Project
averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GLIS2
Z-value: 1.00
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Transcription factors associated with GLIS2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
GLIS2
|
ENSG00000126603.4 | GLIS family zinc finger 2 |
Activity profile of GLIS2 motif
Sorted Z-values of GLIS2 motif
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_18466026 | 11.47 |
ENST00000417717.2
|
SATB1
|
SATB homeobox 1 |
| chr19_+_45418067 | 10.99 |
ENST00000589078.1
ENST00000586638.1 |
APOC1
|
apolipoprotein C-I |
| chr19_+_45409011 | 10.82 |
ENST00000252486.4
ENST00000446996.1 ENST00000434152.1 |
APOE
|
apolipoprotein E |
| chr19_+_45417504 | 9.43 |
ENST00000588750.1
ENST00000588802.1 |
APOC1
|
apolipoprotein C-I |
| chr2_+_24272576 | 9.25 |
ENST00000380986.4
ENST00000452109.1 |
FKBP1B
|
FK506 binding protein 1B, 12.6 kDa |
| chr20_+_30640004 | 8.77 |
ENST00000520553.1
ENST00000518730.1 ENST00000375852.2 |
HCK
|
hemopoietic cell kinase |
| chr19_+_45417812 | 8.62 |
ENST00000592535.1
|
APOC1
|
apolipoprotein C-I |
| chr6_+_33048222 | 8.34 |
ENST00000428835.1
|
HLA-DPB1
|
major histocompatibility complex, class II, DP beta 1 |
| chr2_+_24272543 | 8.34 |
ENST00000380991.4
|
FKBP1B
|
FK506 binding protein 1B, 12.6 kDa |
| chr19_+_45417921 | 7.76 |
ENST00000252491.4
ENST00000592885.1 ENST00000589781.1 |
APOC1
|
apolipoprotein C-I |
| chr7_-_73133959 | 7.70 |
ENST00000395155.3
ENST00000395154.3 ENST00000222812.3 ENST00000395156.3 |
STX1A
|
syntaxin 1A (brain) |
| chr19_+_45973120 | 7.36 |
ENST00000592811.1
ENST00000586615.1 |
FOSB
|
FBJ murine osteosarcoma viral oncogene homolog B |
| chrX_+_102469997 | 7.20 |
ENST00000372695.5
ENST00000372691.3 |
BEX4
|
brain expressed, X-linked 4 |
| chr11_-_72353451 | 7.07 |
ENST00000376450.3
|
PDE2A
|
phosphodiesterase 2A, cGMP-stimulated |
| chr20_+_30639991 | 6.81 |
ENST00000534862.1
ENST00000538448.1 ENST00000375862.2 |
HCK
|
hemopoietic cell kinase |
| chr14_-_21493649 | 6.80 |
ENST00000553442.1
ENST00000555869.1 ENST00000556457.1 ENST00000397844.2 ENST00000554415.1 |
NDRG2
|
NDRG family member 2 |
| chr14_-_21493884 | 6.70 |
ENST00000556974.1
ENST00000554419.1 ENST00000298687.5 ENST00000397858.1 ENST00000360463.3 ENST00000350792.3 ENST00000397847.2 |
NDRG2
|
NDRG family member 2 |
| chr14_+_100150622 | 6.66 |
ENST00000261835.3
|
CYP46A1
|
cytochrome P450, family 46, subfamily A, polypeptide 1 |
| chr5_-_131826457 | 6.31 |
ENST00000437654.1
ENST00000245414.4 |
IRF1
|
interferon regulatory factor 1 |
| chr22_+_23264766 | 6.17 |
ENST00000390331.2
|
IGLC7
|
immunoglobulin lambda constant 7 |
| chr11_-_64510409 | 5.96 |
ENST00000394429.1
ENST00000394428.1 |
RASGRP2
|
RAS guanyl releasing protein 2 (calcium and DAG-regulated) |
| chr19_-_54784937 | 5.73 |
ENST00000434421.1
ENST00000314446.5 ENST00000391749.4 |
LILRB2
|
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 |
| chrX_-_102319092 | 5.69 |
ENST00000372728.3
|
BEX1
|
brain expressed, X-linked 1 |
| chr22_-_21213029 | 5.68 |
ENST00000572273.1
ENST00000255882.6 |
PI4KA
|
phosphatidylinositol 4-kinase, catalytic, alpha |
| chr16_-_29910853 | 5.60 |
ENST00000308713.5
|
SEZ6L2
|
seizure related 6 homolog (mouse)-like 2 |
| chr8_+_27183033 | 5.44 |
ENST00000420218.2
|
PTK2B
|
protein tyrosine kinase 2 beta |
| chr20_+_44657845 | 5.34 |
ENST00000243964.3
|
SLC12A5
|
solute carrier family 12 (potassium/chloride transporter), member 5 |
| chr8_-_103136481 | 5.26 |
ENST00000524209.1
ENST00000517822.1 ENST00000523923.1 ENST00000521599.1 ENST00000521964.1 ENST00000311028.3 ENST00000518166.1 |
NCALD
|
neurocalcin delta |
| chr16_-_29910365 | 5.21 |
ENST00000346932.5
ENST00000350527.3 ENST00000537485.1 ENST00000568380.1 |
SEZ6L2
|
seizure related 6 homolog (mouse)-like 2 |
| chr6_-_32908792 | 5.03 |
ENST00000418107.2
|
HLA-DMB
|
major histocompatibility complex, class II, DM beta |
| chr11_+_121447469 | 5.03 |
ENST00000532694.1
ENST00000534286.1 |
SORL1
|
sortilin-related receptor, L(DLR class) A repeats containing |
| chr20_+_57466461 | 4.97 |
ENST00000306090.10
|
GNAS
|
GNAS complex locus |
| chr10_+_106014468 | 4.94 |
ENST00000369710.4
ENST00000369713.5 ENST00000445155.1 |
GSTO1
|
glutathione S-transferase omega 1 |
| chr19_+_19322758 | 4.79 |
ENST00000252575.6
|
NCAN
|
neurocan |
| chr1_-_36947120 | 4.59 |
ENST00000361632.4
|
CSF3R
|
colony stimulating factor 3 receptor (granulocyte) |
| chr1_-_19229248 | 4.17 |
ENST00000375341.3
|
ALDH4A1
|
aldehyde dehydrogenase 4 family, member A1 |
| chrX_+_51927919 | 4.07 |
ENST00000416960.1
|
MAGED4
|
melanoma antigen family D, 4 |
| chr2_+_102508955 | 4.05 |
ENST00000414004.2
|
FLJ20373
|
FLJ20373 |
| chr1_+_2487800 | 4.05 |
ENST00000355716.4
|
TNFRSF14
|
tumor necrosis factor receptor superfamily, member 14 |
| chr11_-_615942 | 4.03 |
ENST00000397562.3
ENST00000330243.5 ENST00000397570.1 ENST00000397574.2 |
IRF7
|
interferon regulatory factor 7 |
| chr2_-_89310012 | 4.02 |
ENST00000493819.1
|
IGKV1-9
|
immunoglobulin kappa variable 1-9 |
| chr8_-_134115118 | 4.02 |
ENST00000395352.3
ENST00000338087.5 |
SLA
|
Src-like-adaptor |
| chr8_+_27182862 | 3.95 |
ENST00000521164.1
ENST00000346049.5 |
PTK2B
|
protein tyrosine kinase 2 beta |
| chr7_-_158380371 | 3.84 |
ENST00000389418.4
ENST00000389416.4 |
PTPRN2
|
protein tyrosine phosphatase, receptor type, N polypeptide 2 |
| chr6_+_44238203 | 3.56 |
ENST00000451188.2
|
TMEM151B
|
transmembrane protein 151B |
| chr6_+_69345166 | 3.54 |
ENST00000370598.1
|
BAI3
|
brain-specific angiogenesis inhibitor 3 |
| chr19_+_17858509 | 3.53 |
ENST00000594202.1
ENST00000252771.7 ENST00000389133.4 |
FCHO1
|
FCH domain only 1 |
| chr19_-_3061397 | 3.53 |
ENST00000586839.1
|
AES
|
amino-terminal enhancer of split |
| chr6_-_2903514 | 3.47 |
ENST00000380698.4
|
SERPINB9
|
serpin peptidase inhibitor, clade B (ovalbumin), member 9 |
| chr1_-_153348067 | 3.36 |
ENST00000368737.3
|
S100A12
|
S100 calcium binding protein A12 |
| chr6_-_32908765 | 3.35 |
ENST00000416244.2
|
HLA-DMB
|
major histocompatibility complex, class II, DM beta |
| chr10_-_73848531 | 3.31 |
ENST00000373109.2
|
SPOCK2
|
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 |
| chr9_+_117373486 | 3.30 |
ENST00000288502.4
ENST00000374049.4 |
C9orf91
|
chromosome 9 open reading frame 91 |
| chr2_-_55277512 | 3.22 |
ENST00000402434.2
|
RTN4
|
reticulon 4 |
| chr19_+_17858547 | 3.20 |
ENST00000600676.1
ENST00000600209.1 ENST00000596309.1 ENST00000598539.1 ENST00000597474.1 ENST00000593385.1 ENST00000598067.1 ENST00000593833.1 |
FCHO1
|
FCH domain only 1 |
| chr1_-_28520447 | 3.12 |
ENST00000539896.1
|
PTAFR
|
platelet-activating factor receptor |
| chr20_-_52687059 | 3.11 |
ENST00000371435.2
ENST00000395961.3 |
BCAS1
|
breast carcinoma amplified sequence 1 |
| chr19_-_19006920 | 3.10 |
ENST00000429504.2
ENST00000427170.2 |
CERS1
|
ceramide synthase 1 |
| chr17_-_27224621 | 3.07 |
ENST00000394906.2
ENST00000585169.1 ENST00000394908.4 |
FLOT2
|
flotillin 2 |
| chr11_-_615570 | 3.02 |
ENST00000525445.1
ENST00000348655.6 ENST00000397566.1 |
IRF7
|
interferon regulatory factor 7 |
| chr19_-_19006890 | 3.01 |
ENST00000247005.6
|
GDF1
|
growth differentiation factor 1 |
| chr19_-_2702681 | 3.00 |
ENST00000382159.3
|
GNG7
|
guanine nucleotide binding protein (G protein), gamma 7 |
| chr3_+_4535025 | 2.99 |
ENST00000302640.8
ENST00000354582.6 ENST00000423119.2 ENST00000357086.4 ENST00000456211.2 |
ITPR1
|
inositol 1,4,5-trisphosphate receptor, type 1 |
| chr2_+_220492373 | 2.94 |
ENST00000317151.3
|
SLC4A3
|
solute carrier family 4 (anion exchanger), member 3 |
| chr19_-_39108568 | 2.93 |
ENST00000586296.1
|
MAP4K1
|
mitogen-activated protein kinase kinase kinase kinase 1 |
| chr7_-_158380465 | 2.93 |
ENST00000389413.3
ENST00000409483.1 |
PTPRN2
|
protein tyrosine phosphatase, receptor type, N polypeptide 2 |
| chr17_+_78075361 | 2.92 |
ENST00000577106.1
ENST00000390015.3 |
GAA
|
glucosidase, alpha; acid |
| chr10_-_75634219 | 2.86 |
ENST00000305762.7
|
CAMK2G
|
calcium/calmodulin-dependent protein kinase II gamma |
| chr1_-_40157345 | 2.80 |
ENST00000372844.3
|
HPCAL4
|
hippocalcin like 4 |
| chr8_+_41347915 | 2.80 |
ENST00000518270.1
ENST00000520817.1 |
GOLGA7
|
golgin A7 |
| chr17_-_4871085 | 2.79 |
ENST00000575142.1
ENST00000206020.3 |
SPAG7
|
sperm associated antigen 7 |
| chr17_+_7461580 | 2.77 |
ENST00000483039.1
ENST00000396542.1 |
TNFSF13
|
tumor necrosis factor (ligand) superfamily, member 13 |
| chr5_-_1524015 | 2.75 |
ENST00000283415.3
|
LPCAT1
|
lysophosphatidylcholine acyltransferase 1 |
| chr2_+_131113580 | 2.74 |
ENST00000175756.5
|
PTPN18
|
protein tyrosine phosphatase, non-receptor type 18 (brain-derived) |
| chr3_+_54157480 | 2.73 |
ENST00000490478.1
|
CACNA2D3
|
calcium channel, voltage-dependent, alpha 2/delta subunit 3 |
| chr7_-_752577 | 2.70 |
ENST00000544935.1
ENST00000430040.1 ENST00000456696.2 ENST00000406797.1 |
PRKAR1B
|
protein kinase, cAMP-dependent, regulatory, type I, beta |
| chr2_-_55277654 | 2.66 |
ENST00000337526.6
ENST00000317610.7 ENST00000357732.4 |
RTN4
|
reticulon 4 |
| chr2_+_169312350 | 2.65 |
ENST00000305747.6
|
CERS6
|
ceramide synthase 6 |
| chr12_-_57941004 | 2.58 |
ENST00000550750.1
ENST00000548249.1 |
DCTN2
|
dynactin 2 (p50) |
| chrX_+_153656978 | 2.52 |
ENST00000369762.2
ENST00000422890.1 |
ATP6AP1
|
ATPase, H+ transporting, lysosomal accessory protein 1 |
| chr7_+_75544397 | 2.50 |
ENST00000461988.1
ENST00000419840.1 |
POR
|
P450 (cytochrome) oxidoreductase |
| chr19_+_17186577 | 2.49 |
ENST00000595618.1
ENST00000594824.1 |
MYO9B
|
myosin IXB |
| chr16_+_2198604 | 2.48 |
ENST00000210187.6
|
RAB26
|
RAB26, member RAS oncogene family |
| chr3_-_48470838 | 2.48 |
ENST00000358459.4
ENST00000358536.4 |
PLXNB1
|
plexin B1 |
| chr3_+_153839149 | 2.47 |
ENST00000465093.1
ENST00000465817.1 |
ARHGEF26
|
Rho guanine nucleotide exchange factor (GEF) 26 |
| chr8_+_41348173 | 2.46 |
ENST00000357743.4
|
GOLGA7
|
golgin A7 |
| chr2_+_131113609 | 2.45 |
ENST00000347849.3
|
PTPN18
|
protein tyrosine phosphatase, non-receptor type 18 (brain-derived) |
| chr20_+_57466357 | 2.44 |
ENST00000371095.3
ENST00000371085.3 ENST00000354359.7 ENST00000265620.7 |
GNAS
|
GNAS complex locus |
| chr2_-_55277692 | 2.44 |
ENST00000394611.2
|
RTN4
|
reticulon 4 |
| chr16_-_89556942 | 2.43 |
ENST00000301030.4
|
ANKRD11
|
ankyrin repeat domain 11 |
| chr3_+_183903811 | 2.41 |
ENST00000429586.2
ENST00000292808.5 |
ABCF3
|
ATP-binding cassette, sub-family F (GCN20), member 3 |
| chrX_+_1710484 | 2.40 |
ENST00000313871.3
ENST00000381261.3 |
AKAP17A
|
A kinase (PRKA) anchor protein 17A |
| chr12_-_57940904 | 2.40 |
ENST00000550954.1
ENST00000434715.3 ENST00000546670.1 ENST00000543672.1 |
DCTN2
|
dynactin 2 (p50) |
| chr7_+_75544466 | 2.37 |
ENST00000421059.1
ENST00000394893.1 ENST00000412521.1 ENST00000414186.1 |
POR
|
P450 (cytochrome) oxidoreductase |
| chr19_+_7733929 | 2.36 |
ENST00000221515.2
|
RETN
|
resistin |
| chr15_+_81475047 | 2.33 |
ENST00000559388.1
|
IL16
|
interleukin 16 |
| chr11_-_61197187 | 2.27 |
ENST00000449811.1
ENST00000413232.1 ENST00000340437.4 ENST00000539952.1 ENST00000544585.1 ENST00000450000.1 |
CPSF7
|
cleavage and polyadenylation specific factor 7, 59kDa |
| chr1_-_201346761 | 2.23 |
ENST00000455702.1
ENST00000422165.1 ENST00000367318.5 ENST00000367320.2 ENST00000438742.1 ENST00000412633.1 ENST00000458432.2 ENST00000421663.2 ENST00000367322.1 ENST00000509001.1 |
TNNT2
|
troponin T type 2 (cardiac) |
| chr11_+_63753883 | 2.23 |
ENST00000538426.1
ENST00000543004.1 |
OTUB1
|
OTU domain, ubiquitin aldehyde binding 1 |
| chr22_+_22681656 | 2.21 |
ENST00000390291.2
|
IGLV1-50
|
immunoglobulin lambda variable 1-50 (non-functional) |
| chr4_+_40058411 | 2.21 |
ENST00000261435.6
ENST00000515550.1 |
N4BP2
|
NEDD4 binding protein 2 |
| chr19_+_10765699 | 2.21 |
ENST00000590009.1
|
ILF3
|
interleukin enhancer binding factor 3, 90kDa |
| chr22_-_18256742 | 2.20 |
ENST00000317361.7
|
BID
|
BH3 interacting domain death agonist |
| chr8_+_41348072 | 2.19 |
ENST00000405786.2
|
GOLGA7
|
golgin A7 |
| chr16_+_67198683 | 2.18 |
ENST00000517685.1
ENST00000521374.1 ENST00000584272.1 |
HSF4
|
heat shock transcription factor 4 |
| chr6_+_29624862 | 2.16 |
ENST00000376894.4
|
MOG
|
myelin oligodendrocyte glycoprotein |
| chr7_+_87257701 | 2.15 |
ENST00000338056.3
ENST00000493037.1 |
RUNDC3B
|
RUN domain containing 3B |
| chr19_+_49622646 | 2.12 |
ENST00000334186.4
|
PPFIA3
|
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 |
| chr19_+_55105085 | 2.11 |
ENST00000251372.3
ENST00000453777.1 |
LILRA1
|
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 |
| chr19_+_54372639 | 2.10 |
ENST00000391769.2
|
MYADM
|
myeloid-associated differentiation marker |
| chr3_-_125803105 | 2.07 |
ENST00000346785.5
ENST00000315891.6 |
SLC41A3
|
solute carrier family 41, member 3 |
| chr20_+_44637526 | 2.06 |
ENST00000372330.3
|
MMP9
|
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) |
| chrX_+_102631844 | 2.06 |
ENST00000372634.1
ENST00000299872.7 |
NGFRAP1
|
nerve growth factor receptor (TNFRSF16) associated protein 1 |
| chr14_+_24540731 | 2.06 |
ENST00000558859.1
ENST00000559197.1 ENST00000560828.1 ENST00000216775.2 ENST00000560884.1 |
CPNE6
|
copine VI (neuronal) |
| chr19_+_17337406 | 2.03 |
ENST00000597836.1
|
OCEL1
|
occludin/ELL domain containing 1 |
| chr4_+_114214125 | 2.02 |
ENST00000509550.1
|
ANK2
|
ankyrin 2, neuronal |
| chr6_+_29624758 | 2.01 |
ENST00000376917.3
ENST00000376902.3 ENST00000533330.2 ENST00000376888.2 |
MOG
|
myelin oligodendrocyte glycoprotein |
| chr3_-_125802765 | 2.00 |
ENST00000514891.1
ENST00000512470.1 ENST00000504035.1 ENST00000360370.4 ENST00000513723.1 ENST00000510651.1 ENST00000514333.1 |
SLC41A3
|
solute carrier family 41, member 3 |
| chr17_-_76719807 | 1.98 |
ENST00000589297.1
|
CYTH1
|
cytohesin 1 |
| chr22_-_18257249 | 1.96 |
ENST00000399765.1
ENST00000399767.1 ENST00000399774.3 |
BID
|
BH3 interacting domain death agonist |
| chr22_-_18257178 | 1.95 |
ENST00000342111.5
|
BID
|
BH3 interacting domain death agonist |
| chr2_+_169312725 | 1.93 |
ENST00000392687.4
|
CERS6
|
ceramide synthase 6 |
| chr6_+_29624898 | 1.89 |
ENST00000396704.3
ENST00000483013.1 ENST00000490427.1 ENST00000416766.2 ENST00000376891.4 ENST00000376898.3 ENST00000396701.2 ENST00000494692.1 ENST00000431798.2 |
MOG
|
myelin oligodendrocyte glycoprotein |
| chr15_+_42694573 | 1.84 |
ENST00000397200.4
ENST00000569827.1 |
CAPN3
|
calpain 3, (p94) |
| chr16_+_765092 | 1.83 |
ENST00000568223.2
|
METRN
|
meteorin, glial cell differentiation regulator |
| chr1_+_1950763 | 1.79 |
ENST00000378585.4
|
GABRD
|
gamma-aminobutyric acid (GABA) A receptor, delta |
| chr7_+_87257854 | 1.76 |
ENST00000394654.3
|
RUNDC3B
|
RUN domain containing 3B |
| chr11_-_64646086 | 1.73 |
ENST00000320631.3
|
EHD1
|
EH-domain containing 1 |
| chr9_-_35112376 | 1.70 |
ENST00000488109.2
|
FAM214B
|
family with sequence similarity 214, member B |
| chr2_+_46769798 | 1.69 |
ENST00000238738.4
|
RHOQ
|
ras homolog family member Q |
| chr2_-_27718052 | 1.69 |
ENST00000264703.3
|
FNDC4
|
fibronectin type III domain containing 4 |
| chr5_-_180237445 | 1.65 |
ENST00000393340.3
|
MGAT1
|
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase |
| chr19_-_17414179 | 1.64 |
ENST00000594194.1
ENST00000247706.3 |
ABHD8
|
abhydrolase domain containing 8 |
| chr17_-_42200996 | 1.62 |
ENST00000587135.1
ENST00000225983.6 ENST00000393622.2 ENST00000588703.1 |
HDAC5
|
histone deacetylase 5 |
| chr6_+_28109703 | 1.61 |
ENST00000457389.2
ENST00000330236.6 |
ZKSCAN8
|
zinc finger with KRAB and SCAN domains 8 |
| chr3_+_4535155 | 1.60 |
ENST00000544951.1
|
ITPR1
|
inositol 1,4,5-trisphosphate receptor, type 1 |
| chr2_+_37571717 | 1.60 |
ENST00000338415.3
ENST00000404976.1 |
QPCT
|
glutaminyl-peptide cyclotransferase |
| chr17_-_5138099 | 1.59 |
ENST00000571800.1
ENST00000574081.1 ENST00000399600.4 ENST00000574297.1 |
SCIMP
|
SLP adaptor and CSK interacting membrane protein |
| chr19_+_56186557 | 1.57 |
ENST00000270460.6
|
EPN1
|
epsin 1 |
| chr19_-_6720686 | 1.55 |
ENST00000245907.6
|
C3
|
complement component 3 |
| chr6_+_31926857 | 1.54 |
ENST00000375394.2
ENST00000544581.1 |
SKIV2L
|
superkiller viralicidic activity 2-like (S. cerevisiae) |
| chr19_-_39108643 | 1.54 |
ENST00000396857.2
|
MAP4K1
|
mitogen-activated protein kinase kinase kinase kinase 1 |
| chr17_+_5389605 | 1.53 |
ENST00000576988.1
ENST00000576570.1 ENST00000573759.1 |
MIS12
|
MIS12 kinetochore complex component |
| chr20_-_34638841 | 1.53 |
ENST00000565493.1
|
LINC00657
|
long intergenic non-protein coding RNA 657 |
| chr19_-_17799008 | 1.53 |
ENST00000519716.2
|
UNC13A
|
unc-13 homolog A (C. elegans) |
| chr19_-_36643329 | 1.51 |
ENST00000589154.1
|
COX7A1
|
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) |
| chr22_+_22786288 | 1.51 |
ENST00000390301.2
|
IGLV1-36
|
immunoglobulin lambda variable 1-36 |
| chr11_-_61197480 | 1.51 |
ENST00000439958.3
ENST00000394888.4 |
CPSF7
|
cleavage and polyadenylation specific factor 7, 59kDa |
| chr12_+_50451462 | 1.49 |
ENST00000447966.2
|
ASIC1
|
acid-sensing (proton-gated) ion channel 1 |
| chr17_-_41985096 | 1.49 |
ENST00000269095.4
ENST00000523220.1 |
MPP2
|
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) |
| chr17_-_47755338 | 1.47 |
ENST00000508805.1
ENST00000515508.2 ENST00000451526.2 ENST00000507970.1 |
SPOP
|
speckle-type POZ protein |
| chr1_-_24127256 | 1.47 |
ENST00000418277.1
|
GALE
|
UDP-galactose-4-epimerase |
| chr3_+_151531810 | 1.44 |
ENST00000232892.7
|
AADAC
|
arylacetamide deacetylase |
| chr19_-_821931 | 1.43 |
ENST00000359894.2
ENST00000520876.3 ENST00000519502.1 |
LPPR3
|
hsa-mir-3187 |
| chr22_-_38794490 | 1.41 |
ENST00000400206.2
|
CSNK1E
|
casein kinase 1, epsilon |
| chr22_-_32026810 | 1.39 |
ENST00000266095.5
ENST00000397500.1 |
PISD
|
phosphatidylserine decarboxylase |
| chr7_-_130080818 | 1.39 |
ENST00000343969.5
ENST00000541543.1 ENST00000489512.1 |
CEP41
|
centrosomal protein 41kDa |
| chr17_-_34257731 | 1.39 |
ENST00000431884.2
ENST00000425909.3 ENST00000394528.3 ENST00000430160.2 |
RDM1
|
RAD52 motif 1 |
| chr19_-_39108552 | 1.39 |
ENST00000591517.1
|
MAP4K1
|
mitogen-activated protein kinase kinase kinase kinase 1 |
| chrX_+_48660287 | 1.37 |
ENST00000444343.2
ENST00000376610.2 ENST00000334136.5 ENST00000376619.2 |
HDAC6
|
histone deacetylase 6 |
| chr17_+_38278826 | 1.36 |
ENST00000577454.1
ENST00000578648.1 ENST00000579565.1 |
MSL1
|
male-specific lethal 1 homolog (Drosophila) |
| chr19_+_56159509 | 1.36 |
ENST00000586790.1
ENST00000591578.1 ENST00000588740.1 |
CCDC106
|
coiled-coil domain containing 106 |
| chr6_+_17393839 | 1.34 |
ENST00000489374.1
ENST00000378990.2 |
CAP2
|
CAP, adenylate cyclase-associated protein, 2 (yeast) |
| chr22_-_19974616 | 1.32 |
ENST00000344269.3
ENST00000401994.1 ENST00000406522.1 |
ARVCF
|
armadillo repeat gene deleted in velocardiofacial syndrome |
| chr17_+_80014359 | 1.31 |
ENST00000578168.1
|
GPS1
|
G protein pathway suppressor 1 |
| chr10_-_104179682 | 1.30 |
ENST00000406432.1
|
PSD
|
pleckstrin and Sec7 domain containing |
| chr14_-_105635090 | 1.29 |
ENST00000331782.3
ENST00000347004.2 |
JAG2
|
jagged 2 |
| chr20_+_57226284 | 1.26 |
ENST00000458280.1
ENST00000355957.5 ENST00000361770.5 ENST00000312283.8 ENST00000412911.1 ENST00000359617.4 ENST00000371141.4 |
STX16
|
syntaxin 16 |
| chr16_-_29415350 | 1.26 |
ENST00000524087.1
|
NPIPB11
|
nuclear pore complex interacting protein family, member B11 |
| chr17_+_6659153 | 1.26 |
ENST00000441631.1
ENST00000438512.1 ENST00000346752.4 ENST00000361842.3 |
XAF1
|
XIAP associated factor 1 |
| chr13_-_108867846 | 1.25 |
ENST00000442234.1
|
LIG4
|
ligase IV, DNA, ATP-dependent |
| chr7_-_752074 | 1.24 |
ENST00000360274.4
|
PRKAR1B
|
protein kinase, cAMP-dependent, regulatory, type I, beta |
| chr6_+_43457317 | 1.23 |
ENST00000438588.2
|
TJAP1
|
tight junction associated protein 1 (peripheral) |
| chr19_+_56159362 | 1.23 |
ENST00000593069.1
ENST00000308964.3 |
CCDC106
|
coiled-coil domain containing 106 |
| chr19_+_10527449 | 1.21 |
ENST00000592685.1
ENST00000380702.2 |
PDE4A
|
phosphodiesterase 4A, cAMP-specific |
| chr19_+_17337473 | 1.19 |
ENST00000598068.1
|
OCEL1
|
occludin/ELL domain containing 1 |
| chr17_-_7120525 | 1.19 |
ENST00000447163.1
ENST00000399506.2 ENST00000302955.6 |
DLG4
|
discs, large homolog 4 (Drosophila) |
| chr20_+_48807351 | 1.19 |
ENST00000303004.3
|
CEBPB
|
CCAAT/enhancer binding protein (C/EBP), beta |
| chr19_-_8408139 | 1.16 |
ENST00000330915.3
ENST00000593649.1 ENST00000595639.1 |
KANK3
|
KN motif and ankyrin repeat domains 3 |
| chrX_-_2418936 | 1.13 |
ENST00000461691.1
ENST00000381223.4 ENST00000381222.2 ENST00000412516.2 ENST00000334651.5 |
ZBED1
DHRSX
|
zinc finger, BED-type containing 1 dehydrogenase/reductase (SDR family) X-linked |
| chr12_+_57853918 | 1.12 |
ENST00000532291.1
ENST00000543426.1 ENST00000228682.2 ENST00000546141.1 |
GLI1
|
GLI family zinc finger 1 |
| chr10_+_43633914 | 1.12 |
ENST00000374466.3
ENST00000374464.1 |
CSGALNACT2
|
chondroitin sulfate N-acetylgalactosaminyltransferase 2 |
| chr7_+_29237354 | 1.12 |
ENST00000546235.1
|
CHN2
|
chimerin 2 |
| chr17_+_7788104 | 1.11 |
ENST00000380358.4
|
CHD3
|
chromodomain helicase DNA binding protein 3 |
| chr16_-_29934558 | 1.10 |
ENST00000568995.1
ENST00000566413.1 |
KCTD13
|
potassium channel tetramerization domain containing 13 |
| chr1_-_235292250 | 1.09 |
ENST00000366607.4
|
TOMM20
|
translocase of outer mitochondrial membrane 20 homolog (yeast) |
| chr2_+_37571845 | 1.09 |
ENST00000537448.1
|
QPCT
|
glutaminyl-peptide cyclotransferase |
| chr9_+_139839686 | 1.08 |
ENST00000371634.2
|
C8G
|
complement component 8, gamma polypeptide |
| chr19_-_5340730 | 1.07 |
ENST00000372412.4
ENST00000357368.4 ENST00000262963.6 ENST00000348075.2 ENST00000353284.2 |
PTPRS
|
protein tyrosine phosphatase, receptor type, S |
| chr17_+_80416050 | 1.06 |
ENST00000579198.1
ENST00000390006.4 ENST00000580296.1 |
NARF
|
nuclear prelamin A recognition factor |
| chr22_+_21400229 | 1.04 |
ENST00000342608.4
ENST00000543388.1 ENST00000442047.1 |
AC002472.13
|
Leucine-rich repeat-containing protein LOC400891 |
| chrX_-_153744434 | 1.04 |
ENST00000369643.1
ENST00000393572.1 |
FAM3A
|
family with sequence similarity 3, member A |
| chr2_+_71357744 | 1.03 |
ENST00000498451.2
|
MPHOSPH10
|
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) |
| chr12_+_121837844 | 1.03 |
ENST00000361234.5
|
RNF34
|
ring finger protein 34, E3 ubiquitin protein ligase |
| chr15_+_69307028 | 1.01 |
ENST00000388866.3
ENST00000530406.2 |
NOX5
|
NADPH oxidase, EF-hand calcium binding domain 5 |
| chr21_-_39288743 | 1.01 |
ENST00000609713.1
|
KCNJ6
|
potassium inwardly-rectifying channel, subfamily J, member 6 |
| chrX_-_8700171 | 0.99 |
ENST00000262648.3
|
KAL1
|
Kallmann syndrome 1 sequence |
| chr19_+_16830774 | 0.98 |
ENST00000524140.2
|
NWD1
|
NACHT and WD repeat domain containing 1 |
| chr12_+_112563335 | 0.96 |
ENST00000549358.1
ENST00000257604.5 ENST00000548092.1 ENST00000552896.1 |
TRAFD1
|
TRAF-type zinc finger domain containing 1 |
| chr19_+_41103063 | 0.95 |
ENST00000308370.7
|
LTBP4
|
latent transforming growth factor beta binding protein 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GLIS2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.2 | 36.8 | GO:0010900 | negative regulation of phosphatidylcholine catabolic process(GO:0010900) |
| 5.2 | 15.6 | GO:0002522 | leukocyte migration involved in immune response(GO:0002522) |
| 3.6 | 10.8 | GO:1902995 | regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) |
| 2.8 | 8.4 | GO:2001190 | positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
| 2.7 | 13.4 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 2.4 | 7.1 | GO:0033159 | negative regulation of protein import into nucleus, translocation(GO:0033159) |
| 2.3 | 9.4 | GO:2000537 | regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538) |
| 1.9 | 7.7 | GO:0010701 | positive regulation of norepinephrine secretion(GO:0010701) |
| 1.8 | 17.6 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 1.7 | 5.0 | GO:1902955 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
| 1.6 | 4.9 | GO:0043602 | nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210) |
| 1.5 | 7.5 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 1.3 | 5.3 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 1.2 | 3.5 | GO:0042270 | protection from natural killer cell mediated cytotoxicity(GO:0042270) |
| 1.1 | 2.2 | GO:0032972 | regulation of muscle filament sliding speed(GO:0032972) |
| 1.1 | 7.4 | GO:0040032 | post-embryonic body morphogenesis(GO:0040032) |
| 1.0 | 4.2 | GO:0019470 | 4-hydroxyproline catabolic process(GO:0019470) |
| 1.0 | 3.1 | GO:1904317 | positive regulation of neutrophil degranulation(GO:0043315) cellular response to gravity(GO:0071258) positive regulation of neutrophil activation(GO:1902565) regulation of transcytosis(GO:1904298) positive regulation of transcytosis(GO:1904300) regulation of maternal process involved in parturition(GO:1904301) positive regulation of maternal process involved in parturition(GO:1904303) response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904316) cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904317) |
| 0.9 | 8.3 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.9 | 4.6 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.9 | 2.7 | GO:2001245 | regulation of phosphatidylcholine biosynthetic process(GO:2001245) |
| 0.9 | 2.7 | GO:0017186 | peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186) |
| 0.9 | 13.7 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.8 | 2.5 | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
| 0.8 | 4.9 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.8 | 4.0 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
| 0.8 | 2.4 | GO:2000196 | positive regulation of female gonad development(GO:2000196) regulation of progesterone secretion(GO:2000870) |
| 0.8 | 3.1 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 0.8 | 11.5 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.7 | 3.0 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.7 | 6.7 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.7 | 2.9 | GO:0002086 | maltose metabolic process(GO:0000023) diaphragm contraction(GO:0002086) |
| 0.7 | 5.7 | GO:0002774 | Fc receptor mediated inhibitory signaling pathway(GO:0002774) |
| 0.7 | 2.0 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.7 | 2.0 | GO:0061760 | antifungal innate immune response(GO:0061760) |
| 0.6 | 2.5 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
| 0.6 | 6.1 | GO:0010918 | positive regulation of mitochondrial membrane potential(GO:0010918) |
| 0.5 | 1.6 | GO:0002894 | positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894) |
| 0.5 | 1.0 | GO:2000374 | regulation of oxygen metabolic process(GO:2000374) |
| 0.5 | 3.1 | GO:1903903 | regulation of establishment of T cell polarity(GO:1903903) |
| 0.5 | 1.4 | GO:0090034 | regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035) |
| 0.4 | 1.3 | GO:0051102 | DNA ligation involved in DNA recombination(GO:0051102) |
| 0.4 | 1.7 | GO:2001137 | positive regulation of endocytic recycling(GO:2001137) |
| 0.4 | 1.6 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.4 | 1.5 | GO:0099525 | presynaptic dense core granule exocytosis(GO:0099525) |
| 0.4 | 1.1 | GO:0032687 | negative regulation of interferon-alpha production(GO:0032687) |
| 0.3 | 2.1 | GO:0051549 | positive regulation of keratinocyte migration(GO:0051549) |
| 0.3 | 1.0 | GO:0043012 | regulation of fusion of sperm to egg plasma membrane(GO:0043012) |
| 0.3 | 2.3 | GO:0050915 | sensory perception of sour taste(GO:0050915) |
| 0.3 | 3.3 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.3 | 3.5 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.3 | 2.2 | GO:1902915 | negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.3 | 1.8 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 0.3 | 3.6 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
| 0.3 | 7.4 | GO:0051412 | response to corticosterone(GO:0051412) |
| 0.3 | 1.1 | GO:0021938 | ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938) |
| 0.3 | 1.1 | GO:0050653 | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
| 0.3 | 5.8 | GO:0032011 | ARF protein signal transduction(GO:0032011) |
| 0.3 | 1.1 | GO:0035927 | RNA import into mitochondrion(GO:0035927) |
| 0.3 | 0.8 | GO:1902303 | negative regulation of potassium ion export(GO:1902303) |
| 0.2 | 3.9 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.2 | 1.5 | GO:2000676 | positive regulation of type B pancreatic cell apoptotic process(GO:2000676) |
| 0.2 | 1.2 | GO:0016188 | synaptic vesicle maturation(GO:0016188) |
| 0.2 | 1.4 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.2 | 6.7 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.2 | 2.1 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.2 | 4.0 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.2 | 4.6 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.2 | 2.5 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.2 | 4.5 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.2 | 5.7 | GO:0044803 | multi-organism membrane organization(GO:0044803) |
| 0.2 | 0.8 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 0.2 | 1.5 | GO:0034427 | nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427) |
| 0.2 | 5.0 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.2 | 4.8 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.2 | 1.3 | GO:0060120 | auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120) |
| 0.2 | 6.1 | GO:0046718 | viral entry into host cell(GO:0046718) |
| 0.2 | 0.3 | GO:0021555 | midbrain-hindbrain boundary morphogenesis(GO:0021555) |
| 0.2 | 0.2 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 0.2 | 1.1 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.2 | 0.6 | GO:0036496 | regulation of translational initiation by eIF2 alpha dephosphorylation(GO:0036496) |
| 0.2 | 0.3 | GO:0097327 | response to antineoplastic agent(GO:0097327) |
| 0.2 | 0.6 | GO:0006272 | leading strand elongation(GO:0006272) |
| 0.2 | 2.9 | GO:1901897 | regulation of relaxation of cardiac muscle(GO:1901897) |
| 0.1 | 8.1 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 0.1 | 1.4 | GO:0010898 | positive regulation of triglyceride catabolic process(GO:0010898) |
| 0.1 | 0.4 | GO:1905167 | positive regulation of lysosomal protein catabolic process(GO:1905167) |
| 0.1 | 0.7 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.1 | 0.2 | GO:0097211 | response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211) |
| 0.1 | 1.5 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.1 | 0.7 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 0.1 | 0.4 | GO:0019046 | release from viral latency(GO:0019046) |
| 0.1 | 2.3 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.1 | 1.6 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade(GO:0070374) |
| 0.1 | 0.5 | GO:0015692 | lead ion transport(GO:0015692) |
| 0.1 | 2.2 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.1 | 0.1 | GO:0090187 | positive regulation of pancreatic juice secretion(GO:0090187) |
| 0.1 | 3.9 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.1 | 8.0 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.1 | 3.4 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.1 | 0.1 | GO:1990034 | calcium ion export from cell(GO:1990034) |
| 0.1 | 1.6 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.1 | 0.7 | GO:1902527 | positive regulation of protein monoubiquitination(GO:1902527) |
| 0.1 | 1.2 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.1 | 6.1 | GO:0032729 | positive regulation of interferon-gamma production(GO:0032729) |
| 0.1 | 0.8 | GO:0032055 | negative regulation of translation in response to stress(GO:0032055) circadian regulation of translation(GO:0097167) |
| 0.1 | 0.3 | GO:2000547 | dendritic cell dendrite assembly(GO:0097026) regulation of dendritic cell dendrite assembly(GO:2000547) |
| 0.1 | 1.4 | GO:2000052 | positive regulation of non-canonical Wnt signaling pathway(GO:2000052) |
| 0.1 | 5.6 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.1 | 0.3 | GO:1903660 | negative regulation of complement-dependent cytotoxicity(GO:1903660) |
| 0.1 | 1.6 | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051) |
| 0.1 | 0.9 | GO:0045046 | protein import into peroxisome membrane(GO:0045046) |
| 0.1 | 0.8 | GO:0072383 | plus-end-directed vesicle transport along microtubule(GO:0072383) |
| 0.1 | 4.6 | GO:0046513 | ceramide biosynthetic process(GO:0046513) |
| 0.1 | 2.4 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.1 | 1.8 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 0.4 | GO:0072553 | terminal button organization(GO:0072553) |
| 0.1 | 0.4 | GO:0099551 | synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) |
| 0.1 | 0.2 | GO:0036072 | intramembranous ossification(GO:0001957) direct ossification(GO:0036072) |
| 0.1 | 0.3 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.1 | 0.5 | GO:0033629 | negative regulation of cell adhesion mediated by integrin(GO:0033629) |
| 0.1 | 4.7 | GO:0048278 | vesicle docking(GO:0048278) |
| 0.1 | 0.5 | GO:0034447 | very-low-density lipoprotein particle clearance(GO:0034447) |
| 0.1 | 2.3 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
| 0.1 | 0.5 | GO:0043435 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.1 | 1.1 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.1 | 0.3 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 0.1 | 1.4 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
| 0.1 | 3.0 | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862) |
| 0.1 | 1.7 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.0 | 7.3 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.0 | 1.6 | GO:0060334 | regulation of interferon-gamma-mediated signaling pathway(GO:0060334) |
| 0.0 | 0.8 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.0 | 1.6 | GO:0009214 | cyclic nucleotide catabolic process(GO:0009214) |
| 0.0 | 0.6 | GO:0021794 | thalamus development(GO:0021794) |
| 0.0 | 1.1 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
| 0.0 | 0.8 | GO:0033081 | regulation of T cell differentiation in thymus(GO:0033081) regulation of thymocyte aggregation(GO:2000398) |
| 0.0 | 1.5 | GO:0046710 | GDP metabolic process(GO:0046710) |
| 0.0 | 1.3 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 0.0 | 1.0 | GO:0030252 | growth hormone secretion(GO:0030252) |
| 0.0 | 2.7 | GO:1901185 | negative regulation of ERBB signaling pathway(GO:1901185) |
| 0.0 | 2.2 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.0 | 0.5 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
| 0.0 | 0.6 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.0 | 0.0 | GO:0072402 | response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) |
| 0.0 | 0.1 | GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) |
| 0.0 | 1.0 | GO:0045824 | negative regulation of innate immune response(GO:0045824) |
| 0.0 | 0.3 | GO:0006621 | protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
| 0.0 | 0.2 | GO:0019509 | L-methionine biosynthetic process from methylthioadenosine(GO:0019509) |
| 0.0 | 0.7 | GO:0002028 | regulation of sodium ion transport(GO:0002028) |
| 0.0 | 0.1 | GO:0071393 | cellular response to progesterone stimulus(GO:0071393) |
| 0.0 | 0.8 | GO:0007030 | Golgi organization(GO:0007030) |
| 0.0 | 0.2 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.0 | 2.7 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.0 | 0.3 | GO:0010001 | glial cell differentiation(GO:0010001) |
| 0.0 | 0.3 | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process(GO:0050650) |
| 0.0 | 0.9 | GO:0071357 | response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.0 | 0.1 | GO:0032487 | regulation of Rap protein signal transduction(GO:0032487) |
| 0.0 | 3.8 | GO:0051262 | protein tetramerization(GO:0051262) |
| 0.0 | 0.7 | GO:0033198 | response to ATP(GO:0033198) |
| 0.0 | 0.8 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 0.9 | GO:0045739 | positive regulation of DNA repair(GO:0045739) |
| 0.0 | 0.4 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 2.7 | GO:0042113 | B cell activation(GO:0042113) |
| 0.0 | 0.7 | GO:0030318 | melanocyte differentiation(GO:0030318) |
| 0.0 | 1.1 | GO:0032508 | DNA duplex unwinding(GO:0032508) |
| 0.0 | 0.8 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.0 | 1.6 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.0 | 0.1 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 0.0 | 0.7 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 1.5 | GO:1902600 | hydrogen ion transmembrane transport(GO:1902600) |
| 0.0 | 0.1 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.0 | 0.6 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.0 | 0.2 | GO:0070997 | neuron death(GO:0070997) |
| 0.0 | 2.1 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.0 | 0.4 | GO:0051091 | positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091) |
| 0.0 | 0.9 | GO:0022900 | electron transport chain(GO:0022900) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 10.8 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 1.9 | 7.7 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044) |
| 1.9 | 5.7 | GO:0019034 | viral replication complex(GO:0019034) |
| 1.7 | 37.4 | GO:0042627 | chylomicron(GO:0042627) |
| 1.1 | 7.5 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.8 | 16.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.6 | 3.8 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.6 | 9.4 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.5 | 1.5 | GO:0000818 | nuclear MIS12/MIND complex(GO:0000818) |
| 0.5 | 1.5 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.5 | 4.6 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.4 | 8.3 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.4 | 2.5 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.4 | 20.4 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.4 | 1.5 | GO:0055087 | Ski complex(GO:0055087) |
| 0.4 | 5.3 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.4 | 4.9 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.3 | 5.0 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.3 | 11.5 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.2 | 3.1 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.2 | 1.3 | GO:0032807 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807) |
| 0.2 | 1.7 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.2 | 1.0 | GO:0034457 | Mpp10 complex(GO:0034457) |
| 0.2 | 1.8 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.2 | 3.9 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 1.4 | GO:0072487 | MSL complex(GO:0072487) |
| 0.2 | 10.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.2 | 2.5 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.2 | 3.8 | GO:0005849 | mRNA cleavage factor complex(GO:0005849) |
| 0.2 | 23.1 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.2 | 15.4 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.2 | 1.6 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.2 | 1.1 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.1 | 0.6 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.1 | 1.1 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 5.6 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 1.1 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.1 | 6.1 | GO:0032592 | integral component of mitochondrial membrane(GO:0032592) |
| 0.1 | 0.5 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.1 | 0.4 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 2.1 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 0.5 | GO:0005594 | collagen type IX trimer(GO:0005594) |
| 0.1 | 8.9 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.1 | 4.9 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.1 | 1.1 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568) |
| 0.1 | 0.3 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.1 | 7.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 0.8 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.1 | 8.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 0.8 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.1 | 0.8 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.1 | 0.6 | GO:0072357 | glycogen granule(GO:0042587) PTW/PP1 phosphatase complex(GO:0072357) |
| 0.1 | 3.9 | GO:0030315 | T-tubule(GO:0030315) |
| 0.1 | 0.7 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.1 | 3.1 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 2.1 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.1 | 4.8 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 1.8 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 1.5 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.1 | 8.3 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 1.7 | GO:0030660 | Golgi-associated vesicle membrane(GO:0030660) |
| 0.0 | 6.2 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 3.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.4 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.0 | 0.8 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 1.1 | GO:0097546 | ciliary base(GO:0097546) |
| 0.0 | 1.3 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 3.5 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 3.5 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 1.0 | GO:0071011 | precatalytic spliceosome(GO:0071011) |
| 0.0 | 1.4 | GO:0030286 | dynein complex(GO:0030286) |
| 0.0 | 0.3 | GO:0098576 | lumenal side of membrane(GO:0098576) |
| 0.0 | 0.7 | GO:0031082 | BLOC complex(GO:0031082) |
| 0.0 | 2.5 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 1.1 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.3 | GO:0097433 | dense body(GO:0097433) |
| 0.0 | 0.2 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.0 | 1.9 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.0 | 0.2 | GO:0032797 | SMN complex(GO:0032797) Gemini of coiled bodies(GO:0097504) |
| 0.0 | 0.4 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 1.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 1.5 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.0 | 15.6 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 1.9 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 0.9 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 0.7 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 3.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 5.0 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.0 | 0.2 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.0 | 0.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.9 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 2.0 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.0 | 0.9 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.0 | 47.6 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 3.5 | 17.6 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) |
| 3.1 | 9.4 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 1.6 | 4.9 | GO:0045174 | oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610) |
| 1.6 | 4.9 | GO:0047726 | nitric oxide dioxygenase activity(GO:0008941) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor(GO:0016708) iron-cytochrome-c reductase activity(GO:0047726) |
| 1.3 | 7.7 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 1.2 | 7.1 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
| 1.1 | 4.6 | GO:0051916 | granulocyte colony-stimulating factor binding(GO:0051916) |
| 1.1 | 4.6 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 1.0 | 2.9 | GO:0004574 | oligo-1,6-glucosidase activity(GO:0004574) |
| 0.9 | 5.7 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
| 0.9 | 2.7 | GO:0016603 | glutaminyl-peptide cyclotransferase activity(GO:0016603) |
| 0.8 | 2.5 | GO:0047192 | 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192) |
| 0.8 | 9.3 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.7 | 5.7 | GO:0032396 | inhibitory MHC class I receptor activity(GO:0032396) |
| 0.7 | 7.4 | GO:0051430 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.6 | 3.1 | GO:0004992 | platelet activating factor receptor activity(GO:0004992) |
| 0.6 | 1.7 | GO:0032427 | GBD domain binding(GO:0032427) |
| 0.6 | 2.2 | GO:0046404 | ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) |
| 0.5 | 7.5 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.5 | 5.3 | GO:0022820 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.5 | 2.3 | GO:0044736 | acid-sensing ion channel activity(GO:0044736) |
| 0.5 | 1.4 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
| 0.4 | 6.7 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.4 | 7.5 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.4 | 1.6 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.4 | 1.6 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.4 | 1.2 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 0.3 | 1.4 | GO:0042903 | tubulin deacetylase activity(GO:0042903) |
| 0.3 | 1.6 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
| 0.3 | 5.0 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.3 | 1.1 | GO:0004803 | transposase activity(GO:0004803) |
| 0.3 | 6.8 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.3 | 8.7 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.3 | 2.5 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.3 | 0.8 | GO:0097158 | pre-mRNA intronic pyrimidine-rich binding(GO:0097158) |
| 0.3 | 0.8 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.3 | 15.6 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.3 | 4.5 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.2 | 8.3 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.2 | 1.1 | GO:0047237 | glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) |
| 0.2 | 2.2 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.2 | 2.9 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) |
| 0.2 | 3.9 | GO:0008603 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.2 | 6.7 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.2 | 6.1 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.2 | 2.5 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.2 | 4.2 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.2 | 0.5 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
| 0.2 | 1.0 | GO:0015252 | hydrogen ion channel activity(GO:0015252) |
| 0.2 | 3.4 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.2 | 4.8 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 2.2 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 4.7 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 3.4 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 0.6 | GO:0042954 | apolipoprotein receptor activity(GO:0030226) lipoprotein transporter activity(GO:0042954) |
| 0.1 | 4.2 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.1 | 1.1 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.1 | 0.9 | GO:0000268 | peroxisome targeting sequence binding(GO:0000268) |
| 0.1 | 1.3 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.1 | 1.8 | GO:0031432 | titin binding(GO:0031432) |
| 0.1 | 2.3 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.1 | 6.4 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 3.3 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 1.1 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 0.1 | 1.9 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.1 | 0.5 | GO:0015056 | corticotrophin-releasing factor receptor activity(GO:0015056) |
| 0.1 | 0.5 | GO:0015639 | cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.1 | 3.5 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 0.6 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) |
| 0.1 | 5.7 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.1 | 0.3 | GO:0003858 | 3-hydroxybutyrate dehydrogenase activity(GO:0003858) |
| 0.1 | 2.5 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 1.5 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.1 | 3.9 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.1 | 1.1 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.1 | 4.0 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 0.4 | GO:0060175 | brain-derived neurotrophic factor-activated receptor activity(GO:0060175) |
| 0.1 | 2.8 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 7.3 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.1 | 0.5 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
| 0.1 | 1.3 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.1 | 1.3 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 4.4 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 0.4 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.1 | 1.8 | GO:0001848 | complement binding(GO:0001848) |
| 0.1 | 3.1 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.1 | 0.7 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.1 | 1.1 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 5.8 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 2.4 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.1 | 0.4 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 0.1 | 0.6 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
| 0.1 | 1.5 | GO:0016675 | oxidoreductase activity, acting on a heme group of donors(GO:0016675) |
| 0.0 | 1.8 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.0 | 1.2 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 0.6 | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.0 | 1.2 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 0.2 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473) |
| 0.0 | 1.1 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 0.7 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 0.3 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 0.2 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.0 | 13.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 0.4 | GO:0043995 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.0 | 0.6 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.5 | GO:0035254 | glutamate receptor binding(GO:0035254) |
| 0.0 | 1.5 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 0.8 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 0.4 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.8 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 0.7 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.0 | 0.3 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.0 | 2.1 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.7 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.6 | GO:0005024 | transforming growth factor beta-activated receptor activity(GO:0005024) |
| 0.0 | 0.4 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.0 | 0.7 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 1.5 | GO:0070035 | ATP-dependent RNA helicase activity(GO:0004004) ATP-dependent helicase activity(GO:0008026) RNA-dependent ATPase activity(GO:0008186) purine NTP-dependent helicase activity(GO:0070035) |
| 0.0 | 5.6 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 0.1 | GO:0034481 | chondroitin sulfotransferase activity(GO:0034481) |
| 0.0 | 0.6 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.0 | 1.1 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 7.6 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.2 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.0 | 0.2 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.0 | 0.1 | GO:0004466 | long-chain-acyl-CoA dehydrogenase activity(GO:0004466) |
| 0.0 | 3.2 | GO:0022832 | voltage-gated ion channel activity(GO:0005244) voltage-gated channel activity(GO:0022832) |
| 0.0 | 0.3 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.0 | 0.8 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 1.7 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 1.1 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.2 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 0.0 | GO:0036033 | mediator complex binding(GO:0036033) |
| 0.0 | 0.2 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 2.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.5 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 1.6 | GO:0004866 | endopeptidase inhibitor activity(GO:0004866) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.6 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.3 | 9.4 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.3 | 5.9 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.2 | 10.7 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.2 | 6.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.2 | 6.7 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 12.1 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 8.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 13.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 13.6 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 3.1 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 2.1 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.1 | 4.0 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 1.7 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 1.4 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 2.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 4.6 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 3.0 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 1.3 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.1 | 1.4 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.8 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.0 | 2.0 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 1.3 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 4.6 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 0.7 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 1.6 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.2 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 1.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.0 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.0 | 1.3 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 2.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 0.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.3 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 7.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.5 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.7 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.4 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 2.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.4 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.3 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 6.7 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.5 | 7.0 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.5 | 10.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.4 | 15.6 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.4 | 7.7 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.4 | 11.3 | REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.4 | 8.3 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.3 | 9.5 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.3 | 5.7 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.2 | 6.1 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.2 | 5.3 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.2 | 3.8 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.2 | 6.0 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.2 | 3.9 | REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION | Genes involved in Glucagon signaling in metabolic regulation |
| 0.2 | 2.7 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |
| 0.2 | 7.3 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.2 | 6.3 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.2 | 6.3 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 4.9 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 4.6 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 3.4 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.1 | 1.3 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 9.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 13.4 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 3.0 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 1.9 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 6.7 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 1.6 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.1 | 1.9 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 1.6 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.1 | 1.3 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |
| 0.1 | 3.1 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 2.4 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 2.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 2.5 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 3.0 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 0.7 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 6.1 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 0.5 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 2.3 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 0.9 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 2.2 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 0.2 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.0 | 1.8 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.0 | 0.6 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 5.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.6 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.0 | 1.9 | REACTOME COSTIMULATION BY THE CD28 FAMILY | Genes involved in Costimulation by the CD28 family |
| 0.0 | 2.2 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 0.5 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.6 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.1 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 2.0 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.7 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 1.7 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 1.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.4 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 1.1 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 2.7 | REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | Genes involved in Transmission across Chemical Synapses |