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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GCM2

Z-value: 1.01

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Transcription factors associated with GCM2

Gene Symbol Gene ID Gene Info
GCM2
ENSG00000124827.6 glial cells missing transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GCM2hg19_v2_chr6_-_10882174_108822740.143.9e-02Click!

Activity profile of GCM2 motif

Sorted Z-values of GCM2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_47105309 13.11 ENST00000599839.1
ENST00000596362.1
CALM3
calmodulin 3 (phosphorylase kinase, delta)
chrX_-_71526813 10.87 ENST00000246139.5
CITED1
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
chr1_+_43824577 9.23 ENST00000310955.6
CDC20
cell division cycle 20
chr1_+_43824669 9.19 ENST00000372462.1
CDC20
cell division cycle 20
chr9_-_130635741 8.33 ENST00000223836.10
AK1
adenylate kinase 1
chr14_-_60097524 8.16 ENST00000342503.4
RTN1
reticulon 1
chrX_-_71526999 7.65 ENST00000453707.2
ENST00000373619.3
CITED1
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
chr1_-_55352834 7.51 ENST00000371269.3
DHCR24
24-dehydrocholesterol reductase
chr14_-_60097297 7.44 ENST00000395090.1
RTN1
reticulon 1
chr6_-_52859968 7.19 ENST00000370959.1
GSTA4
glutathione S-transferase alpha 4
chr7_-_44365020 6.86 ENST00000395747.2
ENST00000347193.4
ENST00000346990.4
ENST00000258682.6
ENST00000353625.4
ENST00000421607.1
ENST00000424197.1
ENST00000502837.2
ENST00000350811.3
ENST00000395749.2
CAMK2B
calcium/calmodulin-dependent protein kinase II beta
chr22_-_20307532 6.83 ENST00000405465.3
ENST00000248879.3
DGCR6L
DiGeorge syndrome critical region gene 6-like
chr6_-_110500905 6.71 ENST00000392587.2
WASF1
WAS protein family, member 1
chr2_+_73114489 6.45 ENST00000234454.5
SPR
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
chr18_+_3449695 5.66 ENST00000343820.5
TGIF1
TGFB-induced factor homeobox 1
chr6_+_31633902 5.58 ENST00000375865.2
ENST00000375866.2
CSNK2B
casein kinase 2, beta polypeptide
chr7_+_12727250 5.04 ENST00000404894.1
ARL4A
ADP-ribosylation factor-like 4A
chr6_+_31633833 4.97 ENST00000375882.2
ENST00000375880.2
CSNK2B
CSNK2B-LY6G5B-1181
casein kinase 2, beta polypeptide
Uncharacterized protein
chr8_+_20054878 4.92 ENST00000276390.2
ENST00000519667.1
ATP6V1B2
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
chr16_+_2564254 4.92 ENST00000565223.1
ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr7_+_6048856 4.81 ENST00000223029.3
ENST00000400479.2
ENST00000395236.2
AIMP2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
chr9_-_99417562 4.79 ENST00000375234.3
ENST00000446045.1
AAED1
AhpC/TSA antioxidant enzyme domain containing 1
chr11_+_63448918 4.78 ENST00000341307.2
ENST00000356000.3
ENST00000542238.1
RTN3
reticulon 3
chr17_-_10017864 4.75 ENST00000323816.4
GAS7
growth arrest-specific 7
chr11_+_63448955 4.71 ENST00000377819.5
ENST00000339997.4
ENST00000540798.1
ENST00000545432.1
ENST00000543552.1
ENST00000537981.1
RTN3
reticulon 3
chr15_-_41624685 4.40 ENST00000560640.1
ENST00000220514.3
OIP5
Opa interacting protein 5
chr20_+_1115821 4.25 ENST00000435720.1
PSMF1
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr1_-_204116078 4.21 ENST00000367198.2
ENST00000452983.1
ETNK2
ethanolamine kinase 2
chr15_-_75248954 4.11 ENST00000499788.2
RPP25
ribonuclease P/MRP 25kDa subunit
chr17_-_7197881 4.10 ENST00000007699.5
YBX2
Y box binding protein 2
chr3_+_50712672 4.01 ENST00000266037.9
DOCK3
dedicator of cytokinesis 3
chr19_+_19626531 3.98 ENST00000507754.4
NDUFA13
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
chr9_+_131873659 3.93 ENST00000452489.2
ENST00000347048.4
ENST00000357197.4
ENST00000445241.1
ENST00000355007.3
ENST00000414331.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr12_-_49582593 3.92 ENST00000295766.5
TUBA1A
tubulin, alpha 1a
chr18_+_3449821 3.86 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGIF1
TGFB-induced factor homeobox 1
chr7_-_150754935 3.84 ENST00000297518.4
CDK5
cyclin-dependent kinase 5
chr10_-_21786179 3.79 ENST00000377113.5
CASC10
cancer susceptibility candidate 10
chr14_+_75536335 3.78 ENST00000554763.1
ENST00000439583.2
ENST00000526130.1
ENST00000525046.1
ZC2HC1C
zinc finger, C2HC-type containing 1C
chr19_+_35783047 3.68 ENST00000595791.1
ENST00000597035.1
ENST00000537831.2
MAG
myelin associated glycoprotein
chr2_-_33824336 3.67 ENST00000431950.1
ENST00000403368.1
ENST00000441530.2
FAM98A
family with sequence similarity 98, member A
chr14_+_75536280 3.65 ENST00000238686.8
ZC2HC1C
zinc finger, C2HC-type containing 1C
chr16_+_71392616 3.63 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
CALB2
calbindin 2
chr19_+_35783028 3.59 ENST00000600291.1
ENST00000392213.3
MAG
myelin associated glycoprotein
chr1_-_167906277 3.54 ENST00000271373.4
MPC2
mitochondrial pyruvate carrier 2
chr2_-_33824382 3.52 ENST00000238823.8
FAM98A
family with sequence similarity 98, member A
chr19_+_6361754 3.44 ENST00000597326.1
CLPP
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chrX_-_77225135 3.42 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr7_+_116139744 3.41 ENST00000343213.2
CAV2
caveolin 2
chr19_+_35783037 3.34 ENST00000361922.4
MAG
myelin associated glycoprotein
chr5_+_82767284 3.31 ENST00000265077.3
VCAN
versican
chr13_-_45010939 3.29 ENST00000261489.2
TSC22D1
TSC22 domain family, member 1
chr3_+_35681081 3.29 ENST00000428373.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr11_+_86511569 3.22 ENST00000441050.1
PRSS23
protease, serine, 23
chr11_+_73882144 3.21 ENST00000328257.8
PPME1
protein phosphatase methylesterase 1
chr2_-_220252603 3.17 ENST00000322176.7
ENST00000273075.4
DNPEP
aspartyl aminopeptidase
chr8_-_98290087 3.14 ENST00000322128.3
TSPYL5
TSPY-like 5
chr15_-_45670924 3.10 ENST00000396659.3
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr7_+_148395959 3.06 ENST00000325222.4
CUL1
cullin 1
chrX_+_128674213 3.03 ENST00000371113.4
ENST00000357121.5
OCRL
oculocerebrorenal syndrome of Lowe
chr2_-_179315786 2.96 ENST00000457633.1
ENST00000438687.3
ENST00000325748.4
PRKRA
protein kinase, interferon-inducible double stranded RNA dependent activator
chr2_-_44588624 2.93 ENST00000438314.1
ENST00000409936.1
PREPL
prolyl endopeptidase-like
chr2_-_44588694 2.93 ENST00000409957.1
PREPL
prolyl endopeptidase-like
chr3_-_79068594 2.91 ENST00000436010.2
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr3_+_126707437 2.90 ENST00000393409.2
ENST00000251772.4
PLXNA1
plexin A1
chr2_-_44588679 2.87 ENST00000409411.1
PREPL
prolyl endopeptidase-like
chr7_+_148395733 2.83 ENST00000602748.1
CUL1
cullin 1
chr5_+_140743859 2.69 ENST00000518069.1
PCDHGA5
protocadherin gamma subfamily A, 5
chr1_+_15272271 2.68 ENST00000400797.3
KAZN
kazrin, periplakin interacting protein
chr11_-_6341724 2.66 ENST00000530979.1
PRKCDBP
protein kinase C, delta binding protein
chr3_+_130650738 2.66 ENST00000504612.1
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr3_+_156008809 2.62 ENST00000302490.8
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr1_+_156105878 2.60 ENST00000508500.1
LMNA
lamin A/C
chr16_+_25123041 2.50 ENST00000399069.3
ENST00000380966.4
LCMT1
leucine carboxyl methyltransferase 1
chr5_+_140345820 2.43 ENST00000289269.5
PCDHAC2
protocadherin alpha subfamily C, 2
chr17_-_41132010 2.39 ENST00000409103.1
ENST00000360221.4
PTGES3L-AARSD1
PTGES3L-AARSD1 readthrough
chr2_-_179315490 2.39 ENST00000487082.1
PRKRA
protein kinase, interferon-inducible double stranded RNA dependent activator
chr1_+_44444865 2.36 ENST00000372324.1
B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr2_-_220436248 2.36 ENST00000265318.4
OBSL1
obscurin-like 1
chr2_-_220408430 2.27 ENST00000243776.6
CHPF
chondroitin polymerizing factor
chr5_-_137878887 2.26 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
ETF1
eukaryotic translation termination factor 1
chr11_-_64410787 2.25 ENST00000301894.2
NRXN2
neurexin 2
chr7_-_100808394 2.14 ENST00000445482.2
VGF
VGF nerve growth factor inducible
chr15_+_89010923 2.08 ENST00000353598.6
MRPS11
mitochondrial ribosomal protein S11
chr8_+_66556936 2.08 ENST00000262146.4
MTFR1
mitochondrial fission regulator 1
chr10_+_102790980 2.06 ENST00000393459.1
ENST00000224807.5
SFXN3
sideroflexin 3
chr12_+_56618102 2.00 ENST00000267023.4
ENST00000380198.2
ENST00000341463.5
NABP2
nucleic acid binding protein 2
chr9_-_13279589 1.99 ENST00000319217.7
MPDZ
multiple PDZ domain protein
chr15_-_89010607 1.99 ENST00000312475.4
MRPL46
mitochondrial ribosomal protein L46
chr7_-_44365216 1.99 ENST00000358707.3
ENST00000457475.1
ENST00000440254.2
CAMK2B
calcium/calmodulin-dependent protein kinase II beta
chr19_+_6361795 1.95 ENST00000596149.1
CLPP
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chrX_-_63005405 1.90 ENST00000374878.1
ENST00000437457.2
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr15_+_43809797 1.82 ENST00000399453.1
ENST00000300231.5
MAP1A
microtubule-associated protein 1A
chr19_+_6361440 1.78 ENST00000245816.4
CLPP
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr16_+_30759563 1.75 ENST00000563588.1
ENST00000565924.1
ENST00000424889.3
PHKG2
phosphorylase kinase, gamma 2 (testis)
chr15_+_40733387 1.73 ENST00000416165.1
BAHD1
bromo adjacent homology domain containing 1
chr1_+_155179012 1.72 ENST00000609421.1
MTX1
metaxin 1
chr15_+_78632666 1.72 ENST00000299529.6
CRABP1
cellular retinoic acid binding protein 1
chr2_-_220435963 1.72 ENST00000373876.1
ENST00000404537.1
ENST00000603926.1
ENST00000373873.4
ENST00000289656.3
OBSL1
obscurin-like 1
chr17_-_76899275 1.64 ENST00000322630.2
ENST00000586713.1
DDC8
Protein DDC8 homolog
chr5_+_157170703 1.61 ENST00000286307.5
LSM11
LSM11, U7 small nuclear RNA associated
chr5_+_134240588 1.59 ENST00000254908.6
PCBD2
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
chr9_-_13279563 1.58 ENST00000541718.1
MPDZ
multiple PDZ domain protein
chr15_-_64665911 1.57 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
CTD-2116N17.1
Uncharacterized protein
chr19_+_6361841 1.48 ENST00000596605.1
CLPP
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr3_-_119813264 1.46 ENST00000264235.8
GSK3B
glycogen synthase kinase 3 beta
chr20_-_30795511 1.46 ENST00000246229.4
PLAGL2
pleiomorphic adenoma gene-like 2
chr5_+_82767487 1.42 ENST00000343200.5
ENST00000342785.4
VCAN
versican
chr19_+_5823813 1.42 ENST00000303212.2
NRTN
neurturin
chr16_+_30759700 1.42 ENST00000328273.7
PHKG2
phosphorylase kinase, gamma 2 (testis)
chr2_+_234627424 1.41 ENST00000373409.3
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chr5_+_82767583 1.34 ENST00000512590.2
ENST00000513960.1
ENST00000513984.1
ENST00000502527.2
VCAN
versican
chr15_+_40731920 1.33 ENST00000561234.1
BAHD1
bromo adjacent homology domain containing 1
chr12_+_56360550 1.33 ENST00000266970.4
CDK2
cyclin-dependent kinase 2
chr1_+_180601139 1.33 ENST00000367590.4
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr15_+_41624892 1.32 ENST00000260359.6
ENST00000450318.1
ENST00000450592.2
ENST00000559596.1
ENST00000414849.2
ENST00000560747.1
ENST00000560177.1
NUSAP1
nucleolar and spindle associated protein 1
chr3_-_11762202 1.23 ENST00000445411.1
ENST00000404339.1
ENST00000273038.3
VGLL4
vestigial like 4 (Drosophila)
chr10_-_102790852 1.22 ENST00000470414.1
ENST00000370215.3
PDZD7
PDZ domain containing 7
chr17_+_53342311 1.20 ENST00000226067.5
HLF
hepatic leukemia factor
chr5_+_137774706 1.18 ENST00000378339.2
ENST00000254901.5
ENST00000506158.1
REEP2
receptor accessory protein 2
chr12_+_56360605 1.18 ENST00000553376.1
ENST00000440311.2
ENST00000354056.4
CDK2
cyclin-dependent kinase 2
chr9_-_127263265 1.17 ENST00000373587.3
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr17_+_7358889 1.16 ENST00000575379.1
CHRNB1
cholinergic receptor, nicotinic, beta 1 (muscle)
chr14_-_75536182 1.15 ENST00000555463.1
ACYP1
acylphosphatase 1, erythrocyte (common) type
chr18_-_29264669 1.12 ENST00000306851.5
B4GALT6
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
chr11_+_92085707 1.12 ENST00000525166.1
FAT3
FAT atypical cadherin 3
chr8_+_117950422 1.11 ENST00000378279.3
AARD
alanine and arginine rich domain containing protein
chr19_-_18653781 1.10 ENST00000596558.2
ENST00000453489.2
FKBP8
FK506 binding protein 8, 38kDa
chr11_+_92085262 1.08 ENST00000298047.6
ENST00000409404.2
ENST00000541502.1
FAT3
FAT atypical cadherin 3
chr5_+_113697983 1.01 ENST00000264773.3
KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr4_-_74864386 1.00 ENST00000296027.4
CXCL5
chemokine (C-X-C motif) ligand 5
chr2_-_179315453 1.00 ENST00000432031.2
PRKRA
protein kinase, interferon-inducible double stranded RNA dependent activator
chr7_-_6048650 0.99 ENST00000382321.4
ENST00000406569.3
PMS2
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chr13_-_47471155 0.93 ENST00000543956.1
ENST00000542664.1
HTR2A
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
chr19_-_14316980 0.92 ENST00000361434.3
ENST00000340736.6
LPHN1
latrophilin 1
chrX_+_120181457 0.92 ENST00000328078.1
GLUD2
glutamate dehydrogenase 2
chr16_+_69221028 0.92 ENST00000336278.4
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr7_-_27169801 0.92 ENST00000511914.1
HOXA4
homeobox A4
chr17_-_46703826 0.91 ENST00000550387.1
ENST00000311177.5
HOXB9
homeobox B9
chrX_+_99839799 0.88 ENST00000373031.4
TNMD
tenomodulin
chr22_+_19710468 0.88 ENST00000366425.3
GP1BB
glycoprotein Ib (platelet), beta polypeptide
chr9_+_4490394 0.87 ENST00000262352.3
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr16_+_28996364 0.87 ENST00000564277.1
LAT
linker for activation of T cells
chr19_+_2236509 0.86 ENST00000221494.5
SF3A2
splicing factor 3a, subunit 2, 66kDa
chr7_-_100808843 0.83 ENST00000249330.2
VGF
VGF nerve growth factor inducible
chr18_+_55102917 0.82 ENST00000491143.2
ONECUT2
one cut homeobox 2
chr2_+_16080659 0.82 ENST00000281043.3
MYCN
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
chr7_-_6048702 0.79 ENST00000265849.7
PMS2
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chrX_-_119763835 0.78 ENST00000371313.2
ENST00000304661.5
C1GALT1C1
C1GALT1-specific chaperone 1
chr1_-_21503337 0.75 ENST00000400422.1
ENST00000602326.1
ENST00000411888.1
ENST00000438975.1
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr12_-_322504 0.74 ENST00000424061.2
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr17_-_42908155 0.71 ENST00000426548.1
ENST00000590758.1
ENST00000591424.1
GJC1
gap junction protein, gamma 1, 45kDa
chr22_-_29457832 0.70 ENST00000216071.4
C22orf31
chromosome 22 open reading frame 31
chr6_+_37787458 0.66 ENST00000373391.2
ZFAND3
zinc finger, AN1-type domain 3
chr22_+_31489344 0.65 ENST00000404574.1
SMTN
smoothelin
chr14_-_105635090 0.65 ENST00000331782.3
ENST00000347004.2
JAG2
jagged 2
chr12_+_56390964 0.65 ENST00000356124.4
ENST00000266971.3
ENST00000394115.2
ENST00000547586.1
ENST00000552258.1
ENST00000548274.1
ENST00000546833.1
SUOX
sulfite oxidase
chr14_-_59932044 0.64 ENST00000395116.1
GPR135
G protein-coupled receptor 135
chr12_-_56122124 0.64 ENST00000552754.1
CD63
CD63 molecule
chr6_+_46761118 0.63 ENST00000230588.4
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr19_-_2236290 0.63 ENST00000591099.2
ENST00000586608.2
ENST00000326631.2
ENST00000587962.2
PLEKHJ1
pleckstrin homology domain containing, family J member 1
chr12_+_5541267 0.60 ENST00000423158.3
NTF3
neurotrophin 3
chr6_-_13621126 0.59 ENST00000600057.1
AL441883.1
Uncharacterized protein
chr1_+_156698708 0.57 ENST00000519086.1
RRNAD1
ribosomal RNA adenine dimethylase domain containing 1
chr14_+_21359558 0.56 ENST00000304639.3
RNASE3
ribonuclease, RNase A family, 3
chr17_-_7218631 0.56 ENST00000577040.2
ENST00000389167.5
ENST00000391950.3
GPS2
G protein pathway suppressor 2
chr5_+_176560007 0.55 ENST00000510954.1
ENST00000354179.4
NSD1
nuclear receptor binding SET domain protein 1
chrX_+_12156582 0.52 ENST00000380682.1
FRMPD4
FERM and PDZ domain containing 4
chr6_-_138539627 0.51 ENST00000527246.2
PBOV1
prostate and breast cancer overexpressed 1
chr17_+_79989500 0.50 ENST00000306897.4
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr19_+_42829702 0.50 ENST00000334370.4
MEGF8
multiple EGF-like-domains 8
chr1_+_46640750 0.49 ENST00000372003.1
TSPAN1
tetraspanin 1
chr15_-_34331243 0.48 ENST00000306730.3
AVEN
apoptosis, caspase activation inhibitor
chr17_-_7123021 0.47 ENST00000399510.2
DLG4
discs, large homolog 4 (Drosophila)
chr11_+_76778033 0.46 ENST00000456580.2
CAPN5
calpain 5
chr13_-_44735393 0.45 ENST00000400419.1
SMIM2
small integral membrane protein 2
chr6_+_7108210 0.45 ENST00000467782.1
ENST00000334984.6
ENST00000349384.6
RREB1
ras responsive element binding protein 1
chr1_-_223537475 0.39 ENST00000344029.6
ENST00000494793.2
ENST00000366878.4
ENST00000366877.3
SUSD4
sushi domain containing 4
chr19_+_36132631 0.39 ENST00000379026.2
ENST00000379023.4
ENST00000402764.2
ENST00000479824.1
ETV2
ets variant 2
chrX_-_41782592 0.38 ENST00000378158.1
CASK
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
chr12_+_5019061 0.36 ENST00000382545.3
KCNA1
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
chr1_+_17944832 0.35 ENST00000167825.4
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr1_+_17944806 0.35 ENST00000375408.3
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr3_-_138553779 0.34 ENST00000461451.1
PIK3CB
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
chr9_+_15422702 0.34 ENST00000380821.3
ENST00000421710.1
SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr10_-_70092635 0.34 ENST00000309049.4
PBLD
phenazine biosynthesis-like protein domain containing
chr11_+_4116054 0.34 ENST00000423050.2
RRM1
ribonucleotide reductase M1
chr5_+_122847781 0.34 ENST00000395412.1
ENST00000395411.1
ENST00000345990.4
CSNK1G3
casein kinase 1, gamma 3
chr16_+_22825475 0.33 ENST00000261374.3
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr19_-_51531210 0.30 ENST00000391804.3
KLK11
kallikrein-related peptidase 11
chr11_+_64001962 0.29 ENST00000309422.2
VEGFB
vascular endothelial growth factor B
chr19_+_41222998 0.27 ENST00000263370.2
ITPKC
inositol-trisphosphate 3-kinase C
chr12_+_81110684 0.27 ENST00000228644.3
MYF5
myogenic factor 5
chrX_+_46937745 0.24 ENST00000397180.1
ENST00000457380.1
ENST00000352078.4
RGN
regucalcin
chr7_-_8301768 0.24 ENST00000265577.7
ICA1
islet cell autoantigen 1, 69kDa
chr8_-_144897138 0.23 ENST00000377533.3
SCRIB
scribbled planar cell polarity protein
chr1_+_156698234 0.22 ENST00000368218.4
ENST00000368216.4
RRNAD1
ribosomal RNA adenine dimethylase domain containing 1
chr11_+_64002292 0.22 ENST00000426086.2
VEGFB
vascular endothelial growth factor B
chr15_-_88799384 0.22 ENST00000540489.2
ENST00000557856.1
ENST00000558676.1
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr1_-_205313304 0.21 ENST00000539253.1
ENST00000607826.1
KLHDC8A
kelch domain containing 8A
chr1_-_223537401 0.21 ENST00000343846.3
ENST00000454695.2
ENST00000484758.2
SUSD4
sushi domain containing 4

Network of associatons between targets according to the STRING database.

First level regulatory network of GCM2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 18.5 GO:0071105 response to interleukin-11(GO:0071105)
1.7 5.1 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
1.6 27.3 GO:0090129 positive regulation of synapse maturation(GO:0090129)
1.5 7.5 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
1.3 10.6 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
1.1 2.2 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
1.1 1.1 GO:0060541 lung development(GO:0030324) respiratory system development(GO:0060541)
1.1 9.5 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
1.0 4.1 GO:0009386 translational attenuation(GO:0009386)
1.0 2.9 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
0.9 8.0 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.9 3.5 GO:1902361 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.9 3.4 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.8 6.7 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.8 10.6 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.6 3.8 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.6 5.9 GO:0010265 SCF complex assembly(GO:0010265)
0.6 1.7 GO:0034653 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.6 3.4 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.5 4.9 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.5 3.2 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
0.5 2.6 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.5 6.4 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.5 1.5 GO:0071109 superior temporal gyrus development(GO:0071109)
0.4 2.7 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.4 4.0 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.4 2.5 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.4 1.2 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.3 1.6 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.3 4.1 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.3 2.9 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.3 3.1 GO:0006600 creatine metabolic process(GO:0006600)
0.2 6.1 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.2 1.4 GO:0006789 bilirubin conjugation(GO:0006789)
0.2 4.1 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.2 0.9 GO:0035992 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.2 0.9 GO:0007538 primary sex determination(GO:0007538)
0.2 7.2 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.2 3.1 GO:0031507 heterochromatin assembly(GO:0031507)
0.2 8.7 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.2 4.2 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.2 1.3 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.2 0.9 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.2 0.9 GO:0086021 SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021) AV node cell to bundle of His cell communication by electrical coupling(GO:0086053)
0.2 2.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.2 1.2 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.2 8.9 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.2 0.9 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.2 2.6 GO:1902260 diaphragm development(GO:0060539) negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.2 2.5 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.2 4.9 GO:0090383 phagosome acidification(GO:0090383)
0.2 2.3 GO:0006449 regulation of translational termination(GO:0006449)
0.1 3.0 GO:0002021 response to dietary excess(GO:0002021)
0.1 4.4 GO:0061641 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 5.0 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 0.9 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.1 0.5 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.1 0.9 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 0.5 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.1 0.7 GO:0010507 negative regulation of autophagy(GO:0010507)
0.1 0.5 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.1 1.5 GO:0034378 chylomicron assembly(GO:0034378)
0.1 0.6 GO:0019418 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.1 1.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 1.0 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.1 3.0 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 2.0 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.1 1.8 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1 1.3 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 3.5 GO:0018146 keratan sulfate biosynthetic process(GO:0018146)
0.1 2.1 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 0.6 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.1 0.4 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.1 0.4 GO:0071286 cellular response to magnesium ion(GO:0071286)
0.1 0.2 GO:0052026 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.1 0.3 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.1 0.8 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1 3.1 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.1 4.3 GO:1901799 negative regulation of proteasomal protein catabolic process(GO:1901799)
0.1 2.1 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.1 0.5 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.1 0.6 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 2.1 GO:0000266 mitochondrial fission(GO:0000266)
0.1 0.2 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.0 0.6 GO:2000680 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.0 0.1 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.2 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.0 0.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 4.0 GO:1990748 cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.7 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.8 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.5 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.0 0.2 GO:0001826 inner cell mass cell differentiation(GO:0001826)
0.0 0.7 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.9 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 6.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.1 GO:0021904 dorsal/ventral neural tube patterning(GO:0021904)
0.0 0.2 GO:0031642 negative regulation of myelination(GO:0031642)
0.0 0.8 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 1.4 GO:0001755 neural crest cell migration(GO:0001755)
0.0 2.0 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.0 0.8 GO:0036344 platelet morphogenesis(GO:0036344)
0.0 0.4 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 4.7 GO:0008213 protein methylation(GO:0006479) protein alkylation(GO:0008213)
0.0 1.5 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 2.7 GO:0070268 cornification(GO:0070268)
0.0 3.3 GO:0034605 cellular response to heat(GO:0034605)
0.0 2.1 GO:0055072 iron ion homeostasis(GO:0055072)
0.0 3.4 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 0.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.6 GO:0001881 receptor recycling(GO:0001881)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.6 GO:0097453 mesaxon(GO:0097453) ensheathing process(GO:1990015)
1.7 8.6 GO:0009368 endopeptidase Clp complex(GO:0009368)
1.5 10.6 GO:0005956 protein kinase CK2 complex(GO:0005956)
1.0 7.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
1.0 3.8 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.8 2.5 GO:0000806 Y chromosome(GO:0000806) cyclin A2-CDK2 complex(GO:0097124) cyclin E1-CDK2 complex(GO:0097134)
0.8 4.1 GO:1990393 3M complex(GO:1990393)
0.7 4.9 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.7 18.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.6 4.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.5 4.9 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.5 2.0 GO:0070876 SOSS complex(GO:0070876)
0.5 6.4 GO:0070578 RISC-loading complex(GO:0070578)
0.4 1.2 GO:0002139 stereocilia coupling link(GO:0002139)
0.4 4.9 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4 2.6 GO:1990635 proximal dendrite(GO:1990635)
0.4 3.2 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.3 3.1 GO:0005677 chromatin silencing complex(GO:0005677)
0.3 2.6 GO:0005638 lamin filament(GO:0005638)
0.3 2.9 GO:0002116 semaphorin receptor complex(GO:0002116)
0.2 3.6 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.2 4.8 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2 1.8 GO:0032389 MutLalpha complex(GO:0032389)
0.2 4.4 GO:0010369 chromocenter(GO:0010369)
0.2 1.6 GO:0071204 U7 snRNP(GO:0005683) histone pre-mRNA 3'end processing complex(GO:0071204)
0.2 2.5 GO:0031209 SCAR complex(GO:0031209)
0.2 8.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 4.5 GO:0005921 gap junction(GO:0005921)
0.1 0.5 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 0.9 GO:0070852 cell body fiber(GO:0070852)
0.1 4.3 GO:0005839 proteasome core complex(GO:0005839)
0.1 3.5 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.1 3.4 GO:0002080 acrosomal membrane(GO:0002080)
0.1 1.5 GO:1990909 Wnt signalosome(GO:1990909)
0.1 2.7 GO:0030057 desmosome(GO:0030057)
0.1 5.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 2.1 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 13.0 GO:0000922 spindle pole(GO:0000922)
0.1 0.4 GO:0005652 nuclear lamina(GO:0005652)
0.1 4.0 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 5.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 1.3 GO:0005876 spindle microtubule(GO:0005876)
0.1 1.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.6 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.1 2.0 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.5 GO:0098839 postsynaptic density membrane(GO:0098839)
0.1 0.2 GO:0018444 translation release factor complex(GO:0018444)
0.1 0.9 GO:0005686 U2 snRNP(GO:0005686)
0.0 6.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 3.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 3.0 GO:0005795 Golgi stack(GO:0005795)
0.0 0.4 GO:0033270 paranode region of axon(GO:0033270)
0.0 4.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.9 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 20.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.6 GO:0098796 membrane protein complex(GO:0098796)
0.0 3.0 GO:0001650 fibrillar center(GO:0001650)
0.0 1.7 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.4 GO:0097228 sperm principal piece(GO:0097228)
0.0 4.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.8 GO:0005875 microtubule associated complex(GO:0005875)
0.0 0.5 GO:0012505 endomembrane system(GO:0012505)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 18.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
1.3 18.1 GO:0050693 LBD domain binding(GO:0050693)
0.9 3.4 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.8 10.6 GO:0033691 sialic acid binding(GO:0033691)
0.8 2.3 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.7 6.4 GO:0070883 pre-miRNA binding(GO:0070883)
0.7 8.3 GO:0004017 adenylate kinase activity(GO:0004017)
0.6 3.8 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.6 2.4 GO:0004461 lactose synthase activity(GO:0004461)
0.5 3.2 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.5 1.6 GO:0071209 U7 snRNA binding(GO:0071209)
0.5 2.5 GO:0051998 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.5 2.9 GO:0008046 axon guidance receptor activity(GO:0008046)
0.5 4.2 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.4 3.5 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.4 2.4 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.4 1.6 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.4 9.5 GO:0070410 co-SMAD binding(GO:0070410)
0.4 8.7 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.4 3.2 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.4 9.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.3 1.3 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.3 9.1 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.3 4.1 GO:0004526 ribonuclease P activity(GO:0004526)
0.3 1.8 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.3 8.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 0.9 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.2 2.7 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.2 1.0 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 6.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 4.3 GO:0070628 proteasome binding(GO:0070628)
0.2 1.1 GO:0003998 acylphosphatase activity(GO:0003998)
0.2 0.6 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.2 0.9 GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020) gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
0.2 2.0 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) G-rich strand telomeric DNA binding(GO:0098505)
0.2 4.1 GO:0051371 muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493)
0.2 2.9 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 2.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 0.8 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.2 0.6 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.1 3.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.5 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 3.4 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 0.6 GO:0030151 molybdenum ion binding(GO:0030151)
0.1 0.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 3.1 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.7 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.1 1.7 GO:0016918 retinal binding(GO:0016918)
0.1 6.7 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 3.2 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.1 0.7 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.1 1.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 0.5 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 10.6 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.1 3.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.9 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 4.0 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 7.5 GO:0032947 protein complex scaffold(GO:0032947)
0.1 4.7 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 1.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.3 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.3 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 0.8 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 0.3 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 1.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.4 GO:0001972 retinoic acid binding(GO:0001972) glucuronosyltransferase activity(GO:0015020)
0.0 0.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 4.0 GO:0016209 antioxidant activity(GO:0016209)
0.0 0.7 GO:0005112 Notch binding(GO:0005112)
0.0 10.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.7 GO:0000339 RNA cap binding(GO:0000339)
0.0 1.5 GO:0030332 cyclin binding(GO:0030332)
0.0 4.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.6 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 2.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.8 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 21.4 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 3.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 5.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.6 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.2 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 3.6 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 2.6 GO:0008017 microtubule binding(GO:0008017)
0.0 0.9 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 10.6 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.3 18.2 PID PLK1 PATHWAY PLK1 signaling events
0.3 7.4 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.2 8.9 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 6.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 30.6 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 6.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.8 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 11.2 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 3.9 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 3.8 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 4.3 PID P53 REGULATION PATHWAY p53 pathway
0.0 2.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 2.6 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 2.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.9 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.5 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.5 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.3 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 2.1 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 22.0 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.7 18.4 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.4 6.5 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.3 9.8 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.3 8.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.3 8.9 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 10.6 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.2 7.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 6.7 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 5.9 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.2 4.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.2 7.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 9.5 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 10.6 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.2 3.2 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.2 3.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 3.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.9 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 3.9 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 4.8 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 1.6 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 6.8 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.1 0.7 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 0.9 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 0.9 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 4.4 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 3.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 2.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 0.9 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 4.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 2.1 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.7 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.9 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 1.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 4.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.6 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 3.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.3 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis