0 2.0 GO:0004519 endonuclease activity(GO:0004519)
0.0 0.5 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 4.7 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.2 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 9.1 GO:0008270 zinc ion binding(GO:0008270)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 26.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.5 21.6 PID S1P S1P3 PATHWAY S1P3 pathway
0.3 5.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2 11.7 PID RAS PATHWAY Regulation of Ras family activation
0.2 8.9 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.2 4.9 PID ARF 3PATHWAY Arf1 pathway
0.2 4.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 4.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 6.8 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 6.4 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 7.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 2.5 PID IL27 PATHWAY IL27-mediated signaling events
0.0 3.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 2.7 PID FGF PATHWAY FGF signaling pathway
0.0 0.5 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.8 PID INSULIN PATHWAY Insulin Pathway
0.0 5.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.6 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 17.5 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
2.6 26.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.4 19.2 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.4 6.8 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.3 8.9 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.3 11.1 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 4.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 6.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.2 4.0 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.2 4.1 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.2 4.4 REACTOME PROLONGED ERK ACTIVATION EVENTS Genes involved in Prolonged ERK activation events
0.2 2.0 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.2 5.5 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.2 7.1 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2 13.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.8 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.8 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 4.3 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.1 2.9 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 4.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 2.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 3.2 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.1 1.9 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.4 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 1.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 3.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.7 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.6 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 1.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 0.6 REACTOME OPSINS Genes involved in Opsins
0.0 3.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.1 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 3.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 2.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 3.2 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 1.1 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.3 REACTOME DEFENSINS Genes involved in Defensins
0.0 0.8 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 3.4 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway