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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GLI2

Z-value: 1.52

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Transcription factors associated with GLI2

Gene Symbol Gene ID Gene Info
GLI2
ENSG00000074047.16 GLI family zinc finger 2

Activity profile of GLI2 motif

Sorted Z-values of GLI2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_35202909 21.28 ENST00000558530.1
ENST00000558028.1
ENST00000560025.1
TGIF2-C20orf24
TGIF2
TGIF2-C20orf24 readthrough
TGFB-induced factor homeobox 2
chr20_+_3776371 16.03 ENST00000245960.5
CDC25B
cell division cycle 25B
chr11_-_57103327 15.73 ENST00000529002.1
ENST00000278412.2
SSRP1
structure specific recognition protein 1
chr16_+_67063036 15.28 ENST00000290858.6
ENST00000564034.1
CBFB
core-binding factor, beta subunit
chr16_+_67063142 14.74 ENST00000412916.2
CBFB
core-binding factor, beta subunit
chr18_+_12948000 14.03 ENST00000585730.1
ENST00000399892.2
ENST00000589446.1
ENST00000587761.1
SEH1L
SEH1-like (S. cerevisiae)
chr14_+_24605389 13.64 ENST00000382708.3
ENST00000561435.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr22_+_23247030 13.55 ENST00000390324.2
IGLJ3
immunoglobulin lambda joining 3
chr1_-_32403370 13.39 ENST00000534796.1
PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr14_-_71107921 12.33 ENST00000553982.1
ENST00000500016.1
CTD-2540L5.5
CTD-2540L5.6
CTD-2540L5.5
CTD-2540L5.6
chr19_-_2050852 12.25 ENST00000541165.1
ENST00000591601.1
MKNK2
MAP kinase interacting serine/threonine kinase 2
chr3_-_49066811 12.11 ENST00000442157.1
ENST00000326739.4
IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr4_+_107236692 11.72 ENST00000510207.1
AIMP1
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
chr21_-_46330545 11.64 ENST00000320216.6
ENST00000397852.1
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr19_-_10464570 11.61 ENST00000529739.1
TYK2
tyrosine kinase 2
chr17_-_79995553 11.61 ENST00000581584.1
ENST00000577712.1
ENST00000582900.1
ENST00000579155.1
ENST00000306869.2
DCXR
dicarbonyl/L-xylulose reductase
chr19_-_42806919 11.56 ENST00000595530.1
ENST00000538771.1
ENST00000601865.1
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr1_+_220267429 11.33 ENST00000366922.1
ENST00000302637.5
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr20_+_3776936 11.18 ENST00000439880.2
CDC25B
cell division cycle 25B
chr19_-_42806723 11.03 ENST00000262890.3
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr13_-_46756351 11.02 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr10_-_120938303 10.89 ENST00000356951.3
ENST00000298510.2
PRDX3
peroxiredoxin 3
chr21_-_40555393 10.83 ENST00000380900.2
PSMG1
proteasome (prosome, macropain) assembly chaperone 1
chr17_+_1944790 10.77 ENST00000575162.1
DPH1
diphthamide biosynthesis 1
chr1_+_26869597 10.68 ENST00000530003.1
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_-_11115877 10.55 ENST00000490101.1
SRM
spermidine synthase
chr15_-_49447771 10.41 ENST00000558843.1
ENST00000542928.1
ENST00000561248.1
COPS2
COP9 signalosome subunit 2
chr3_+_127317066 10.41 ENST00000265056.7
MCM2
minichromosome maintenance complex component 2
chr14_-_55369525 10.40 ENST00000543643.2
ENST00000536224.2
ENST00000395514.1
ENST00000491895.2
GCH1
GTP cyclohydrolase 1
chr12_-_122712038 9.85 ENST00000413918.1
ENST00000443649.3
DIABLO
diablo, IAP-binding mitochondrial protein
chr20_+_43514320 9.79 ENST00000372839.3
ENST00000428262.1
ENST00000445830.1
YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
chr12_-_48099754 9.49 ENST00000380650.4
RPAP3
RNA polymerase II associated protein 3
chr20_-_32891151 9.48 ENST00000217426.2
AHCY
adenosylhomocysteinase
chr19_-_42806444 9.41 ENST00000594989.1
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chrX_+_19373700 9.38 ENST00000379804.1
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr8_+_96145974 9.31 ENST00000315367.3
PLEKHF2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr14_-_24615805 9.27 ENST00000560410.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr12_+_120933904 9.21 ENST00000550178.1
ENST00000550845.1
ENST00000549989.1
ENST00000552870.1
DYNLL1
dynein, light chain, LC8-type 1
chr14_-_94856987 9.18 ENST00000449399.3
ENST00000404814.4
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr11_-_34937858 9.15 ENST00000278359.5
APIP
APAF1 interacting protein
chr4_-_71705027 9.05 ENST00000545193.1
GRSF1
G-rich RNA sequence binding factor 1
chr16_+_30075595 8.98 ENST00000563060.2
ALDOA
aldolase A, fructose-bisphosphate
chr16_+_30064444 8.81 ENST00000395248.1
ENST00000566897.1
ENST00000568435.1
ALDOA
aldolase A, fructose-bisphosphate
chr19_-_10450328 8.75 ENST00000160262.5
ICAM3
intercellular adhesion molecule 3
chr8_-_145331153 8.75 ENST00000377412.4
KM-PA-2
KM-PA-2 protein; Uncharacterized protein
chr14_+_24605361 8.75 ENST00000206451.6
ENST00000559123.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr15_-_69113218 8.66 ENST00000560303.1
ENST00000465139.2
ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr1_+_47799446 8.62 ENST00000371873.5
CMPK1
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
chr16_+_30075783 8.62 ENST00000412304.2
ALDOA
aldolase A, fructose-bisphosphate
chr1_+_154947148 8.38 ENST00000368436.1
ENST00000308987.5
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr12_-_110883346 8.31 ENST00000547365.1
ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chrX_+_12809463 8.29 ENST00000380663.3
ENST00000380668.5
ENST00000398491.2
ENST00000489404.1
PRPS2
phosphoribosyl pyrophosphate synthetase 2
chr10_+_14880157 8.28 ENST00000378372.3
HSPA14
heat shock 70kDa protein 14
chr19_-_10530784 8.19 ENST00000593124.1
CDC37
cell division cycle 37
chr17_-_73149921 8.13 ENST00000481647.1
ENST00000470924.1
HN1
hematological and neurological expressed 1
chr22_+_23248512 8.03 ENST00000390325.2
IGLC3
immunoglobulin lambda constant 3 (Kern-Oz+ marker)
chr21_-_40720995 7.99 ENST00000380749.5
HMGN1
high mobility group nucleosome binding domain 1
chr12_-_48099773 7.95 ENST00000432584.3
ENST00000005386.3
RPAP3
RNA polymerase II associated protein 3
chr14_-_94856951 7.93 ENST00000553327.1
ENST00000556955.1
ENST00000557118.1
ENST00000440909.1
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr12_+_120933859 7.93 ENST00000242577.6
ENST00000548214.1
ENST00000392508.2
DYNLL1
dynein, light chain, LC8-type 1
chr1_+_154947126 7.90 ENST00000368439.1
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr14_-_94857004 7.87 ENST00000557492.1
ENST00000448921.1
ENST00000437397.1
ENST00000355814.4
ENST00000393088.4
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr3_-_63849571 7.76 ENST00000295899.5
THOC7
THO complex 7 homolog (Drosophila)
chr5_-_89705537 7.76 ENST00000522864.1
ENST00000522083.1
ENST00000522565.1
ENST00000522842.1
ENST00000283122.3
CETN3
centrin, EF-hand protein, 3
chr14_-_94854926 7.67 ENST00000402629.1
ENST00000556091.1
ENST00000554720.1
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr21_-_40720974 7.66 ENST00000380748.1
HMGN1
high mobility group nucleosome binding domain 1
chr11_-_34938039 7.52 ENST00000395787.3
APIP
APAF1 interacting protein
chr4_+_57843876 7.52 ENST00000450656.1
ENST00000381227.1
POLR2B
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
chr16_-_69368774 7.50 ENST00000562949.1
RP11-343C2.12
Conserved oligomeric Golgi complex subunit 8
chr5_-_150284532 7.44 ENST00000394226.2
ENST00000446148.2
ENST00000274599.5
ENST00000418587.2
ZNF300
zinc finger protein 300
chr1_+_165796753 7.38 ENST00000367879.4
UCK2
uridine-cytidine kinase 2
chr12_+_7079944 7.38 ENST00000261406.6
EMG1
EMG1 N1-specific pseudouridine methyltransferase
chr3_+_184080387 7.37 ENST00000455712.1
POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
chrX_-_107334790 7.34 ENST00000217958.3
PSMD10
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
chr12_+_7055767 7.31 ENST00000447931.2
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr16_-_11681023 7.16 ENST00000570904.1
ENST00000574701.1
LITAF
lipopolysaccharide-induced TNF factor
chr11_+_64009072 7.09 ENST00000535135.1
ENST00000394540.3
FKBP2
FK506 binding protein 2, 13kDa
chr16_+_30064411 7.07 ENST00000338110.5
ALDOA
aldolase A, fructose-bisphosphate
chr19_+_572543 7.06 ENST00000333511.3
ENST00000573216.1
ENST00000353555.4
BSG
basigin (Ok blood group)
chr19_+_17858509 7.05 ENST00000594202.1
ENST00000252771.7
ENST00000389133.4
FCHO1
FCH domain only 1
chr16_-_11681316 7.01 ENST00000571688.1
LITAF
lipopolysaccharide-induced TNF factor
chrX_-_107334750 7.01 ENST00000340200.5
ENST00000372296.1
ENST00000372295.1
ENST00000361815.5
PSMD10
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
chr1_-_40042416 7.00 ENST00000372857.3
ENST00000372856.3
ENST00000531243.2
ENST00000451091.2
PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr19_-_55791058 6.98 ENST00000587959.1
ENST00000585927.1
ENST00000587922.1
ENST00000585698.1
HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr5_-_150284351 6.98 ENST00000427179.1
ZNF300
zinc finger protein 300
chr1_+_6105974 6.97 ENST00000378083.3
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr20_+_43514315 6.89 ENST00000353703.4
YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
chr16_+_67063262 6.87 ENST00000565389.1
CBFB
core-binding factor, beta subunit
chr2_-_225434538 6.83 ENST00000409096.1
CUL3
cullin 3
chr17_+_76164639 6.80 ENST00000225777.3
ENST00000585591.1
ENST00000589711.1
ENST00000588282.1
ENST00000589168.1
SYNGR2
synaptogyrin 2
chr19_+_50180409 6.79 ENST00000391851.4
PRMT1
protein arginine methyltransferase 1
chr6_-_53213780 6.77 ENST00000304434.6
ENST00000370918.4
ELOVL5
ELOVL fatty acid elongase 5
chr3_+_184081213 6.75 ENST00000429568.1
POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
chr15_-_59225758 6.70 ENST00000558486.1
ENST00000560682.1
ENST00000249736.7
ENST00000559880.1
ENST00000536328.1
SLTM
SAFB-like, transcription modulator
chr15_+_52311398 6.70 ENST00000261845.5
MAPK6
mitogen-activated protein kinase 6
chr3_+_184081175 6.68 ENST00000452961.1
ENST00000296223.3
POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
chr11_+_65819802 6.57 ENST00000528302.1
ENST00000322535.6
ENST00000524627.1
ENST00000533595.1
ENST00000530322.1
SF3B2
splicing factor 3b, subunit 2, 145kDa
chr17_-_61920280 6.55 ENST00000448276.2
ENST00000577990.1
SMARCD2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
chr1_-_153522562 6.54 ENST00000368714.1
S100A4
S100 calcium binding protein A4
chrX_-_152989531 6.49 ENST00000458587.2
ENST00000416815.1
BCAP31
B-cell receptor-associated protein 31
chr4_-_7069760 6.49 ENST00000264954.4
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr20_-_62710832 6.45 ENST00000395042.1
RGS19
regulator of G-protein signaling 19
chr5_+_154238042 6.43 ENST00000519211.1
ENST00000522458.1
ENST00000519903.1
ENST00000521450.1
ENST00000403027.2
CNOT8
CCR4-NOT transcription complex, subunit 8
chr11_+_124609823 6.40 ENST00000412681.2
NRGN
neurogranin (protein kinase C substrate, RC3)
chr19_-_59066327 6.34 ENST00000596708.1
ENST00000601220.1
ENST00000597848.1
CHMP2A
charged multivesicular body protein 2A
chr16_+_2521500 6.33 ENST00000293973.1
NTN3
netrin 3
chr22_+_23243156 6.22 ENST00000390323.2
IGLC2
immunoglobulin lambda constant 2 (Kern-Oz- marker)
chr19_+_48828582 6.15 ENST00000270221.6
ENST00000596315.1
EMP3
epithelial membrane protein 3
chr19_+_47105309 6.14 ENST00000599839.1
ENST00000596362.1
CALM3
calmodulin 3 (phosphorylase kinase, delta)
chr4_+_107236722 6.11 ENST00000442366.1
AIMP1
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
chr16_+_22308717 6.10 ENST00000299853.5
ENST00000564209.1
ENST00000565358.1
ENST00000418581.2
ENST00000564883.1
ENST00000359210.4
ENST00000563024.1
POLR3E
polymerase (RNA) III (DNA directed) polypeptide E (80kD)
chr12_-_2986107 6.10 ENST00000359843.3
ENST00000342628.2
ENST00000361953.3
FOXM1
forkhead box M1
chr5_+_154238149 6.08 ENST00000519430.1
ENST00000520671.1
ENST00000521583.1
ENST00000518028.1
ENST00000519404.1
ENST00000519394.1
ENST00000518775.1
CNOT8
CCR4-NOT transcription complex, subunit 8
chr3_-_107809816 6.04 ENST00000361309.5
ENST00000355354.7
CD47
CD47 molecule
chr17_+_41158742 6.02 ENST00000415816.2
ENST00000438323.2
IFI35
interferon-induced protein 35
chr22_-_19419205 6.02 ENST00000340170.4
ENST00000263208.5
HIRA
histone cell cycle regulator
chr8_+_74888417 5.99 ENST00000517439.1
ENST00000312184.5
TMEM70
transmembrane protein 70
chr4_+_107236847 5.97 ENST00000358008.3
AIMP1
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
chr8_-_145642267 5.97 ENST00000301305.3
SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr17_-_79827808 5.97 ENST00000580685.1
ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha
chrX_+_23682379 5.97 ENST00000379349.1
PRDX4
peroxiredoxin 4
chr12_-_109125285 5.96 ENST00000552871.1
ENST00000261401.3
CORO1C
coronin, actin binding protein, 1C
chrX_+_70503433 5.95 ENST00000276079.8
ENST00000373856.3
ENST00000373841.1
ENST00000420903.1
NONO
non-POU domain containing, octamer-binding
chrY_+_2709527 5.95 ENST00000250784.8
RPS4Y1
ribosomal protein S4, Y-linked 1
chr11_+_34460447 5.92 ENST00000241052.4
CAT
catalase
chr11_+_16760161 5.90 ENST00000524439.1
ENST00000422258.2
ENST00000528634.1
ENST00000525684.1
C11orf58
chromosome 11 open reading frame 58
chr6_+_33172407 5.89 ENST00000374662.3
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr11_+_34938119 5.86 ENST00000227868.4
ENST00000430469.2
ENST00000533262.1
PDHX
pyruvate dehydrogenase complex, component X
chr1_+_64059332 5.82 ENST00000540265.1
PGM1
phosphoglucomutase 1
chr13_+_115000521 5.78 ENST00000252457.5
ENST00000375308.1
CDC16
cell division cycle 16
chr16_+_88872176 5.78 ENST00000569140.1
CDT1
chromatin licensing and DNA replication factor 1
chr12_-_110888103 5.76 ENST00000426440.1
ENST00000228825.7
ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr12_+_51632638 5.75 ENST00000549732.2
DAZAP2
DAZ associated protein 2
chr1_+_64058939 5.69 ENST00000371084.3
PGM1
phosphoglucomutase 1
chr10_-_43904235 5.68 ENST00000356053.3
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr22_+_23241661 5.67 ENST00000390322.2
IGLJ2
immunoglobulin lambda joining 2
chr3_+_179280668 5.64 ENST00000429709.2
ENST00000450518.2
ENST00000392662.1
ENST00000490364.1
ACTL6A
actin-like 6A
chr10_+_120863587 5.63 ENST00000535029.1
ENST00000361432.2
ENST00000544016.1
FAM45A
family with sequence similarity 45, member A
chr11_+_68451943 5.59 ENST00000265643.3
GAL
galanin/GMAP prepropeptide
chr3_+_184081137 5.57 ENST00000443489.1
POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
chr19_+_17858547 5.57 ENST00000600676.1
ENST00000600209.1
ENST00000596309.1
ENST00000598539.1
ENST00000597474.1
ENST00000593385.1
ENST00000598067.1
ENST00000593833.1
FCHO1
FCH domain only 1
chr19_+_50180507 5.55 ENST00000454376.2
ENST00000524771.1
PRMT1
protein arginine methyltransferase 1
chr19_-_10305752 5.48 ENST00000540357.1
ENST00000359526.4
ENST00000340748.4
DNMT1
DNA (cytosine-5-)-methyltransferase 1
chrX_+_24072833 5.47 ENST00000253039.4
EIF2S3
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr3_-_58419537 5.46 ENST00000474765.1
ENST00000485460.1
ENST00000302746.6
ENST00000383714.4
PDHB
pyruvate dehydrogenase (lipoamide) beta
chr2_-_136875712 5.41 ENST00000241393.3
CXCR4
chemokine (C-X-C motif) receptor 4
chr2_-_96874553 5.35 ENST00000337288.5
ENST00000443962.1
STARD7
StAR-related lipid transfer (START) domain containing 7
chr19_+_48824711 5.34 ENST00000599704.1
EMP3
epithelial membrane protein 3
chr17_+_30677136 5.34 ENST00000394670.4
ENST00000321233.6
ENST00000394673.2
ENST00000341711.6
ENST00000579634.1
ENST00000580759.1
ENST00000342555.6
ENST00000577908.1
ENST00000394679.5
ENST00000582165.1
ZNF207
zinc finger protein 207
chr4_+_107237660 5.33 ENST00000394701.4
AIMP1
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
chr15_-_49447835 5.32 ENST00000388901.5
ENST00000299259.6
COPS2
COP9 signalosome subunit 2
chr6_-_133084580 5.32 ENST00000525270.1
ENST00000530536.1
ENST00000524919.1
VNN2
vanin 2
chr12_+_51633061 5.30 ENST00000551313.1
DAZAP2
DAZ associated protein 2
chr19_-_59070239 5.30 ENST00000595957.1
ENST00000253023.3
UBE2M
ubiquitin-conjugating enzyme E2M
chr22_-_50964849 5.26 ENST00000543927.1
ENST00000423348.1
SCO2
SCO2 cytochrome c oxidase assembly protein
chr12_-_120687948 5.25 ENST00000458477.2
PXN
paxillin
chrX_-_152989798 5.25 ENST00000441714.1
ENST00000442093.1
ENST00000429550.1
ENST00000345046.6
BCAP31
B-cell receptor-associated protein 31
chr14_-_60632162 5.25 ENST00000557185.1
DHRS7
dehydrogenase/reductase (SDR family) member 7
chr1_-_19811132 5.23 ENST00000433834.1
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr12_-_125348448 5.21 ENST00000339570.5
SCARB1
scavenger receptor class B, member 1
chr14_-_105262055 5.21 ENST00000349310.3
AKT1
v-akt murine thymoma viral oncogene homolog 1
chr22_+_39378375 5.20 ENST00000402182.3
ENST00000333467.3
APOBEC3B
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
chr14_-_24615523 5.20 ENST00000559056.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr2_+_48010312 5.19 ENST00000540021.1
MSH6
mutS homolog 6
chr17_-_73761222 5.16 ENST00000437911.1
ENST00000225614.2
GALK1
galactokinase 1
chr7_-_55606346 5.14 ENST00000545390.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr19_-_59066452 5.13 ENST00000312547.2
CHMP2A
charged multivesicular body protein 2A
chr6_+_44214824 5.13 ENST00000371646.5
ENST00000353801.3
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr11_-_6640585 5.09 ENST00000533371.1
ENST00000528657.1
ENST00000436873.2
ENST00000299427.6
TPP1
tripeptidyl peptidase I
chr22_+_41258250 5.09 ENST00000544094.1
XPNPEP3
X-prolyl aminopeptidase (aminopeptidase P) 3, putative
chrX_+_23685653 5.09 ENST00000379331.3
PRDX4
peroxiredoxin 4
chr22_+_39378346 5.04 ENST00000407298.3
APOBEC3B
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
chr16_-_3767551 5.01 ENST00000246957.5
TRAP1
TNF receptor-associated protein 1
chr14_-_106209368 5.00 ENST00000390548.2
ENST00000390549.2
ENST00000390542.2
IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_+_72148614 5.00 ENST00000261263.3
RAB21
RAB21, member RAS oncogene family
chr19_-_55791431 4.99 ENST00000593263.1
ENST00000376343.3
HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr3_-_72496035 4.97 ENST00000477973.2
RYBP
RING1 and YY1 binding protein
chr2_-_197041193 4.95 ENST00000409228.1
STK17B
serine/threonine kinase 17b
chr6_-_16761678 4.94 ENST00000244769.4
ENST00000436367.1
ATXN1
ataxin 1
chr5_+_154237778 4.93 ENST00000523698.1
ENST00000517876.1
ENST00000520472.1
CNOT8
CCR4-NOT transcription complex, subunit 8
chr12_+_53689309 4.89 ENST00000351500.3
ENST00000550846.1
ENST00000334478.4
ENST00000549759.1
PFDN5
prefoldin subunit 5
chr3_-_25824872 4.87 ENST00000308710.5
NGLY1
N-glycanase 1
chr11_-_414948 4.83 ENST00000530494.1
ENST00000528209.1
ENST00000431843.2
ENST00000528058.1
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr19_-_55791540 4.82 ENST00000433386.2
HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr2_+_48010221 4.81 ENST00000234420.5
MSH6
mutS homolog 6
chr14_+_50359773 4.81 ENST00000298316.5
ARF6
ADP-ribosylation factor 6
chr5_-_150460914 4.76 ENST00000389378.2
TNIP1
TNFAIP3 interacting protein 1
chrX_+_64887512 4.76 ENST00000360270.5
MSN
moesin
chr14_-_105262016 4.73 ENST00000407796.2
AKT1
v-akt murine thymoma viral oncogene homolog 1
chr20_+_62327996 4.68 ENST00000369996.1
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr7_-_6098770 4.66 ENST00000536084.1
ENST00000446699.1
ENST00000199389.6
EIF2AK1
eukaryotic translation initiation factor 2-alpha kinase 1
chr10_-_99258135 4.63 ENST00000327238.10
ENST00000327277.7
ENST00000355839.6
ENST00000437002.1
ENST00000422685.1
MMS19
MMS19 nucleotide excision repair homolog (S. cerevisiae)
chr16_-_28506840 4.62 ENST00000569430.1
CLN3
ceroid-lipofuscinosis, neuronal 3
chr21_-_33984456 4.61 ENST00000431216.1
ENST00000553001.1
ENST00000440966.1
AP000275.65
C21orf59
Uncharacterized protein
chromosome 21 open reading frame 59
chr19_-_51512804 4.58 ENST00000594211.1
ENST00000376832.4
KLK9
kallikrein-related peptidase 9
chr19_+_23299777 4.56 ENST00000597761.2
ZNF730
zinc finger protein 730
chr5_+_154238096 4.54 ENST00000517568.1
ENST00000524105.1
ENST00000285896.6
CNOT8
CCR4-NOT transcription complex, subunit 8
chr19_-_2051223 4.54 ENST00000309340.7
ENST00000589534.1
ENST00000250896.3
ENST00000589509.1
MKNK2
MAP kinase interacting serine/threonine kinase 2
chr12_+_53645870 4.52 ENST00000329548.4
MFSD5
major facilitator superfamily domain containing 5
chr20_+_30639991 4.51 ENST00000534862.1
ENST00000538448.1
ENST00000375862.2
HCK
hemopoietic cell kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of GLI2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 11.5 GO:1903722 regulation of centriole elongation(GO:1903722)
3.8 11.3 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
3.6 10.9 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
3.5 10.4 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
2.9 11.6 GO:0005997 xylulose metabolic process(GO:0005997)
2.9 14.4 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
2.8 8.3 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
2.7 27.2 GO:0007144 female meiosis I(GO:0007144)
2.7 13.3 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
2.6 7.8 GO:0015920 lipopolysaccharide transport(GO:0015920)
2.5 15.0 GO:0006177 GMP biosynthetic process(GO:0006177)
2.5 9.9 GO:1903719 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
2.4 7.3 GO:0033277 abortive mitotic cell cycle(GO:0033277)
2.4 17.0 GO:0046984 regulation of hemoglobin biosynthetic process(GO:0046984)
2.4 16.7 GO:0070269 pyroptosis(GO:0070269)
2.4 9.5 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
2.4 9.5 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
2.4 2.4 GO:1902739 interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
2.3 11.7 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
2.3 7.0 GO:0044209 AMP salvage(GO:0044209)
2.3 20.7 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
2.0 6.0 GO:0043461 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
2.0 7.8 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
1.9 5.8 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
1.9 5.8 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
1.9 33.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.9 5.6 GO:0051795 cortisol secretion(GO:0043400) regulation of cortisol secretion(GO:0051462) positive regulation of catagen(GO:0051795)
1.8 7.4 GO:0009224 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
1.8 9.0 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
1.7 5.2 GO:0006059 hexitol metabolic process(GO:0006059)
1.7 6.8 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
1.7 8.3 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
1.6 4.8 GO:0085032 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
1.6 4.8 GO:0002522 leukocyte migration involved in immune response(GO:0002522)
1.6 17.1 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
1.5 10.7 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
1.5 10.6 GO:0008295 spermidine biosynthetic process(GO:0008295)
1.5 4.5 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621) gall bladder development(GO:0061010)
1.5 5.9 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
1.5 5.9 GO:0033591 response to L-ascorbic acid(GO:0033591)
1.4 8.6 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
1.4 10.0 GO:0000710 meiotic mismatch repair(GO:0000710)
1.4 4.2 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
1.4 8.2 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
1.4 5.5 GO:0010216 maintenance of DNA methylation(GO:0010216)
1.4 4.1 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
1.3 10.8 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
1.3 7.8 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
1.3 41.8 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
1.3 7.6 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
1.3 5.0 GO:0009386 translational attenuation(GO:0009386)
1.2 3.6 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
1.2 10.8 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
1.2 1.2 GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy(GO:0061740)
1.2 4.6 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
1.1 18.0 GO:0000338 protein deneddylation(GO:0000338)
1.1 4.4 GO:0046952 ketone body catabolic process(GO:0046952)
1.0 5.2 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
1.0 10.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.0 5.2 GO:0002442 serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554)
1.0 2.1 GO:0032079 positive regulation of endodeoxyribonuclease activity(GO:0032079)
1.0 3.1 GO:0006404 RNA import into nucleus(GO:0006404)
1.0 7.1 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
1.0 4.0 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
1.0 10.8 GO:0043248 proteasome assembly(GO:0043248)
1.0 17.6 GO:0038092 nodal signaling pathway(GO:0038092)
1.0 9.8 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
1.0 3.9 GO:1903826 arginine transmembrane transport(GO:1903826)
1.0 2.9 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.9 2.8 GO:0006550 isoleucine catabolic process(GO:0006550)
0.9 5.7 GO:0006540 glutamate decarboxylation to succinate(GO:0006540) gamma-aminobutyric acid catabolic process(GO:0009450)
0.9 16.0 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.9 7.4 GO:0070475 rRNA base methylation(GO:0070475)
0.9 18.8 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.9 4.5 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.9 12.5 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.9 2.6 GO:1902499 positive regulation of protein autoubiquitination(GO:1902499)
0.9 7.0 GO:0070995 NADPH oxidation(GO:0070995)
0.9 5.2 GO:0044789 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.9 2.6 GO:0060018 astrocyte fate commitment(GO:0060018)
0.8 6.6 GO:1904469 positive regulation of tumor necrosis factor secretion(GO:1904469)
0.8 11.2 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.8 3.2 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.8 2.4 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
0.8 4.7 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.8 5.4 GO:0060154 response to cycloheximide(GO:0046898) cellular process regulating host cell cycle in response to virus(GO:0060154)
0.8 5.4 GO:0019064 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.8 36.8 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.8 7.7 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.8 9.2 GO:0019388 galactose catabolic process(GO:0019388)
0.7 11.7 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.7 4.4 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.7 2.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.7 6.3 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.7 3.5 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.7 11.0 GO:0051639 actin filament network formation(GO:0051639)
0.7 22.8 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.7 31.4 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.7 4.6 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.7 1.3 GO:0033594 response to hydroxyisoflavone(GO:0033594)
0.6 11.6 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.6 1.9 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752)
0.6 1.9 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.6 2.5 GO:0035546 gamma-delta T cell activation involved in immune response(GO:0002290) interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) negative regulation of interferon-beta secretion(GO:0035548) type I interferon secretion(GO:0072641) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)
0.6 2.5 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.6 1.9 GO:0002625 regulation of T cell antigen processing and presentation(GO:0002625)
0.6 12.3 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.6 6.1 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.6 4.2 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.6 1.8 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.6 3.0 GO:1990034 calcium ion export from cell(GO:1990034)
0.6 6.0 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.6 2.4 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.6 7.1 GO:0046689 response to mercury ion(GO:0046689)
0.6 19.3 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.6 1.7 GO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome(GO:0098968)
0.6 9.2 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.6 4.0 GO:0015755 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.6 1.7 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.5 3.8 GO:0009146 purine nucleoside triphosphate catabolic process(GO:0009146)
0.5 5.3 GO:0015939 pantothenate metabolic process(GO:0015939)
0.5 52.6 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436)
0.5 5.5 GO:1902969 mitotic DNA replication(GO:1902969)
0.5 2.0 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.5 4.9 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.5 1.9 GO:0014038 regulation of Schwann cell differentiation(GO:0014038) positive regulation of Schwann cell differentiation(GO:0014040)
0.5 16.3 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.4 18.3 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.4 18.2 GO:0051220 cytoplasmic sequestering of protein(GO:0051220)
0.4 3.0 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.4 6.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.4 1.7 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.4 29.7 GO:0006953 acute-phase response(GO:0006953)
0.4 2.6 GO:0007296 vitellogenesis(GO:0007296) regulation of pro-B cell differentiation(GO:2000973)
0.4 2.9 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.4 5.0 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.4 2.1 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.4 1.6 GO:1900535 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.4 2.9 GO:0035898 parathyroid hormone secretion(GO:0035898) post-embryonic body morphogenesis(GO:0040032) regulation of parathyroid hormone secretion(GO:2000828)
0.4 12.6 GO:0048268 clathrin coat assembly(GO:0048268)
0.4 11.2 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.4 3.6 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.4 1.9 GO:0044860 protein localization to plasma membrane raft(GO:0044860)
0.4 6.0 GO:0008228 opsonization(GO:0008228)
0.4 3.7 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781)
0.4 7.5 GO:0031935 regulation of chromatin silencing(GO:0031935)
0.4 1.5 GO:0051958 methotrexate transport(GO:0051958) reduced folate transmembrane transport(GO:0098838)
0.4 1.5 GO:0044821 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.4 1.8 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.4 1.1 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.4 1.8 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.4 5.5 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.4 1.1 GO:0006490 dolichol-linked oligosaccharide biosynthetic process(GO:0006488) oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.4 1.1 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.4 1.8 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.4 5.3 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.3 2.1 GO:0019372 lipoxygenase pathway(GO:0019372)
0.3 8.9 GO:0009235 cobalamin metabolic process(GO:0009235)
0.3 4.4 GO:0000212 meiotic spindle organization(GO:0000212)
0.3 5.1 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.3 14.1 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.3 2.3 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.3 4.0 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.3 4.0 GO:0006089 lactate metabolic process(GO:0006089)
0.3 5.3 GO:0045116 protein neddylation(GO:0045116)
0.3 2.6 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.3 14.0 GO:0006378 mRNA polyadenylation(GO:0006378)
0.3 2.2 GO:1902659 regulation of glucose mediated signaling pathway(GO:1902659)
0.3 28.0 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.3 0.9 GO:1990869 beta selection(GO:0043366) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.3 5.3 GO:0007172 signal complex assembly(GO:0007172)
0.3 3.4 GO:0070986 left/right axis specification(GO:0070986)
0.3 0.9 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.3 23.3 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.3 2.6 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.3 1.2 GO:0046683 response to organophosphorus(GO:0046683)
0.3 0.8 GO:1901624 negative regulation of lymphocyte chemotaxis(GO:1901624)
0.3 1.6 GO:0006012 galactose metabolic process(GO:0006012)
0.3 1.9 GO:1903337 positive regulation of vacuolar transport(GO:1903337) positive regulation of endocytic recycling(GO:2001137)
0.3 0.8 GO:0060535 trachea cartilage morphogenesis(GO:0060535) renal inner medulla development(GO:0072053) renal outer medulla development(GO:0072054)
0.3 5.2 GO:0030252 growth hormone secretion(GO:0030252)
0.3 1.0 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.3 1.3 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.2 2.7 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.2 2.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 10.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 0.9 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.2 0.7 GO:1901143 insulin catabolic process(GO:1901143)
0.2 1.1 GO:0034971 regulation of growth plate cartilage chondrocyte proliferation(GO:0003420) histone H3-R17 methylation(GO:0034971)
0.2 0.7 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.2 1.5 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.2 1.9 GO:0005984 disaccharide metabolic process(GO:0005984)
0.2 1.9 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.2 2.3 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.2 4.7 GO:0071294 cellular response to zinc ion(GO:0071294)
0.2 3.0 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.2 5.8 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.2 0.8 GO:0006808 regulation of nitrogen utilization(GO:0006808) nitrogen utilization(GO:0019740) negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.2 3.6 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.2 0.9 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.2 2.4 GO:0006449 regulation of translational termination(GO:0006449)
0.2 0.7 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.2 24.1 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.2 2.5 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.2 4.0 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.2 2.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.2 0.2 GO:1902896 terminal web assembly(GO:1902896)
0.2 7.5 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.2 1.4 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.2 3.1 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.2 2.5 GO:0036109 alpha-linolenic acid metabolic process(GO:0036109)
0.1 3.0 GO:0032060 bleb assembly(GO:0032060)
0.1 2.6 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 2.2 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 8.3 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.1 1.0 GO:0048664 neuron fate determination(GO:0048664)
0.1 4.6 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.1 6.7 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.1 2.2 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 3.9 GO:0034453 microtubule anchoring(GO:0034453)
0.1 6.8 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 0.8 GO:0030578 PML body organization(GO:0030578)
0.1 1.4 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.1 5.3 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.1 1.5 GO:0070307 lens fiber cell development(GO:0070307)
0.1 1.0 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 1.7 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 8.7 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.1 13.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 1.1 GO:0034724 DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724)
0.1 5.1 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.1 1.6 GO:0051014 actin filament severing(GO:0051014)
0.1 1.3 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.1 1.1 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.1 0.3 GO:0042045 epithelial fluid transport(GO:0042045)
0.1 0.6 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 5.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 2.7 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.1 0.7 GO:0015074 DNA integration(GO:0015074)
0.1 1.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 1.3 GO:0007498 mesoderm development(GO:0007498)
0.1 0.3 GO:0090298 late nucleophagy(GO:0044805) cellular response to morphine(GO:0071315) cellular response to isoquinoline alkaloid(GO:0071317) negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859) single-organism membrane invagination(GO:1902534)
0.1 1.1 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 6.6 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.1 1.5 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.1 1.8 GO:0019216 regulation of lipid metabolic process(GO:0019216)
0.1 1.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 5.5 GO:0007062 sister chromatid cohesion(GO:0007062)
0.1 1.1 GO:1900273 positive regulation of long-term synaptic potentiation(GO:1900273)
0.1 0.6 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.1 1.9 GO:1902547 regulation of vascular endothelial growth factor signaling pathway(GO:1900746) regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902547)
0.1 2.8 GO:0032508 DNA duplex unwinding(GO:0032508)
0.1 2.6 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.1 0.4 GO:0048846 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.1 3.6 GO:0001895 retina homeostasis(GO:0001895)
0.1 0.8 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.1 0.6 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA transport(GO:0051031) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 3.3 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 1.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 2.4 GO:0043525 positive regulation of neuron apoptotic process(GO:0043525)
0.1 2.3 GO:0006739 NADP metabolic process(GO:0006739)
0.1 4.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 3.4 GO:0050684 regulation of mRNA processing(GO:0050684)
0.1 0.5 GO:0031297 replication fork processing(GO:0031297)
0.1 0.9 GO:0032098 regulation of appetite(GO:0032098)
0.0 0.6 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.6 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 1.6 GO:0048286 lung alveolus development(GO:0048286)
0.0 1.8 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.0 5.2 GO:1901796 regulation of signal transduction by p53 class mediator(GO:1901796)
0.0 9.8 GO:0016042 lipid catabolic process(GO:0016042)
0.0 0.9 GO:0033198 response to ATP(GO:0033198)
0.0 2.6 GO:0055088 lipid homeostasis(GO:0055088)
0.0 0.5 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 0.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.3 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.5 GO:0003094 glomerular filtration(GO:0003094)
0.0 3.3 GO:0038095 Fc-epsilon receptor signaling pathway(GO:0038095)
0.0 0.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.9 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.0 1.5 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 3.2 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.0 0.7 GO:0050714 positive regulation of protein secretion(GO:0050714)
0.0 0.4 GO:0051272 positive regulation of cellular component movement(GO:0051272)
0.0 1.4 GO:0042035 regulation of cytokine biosynthetic process(GO:0042035)
0.0 2.7 GO:0006413 translational initiation(GO:0006413)
0.0 0.2 GO:0006505 GPI anchor metabolic process(GO:0006505) GPI anchor biosynthetic process(GO:0006506)
0.0 0.2 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 0.9 GO:0061337 cardiac conduction(GO:0061337)
0.0 9.7 GO:0006396 RNA processing(GO:0006396)
0.0 1.5 GO:0006414 translational elongation(GO:0006414)
0.0 0.2 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 36.9 GO:0008537 proteasome activator complex(GO:0008537)
5.8 29.1 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
3.0 17.8 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
2.6 7.8 GO:0097447 dendritic tree(GO:0097447)
2.5 10.0 GO:0032301 MutSalpha complex(GO:0032301)
2.3 11.6 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
2.2 22.0 GO:0030015 CCR4-NOT core complex(GO:0030015)
2.1 8.3 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
2.1 20.7 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
2.0 14.0 GO:0061700 GATOR2 complex(GO:0061700)
2.0 11.7 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
2.0 7.8 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
1.8 18.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
1.8 5.5 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
1.7 17.4 GO:0097255 R2TP complex(GO:0097255)
1.7 7.0 GO:1990031 pinceau fiber(GO:1990031)
1.7 5.0 GO:0010009 cytoplasmic side of endosome membrane(GO:0010009) cytoplasmic side of early endosome membrane(GO:0098559)
1.6 6.5 GO:0001405 presequence translocase-associated import motor(GO:0001405)
1.5 26.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
1.4 4.2 GO:0031262 Ndc80 complex(GO:0031262)
1.2 11.2 GO:0005827 polar microtubule(GO:0005827)
1.2 3.7 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
1.1 3.3 GO:0031523 Myb complex(GO:0031523)
1.1 7.7 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
1.0 13.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.9 2.8 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.9 5.5 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.9 11.5 GO:0000815 ESCRT III complex(GO:0000815)
0.9 7.9 GO:0016600 flotillin complex(GO:0016600)
0.8 4.9 GO:0071817 MMXD complex(GO:0071817)
0.8 10.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) MCM complex(GO:0042555)
0.8 8.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.8 9.8 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.8 14.4 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.8 37.7 GO:0008180 COP9 signalosome(GO:0008180)
0.7 5.2 GO:0071203 WASH complex(GO:0071203)
0.7 5.9 GO:0042382 paraspeckles(GO:0042382)
0.7 14.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.7 3.6 GO:0032021 NELF complex(GO:0032021)
0.7 62.7 GO:1904724 tertiary granule lumen(GO:1904724)
0.7 4.9 GO:0016272 prefoldin complex(GO:0016272)
0.7 12.3 GO:0034709 methylosome(GO:0034709)
0.6 5.8 GO:0061574 ASAP complex(GO:0061574)
0.6 3.9 GO:0070545 PeBoW complex(GO:0070545)
0.6 3.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.6 1.9 GO:0071159 NF-kappaB complex(GO:0071159)
0.6 7.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.6 8.9 GO:0042405 nuclear inclusion body(GO:0042405)
0.6 1.7 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.6 10.0 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.6 11.0 GO:0001891 phagocytic cup(GO:0001891)
0.5 2.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.5 14.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.5 1.8 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.4 4.0 GO:0005638 lamin filament(GO:0005638)
0.4 6.6 GO:0005686 U2 snRNP(GO:0005686)
0.4 66.6 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.4 10.6 GO:0016514 SWI/SNF complex(GO:0016514)
0.4 7.5 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.4 20.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.4 2.6 GO:0097165 nuclear stress granule(GO:0097165)
0.4 1.9 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.4 3.0 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.4 8.8 GO:0042627 chylomicron(GO:0042627)
0.3 3.1 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.3 4.8 GO:0090543 Flemming body(GO:0090543)
0.3 3.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.3 2.4 GO:0045171 intercellular bridge(GO:0045171)
0.3 3.2 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.3 2.1 GO:0000813 ESCRT I complex(GO:0000813)
0.3 4.8 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.3 3.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.3 2.6 GO:0097470 ribbon synapse(GO:0097470)
0.3 6.7 GO:0032156 septin cytoskeleton(GO:0032156)
0.3 1.2 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.3 16.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 2.0 GO:0019815 B cell receptor complex(GO:0019815)
0.3 7.1 GO:0002080 acrosomal membrane(GO:0002080)
0.3 5.9 GO:0031528 microvillus membrane(GO:0031528)
0.3 1.5 GO:0005682 U5 snRNP(GO:0005682)
0.2 3.0 GO:0035631 CD40 receptor complex(GO:0035631)
0.2 4.7 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.2 8.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 17.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 4.4 GO:0098576 lumenal side of membrane(GO:0098576)
0.2 4.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.2 1.3 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.2 1.9 GO:0005955 calcineurin complex(GO:0005955)
0.2 26.8 GO:0016605 PML body(GO:0016605)
0.2 32.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 5.5 GO:0005721 pericentric heterochromatin(GO:0005721)
0.2 4.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 5.9 GO:0035580 specific granule lumen(GO:0035580)
0.2 1.5 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.2 1.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 0.5 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.2 23.1 GO:0005903 brush border(GO:0005903)
0.2 4.9 GO:0032040 small-subunit processome(GO:0032040)
0.2 3.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.2 5.2 GO:0005844 polysome(GO:0005844)
0.2 3.0 GO:0071437 invadopodium(GO:0071437)
0.1 1.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 15.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 1.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.1 4.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 2.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 12.5 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 0.7 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.1 9.7 GO:0031594 neuromuscular junction(GO:0031594)
0.1 8.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 2.0 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 16.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 4.5 GO:0032993 protein-DNA complex(GO:0032993)
0.1 5.8 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 10.5 GO:0005840 ribosome(GO:0005840)
0.1 2.8 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 9.7 GO:0035579 specific granule membrane(GO:0035579)
0.1 5.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 1.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 5.4 GO:0005811 lipid particle(GO:0005811)
0.1 0.7 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 4.0 GO:0019814 immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571)
0.1 1.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 6.7 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 9.3 GO:0072562 blood microparticle(GO:0072562)
0.1 0.8 GO:0046930 pore complex(GO:0046930)
0.1 3.1 GO:0000502 proteasome complex(GO:0000502)
0.1 3.6 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.1 3.8 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 0.4 GO:0005610 laminin-5 complex(GO:0005610)
0.1 2.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 2.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.8 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 16.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 3.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0030891 VCB complex(GO:0030891)
0.0 2.1 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 0.3 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 3.4 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.9 GO:0000791 euchromatin(GO:0000791)
0.0 3.0 GO:0005681 spliceosomal complex(GO:0005681)
0.0 1.5 GO:0031201 SNARE complex(GO:0031201)
0.0 0.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.9 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 1.8 GO:0005643 nuclear pore(GO:0005643)
0.0 0.7 GO:0002102 podosome(GO:0002102)
0.0 7.2 GO:0005769 early endosome(GO:0005769)
0.0 0.6 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 1.9 GO:0016363 nuclear matrix(GO:0016363)
0.0 3.5 GO:0030027 lamellipodium(GO:0030027)
0.0 47.8 GO:0005654 nucleoplasm(GO:0005654)
0.0 1.3 GO:0005882 intermediate filament(GO:0005882)
0.0 0.2 GO:0033270 paranode region of axon(GO:0033270)
0.0 1.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0097381 photoreceptor disc membrane(GO:0097381)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 32.0 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
5.3 36.9 GO:0061133 endopeptidase activator activity(GO:0061133)
3.8 11.3 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
3.7 15.0 GO:0003938 IMP dehydrogenase activity(GO:0003938)
3.7 14.8 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
3.5 10.6 GO:0004766 spermidine synthase activity(GO:0004766)
3.3 13.4 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
3.0 33.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
3.0 24.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
2.6 7.8 GO:0032551 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
2.5 10.0 GO:0032143 single thymine insertion binding(GO:0032143)
2.4 16.7 GO:0050815 phosphoserine binding(GO:0050815)
2.3 7.0 GO:0017130 poly(C) RNA binding(GO:0017130)
2.3 16.3 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
2.3 16.0 GO:0004849 uridine kinase activity(GO:0004849)
2.1 8.3 GO:0034186 apolipoprotein A-I binding(GO:0034186)
2.1 12.3 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
2.0 10.2 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
1.9 5.8 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
1.8 18.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
1.7 10.4 GO:0019238 cyclohydrolase activity(GO:0019238)
1.7 6.8 GO:0031208 POZ domain binding(GO:0031208)
1.7 6.8 GO:0004335 galactokinase activity(GO:0004335)
1.7 11.6 GO:0030369 ICAM-3 receptor activity(GO:0030369)
1.6 33.9 GO:0001055 RNA polymerase II activity(GO:0001055)
1.6 9.5 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
1.6 4.7 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
1.5 9.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
1.5 5.9 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
1.5 4.4 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
1.4 5.6 GO:0004966 galanin receptor activity(GO:0004966)
1.4 8.3 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
1.4 4.1 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
1.3 7.8 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
1.3 15.2 GO:0005131 growth hormone receptor binding(GO:0005131)
1.3 3.8 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
1.2 8.7 GO:0004457 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
1.2 22.0 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
1.2 9.5 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
1.2 5.9 GO:0070404 NADH binding(GO:0070404)
1.1 1.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
1.1 5.3 GO:0017159 pantetheine hydrolase activity(GO:0017159)
1.0 4.9 GO:0034046 poly(G) binding(GO:0034046)
1.0 3.9 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
1.0 17.1 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.9 4.7 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.9 3.7 GO:0036033 mediator complex binding(GO:0036033)
0.9 5.5 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.9 16.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.9 5.3 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.9 1.8 GO:0008469 histone-arginine N-methyltransferase activity(GO:0008469) protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.8 5.1 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.8 5.9 GO:0004046 aminoacylase activity(GO:0004046)
0.8 12.6 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.8 2.5 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.7 12.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.7 32.7 GO:0050699 WW domain binding(GO:0050699)
0.7 2.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.7 5.6 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.7 7.0 GO:0019206 nucleoside kinase activity(GO:0019206)
0.7 4.2 GO:0003998 acylphosphatase activity(GO:0003998)
0.7 2.1 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.7 2.6 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.7 7.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.6 30.5 GO:0000049 tRNA binding(GO:0000049)
0.6 1.9 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.6 2.5 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
0.6 6.0 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.6 1.8 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.6 6.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.6 2.4 GO:0008384 IkappaB kinase activity(GO:0008384)
0.6 27.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.6 4.0 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.6 6.2 GO:0051434 BH3 domain binding(GO:0051434)
0.6 2.3 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.6 1.7 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.5 16.4 GO:0042288 MHC class I protein binding(GO:0042288)
0.5 10.8 GO:0070628 proteasome binding(GO:0070628)
0.5 0.5 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.5 2.6 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.5 9.0 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.5 5.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.5 6.1 GO:0001056 RNA polymerase III activity(GO:0001056)
0.5 11.5 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.5 1.5 GO:0033149 FFAT motif binding(GO:0033149)
0.5 3.5 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.5 7.4 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.5 4.4 GO:0051400 BH domain binding(GO:0051400)
0.5 2.4 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.5 2.8 GO:0052655 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.5 3.7 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.5 5.4 GO:0032027 myosin light chain binding(GO:0032027)
0.4 1.3 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.4 2.7 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.4 2.6 GO:0008266 poly(U) RNA binding(GO:0008266)
0.4 2.4 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.4 1.1 GO:0035500 MH2 domain binding(GO:0035500)
0.4 2.6 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.4 3.3 GO:0015288 porin activity(GO:0015288)
0.4 1.5 GO:0008518 reduced folate carrier activity(GO:0008518) methotrexate transporter activity(GO:0015350)
0.4 2.9 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.4 10.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.4 1.8 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.4 3.5 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.3 5.8 GO:0043274 phospholipase binding(GO:0043274)
0.3 3.1 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.3 3.3 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.3 2.2 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.3 4.8 GO:0031996 thioesterase binding(GO:0031996)
0.3 0.9 GO:0098770 FBXO family protein binding(GO:0098770)
0.3 0.9 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.3 1.8 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.3 4.2 GO:0032395 MHC class II receptor activity(GO:0032395)
0.3 5.4 GO:0004707 MAP kinase activity(GO:0004707)
0.3 18.7 GO:0016836 hydro-lyase activity(GO:0016836)
0.3 3.3 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.3 18.0 GO:0001784 phosphotyrosine binding(GO:0001784)
0.3 1.2 GO:0004803 transposase activity(GO:0004803)
0.3 10.2 GO:0017025 TBP-class protein binding(GO:0017025)
0.3 1.5 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.3 1.2 GO:0015250 water channel activity(GO:0015250)
0.3 6.3 GO:0031491 nucleosome binding(GO:0031491)
0.3 2.0 GO:0050321 tau-protein kinase activity(GO:0050321)
0.3 1.9 GO:0071532 ankyrin repeat binding(GO:0071532)
0.3 17.4 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.3 28.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 9.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 1.7 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.2 2.4 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.2 2.1 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 4.0 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 0.9 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.2 27.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 1.1 GO:0070402 NADPH binding(GO:0070402)
0.2 10.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 5.4 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.2 1.7 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.2 2.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.2 5.7 GO:0008143 poly(A) binding(GO:0008143)
0.2 1.0 GO:0004771 sterol esterase activity(GO:0004771)
0.2 4.2 GO:0030331 estrogen receptor binding(GO:0030331)
0.2 2.4 GO:0008494 translation activator activity(GO:0008494)
0.2 2.8 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 3.6 GO:0017166 vinculin binding(GO:0017166)
0.2 1.9 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 4.5 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.2 7.0 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.2 3.0 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.2 4.3 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.2 0.7 GO:0043559 insulin binding(GO:0043559)
0.2 39.5 GO:0051015 actin filament binding(GO:0051015)
0.2 3.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 4.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.2 1.6 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.2 3.1 GO:0000339 RNA cap binding(GO:0000339)
0.2 4.3 GO:0015631 tubulin binding(GO:0015631)
0.2 4.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.2 2.2 GO:0003680 AT DNA binding(GO:0003680)
0.2 19.5 GO:0051082 unfolded protein binding(GO:0051082)
0.2 2.9 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.6 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 1.8 GO:0098847 sequence-specific single stranded DNA binding(GO:0098847)
0.1 1.9 GO:0004985 opioid receptor activity(GO:0004985)
0.1 31.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 2.4 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.1 10.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 3.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 7.8 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 6.9 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 1.3 GO:0097016 L27 domain binding(GO:0097016)
0.1 1.9 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.6 GO:0070513 death domain binding(GO:0070513)
0.1 1.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 5.1 GO:0030145 manganese ion binding(GO:0030145)
0.1 1.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 1.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 5.5 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 2.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 4.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 0.7 GO:0030274 LIM domain binding(GO:0030274)
0.1 1.6 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 4.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 1.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 25.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.8 GO:0004645 phosphorylase activity(GO:0004645)
0.1 0.2 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 1.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 3.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.8 GO:0005518 collagen binding(GO:0005518)
0.1 2.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 4.2 GO:0008289 lipid binding(GO:0008289)
0.1 7.6 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 1.8 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 3.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 1.5 GO:0030506 ankyrin binding(GO:0030506)
0.1 1.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 1.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 2.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 16.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.7 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 2.7 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 7.1 GO:0003823 antigen binding(GO:0003823)
0.0 0.3 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 2.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 6.0 GO:0042393 histone binding(GO:0042393)
0.0 0.2 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 1.0 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 1.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.5 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 2.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.5 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.8 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.9 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 1.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 3.7 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.7 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.3 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.3 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 2.3 GO:0004386 helicase activity(GO:0004386)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 2.1 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.8 GO:0005109 frizzled binding(GO:0005109)
0.0 1.7 GO:0019003 GDP binding(GO:0019003)
0.0 0.7 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.5 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 0.5 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.4 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.2 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 2.8 GO:0003682 chromatin binding(GO:0003682)
0.0 1.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.2 GO:0008565 protein transporter activity(GO:0008565)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 27.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.5 15.2 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.7 32.9 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.7 79.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.6 2.5 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.6 53.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.6 30.0 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.6 33.2 PID ATR PATHWAY ATR signaling pathway
0.5 25.8 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.5 13.4 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.5 32.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.5 8.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.4 25.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.4 1.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.3 5.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.3 23.9 PID RAC1 PATHWAY RAC1 signaling pathway
0.3 8.4 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.2 16.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.2 3.9 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.2 7.3 PID EPO PATHWAY EPO signaling pathway
0.2 6.0 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.2 11.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.2 16.5 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.2 10.2 PID E2F PATHWAY E2F transcription factor network
0.2 5.0 PID AURORA A PATHWAY Aurora A signaling
0.2 17.2 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 8.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.2 14.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 5.2 PID FOXO PATHWAY FoxO family signaling
0.1 2.5 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 6.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 7.1 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 15.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 2.4 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 6.7 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 2.9 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 0.7 PID REELIN PATHWAY Reelin signaling pathway
0.1 6.2 PID CMYB PATHWAY C-MYB transcription factor network
0.1 3.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 4.0 PID P73PATHWAY p73 transcription factor network
0.1 2.0 PID ALK1 PATHWAY ALK1 signaling events
0.1 4.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 2.8 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 1.2 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.1 2.0 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.0 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.8 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.9 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.3 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.6 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.5 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 0.9 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.9 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 44.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
1.4 33.9 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
1.2 29.6 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
1.1 5.4 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
1.0 28.8 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
1.0 27.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.9 15.0 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.8 15.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.8 30.2 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.8 16.5 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.8 15.7 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.8 67.6 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.7 16.2 REACTOME ORC1 REMOVAL FROM CHROMATIN Genes involved in Orc1 removal from chromatin
0.7 14.3 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.6 11.3 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.6 21.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.6 17.2 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.6 28.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.5 12.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.5 10.3 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.5 5.9 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.5 22.7 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.5 6.1 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.5 3.3 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.5 7.6 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.4 15.9 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.4 7.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.4 10.6 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.4 3.6 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint
0.4 4.4 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.4 10.8 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.4 11.5 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.4 6.5 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.4 7.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.3 7.0 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.3 8.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.3 7.0 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.3 7.9 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.3 5.9 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
0.3 21.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3 8.9 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 1.9 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.3 3.3 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.3 27.7 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.3 7.4 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.3 3.0 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.2 18.2 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.2 4.0 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 8.1 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.2 1.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.2 5.8 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.2 2.9 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.2 9.5 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.2 3.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 3.0 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2 2.4 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.2 18.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 24.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 5.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 2.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 5.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 2.9 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.2 6.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.2 2.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 4.8 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.1 1.6 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.7 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 4.7 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 3.1 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 6.2 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 2.5 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 7.1 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.1 7.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 2.8 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 16.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 3.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 7.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 5.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 6.4 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 3.7 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 4.8 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 2.1 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 3.1 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 3.9 REACTOME TRANSLATION Genes involved in Translation
0.1 1.5 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.7 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 0.8 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.3 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.8 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 2.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 2.0 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.8 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 2.5 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.9 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.1 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.6 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 2.7 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.0 6.8 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.0 1.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.6 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.5 REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES Genes involved in Recruitment of mitotic centrosome proteins and complexes
0.0 0.3 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.2 REACTOME OPSINS Genes involved in Opsins
0.0 0.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.3 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.5 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors