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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GLIS3

Z-value: 0.63

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Transcription factors associated with GLIS3

Gene Symbol Gene ID Gene Info
GLIS3
ENSG00000107249.17 GLIS family zinc finger 3

Activity profile of GLIS3 motif

Sorted Z-values of GLIS3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_48828582 17.95 ENST00000270221.6
ENST00000596315.1
EMP3
epithelial membrane protein 3
chr18_+_3451584 9.60 ENST00000551541.1
TGIF1
TGFB-induced factor homeobox 1
chr1_-_45987526 9.01 ENST00000372079.1
ENST00000262746.1
ENST00000447184.1
ENST00000319248.8
PRDX1
peroxiredoxin 1
chr1_-_45988542 8.87 ENST00000424390.1
PRDX1
peroxiredoxin 1
chrX_+_64887512 8.76 ENST00000360270.5
MSN
moesin
chr19_-_41859814 7.89 ENST00000221930.5
TGFB1
transforming growth factor, beta 1
chr21_-_46330545 7.63 ENST00000320216.6
ENST00000397852.1
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr5_+_172386419 7.11 ENST00000265100.2
ENST00000519239.1
RPL26L1
ribosomal protein L26-like 1
chr7_+_150758304 6.87 ENST00000482950.1
ENST00000463414.1
ENST00000310317.5
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr5_-_180671172 6.75 ENST00000512805.1
GNB2L1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
chr18_+_3451646 6.62 ENST00000345133.5
ENST00000330513.5
ENST00000549546.1
TGIF1
TGFB-induced factor homeobox 1
chr3_-_25824925 5.52 ENST00000396649.3
ENST00000428257.1
ENST00000280700.5
NGLY1
N-glycanase 1
chr11_+_68451943 5.51 ENST00000265643.3
GAL
galanin/GMAP prepropeptide
chr17_-_73178599 5.06 ENST00000578238.1
SUMO2
small ubiquitin-like modifier 2
chr13_+_25670268 4.85 ENST00000281589.3
PABPC3
poly(A) binding protein, cytoplasmic 3
chr3_-_25824872 4.41 ENST00000308710.5
NGLY1
N-glycanase 1
chr6_+_44191507 4.11 ENST00000371724.1
ENST00000371713.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr3_+_38029462 3.78 ENST00000283713.6
VILL
villin-like
chr17_-_73179046 3.73 ENST00000314523.7
ENST00000420826.2
SUMO2
small ubiquitin-like modifier 2
chr6_+_44191290 3.71 ENST00000371755.3
ENST00000371740.5
ENST00000371731.1
ENST00000393841.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr19_+_46850251 3.45 ENST00000012443.4
PPP5C
protein phosphatase 5, catalytic subunit
chr15_+_91478493 3.27 ENST00000418476.2
UNC45A
unc-45 homolog A (C. elegans)
chr11_-_8680383 3.24 ENST00000299550.6
TRIM66
tripartite motif containing 66
chr19_+_46850320 3.20 ENST00000391919.1
PPP5C
protein phosphatase 5, catalytic subunit
chr4_-_84255935 3.10 ENST00000513463.1
HPSE
heparanase
chr1_-_42801540 3.06 ENST00000372573.1
FOXJ3
forkhead box J3
chr6_+_33172407 3.03 ENST00000374662.3
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr22_-_50964849 2.99 ENST00000543927.1
ENST00000423348.1
SCO2
SCO2 cytochrome c oxidase assembly protein
chr6_+_89791507 2.76 ENST00000354922.3
PNRC1
proline-rich nuclear receptor coactivator 1
chr14_+_22931924 2.67 ENST00000390477.2
TRDC
T cell receptor delta constant
chr22_+_50628999 2.56 ENST00000395827.1
TRABD
TraB domain containing
chr1_-_53018654 2.48 ENST00000257177.4
ENST00000355809.4
ENST00000528642.1
ENST00000470626.1
ENST00000371544.3
ZCCHC11
zinc finger, CCHC domain containing 11
chr5_+_172386517 2.37 ENST00000519522.1
RPL26L1
ribosomal protein L26-like 1
chr6_+_24495185 2.34 ENST00000348925.2
ALDH5A1
aldehyde dehydrogenase 5 family, member A1
chr20_-_30310693 2.30 ENST00000307677.4
ENST00000420653.1
BCL2L1
BCL2-like 1
chr22_+_31489344 2.25 ENST00000404574.1
SMTN
smoothelin
chr17_+_7792101 2.23 ENST00000358181.4
ENST00000330494.7
CHD3
chromodomain helicase DNA binding protein 3
chr20_-_30310656 2.03 ENST00000376055.4
BCL2L1
BCL2-like 1
chr8_-_74791051 1.88 ENST00000453587.2
ENST00000602969.1
ENST00000602593.1
ENST00000419880.3
ENST00000517608.1
UBE2W
ubiquitin-conjugating enzyme E2W (putative)
chrX_-_132549506 1.83 ENST00000370828.3
GPC4
glypican 4
chr10_+_105314881 1.53 ENST00000437579.1
NEURL
neuralized E3 ubiquitin protein ligase 1
chr22_+_18834324 1.45 ENST00000342005.4
AC008132.13
Uncharacterized protein
chr2_-_208030647 1.40 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr1_-_42800860 1.21 ENST00000445886.1
ENST00000361346.1
ENST00000361776.1
FOXJ3
forkhead box J3
chrX_+_118370288 1.16 ENST00000535419.1
PGRMC1
progesterone receptor membrane component 1
chr19_+_41281060 1.11 ENST00000594436.1
ENST00000597784.1
MIA
melanoma inhibitory activity
chr17_-_3819751 0.99 ENST00000225538.3
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr18_+_11752040 0.92 ENST00000423027.3
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr17_-_5015129 0.89 ENST00000575898.1
ENST00000416429.2
ZNF232
zinc finger protein 232
chr20_+_61867235 0.85 ENST00000342412.6
ENST00000217169.3
BIRC7
baculoviral IAP repeat containing 7
chr18_+_11751493 0.85 ENST00000269162.5
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr6_+_24495067 0.83 ENST00000357578.3
ENST00000546278.1
ENST00000491546.1
ALDH5A1
aldehyde dehydrogenase 5 family, member A1
chr19_-_10613421 0.82 ENST00000393623.2
KEAP1
kelch-like ECH-associated protein 1
chrX_+_118370211 0.81 ENST00000217971.7
PGRMC1
progesterone receptor membrane component 1
chr2_-_211168332 0.66 ENST00000341685.4
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr3_+_173116225 0.62 ENST00000457714.1
NLGN1
neuroligin 1
chr11_+_66886717 0.50 ENST00000398645.2
KDM2A
lysine (K)-specific demethylase 2A
chr14_+_77228532 0.50 ENST00000167106.4
ENST00000554237.1
VASH1
vasohibin 1
chr21_+_38071430 0.48 ENST00000290399.6
SIM2
single-minded family bHLH transcription factor 2
chr12_+_132312931 0.45 ENST00000360564.1
ENST00000545671.1
ENST00000545790.1
MMP17
matrix metallopeptidase 17 (membrane-inserted)
chr20_+_18447771 0.38 ENST00000377603.4
POLR3F
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
chr19_-_48673552 0.34 ENST00000536218.1
ENST00000596549.1
LIG1
ligase I, DNA, ATP-dependent
chr20_-_23969416 0.22 ENST00000335694.4
GGTLC1
gamma-glutamyltransferase light chain 1
chr1_+_110527308 0.11 ENST00000369799.5
AHCYL1
adenosylhomocysteinase-like 1
chr8_+_27183033 0.05 ENST00000420218.2
PTK2B
protein tyrosine kinase 2 beta

Network of associatons between targets according to the STRING database.

First level regulatory network of GLIS3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.9 GO:0052553 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
1.8 5.5 GO:0051795 cortisol secretion(GO:0043400) regulation of cortisol secretion(GO:0051462) positive regulation of catagen(GO:0051795)
1.6 7.8 GO:0015862 uridine transport(GO:0015862)
1.5 8.8 GO:0022614 membrane to membrane docking(GO:0022614)
1.1 6.6 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.9 18.0 GO:0032060 bleb assembly(GO:0032060)
0.7 13.0 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.6 4.3 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.5 3.2 GO:0006540 glutamate decarboxylation to succinate(GO:0006540) gamma-aminobutyric acid catabolic process(GO:0009450)
0.5 17.9 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.5 2.5 GO:0010587 miRNA catabolic process(GO:0010587)
0.4 7.6 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.3 2.8 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.2 0.6 GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.2 3.0 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.2 1.0 GO:0002442 serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554)
0.2 8.8 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.2 0.5 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.1 3.0 GO:0006878 cellular copper ion homeostasis(GO:0006878) respiratory chain complex IV assembly(GO:0008535)
0.1 6.9 GO:0015701 bicarbonate transport(GO:0015701)
0.1 9.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 0.8 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.3 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.1 3.8 GO:0051693 actin filament capping(GO:0051693)
0.1 1.9 GO:0071218 cellular response to misfolded protein(GO:0071218)
0.1 0.5 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 0.9 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0 0.5 GO:0042756 drinking behavior(GO:0042756)
0.0 2.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 3.0 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 2.2 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.1 GO:0042045 epithelial fluid transport(GO:0042045)
0.0 12.9 GO:0042493 response to drug(GO:0042493)
0.0 1.8 GO:0001523 retinoid metabolic process(GO:0001523)
0.0 1.1 GO:0008283 cell proliferation(GO:0008283)
0.0 2.3 GO:0006939 smooth muscle contraction(GO:0006939)
0.0 0.2 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.4 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.6 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.9 6.6 GO:1990635 proximal dendrite(GO:1990635)
0.4 8.8 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.3 4.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.5 GO:0045177 apical part of cell(GO:0045177)
0.1 17.9 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 9.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 2.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 9.0 GO:0005796 Golgi lumen(GO:0005796)
0.1 3.2 GO:0016235 aggresome(GO:0016235)
0.1 8.8 GO:0016605 PML body(GO:0016605)
0.1 2.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.0 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 14.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.1 GO:0035580 specific granule lumen(GO:0035580)
0.0 2.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.7 GO:0005859 muscle myosin complex(GO:0005859)
0.0 9.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.0 GO:0035579 specific granule membrane(GO:0035579)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 5.5 GO:0043025 neuronal cell body(GO:0043025)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.9 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
2.2 17.9 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
1.4 5.5 GO:0004966 galanin receptor activity(GO:0004966)
1.1 7.6 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.8 3.1 GO:0030305 beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
0.7 8.8 GO:0031386 protein tag(GO:0031386)
0.6 2.5 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.6 3.0 GO:0070404 NADH binding(GO:0070404)
0.6 16.2 GO:0070410 co-SMAD binding(GO:0070410)
0.4 4.3 GO:0051434 BH3 domain binding(GO:0051434)
0.4 6.9 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.4 7.8 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.3 1.8 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.3 3.0 GO:0004645 phosphorylase activity(GO:0004645)
0.2 6.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 4.8 GO:0008143 poly(A) binding(GO:0008143)
0.1 12.2 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 1.0 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 8.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 3.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 0.5 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 3.2 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 2.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 9.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.3 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 2.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 3.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.0 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.2 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 1.6 GO:0005496 steroid binding(GO:0005496)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 17.9 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.3 15.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 4.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2 8.3 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.2 6.8 PID IGF1 PATHWAY IGF1 pathway
0.1 14.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 14.4 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 3.1 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 10.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.2 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 1.5 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.9 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3 16.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 8.8 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.2 4.9 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.2 7.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 4.3 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 3.2 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.0 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 7.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 9.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 6.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.5 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.3 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
0.0 3.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 2.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation