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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GUAACAG

Z-value: 0.56

Motif logo

logo of

miRNA associated with seed GUAACAG

NamemiRBASE accession
hsa-miR-194-5p
MIMAT0000460

Activity profile of GUAACAG motif

Sorted Z-values of GUAACAG motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_62658186 8.13 ENST00000262435.9
SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr20_-_43977055 6.24 ENST00000372733.3
ENST00000537976.1
SDC4
syndecan 4
chrX_+_119737806 5.89 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr1_-_225840747 5.70 ENST00000366843.2
ENST00000366844.3
ENAH
enabled homolog (Drosophila)
chr7_-_94285511 5.42 ENST00000265735.7
SGCE
sarcoglycan, epsilon
chr9_+_131445928 5.37 ENST00000372692.4
SET
SET nuclear oncogene
chr3_+_180630090 5.32 ENST00000357559.4
ENST00000305586.7
FXR1
fragile X mental retardation, autosomal homolog 1
chr3_-_149688896 5.24 ENST00000239940.7
PFN2
profilin 2
chr11_+_74660278 5.12 ENST00000263672.6
ENST00000530257.1
ENST00000526361.1
ENST00000532972.1
SPCS2
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr17_-_57784755 4.80 ENST00000537860.1
ENST00000393038.2
ENST00000409433.2
PTRH2
peptidyl-tRNA hydrolase 2
chr16_-_58768177 4.32 ENST00000434819.2
ENST00000245206.5
GOT2
glutamic-oxaloacetic transaminase 2, mitochondrial
chr12_+_124069070 4.29 ENST00000262225.3
ENST00000438031.2
TMED2
transmembrane emp24 domain trafficking protein 2
chr12_-_29534074 4.27 ENST00000546839.1
ENST00000360150.4
ENST00000552155.1
ENST00000550353.1
ENST00000548441.1
ENST00000552132.1
ERGIC2
ERGIC and golgi 2
chr1_-_205719295 4.16 ENST00000367142.4
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr3_+_69812877 3.98 ENST00000457080.1
ENST00000328528.6
MITF
microphthalmia-associated transcription factor
chr3_+_62304712 3.97 ENST00000494481.1
C3orf14
chromosome 3 open reading frame 14
chr17_-_73179046 3.95 ENST00000314523.7
ENST00000420826.2
SUMO2
small ubiquitin-like modifier 2
chr17_+_66508537 3.95 ENST00000392711.1
ENST00000585427.1
ENST00000589228.1
ENST00000536854.2
ENST00000588702.1
ENST00000589309.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr8_+_48920960 3.86 ENST00000523111.2
ENST00000523432.1
ENST00000521346.1
ENST00000517630.1
UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
chr1_-_11120057 3.80 ENST00000376957.2
SRM
spermidine synthase
chr5_+_177019159 3.67 ENST00000332598.6
TMED9
transmembrane emp24 protein transport domain containing 9
chr11_-_115375107 3.52 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
CADM1
cell adhesion molecule 1
chr2_+_85198216 3.51 ENST00000456682.1
ENST00000409785.4
KCMF1
potassium channel modulatory factor 1
chr19_+_34919257 3.47 ENST00000246548.4
ENST00000590048.2
UBA2
ubiquitin-like modifier activating enzyme 2
chr3_-_113465065 3.45 ENST00000497255.1
ENST00000478020.1
ENST00000240922.3
ENST00000493900.1
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr1_+_27248203 3.29 ENST00000321265.5
NUDC
nudC nuclear distribution protein
chr5_-_98262240 3.15 ENST00000284049.3
CHD1
chromodomain helicase DNA binding protein 1
chr2_-_174830430 3.02 ENST00000310015.6
ENST00000455789.2
SP3
Sp3 transcription factor
chr7_+_77166592 3.00 ENST00000248594.6
PTPN12
protein tyrosine phosphatase, non-receptor type 12
chr3_-_72496035 2.99 ENST00000477973.2
RYBP
RING1 and YY1 binding protein
chr15_-_37390482 2.75 ENST00000559085.1
ENST00000397624.3
MEIS2
Meis homeobox 2
chr4_-_24586140 2.68 ENST00000336812.4
DHX15
DEAH (Asp-Glu-Ala-His) box helicase 15
chr1_+_93811438 2.64 ENST00000370272.4
ENST00000370267.1
DR1
down-regulator of transcription 1, TBP-binding (negative cofactor 2)
chr3_-_57583130 2.44 ENST00000303436.6
ARF4
ADP-ribosylation factor 4
chr21_-_16437255 2.43 ENST00000400199.1
ENST00000400202.1
NRIP1
nuclear receptor interacting protein 1
chr18_+_9913977 2.36 ENST00000400000.2
ENST00000340541.4
VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr1_+_51701924 2.33 ENST00000242719.3
RNF11
ring finger protein 11
chr6_-_111804393 2.29 ENST00000368802.3
ENST00000368805.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr3_+_9439400 2.21 ENST00000450326.1
ENST00000402198.1
ENST00000402466.1
SETD5
SET domain containing 5
chr12_-_76425368 2.16 ENST00000602540.1
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr10_+_114709999 2.10 ENST00000355995.4
ENST00000545257.1
ENST00000543371.1
ENST00000536810.1
ENST00000355717.4
ENST00000538897.1
ENST00000534894.1
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr11_+_101981169 2.07 ENST00000526343.1
ENST00000282441.5
ENST00000537274.1
ENST00000345877.2
YAP1
Yes-associated protein 1
chr17_+_2496971 2.02 ENST00000397195.5
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr11_-_46142948 2.02 ENST00000257821.4
PHF21A
PHD finger protein 21A
chr7_-_87849340 2.01 ENST00000419179.1
ENST00000265729.2
SRI
sorcin
chr4_+_39699664 1.96 ENST00000261427.5
ENST00000510934.1
ENST00000295963.6
UBE2K
ubiquitin-conjugating enzyme E2K
chr2_-_230786679 1.90 ENST00000543084.1
ENST00000343290.5
ENST00000389044.4
ENST00000283943.5
TRIP12
thyroid hormone receptor interactor 12
chr3_-_58419537 1.88 ENST00000474765.1
ENST00000485460.1
ENST00000302746.6
ENST00000383714.4
PDHB
pyruvate dehydrogenase (lipoamide) beta
chr10_+_105726862 1.72 ENST00000335753.4
ENST00000369755.3
SLK
STE20-like kinase
chr13_-_107187462 1.64 ENST00000245323.4
EFNB2
ephrin-B2
chr16_+_53088885 1.62 ENST00000566029.1
ENST00000447540.1
CHD9
chromodomain helicase DNA binding protein 9
chr15_-_59225844 1.61 ENST00000380516.2
SLTM
SAFB-like, transcription modulator
chr3_+_150126101 1.57 ENST00000361875.3
ENST00000361136.2
TSC22D2
TSC22 domain family, member 2
chr14_-_57735528 1.52 ENST00000340918.7
ENST00000413566.2
EXOC5
exocyst complex component 5
chr9_-_74980113 1.51 ENST00000376962.5
ENST00000376960.4
ENST00000237937.3
ZFAND5
zinc finger, AN1-type domain 5
chr10_-_88281494 1.50 ENST00000298767.5
WAPAL
wings apart-like homolog (Drosophila)
chr15_+_96873921 1.40 ENST00000394166.3
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr12_-_26278030 1.39 ENST00000242728.4
BHLHE41
basic helix-loop-helix family, member e41
chr1_-_211752073 1.37 ENST00000367001.4
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr16_-_12009735 1.29 ENST00000439887.2
ENST00000434724.2
GSPT1
G1 to S phase transition 1
chr6_-_136610911 1.28 ENST00000530767.1
ENST00000527759.1
ENST00000527536.1
ENST00000529826.1
ENST00000531224.1
ENST00000353331.4
BCLAF1
BCL2-associated transcription factor 1
chr20_-_524455 1.24 ENST00000349736.5
ENST00000217244.3
CSNK2A1
casein kinase 2, alpha 1 polypeptide
chr14_-_21905395 1.23 ENST00000430710.3
ENST00000553283.1
CHD8
chromodomain helicase DNA binding protein 8
chr1_-_153958805 1.22 ENST00000368575.3
RAB13
RAB13, member RAS oncogene family
chr10_-_72648541 1.20 ENST00000299299.3
PCBD1
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
chr10_-_33623564 1.17 ENST00000374875.1
ENST00000374822.4
NRP1
neuropilin 1
chr3_-_98620500 1.14 ENST00000326840.6
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr4_-_66536057 1.13 ENST00000273854.3
EPHA5
EPH receptor A5
chr21_-_34960948 1.13 ENST00000453626.1
ENST00000303113.6
ENST00000432378.1
ENST00000303071.5
DONSON
downstream neighbor of SON
chr15_+_64388166 1.10 ENST00000353874.4
ENST00000261889.5
ENST00000559844.1
ENST00000561026.1
ENST00000558040.1
SNX1
sorting nexin 1
chr10_-_13390270 1.08 ENST00000378614.4
ENST00000545675.1
ENST00000327347.5
SEPHS1
selenophosphate synthetase 1
chr22_+_41347363 0.99 ENST00000216225.8
RBX1
ring-box 1, E3 ubiquitin protein ligase
chr2_+_46926048 0.96 ENST00000306503.5
SOCS5
suppressor of cytokine signaling 5
chrX_-_41782249 0.95 ENST00000442742.2
ENST00000421587.2
ENST00000378166.4
ENST00000318588.9
ENST00000361962.4
CASK
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
chr14_-_38064198 0.94 ENST00000250448.2
FOXA1
forkhead box A1
chr2_-_11484710 0.93 ENST00000315872.6
ROCK2
Rho-associated, coiled-coil containing protein kinase 2
chr17_+_40985407 0.93 ENST00000586114.1
ENST00000590720.1
ENST00000585805.1
ENST00000541124.1
ENST00000441946.2
ENST00000591152.1
ENST00000589469.1
ENST00000293362.3
ENST00000592169.1
PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr14_+_55034599 0.90 ENST00000392067.3
ENST00000357634.3
SAMD4A
sterile alpha motif domain containing 4A
chr4_+_128703295 0.89 ENST00000296464.4
ENST00000508549.1
HSPA4L
heat shock 70kDa protein 4-like
chr3_+_37903432 0.86 ENST00000443503.2
CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr1_-_52456352 0.84 ENST00000371655.3
RAB3B
RAB3B, member RAS oncogene family
chr8_-_116681221 0.83 ENST00000395715.3
TRPS1
trichorhinophalangeal syndrome I
chr1_+_82266053 0.79 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2
latrophilin 2
chr3_+_152879985 0.79 ENST00000323534.2
RAP2B
RAP2B, member of RAS oncogene family
chr11_+_95523621 0.77 ENST00000325542.5
ENST00000325486.5
ENST00000544522.1
ENST00000541365.1
CEP57
centrosomal protein 57kDa
chr10_-_65225722 0.75 ENST00000399251.1
JMJD1C
jumonji domain containing 1C
chr7_-_26578407 0.75 ENST00000242109.3
KIAA0087
KIAA0087
chr4_-_140098339 0.71 ENST00000394235.2
ELF2
E74-like factor 2 (ets domain transcription factor)
chr18_-_23670546 0.60 ENST00000542743.1
ENST00000545952.1
ENST00000539849.1
ENST00000415083.2
SS18
synovial sarcoma translocation, chromosome 18
chr15_+_77712993 0.58 ENST00000336216.4
ENST00000381714.3
ENST00000558651.1
HMG20A
high mobility group 20A
chr3_+_196466710 0.55 ENST00000327134.3
PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr2_+_102508955 0.54 ENST00000414004.2
FLJ20373
FLJ20373
chr16_+_69599861 0.54 ENST00000354436.2
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr16_-_73082274 0.52 ENST00000268489.5
ZFHX3
zinc finger homeobox 3
chr17_+_37618257 0.52 ENST00000447079.4
CDK12
cyclin-dependent kinase 12
chr5_-_139726181 0.51 ENST00000507104.1
ENST00000230990.6
HBEGF
heparin-binding EGF-like growth factor
chrX_-_119694538 0.48 ENST00000371322.5
CUL4B
cullin 4B
chr7_-_152133059 0.47 ENST00000262189.6
ENST00000355193.2
KMT2C
lysine (K)-specific methyltransferase 2C
chr15_+_39873268 0.43 ENST00000397591.2
ENST00000260356.5
THBS1
thrombospondin 1
chr8_-_103425047 0.43 ENST00000520539.1
UBR5
ubiquitin protein ligase E3 component n-recognin 5
chr6_+_163835669 0.42 ENST00000453779.2
ENST00000275262.7
ENST00000392127.2
ENST00000361752.3
QKI
QKI, KH domain containing, RNA binding
chr12_+_93965451 0.38 ENST00000548537.1
SOCS2
suppressor of cytokine signaling 2
chr8_-_28243934 0.32 ENST00000521185.1
ENST00000520290.1
ENST00000344423.5
ZNF395
zinc finger protein 395
chr17_+_48796905 0.29 ENST00000505658.1
ENST00000393227.2
ENST00000240304.1
ENST00000311571.3
ENST00000505619.1
ENST00000544170.1
ENST00000510984.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr19_-_14606900 0.28 ENST00000393029.3
ENST00000393028.1
ENST00000393033.4
ENST00000345425.2
ENST00000586027.1
ENST00000591349.1
ENST00000587210.1
GIPC1
GIPC PDZ domain containing family, member 1
chr4_-_57301748 0.27 ENST00000264220.2
PPAT
phosphoribosyl pyrophosphate amidotransferase
chr10_+_102505468 0.25 ENST00000361791.3
ENST00000355243.3
ENST00000428433.1
ENST00000370296.2
PAX2
paired box 2
chr17_-_80231557 0.23 ENST00000392334.2
ENST00000314028.6
CSNK1D
casein kinase 1, delta
chr2_-_122407097 0.23 ENST00000409078.3
CLASP1
cytoplasmic linker associated protein 1
chr1_-_243418344 0.22 ENST00000366542.1
CEP170
centrosomal protein 170kDa
chr9_+_4679555 0.22 ENST00000381858.1
ENST00000381854.3
CDC37L1
cell division cycle 37-like 1
chr14_+_39735411 0.21 ENST00000603904.1
RP11-407N17.3
cTAGE family member 5 isoform 4
chr3_-_114790179 0.20 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr3_-_122233723 0.20 ENST00000493510.1
ENST00000344337.6
ENST00000476916.1
ENST00000465882.1
KPNA1
karyopherin alpha 1 (importin alpha 5)
chr2_-_40679186 0.19 ENST00000406785.2
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr7_-_558876 0.18 ENST00000354513.5
ENST00000402802.3
PDGFA
platelet-derived growth factor alpha polypeptide
chr3_+_14166440 0.16 ENST00000306077.4
TMEM43
transmembrane protein 43
chr12_-_31744031 0.15 ENST00000389082.5
DENND5B
DENN/MADD domain containing 5B
chr4_-_23891693 0.12 ENST00000264867.2
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr1_-_93645818 0.09 ENST00000370280.1
ENST00000479918.1
TMED5
transmembrane emp24 protein transport domain containing 5
chr20_-_56284816 0.08 ENST00000395819.3
ENST00000341744.3
PMEPA1
prostate transmembrane protein, androgen induced 1
chr2_-_208634287 0.07 ENST00000295417.3
FZD5
frizzled family receptor 5
chr7_+_145813453 0.05 ENST00000361727.3
CNTNAP2
contactin associated protein-like 2
chrX_-_71933888 0.02 ENST00000373542.4
ENST00000339490.3
ENST00000541944.1
ENST00000373539.3
ENST00000373545.3
PHKA1
phosphorylase kinase, alpha 1 (muscle)
chr11_-_36531774 0.02 ENST00000348124.5
ENST00000526995.1
TRAF6
TNF receptor-associated factor 6, E3 ubiquitin protein ligase
chr12_-_498620 0.02 ENST00000399788.2
ENST00000382815.4
KDM5A
lysine (K)-specific demethylase 5A
chr20_+_57226284 0.01 ENST00000458280.1
ENST00000355957.5
ENST00000361770.5
ENST00000312283.8
ENST00000412911.1
ENST00000359617.4
ENST00000371141.4
STX16
syntaxin 16
chr11_+_35684288 0.00 ENST00000299413.5
TRIM44
tripartite motif containing 44
chr8_+_102504651 0.00 ENST00000251808.3
ENST00000521085.1
GRHL2
grainyhead-like 2 (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of GUAACAG

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 8.1 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
2.0 8.0 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
2.0 5.9 GO:0002188 translation reinitiation(GO:0002188)
1.4 4.3 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) L-kynurenine metabolic process(GO:0097052)
1.2 6.2 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
1.0 4.2 GO:0019046 release from viral latency(GO:0019046)
0.9 3.5 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.8 2.4 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.7 2.2 GO:0045210 FasL biosynthetic process(GO:0045210)
0.5 3.8 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.5 2.1 GO:1902730 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.5 3.0 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.4 5.2 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.4 4.8 GO:2000210 positive regulation of anoikis(GO:2000210)
0.4 3.5 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.4 1.3 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.4 1.2 GO:1902463 protein localization to cell leading edge(GO:1902463)
0.4 1.1 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.3 1.4 GO:0009956 radial pattern formation(GO:0009956)
0.3 2.0 GO:0051661 maintenance of centrosome location(GO:0051661)
0.3 2.3 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
0.3 2.0 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.3 2.1 GO:0060449 bud elongation involved in lung branching(GO:0060449)
0.2 4.0 GO:2000480 negative regulation of meiotic nuclear division(GO:0045835) negative regulation of activated T cell proliferation(GO:0046007) negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 2.0 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.2 3.2 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.2 1.2 GO:1902378 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) endothelial tip cell fate specification(GO:0097102) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.2 0.9 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.2 5.1 GO:0006465 signal peptide processing(GO:0006465)
0.2 0.9 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.2 2.4 GO:0031584 activation of phospholipase D activity(GO:0031584) apical protein localization(GO:0045176)
0.2 1.9 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.2 5.4 GO:0006337 nucleosome disassembly(GO:0006337)
0.2 5.3 GO:0060148 positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637)
0.2 3.1 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.2 1.4 GO:0097501 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.2 9.3 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.2 2.4 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.2 2.6 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.2 0.5 GO:0051541 elastin metabolic process(GO:0051541)
0.2 0.8 GO:0051586 peptidyl-cysteine methylation(GO:0018125) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
0.2 2.1 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.2 1.0 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.2 1.2 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.1 0.4 GO:0002605 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) negative regulation of dendritic cell antigen processing and presentation(GO:0002605)
0.1 1.2 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.1 0.5 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 2.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 0.2 GO:0035564 regulation of kidney size(GO:0035564)
0.1 0.1 GO:1901857 positive regulation of cellular respiration(GO:1901857)
0.1 1.2 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.1 5.3 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1 1.1 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 2.6 GO:0043966 histone H3 acetylation(GO:0043966)
0.1 0.3 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 1.1 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 1.5 GO:0003016 respiratory system process(GO:0003016)
0.0 2.8 GO:0008542 visual learning(GO:0008542)
0.0 0.8 GO:0032486 Rap protein signal transduction(GO:0032486) establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.4 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0 2.4 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.8 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 2.2 GO:0035065 regulation of histone acetylation(GO:0035065)
0.0 0.6 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 3.5 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.5 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 1.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 1.5 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 1.1 GO:0033260 nuclear DNA replication(GO:0033260)
0.0 0.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 1.6 GO:0019216 regulation of lipid metabolic process(GO:0019216)
0.0 0.1 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 1.8 GO:0016575 histone deacetylation(GO:0016575)
0.0 1.7 GO:0051893 regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109)
0.0 0.4 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 5.6 GO:0006457 protein folding(GO:0006457)
0.0 0.1 GO:0071109 superior temporal gyrus development(GO:0071109)
0.0 3.8 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.9 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 1.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.2 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0 0.3 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 1.8 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.0 0.5 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.5 GO:0000060 protein import into nucleus, translocation(GO:0000060)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.9 3.5 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.7 5.1 GO:0005787 signal peptidase complex(GO:0005787)
0.7 5.4 GO:0016012 sarcoglycan complex(GO:0016012)
0.5 2.7 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.5 3.5 GO:0031415 NatA complex(GO:0031415)
0.4 1.3 GO:0018444 translation release factor complex(GO:0018444)
0.4 2.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 1.0 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.3 4.3 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.3 2.0 GO:0044326 dendritic spine neck(GO:0044326)
0.3 2.0 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
0.3 1.3 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.2 11.1 GO:0043034 costamere(GO:0043034)
0.2 2.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 4.0 GO:0031588 cAMP-dependent protein kinase complex(GO:0005952) nucleotide-activated protein kinase complex(GO:0031588)
0.2 1.9 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.2 1.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.2 1.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.2 2.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 2.3 GO:0042575 DNA polymerase complex(GO:0042575)
0.2 0.9 GO:0008537 proteasome activator complex(GO:0008537)
0.2 1.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 1.2 GO:0097443 sorting endosome(GO:0097443)
0.1 2.0 GO:0032433 filopodium tip(GO:0032433)
0.1 3.7 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 5.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.5 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 5.4 GO:0005811 lipid particle(GO:0005811)
0.1 0.9 GO:0005652 nuclear lamina(GO:0005652)
0.1 3.0 GO:0002102 podosome(GO:0002102)
0.1 0.5 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 1.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 5.3 GO:0030175 filopodium(GO:0030175)
0.0 4.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 3.9 GO:0043195 terminal bouton(GO:0043195)
0.0 0.5 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 2.1 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.2 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.6 GO:0000145 exocyst(GO:0000145)
0.0 2.4 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 3.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.6 GO:0071564 npBAF complex(GO:0071564)
0.0 7.8 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 1.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 3.8 GO:0001650 fibrillar center(GO:0001650)
0.0 1.6 GO:0030315 T-tubule(GO:0030315)
0.0 2.7 GO:0043197 dendritic spine(GO:0043197)
0.0 0.8 GO:0044291 cell-cell contact zone(GO:0044291)
0.0 2.9 GO:0043204 perikaryon(GO:0043204)
0.0 3.5 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 1.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.1 GO:0097440 apical dendrite(GO:0097440)
0.0 0.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.2 GO:0031089 platelet dense granule lumen(GO:0031089)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
1.4 4.3 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
1.3 3.8 GO:0004766 spermidine synthase activity(GO:0004766)
0.8 2.4 GO:0033149 FFAT motif binding(GO:0033149)
0.6 6.2 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.5 5.3 GO:0002151 G-quadruplex RNA binding(GO:0002151) RNA strand annealing activity(GO:0033592)
0.5 1.9 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.4 3.5 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.4 4.0 GO:0031386 protein tag(GO:0031386)
0.4 1.1 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.3 1.2 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.3 3.5 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.3 1.3 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.2 3.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.2 1.1 GO:1990460 leptin receptor binding(GO:1990460)
0.2 5.2 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.2 2.0 GO:0034452 dynactin binding(GO:0034452)
0.2 3.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 1.4 GO:0043426 MRF binding(GO:0043426)
0.1 0.4 GO:0070052 collagen V binding(GO:0070052)
0.1 0.9 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.2 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 5.8 GO:0050699 WW domain binding(GO:0050699)
0.1 8.1 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 5.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 1.4 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 5.2 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 1.5 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 2.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 3.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.1 5.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 2.1 GO:0070064 proline-rich region binding(GO:0070064)
0.1 2.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 2.6 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 4.0 GO:0070888 E-box binding(GO:0070888)
0.1 0.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 2.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 0.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1 0.2 GO:0043515 kinetochore binding(GO:0043515)
0.1 1.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 2.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.8 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 2.7 GO:0008026 ATP-dependent RNA helicase activity(GO:0004004) ATP-dependent helicase activity(GO:0008026) RNA-dependent ATPase activity(GO:0008186) purine NTP-dependent helicase activity(GO:0070035)
0.0 2.0 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 3.7 GO:0019905 syntaxin binding(GO:0019905)
0.0 1.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.9 GO:0030371 translation repressor activity(GO:0030371)
0.0 4.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.5 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 1.2 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 1.6 GO:0004386 helicase activity(GO:0004386)
0.0 3.5 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.8 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.5 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 2.3 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.8 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 5.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.0 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.2 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.5 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.5 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.8 GO:0019003 GDP binding(GO:0019003)
0.0 0.9 GO:0017048 Rho GTPase binding(GO:0017048)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 7.9 PID BMP PATHWAY BMP receptor signaling
0.1 7.0 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 6.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 5.7 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 4.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 7.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 4.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 1.2 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 1.1 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 4.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.6 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 2.9 PID E2F PATHWAY E2F transcription factor network
0.0 3.3 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.7 PID FOXO PATHWAY FoxO family signaling
0.0 1.0 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 2.5 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 1.6 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 1.1 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 1.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.7 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.5 PID INSULIN PATHWAY Insulin Pathway
0.0 0.4 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.1 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.2 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 6.2 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.2 11.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.2 4.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 7.0 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.2 3.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.2 4.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 4.0 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 1.9 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 3.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 2.1 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 2.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 5.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.0 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 2.0 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 6.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.9 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.3 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 0.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.2 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 0.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.8 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes