ISMARA results: GTF2I

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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GTF2I

Z-value: 1.17

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Transcription factors associated with GTF2I

Gene Symbol	Gene ID	Gene Info
GTF2I Ensembl NCBI GeneCards UniProt NextProt	ENSG00000077809.8	general transcription factor IIi

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GTF2I	hg19_v2_chr7_+_74072011_74072119	0.44	1.4e-11	Click!

Activity profile of GTF2I motif

Sorted Z-values of GTF2I motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_+_23775971 Show fit	14.92	ENST00000250405.5	BCL2L2 Ensembl NCBI GeneCards UniProt NextProt Show fit	BCL2-like 2
chr1_+_169075554 Show fit	13.63	ENST00000367815.4	ATP1B1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ATPase, Na+/K+ transporting, beta 1 polypeptide
chr1_+_169077172 Show fit	13.28	ENST00000499679.3	ATP1B1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ATPase, Na+/K+ transporting, beta 1 polypeptide
chr15_-_37392703 Show fit	12.90	ENST00000382766.2 ENST00000444725.1	MEIS2 Ensembl NCBI GeneCards UniProt NextProt Show fit	Meis homeobox 2
chrX_+_102631844 Show fit	10.65	ENST00000372634.1 ENST00000299872.7	NGFRAP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	nerve growth factor receptor (TNFRSF16) associated protein 1
chr22_-_36236265 Show fit	10.16	ENST00000414461.2 ENST00000416721.2 ENST00000449924.2 ENST00000262829.7 ENST00000397305.3	RBFOX2 Ensembl NCBI GeneCards UniProt NextProt Show fit	RNA binding protein, fox-1 homolog (C. elegans) 2
chr1_-_20812690 Show fit	10.06	ENST00000375078.3	CAMK2N1 Ensembl NCBI GeneCards UniProt NextProt Show fit	calcium/calmodulin-dependent protein kinase II inhibitor 1
chr4_-_16900242 Show fit	9.76	ENST00000502640.1 ENST00000506732.1	LDB2 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain binding 2
chr12_-_16759711 Show fit	9.62	ENST00000447609.1	LMO3 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain only 3 (rhombotin-like 2)
chr12_-_45270151 Show fit	8.98	ENST00000429094.2	NELL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NEL-like 2 (chicken)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of GTF2I

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	29.4	GO:0010669	epithelial structure maintenance(GO:0010669)
0.4	27.7	GO:0008542	visual learning(GO:0008542)
6.7	26.9	GO:1903288	protein transport into plasma membrane raft(GO:0044861) positive regulation of potassium ion import(GO:1903288)
1.6	22.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
1.7	15.6	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
2.8	13.8	GO:1903275	regulation of sodium ion export(GO:1903273) positive regulation of sodium ion export(GO:1903275) regulation of sodium ion export from cell(GO:1903276) positive regulation of sodium ion export from cell(GO:1903278)
1.8	12.7	GO:0060011	Sertoli cell proliferation(GO:0060011)
2.0	12.2	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
2.1	10.7	GO:1904274	tricellular tight junction assembly(GO:1904274)
1.5	10.6	GO:0021540	corpus callosum morphogenesis(GO:0021540)

Showing 1 to 10 of 445 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.2	44.3	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2	40.5	GO:0014069	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1	32.7	GO:0043025	neuronal cell body(GO:0043025)
0.1	31.6	GO:0031252	cell leading edge(GO:0031252)
0.2	30.1	GO:0030426	growth cone(GO:0030426)
0.1	27.8	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.1	22.9	GO:0016324	apical plasma membrane(GO:0016324)
1.0	20.6	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.1	17.2	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	16.4	GO:0005789	endoplasmic reticulum membrane(GO:0005789)

Showing 1 to 10 of 208 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	34.5	GO:0003714	transcription corepressor activity(GO:0003714)
0.1	29.4	GO:0045296	cadherin binding(GO:0045296)
1.8	29.0	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
2.5	27.3	GO:0030274	LIM domain binding(GO:0030274)
0.3	22.4	GO:0005507	copper ion binding(GO:0005507)
0.0	20.8	GO:0005509	calcium ion binding(GO:0005509)
1.2	15.4	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.3	14.6	GO:0005080	protein kinase C binding(GO:0005080)
0.3	13.7	GO:0017080	sodium channel regulator activity(GO:0017080)
0.7	13.3	GO:0051400	BH domain binding(GO:0051400)

Showing 1 to 10 of 287 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	39.2	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.2	34.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.4	25.4	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.2	16.3	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.2	13.6	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.3	10.0	PID S1P S1P3 PATHWAY	S1P3 pathway
0.2	9.1	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.1	8.1	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.2	7.9	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.4	7.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network

Showing 1 to 10 of 67 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	37.3	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.2	23.9	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.6	17.7	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.5	17.2	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.5	13.3	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.4	12.5	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.3	11.8	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.4	11.2	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.4	10.8	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.1	10.8	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport

Showing 1 to 10 of 101 entries

Results for GTF2I

Z-value: 1.17

Motif logo

Transcription factors associated with GTF2I

Activity-expression correlation:

Activity profile of GTF2I motif

Sorted Z-values of GTF2I motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of GTF2I

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: