ISMARA results: HIC1

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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HIC1

Z-value: 2.77

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Transcription factors associated with HIC1

Gene Symbol	Gene ID	Gene Info
HIC1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000177374.8	HIC ZBTB transcriptional repressor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HIC1	hg19_v2_chr17_+_1959369_1959604, hg19_v2_chr17_+_1958388_1958404	0.40	1.0e-09	Click!

Activity profile of HIC1 motif

Sorted Z-values of HIC1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_6845384 Show fit	77.19	ENST00000303635.7	CAMTA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	calmodulin binding transcription activator 1
chr15_+_68871308 Show fit	47.32	ENST00000261861.5	CORO2B Ensembl NCBI GeneCards UniProt NextProt Show fit	coronin, actin binding protein, 2B
chr16_+_58497567 Show fit	43.51	ENST00000258187.5	NDRG4 Ensembl NCBI GeneCards UniProt NextProt Show fit	NDRG family member 4
chr19_+_709101 Show fit	43.51	ENST00000338448.5	PALM Ensembl NCBI GeneCards UniProt NextProt Show fit	paralemmin
chr19_+_708910 Show fit	42.23	ENST00000264560.7	PALM Ensembl NCBI GeneCards UniProt NextProt Show fit	paralemmin
chr16_+_1662326 Show fit	41.01	ENST00000397412.3	CRAMP1L Ensembl NCBI GeneCards UniProt NextProt Show fit	Crm, cramped-like (Drosophila)
chr18_-_74844727 Show fit	40.67	ENST00000355994.2 ENST00000579129.1	MBP Ensembl NCBI GeneCards UniProt NextProt Show fit	myelin basic protein
chr9_-_101471479 Show fit	40.29	ENST00000259455.2	GABBR2 Ensembl NCBI GeneCards UniProt NextProt Show fit	gamma-aminobutyric acid (GABA) B receptor, 2
chr9_+_137979506 Show fit	39.96	ENST00000539529.1 ENST00000392991.4 ENST00000371793.3	OLFM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	olfactomedin 1
chr20_+_44034804 Show fit	39.96	ENST00000357275.2 ENST00000372720.3	DBNDD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	dysbindin (dystrobrevin binding protein 1) domain containing 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HIC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.7	106.4	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
6.5	91.3	GO:0070050	neuron cellular homeostasis(GO:0070050)
11.0	88.3	GO:0060160	negative regulation of dopamine receptor signaling pathway(GO:0060160)
6.8	87.8	GO:2001135	regulation of endocytic recycling(GO:2001135)
8.7	78.7	GO:0003190	atrioventricular valve formation(GO:0003190)
24.0	71.9	GO:0021966	corticospinal neuron axon guidance(GO:0021966)
4.6	60.4	GO:0051823	regulation of synapse structural plasticity(GO:0051823)
1.0	59.3	GO:0050885	neuromuscular process controlling balance(GO:0050885)
4.7	56.1	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
1.7	52.8	GO:0008045	motor neuron axon guidance(GO:0008045)

Showing 1 to 10 of 515 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	254.2	GO:0005905	clathrin-coated pit(GO:0005905)
1.5	119.4	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1	98.5	GO:0005887	integral component of plasma membrane(GO:0005887)
0.4	95.1	GO:0060076	excitatory synapse(GO:0060076)
4.0	87.6	GO:0032591	dendritic spine membrane(GO:0032591)
3.7	78.0	GO:0044295	axonal growth cone(GO:0044295)
4.2	71.0	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.8	58.1	GO:0043195	terminal bouton(GO:0043195)
1.2	53.3	GO:1904115	axon cytoplasm(GO:1904115)
0.0	51.6	GO:0016021	integral component of membrane(GO:0016021)

Showing 1 to 10 of 194 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	133.3	GO:0005509	calcium ion binding(GO:0005509)
3.4	92.1	GO:0050780	dopamine receptor binding(GO:0050780)
3.9	89.4	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.5	73.2	GO:0003774	motor activity(GO:0003774)
0.7	72.7	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
23.7	71.0	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
1.3	61.2	GO:0003785	actin monomer binding(GO:0003785)
0.5	55.8	GO:0004222	metalloendopeptidase activity(GO:0004222)
1.2	54.5	GO:0046875	ephrin receptor binding(GO:0046875)
1.4	52.8	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)

Showing 1 to 10 of 327 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	158.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6	132.5	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
1.1	92.3	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
2.0	71.4	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
1.4	60.7	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.7	59.7	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
1.0	52.2	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.9	50.0	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
1.1	45.9	PID NCADHERIN PATHWAY	N-cadherin signaling events
1.0	42.5	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development

Showing 1 to 10 of 80 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.6	100.1	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
2.7	90.8	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	83.3	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
1.7	64.0	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
1.2	55.7	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
2.1	53.7	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
1.3	50.6	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
1.2	49.7	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
2.3	48.8	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
2.5	45.7	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle

Showing 1 to 10 of 115 entries

Results for HIC1

Z-value: 2.77

Motif logo

Transcription factors associated with HIC1

Activity-expression correlation:

Activity profile of HIC1 motif

Sorted Z-values of HIC1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HIC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: