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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HES7_HES5

Z-value: 0.85

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Transcription factors associated with HES7_HES5

Gene Symbol Gene ID Gene Info
ENSG00000179111.4 hes family bHLH transcription factor 7
ENSG00000197921.5 hes family bHLH transcription factor 5

Activity profile of HES7_HES5 motif

Sorted Z-values of HES7_HES5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_26233423 21.07 ENST00000357865.2
stathmin 1
chr1_-_26232951 10.56 ENST00000426559.2
ENST00000455785.2
stathmin 1
chr1_-_26232522 10.24 ENST00000399728.1
stathmin 1
chr17_-_41465674 7.97 ENST00000592135.1
ENST00000587874.1
ENST00000588654.1
ENST00000592094.1
long intergenic non-protein coding RNA 910
chr19_+_4304632 7.47 ENST00000597590.1
fibronectin type III and SPRY domain containing 1
chr2_-_175870085 7.41 ENST00000409156.3
chimerin 1
chr19_+_4304585 7.18 ENST00000221856.6
fibronectin type III and SPRY domain containing 1
chr17_+_30813576 7.15 ENST00000313401.3
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr14_+_65879437 6.95 ENST00000394585.1
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr8_+_38089198 6.50 ENST00000528358.1
ENST00000529642.1
ENST00000532222.1
ENST00000520272.2
DDHD domain containing 2
chr13_+_35516390 6.47 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
neurobeachin
chr14_+_65879668 5.92 ENST00000553924.1
ENST00000358307.2
ENST00000557338.1
ENST00000554610.1
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr16_-_21416640 5.51 ENST00000542817.1
nuclear pore complex interacting protein family, member B3
chr5_+_152870106 5.43 ENST00000285900.5
glutamate receptor, ionotropic, AMPA 1
chr19_-_3700388 5.39 ENST00000589578.1
ENST00000537021.1
ENST00000539785.1
ENST00000335312.3
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
chr5_+_95066823 5.35 ENST00000506817.1
ENST00000379982.3
Rho-related BTB domain containing 3
chr1_+_16083154 5.12 ENST00000375771.1
filamin binding LIM protein 1
chr16_-_21849091 5.07 ENST00000537951.1
nuclear pore complex interacting protein family, member B4
chr4_+_76439665 5.05 ENST00000508105.1
ENST00000311638.3
ENST00000380837.3
ENST00000507556.1
ENST00000504190.1
ENST00000507885.1
ENST00000502620.1
ENST00000514480.1
THAP domain containing 6
chr19_+_35168633 4.92 ENST00000505365.2
zinc finger protein 302
chr16_-_81129845 4.56 ENST00000569885.1
ENST00000566566.1
glycine cleavage system protein H (aminomethyl carrier)
chr16_-_30237150 4.50 ENST00000543463.1
Putative NPIP-like protein LOC613037
chr1_+_28261533 4.11 ENST00000411604.1
ENST00000373888.4
sphingomyelin phosphodiesterase, acid-like 3B
chr19_+_58095501 3.93 ENST00000536878.2
ENST00000597850.1
ENST00000597219.1
ENST00000598689.1
ENST00000599456.1
ENST00000307468.4
zinc finger protein interacting with K protein 1
chr2_+_201171242 3.87 ENST00000360760.5
spermatogenesis associated, serine-rich 2-like
chr4_-_170924888 3.77 ENST00000502832.1
ENST00000393704.3
microfibrillar-associated protein 3-like
chr15_+_68871569 3.70 ENST00000566799.1
coronin, actin binding protein, 2B
chr4_-_144940477 3.61 ENST00000513128.1
ENST00000429670.2
ENST00000502664.1
glycophorin B (MNS blood group)
chr2_+_201170596 3.50 ENST00000439084.1
ENST00000409718.1
spermatogenesis associated, serine-rich 2-like
chr2_-_86564776 3.47 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
receptor accessory protein 1
chr2_+_201171372 3.42 ENST00000409140.3
spermatogenesis associated, serine-rich 2-like
chr3_+_39851094 3.31 ENST00000302541.6
myosin VIIA and Rab interacting protein
chr14_-_67826486 3.21 ENST00000555431.1
ENST00000554236.1
ENST00000555474.1
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
chr5_+_112227311 3.14 ENST00000391338.1
zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1
chr16_+_222846 3.14 ENST00000251595.6
ENST00000397806.1
hemoglobin, alpha 2
chr2_+_201170770 2.96 ENST00000409988.3
ENST00000409385.1
spermatogenesis associated, serine-rich 2-like
chr4_-_145061788 2.79 ENST00000512064.1
ENST00000512789.1
ENST00000504786.1
ENST00000503627.1
ENST00000535709.1
ENST00000324022.10
ENST00000360771.4
ENST00000283126.7
glycophorin A (MNS blood group)
glycophorin B (MNS blood group)
chr14_-_77737543 2.77 ENST00000298352.4
neuroglobin
chr9_+_103204553 2.77 ENST00000502978.1
ENST00000334943.6
MSANTD3-TMEFF1 readthrough
transmembrane protein with EGF-like and two follistatin-like domains 1
chr22_-_50523760 2.57 ENST00000395876.2
megalencephalic leukoencephalopathy with subcortical cysts 1
chr6_-_74161977 2.56 ENST00000370318.1
ENST00000370315.3
Mab-21 domain containing 1
chr3_+_49027308 2.56 ENST00000383729.4
ENST00000343546.4
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr4_-_144826682 2.48 ENST00000358615.4
ENST00000437468.2
glycophorin E (MNS blood group)
chr9_+_706842 2.42 ENST00000382293.3
KN motif and ankyrin repeat domains 1
chr13_+_115047097 2.39 ENST00000351487.5
UPF3 regulator of nonsense transcripts homolog A (yeast)
chr2_+_201171064 2.38 ENST00000451764.2
spermatogenesis associated, serine-rich 2-like
chr11_-_6440624 2.38 ENST00000311051.3
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr20_-_45985464 2.37 ENST00000458360.2
ENST00000262975.4
zinc finger, MYND-type containing 8
chr3_-_125820348 2.37 ENST00000509064.1
ENST00000508835.1
solute carrier family 41, member 3
chrX_-_20159934 2.23 ENST00000379593.1
ENST00000379607.5
eukaryotic translation initiation factor 1A, X-linked
chr12_+_49621658 2.14 ENST00000541364.1
tubulin, alpha 1c
chr2_+_65216462 2.04 ENST00000234256.3
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr1_-_201476274 2.02 ENST00000340006.2
cysteine and glycine-rich protein 1
chr14_-_81687197 2.02 ENST00000553612.1
general transcription factor IIA, 1, 19/37kDa
chr3_-_189840223 2.01 ENST00000427335.2
leprecan-like 1
chr10_-_71169031 1.98 ENST00000373307.1
tachykinin receptor 2
chr9_+_100174344 1.98 ENST00000422139.2
tudor domain containing 7
chr20_+_306221 1.98 ENST00000342665.2
SRY (sex determining region Y)-box 12
chr4_+_2965307 1.92 ENST00000398051.4
ENST00000503518.2
ENST00000398052.4
ENST00000345167.6
ENST00000504933.1
ENST00000442472.2
G protein-coupled receptor kinase 4
chr12_+_103351444 1.89 ENST00000266744.3
achaete-scute family bHLH transcription factor 1
chr11_+_60197069 1.87 ENST00000528905.1
ENST00000528093.1
membrane-spanning 4-domains, subfamily A, member 5
chr3_+_38537763 1.86 ENST00000287675.5
ENST00000358249.2
ENST00000422077.2
endo/exonuclease (5'-3'), endonuclease G-like
chr20_-_45985414 1.86 ENST00000461685.1
ENST00000372023.3
ENST00000540497.1
ENST00000435836.1
ENST00000471951.2
ENST00000352431.2
ENST00000396281.4
ENST00000355972.4
ENST00000360911.3
zinc finger, MYND-type containing 8
chr16_-_57513657 1.86 ENST00000566936.1
ENST00000568617.1
ENST00000567276.1
ENST00000569548.1
ENST00000569250.1
ENST00000564378.1
docking protein 4
chr1_-_31661000 1.85 ENST00000263693.1
ENST00000398657.2
ENST00000526106.1
Na+/K+ transporting ATPase interacting 1
chr14_+_65878565 1.80 ENST00000556518.1
ENST00000557164.1
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr5_-_114598548 1.77 ENST00000379615.3
ENST00000419445.1
protein geranylgeranyltransferase type I, beta subunit
chr4_+_6202448 1.77 ENST00000508601.1
RP11-586D19.1
chr22_+_41777927 1.77 ENST00000266304.4
thyrotrophic embryonic factor
chr19_-_4723761 1.65 ENST00000597849.1
ENST00000598800.1
ENST00000602161.1
ENST00000597726.1
ENST00000601130.1
ENST00000262960.9
dipeptidyl-peptidase 9
chr2_+_201980961 1.62 ENST00000342795.5
CASP8 and FADD-like apoptosis regulator
chr11_+_35684288 1.60 ENST00000299413.5
tripartite motif containing 44
chr1_+_28832455 1.46 ENST00000398958.2
ENST00000427469.1
ENST00000434290.1
ENST00000373833.6
regulator of chromosome condensation 1
chr1_+_44445549 1.45 ENST00000356836.6
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chrX_+_133594168 1.44 ENST00000298556.7
hypoxanthine phosphoribosyltransferase 1
chr22_+_30752606 1.43 ENST00000399824.2
ENST00000405659.1
ENST00000338306.3
coiled-coil domain containing 157
chr22_+_24891210 1.32 ENST00000382760.2
ureidopropionase, beta
chr11_+_9595180 1.29 ENST00000450114.2
WEE1 G2 checkpoint kinase
chr16_-_5115913 1.28 ENST00000474471.3
chromosome 16 open reading frame 89
chr11_+_60197040 1.20 ENST00000300190.2
membrane-spanning 4-domains, subfamily A, member 5
chr5_+_148521136 1.19 ENST00000506113.1
actin binding LIM protein family, member 3
chr20_-_36793774 1.16 ENST00000361475.2
transglutaminase 2
chr9_-_100395756 1.12 ENST00000341170.4
ENST00000354801.2
thiosulfate sulfurtransferase (rhodanese)-like domain containing 2
chr5_+_148521046 1.11 ENST00000326685.7
ENST00000356541.3
ENST00000309868.7
actin binding LIM protein family, member 3
chr19_+_6135646 1.05 ENST00000588304.1
ENST00000588485.1
ENST00000588722.1
ENST00000591403.1
ENST00000586696.1
ENST00000589401.1
ENST00000252669.5
acyl-CoA synthetase bubblegum family member 2
chr17_+_48172639 1.02 ENST00000503176.1
ENST00000503614.1
pyruvate dehydrogenase kinase, isozyme 2
chr3_+_46283863 1.01 ENST00000545097.1
ENST00000541018.1
chemokine (C-C motif) receptor 3
chr10_+_72194585 1.00 ENST00000420338.2
Uncharacterized protein
chr11_-_63376013 1.00 ENST00000540943.1
phospholipase A2, group XVI
chr16_+_333152 0.97 ENST00000219406.6
ENST00000404312.1
ENST00000456379.1
protein disulfide isomerase family A, member 2
chr12_+_6644443 0.97 ENST00000396858.1
glyceraldehyde-3-phosphate dehydrogenase
chr11_-_777467 0.95 ENST00000397472.2
ENST00000524550.1
ENST00000319863.8
ENST00000526325.1
ENST00000442059.2
Parkinson disease 7 domain containing 1
chr3_+_46283916 0.93 ENST00000395940.2
chemokine (C-C motif) receptor 3
chr6_-_114292449 0.91 ENST00000519065.1
histone deacetylase 2
chr6_+_13182751 0.90 ENST00000415087.1
phosphatase and actin regulator 1
chr2_-_220108309 0.88 ENST00000409640.1
galactosidase, beta 1-like
chr5_+_152870287 0.87 ENST00000340592.5
glutamate receptor, ionotropic, AMPA 1
chr4_-_76439596 0.86 ENST00000451788.1
ENST00000512706.1
ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
chr1_-_93426998 0.86 ENST00000370310.4
family with sequence similarity 69, member A
chr19_-_52511334 0.85 ENST00000602063.1
ENST00000597747.1
ENST00000594083.1
ENST00000593650.1
ENST00000599631.1
ENST00000598071.1
ENST00000601178.1
ENST00000376716.5
ENST00000391795.3
zinc finger protein 615
chr5_+_148521381 0.81 ENST00000504238.1
actin binding LIM protein family, member 3
chr1_-_45140074 0.78 ENST00000420706.1
ENST00000372235.3
ENST00000372242.3
ENST00000372243.3
ENST00000372244.3
transmembrane protein 53
chr9_-_23821842 0.75 ENST00000544538.1
ELAV like neuron-specific RNA binding protein 2
chr14_+_67826709 0.72 ENST00000256383.4
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr10_+_180405 0.71 ENST00000439456.1
ENST00000397962.3
ENST00000309776.4
ENST00000381602.4
zinc finger, MYND-type containing 11
chr10_+_49514698 0.70 ENST00000432379.1
ENST00000429041.1
ENST00000374189.1
mitogen-activated protein kinase 8
chr22_+_18560675 0.69 ENST00000329627.7
peroxisomal biogenesis factor 26
chr3_+_38080691 0.69 ENST00000308059.6
ENST00000346219.3
ENST00000452631.2
deleted in lung and esophageal cancer 1
chr8_+_104033296 0.69 ENST00000521514.1
ENST00000518738.1
ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
chr12_+_112204691 0.69 ENST00000416293.3
ENST00000261733.2
aldehyde dehydrogenase 2 family (mitochondrial)
chr15_-_57025759 0.66 ENST00000267807.7
zinc finger protein 280D
chr14_+_24641062 0.63 ENST00000311457.3
ENST00000557806.1
ENST00000559919.1
REC8 meiotic recombination protein
chr15_+_22833395 0.58 ENST00000283645.4
tubulin, gamma complex associated protein 5
chr5_-_54529415 0.57 ENST00000282572.4
cyclin O
chr2_-_220118631 0.54 ENST00000248437.4
tubulin, alpha 4a
chr15_+_22833482 0.54 ENST00000453949.2
tubulin, gamma complex associated protein 5
chr6_-_27880174 0.54 ENST00000303324.2
olfactory receptor, family 2, subfamily B, member 2
chr17_-_18950950 0.53 ENST00000284154.5
GRB2-related adaptor protein
chr6_-_114292284 0.52 ENST00000520895.1
ENST00000521163.1
ENST00000524334.1
ENST00000368632.2
ENST00000398283.2
histone deacetylase 2
chr2_+_25264933 0.52 ENST00000401432.3
ENST00000403714.3
EFR3 homolog B (S. cerevisiae)
chr8_+_104033277 0.51 ENST00000518857.1
ENST00000395862.3
ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
chr12_+_27175476 0.50 ENST00000546323.1
ENST00000282892.3
mediator complex subunit 21
chrX_+_153524024 0.49 ENST00000369915.3
ENST00000217905.7
transketolase-like 1
chrX_-_152736013 0.49 ENST00000330912.2
ENST00000338525.2
ENST00000334497.2
ENST00000370232.1
ENST00000370212.3
ENST00000370211.4
three prime repair exonuclease 2
HAUS augmin-like complex, subunit 7
chr1_+_152658599 0.47 ENST00000368780.3
late cornified envelope 2B
chr7_+_112090483 0.46 ENST00000403825.3
ENST00000429071.1
interferon-related developmental regulator 1
chr4_+_128886532 0.46 ENST00000444616.1
ENST00000388795.5
chromosome 4 open reading frame 29
chr8_+_142402089 0.45 ENST00000521578.1
ENST00000520105.1
ENST00000523147.1
protein tyrosine phosphatase type IVA, member 3
chr4_-_52904425 0.44 ENST00000535450.1
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
chr5_+_179125907 0.43 ENST00000247461.4
ENST00000452673.2
ENST00000502498.1
ENST00000507307.1
ENST00000513246.1
ENST00000502673.1
ENST00000506654.1
ENST00000512607.2
ENST00000510810.1
calnexin
chr20_-_44539538 0.42 ENST00000372420.1
phospholipid transfer protein
chr20_-_36793663 0.41 ENST00000536701.1
ENST00000536724.1
transglutaminase 2
chr1_+_28261492 0.40 ENST00000373894.3
sphingomyelin phosphodiesterase, acid-like 3B
chr12_+_57881740 0.39 ENST00000262027.5
ENST00000315473.5
methionyl-tRNA synthetase
chr9_+_100395891 0.37 ENST00000375147.3
nuclear cap binding protein subunit 1, 80kDa
chr20_+_306177 0.37 ENST00000544632.1
SRY (sex determining region Y)-box 12
chr8_+_17780346 0.33 ENST00000325083.8
pericentriolar material 1
chr9_+_131549483 0.32 ENST00000372648.5
ENST00000539497.1
TBC1 domain family, member 13
chr12_+_31226779 0.31 ENST00000542838.1
ENST00000407793.2
ENST00000251758.5
ENST00000228264.6
ENST00000438391.2
ENST00000415475.2
ENST00000545668.1
ENST00000350437.4
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
chr11_+_65154070 0.29 ENST00000317568.5
ENST00000531296.1
ENST00000533782.1
ENST00000355991.5
ENST00000416776.2
ENST00000526201.1
FERM domain containing 8
chr20_-_44993012 0.28 ENST00000372229.1
ENST00000372230.5
ENST00000543605.1
ENST00000243896.2
ENST00000317734.8
solute carrier family 35 (GDP-fucose transporter), member C2
chr17_-_42907564 0.26 ENST00000592524.1
gap junction protein, gamma 1, 45kDa
chr4_-_76439483 0.25 ENST00000380840.2
ENST00000513257.1
ENST00000507014.1
ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
chr11_-_116968987 0.24 ENST00000434315.2
ENST00000292055.4
ENST00000375288.1
ENST00000542607.1
ENST00000445177.1
ENST00000375300.1
ENST00000446921.2
SIK family kinase 3
chr17_-_43025005 0.22 ENST00000587309.1
ENST00000593135.1
ENST00000339151.4
kinesin family member 18B
chrX_+_105969893 0.21 ENST00000255499.2
ring finger protein 128, E3 ubiquitin protein ligase
chr13_+_43597269 0.21 ENST00000379221.2
DnaJ (Hsp40) homolog, subfamily C, member 15
chr17_-_42908155 0.20 ENST00000426548.1
ENST00000590758.1
ENST00000591424.1
gap junction protein, gamma 1, 45kDa
chr3_-_50329835 0.20 ENST00000429673.2
interferon-related developmental regulator 2
chr18_+_11752040 0.19 ENST00000423027.3
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr8_+_17780483 0.18 ENST00000517730.1
ENST00000518537.1
ENST00000523055.1
ENST00000519253.1
pericentriolar material 1
chr4_+_184427235 0.18 ENST00000412117.1
ENST00000434682.2
inhibitor of growth family, member 2
chrX_-_153523462 0.17 ENST00000361930.3
ENST00000369926.1
testis expressed 28
chr5_-_143550241 0.14 ENST00000522203.1
Yip1 domain family, member 5
chr19_+_45281118 0.14 ENST00000270279.3
ENST00000341505.4
Cbl proto-oncogene C, E3 ubiquitin protein ligase
chr1_-_220220000 0.12 ENST00000366923.3
glutamyl-prolyl-tRNA synthetase
chr7_+_148959262 0.11 ENST00000434415.1
zinc finger family member 783
chr1_+_28261621 0.11 ENST00000549094.1
sphingomyelin phosphodiesterase, acid-like 3B
chr20_+_35201857 0.08 ENST00000373874.2
TGFB-induced factor homeobox 2
chr2_-_169769787 0.06 ENST00000451987.1
SPC25, NDC80 kinetochore complex component
chr17_-_5015129 0.05 ENST00000575898.1
ENST00000416429.2
zinc finger protein 232
chr14_+_39736299 0.05 ENST00000341502.5
ENST00000396158.2
ENST00000280083.3
CTAGE family, member 5
chr21_-_33985127 0.04 ENST00000290155.3
chromosome 21 open reading frame 59
chr21_+_45432174 0.02 ENST00000380221.3
ENST00000291574.4
trafficking protein particle complex 10

Network of associatons between targets according to the STRING database.

First level regulatory network of HES7_HES5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
8.5 42.6 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
4.9 14.7 GO:0036071 N-glycan fucosylation(GO:0036071)
2.4 7.2 GO:0021722 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.9 4.6 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.8 2.4 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.8 2.4 GO:0050760 negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
0.8 6.3 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.7 4.2 GO:1903758 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.7 2.0 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.6 1.9 GO:0048867 noradrenergic neuron development(GO:0003358) neuroblast differentiation(GO:0014016) spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) stem cell fate determination(GO:0048867) regulation of timing of neuron differentiation(GO:0060164) olfactory pit development(GO:0060166)
0.5 1.6 GO:0018262 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.5 2.0 GO:0015808 L-alanine transport(GO:0015808)
0.5 1.4 GO:0046098 hypoxanthine salvage(GO:0043103) guanine metabolic process(GO:0046098)
0.5 4.6 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.4 1.8 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.4 1.3 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.3 5.1 GO:0033623 regulation of integrin activation(GO:0033623)
0.3 1.0 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.3 1.4 GO:0061198 fungiform papilla formation(GO:0061198)
0.3 6.5 GO:0034389 lipid particle organization(GO:0034389)
0.2 0.7 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.2 3.5 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.2 3.3 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.2 7.4 GO:0008045 motor neuron axon guidance(GO:0008045)
0.2 0.2 GO:1902957 negative regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902957)
0.2 2.8 GO:0015671 oxygen transport(GO:0015671)
0.2 2.6 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.2 1.1 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.2 0.5 GO:0007518 myoblast fate determination(GO:0007518)
0.1 1.0 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 4.4 GO:0090383 phagosome acidification(GO:0090383)
0.1 0.5 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.1 5.8 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.1 2.6 GO:0071360 cellular response to exogenous dsRNA(GO:0071360)
0.1 0.4 GO:0042360 vitamin E metabolic process(GO:0042360)
0.1 0.5 GO:0086021 SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021) AV node cell to bundle of His cell communication by electrical coupling(GO:0086053)
0.1 1.9 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.1 1.0 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 2.0 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 0.3 GO:0032079 positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.1 5.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 0.5 GO:0006772 thiamine metabolic process(GO:0006772)
0.1 0.7 GO:0006069 ethanol oxidation(GO:0006069)
0.1 0.7 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.1 0.8 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 1.0 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.1 0.5 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.1 1.5 GO:0051290 protein heterotetramerization(GO:0051290)
0.1 1.5 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.0 1.0 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 1.1 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 0.4 GO:0097084 vascular smooth muscle cell development(GO:0097084)
0.0 0.4 GO:1905216 positive regulation of RNA binding(GO:1905216)
0.0 2.2 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.4 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0 0.3 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) protein O-linked fucosylation(GO:0036066)
0.0 3.1 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.7 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 0.2 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 1.9 GO:0006968 cellular defense response(GO:0006968)
0.0 2.0 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 18.3 GO:0051301 cell division(GO:0051301)
0.0 2.0 GO:0070527 platelet aggregation(GO:0070527)
0.0 2.8 GO:0046718 viral entry into host cell(GO:0046718)
0.0 1.8 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.0 0.2 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 2.4 GO:0045727 positive regulation of translation(GO:0045727)
0.0 0.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.5 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
1.5 4.6 GO:0005960 glycine cleavage complex(GO:0005960)
1.3 6.3 GO:0044308 axonal spine(GO:0044308)
0.6 3.1 GO:0089701 U2AF(GO:0089701)
0.6 1.8 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.3 5.4 GO:0001891 phagocytic cup(GO:0001891)
0.3 2.4 GO:1990812 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.3 1.0 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.3 2.0 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.2 0.7 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.2 1.2 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.2 0.6 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.2 2.0 GO:0033391 chromatoid body(GO:0033391)
0.2 3.3 GO:0031045 dense core granule(GO:0031045)
0.2 3.5 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.2 15.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 1.1 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.1 59.6 GO:0005874 microtubule(GO:0005874)
0.1 3.2 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)
0.1 0.8 GO:0097452 GAIT complex(GO:0097452)
0.1 4.2 GO:0043198 dendritic shaft(GO:0043198)
0.1 0.4 GO:0005846 nuclear cap binding complex(GO:0005846)
0.1 2.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 8.1 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.9 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.1 5.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.6 GO:0016580 Sin3 complex(GO:0016580)
0.1 6.5 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 0.3 GO:0008278 cohesin complex(GO:0008278)
0.1 0.4 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.4 GO:0098553 integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 6.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.5 GO:0000242 pericentriolar material(GO:0000242)
0.0 4.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.7 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 2.5 GO:0005901 caveola(GO:0005901)
0.0 2.4 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 1.0 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.5 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 2.0 GO:0005882 intermediate filament(GO:0005882)
0.0 2.4 GO:0043204 perikaryon(GO:0043204)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 1.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 2.3 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.5 GO:0001533 cornified envelope(GO:0001533)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.7 GO:0046921 glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921)
2.4 7.2 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
1.3 5.4 GO:0052812 phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
1.1 4.6 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.8 6.3 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.6 3.1 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.6 1.8 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.5 2.0 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.5 4.6 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.4 2.0 GO:0004995 tachykinin receptor activity(GO:0004995)
0.4 1.9 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.4 1.5 GO:0004461 lactose synthase activity(GO:0004461)
0.3 1.0 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.2 6.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 5.1 GO:0031005 filamin binding(GO:0031005)
0.2 1.0 GO:0031545 peptidyl-proline dioxygenase activity(GO:0031543) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.2 1.0 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) aspartic-type endopeptidase inhibitor activity(GO:0019828) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.2 0.7 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.2 2.8 GO:0005344 oxygen transporter activity(GO:0005344)
0.2 1.5 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.2 1.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 1.0 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.2 1.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 0.5 GO:0004802 transketolase activity(GO:0004802)
0.1 1.9 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 6.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 2.4 GO:0048156 tau protein binding(GO:0048156)
0.1 1.4 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 45.7 GO:0015631 tubulin binding(GO:0015631)
0.1 0.5 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.1 2.6 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.1 0.9 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 4.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106) lysine-acetylated histone binding(GO:0070577)
0.1 1.9 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.1 0.5 GO:0086077 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020) gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
0.1 0.5 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 1.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.6 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.1 2.0 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 2.4 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 3.3 GO:0051018 protein kinase A binding(GO:0051018)
0.0 2.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.4 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.3 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 3.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.9 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.9 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 5.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 2.8 GO:0001618 virus receptor activity(GO:0001618)
0.0 1.7 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 1.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 2.4 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.4 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 2.5 GO:0051117 ATPase binding(GO:0051117)
0.0 2.6 GO:0008565 protein transporter activity(GO:0008565)
0.0 2.7 GO:0015399 primary active transmembrane transporter activity(GO:0015399) P-P-bond-hydrolysis-driven transmembrane transporter activity(GO:0015405) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 3.1 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 3.5 GO:0051015 actin filament binding(GO:0051015)
0.0 1.1 GO:0002039 p53 binding(GO:0002039)
0.0 2.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.0 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 0.6 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.5 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.7 GO:0051287 NAD binding(GO:0051287)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 41.9 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 7.4 PID REELIN PATHWAY Reelin signaling pathway
0.1 5.3 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 6.3 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 7.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 1.3 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.9 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.0 PID AURORA A PATHWAY Aurora A signaling
0.0 1.9 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 2.4 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.1 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.4 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 16.1 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.5 7.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.3 6.3 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.2 4.9 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 4.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 3.0 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 2.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.7 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.3 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 1.3 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 0.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 1.1 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 1.0 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.1 1.0 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 0.7 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 2.0 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 7.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.0 3.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 2.0 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.6 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 2.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.4 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 1.5 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 0.4 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.5 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.0 2.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 4.5 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 0.5 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.5 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation