ISMARA results: HES1

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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HES1

Z-value: 1.21

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Transcription factors associated with HES1

Gene Symbol	Gene ID	Gene Info
HES1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000114315.3	hes family bHLH transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HES1	hg19_v2_chr3_+_193853927_193853944	-0.12	7.5e-02	Click!

Activity profile of HES1 motif

Sorted Z-values of HES1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_+_7023491 Show fit	13.21	ENST00000541477.1 ENST00000229277.1	ENO2 Ensembl NCBI GeneCards UniProt NextProt Show fit	enolase 2 (gamma, neuronal)
chr3_-_138763734 Show fit	9.00	ENST00000413199.1 ENST00000502927.2	PRR23C Ensembl NCBI GeneCards UniProt NextProt Show fit	proline rich 23C
chr19_-_1652575 Show fit	8.86	ENST00000587235.1 ENST00000262965.5	TCF3 Ensembl NCBI GeneCards UniProt NextProt Show fit	transcription factor 3
chr12_+_7023735 Show fit	8.42	ENST00000538763.1 ENST00000544774.1 ENST00000545045.2	ENO2 Ensembl NCBI GeneCards UniProt NextProt Show fit	enolase 2 (gamma, neuronal)
chr20_-_43280325 Show fit	7.55	ENST00000537820.1	ADA Ensembl NCBI GeneCards UniProt NextProt Show fit	adenosine deaminase
chr9_+_91926103 Show fit	6.70	ENST00000314355.6	CKS2 Ensembl NCBI GeneCards UniProt NextProt Show fit	CDC28 protein kinase regulatory subunit 2
chr2_-_73511559 Show fit	6.51	ENST00000521871.1	FBXO41 Ensembl NCBI GeneCards UniProt NextProt Show fit	F-box protein 41
chr20_-_3154162 Show fit	6.47	ENST00000360342.3	LZTS3 Ensembl NCBI GeneCards UniProt NextProt Show fit	Homo sapiens leucine zipper, putative tumor suppressor family member 3 (LZTS3), mRNA.
chr1_-_32801825 Show fit	6.13	ENST00000329421.7	MARCKSL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	MARCKS-like 1
chr5_+_156693091 Show fit	6.11	ENST00000318218.6 ENST00000442283.2 ENST00000522463.1 ENST00000521420.1	CYFIP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	cytoplasmic FMR1 interacting protein 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HES1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	24.1	GO:0006735	NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.4	18.4	GO:0006363	termination of RNA polymerase I transcription(GO:0006363)
0.1	14.4	GO:0006334	nucleosome assembly(GO:0006334)
0.5	14.3	GO:0035590	purinergic nucleotide receptor signaling pathway(GO:0035590)
4.1	12.3	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
4.0	11.9	GO:0019242	methylglyoxal biosynthetic process(GO:0019242)
1.5	11.8	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0	10.4	GO:0000209	protein polyubiquitination(GO:0000209)
3.2	9.7	GO:0046102	inosine metabolic process(GO:0046102)
3.2	9.6	GO:0036333	hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)

Showing 1 to 10 of 332 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	22.3	GO:0035098	ESC/E(Z) complex(GO:0035098)
3.6	21.6	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
1.0	18.3	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.2	12.9	GO:0015030	Cajal body(GO:0015030)
0.2	12.7	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	11.7	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.1	11.5	GO:0060170	ciliary membrane(GO:0060170)
0.1	8.9	GO:0043679	axon terminus(GO:0043679)
0.3	8.7	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	8.6	GO:0031965	nuclear membrane(GO:0031965)

Showing 1 to 10 of 161 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.6	21.6	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
1.0	18.3	GO:0001054	RNA polymerase I activity(GO:0001054)
1.3	14.5	GO:0004931	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
4.1	12.3	GO:0008859	exoribonuclease II activity(GO:0008859)
4.0	11.9	GO:0004347	glucose-6-phosphate isomerase activity(GO:0004347)
0.2	10.4	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.2	9.8	GO:0031492	nucleosomal DNA binding(GO:0031492)
1.1	9.6	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.8	8.9	GO:0070644	vitamin D response element binding(GO:0070644)
1.2	8.4	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)

Showing 1 to 10 of 244 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	14.3	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.3	13.3	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	11.9	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	8.4	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	7.8	PID PLK1 PATHWAY	PLK1 signaling events
0.1	6.5	PID ATR PATHWAY	ATR signaling pathway
0.1	6.3	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.1	6.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	5.0	PID REELIN PATHWAY	Reelin signaling pathway
0.1	4.7	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling

Showing 1 to 10 of 46 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	35.4	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.1	21.6	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.8	18.3	REACTOME RNA POL III CHAIN ELONGATION	Genes involved in RNA Polymerase III Chain Elongation
0.2	14.3	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.5	12.2	REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway
0.7	10.8	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.4	9.0	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.3	7.5	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.2	7.5	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.4	6.5	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis

Showing 1 to 10 of 97 entries

Results for HES1

Z-value: 1.21

Motif logo

Transcription factors associated with HES1

Activity-expression correlation:

Activity profile of HES1 motif

Sorted Z-values of HES1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HES1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: