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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HMGA2

Z-value: 0.64

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Transcription factors associated with HMGA2

Gene Symbol Gene ID Gene Info
ENSG00000149948.9 high mobility group AT-hook 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HMGA2hg19_v2_chr12_+_66218212_662182440.454.8e-12Click!

Activity profile of HMGA2 motif

Sorted Z-values of HMGA2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_111580508 11.73 ENST00000368847.4
KIAA1919
chr1_+_196621002 8.13 ENST00000367429.4
ENST00000439155.2
complement factor H
chr10_-_5046042 7.84 ENST00000421196.3
ENST00000455190.1
aldo-keto reductase family 1, member C2
chr12_-_122751002 7.57 ENST00000267199.4
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr6_-_52705641 5.95 ENST00000370989.2
glutathione S-transferase alpha 5
chr1_+_196621156 5.92 ENST00000359637.2
complement factor H
chr2_-_216257849 5.84 ENST00000456923.1
fibronectin 1
chr15_+_43985084 5.76 ENST00000434505.1
ENST00000411750.1
creatine kinase, mitochondrial 1A
chr15_+_43885252 5.60 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
creatine kinase, mitochondrial 1B
chr19_-_36297632 4.76 ENST00000588266.2
proline dehydrogenase (oxidase) 2
chr15_+_58702742 4.73 ENST00000356113.6
ENST00000414170.3
lipase, hepatic
chr19_-_12267524 4.66 ENST00000455799.1
ENST00000355738.1
ENST00000439556.2
ENST00000542938.1
zinc finger protein 625
chr18_-_21017817 4.55 ENST00000542162.1
ENST00000383233.3
ENST00000582336.1
ENST00000450466.2
ENST00000578520.1
ENST00000399707.1
transmembrane protein 241
chr11_+_73661364 4.52 ENST00000339764.1
DnaJ (Hsp40) homolog, subfamily B, member 13
chr4_+_40058411 4.26 ENST00000261435.6
ENST00000515550.1
NEDD4 binding protein 2
chr2_+_1417228 3.80 ENST00000382269.3
ENST00000337415.3
ENST00000345913.4
ENST00000346956.3
ENST00000349624.3
ENST00000539820.1
ENST00000329066.4
ENST00000382201.3
thyroid peroxidase
chr5_+_36608422 3.34 ENST00000381918.3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chrX_-_7895755 3.24 ENST00000444736.1
ENST00000537427.1
ENST00000442940.1
patatin-like phospholipase domain containing 4
chr9_-_115480303 2.83 ENST00000374234.1
ENST00000374238.1
ENST00000374236.1
ENST00000374242.4
INTS3 and NABP interacting protein
chr1_+_55464600 2.68 ENST00000371265.4
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr14_+_99947715 2.66 ENST00000389879.5
ENST00000557441.1
ENST00000555049.1
ENST00000555842.1
cyclin K
chr10_-_62332357 2.63 ENST00000503366.1
ankyrin 3, node of Ranvier (ankyrin G)
chr2_+_220143989 2.61 ENST00000336576.5
DnaJ (Hsp40) homolog, subfamily B, member 2
chrX_-_7895479 2.58 ENST00000381042.4
patatin-like phospholipase domain containing 4
chr2_+_172543967 2.52 ENST00000534253.2
ENST00000263811.4
ENST00000397119.3
ENST00000410079.3
ENST00000438879.1
dynein, cytoplasmic 1, intermediate chain 2
chrY_+_22918021 2.51 ENST00000288666.5
ribosomal protein S4, Y-linked 2
chr17_-_4607335 2.35 ENST00000570571.1
ENST00000575101.1
ENST00000436683.2
ENST00000574876.1
proline, glutamate and leucine rich protein 1
chr8_-_105479270 2.33 ENST00000521573.2
ENST00000351513.2
dihydropyrimidinase
chr6_+_123110302 2.29 ENST00000368440.4
sphingomyelin phosphodiesterase, acid-like 3A
chr3_-_106959424 2.20 ENST00000607801.1
ENST00000479612.2
ENST00000484698.1
ENST00000477210.2
ENST00000473636.1
long intergenic non-protein coding RNA 882
chr2_+_172543919 2.02 ENST00000452242.1
ENST00000340296.4
dynein, cytoplasmic 1, intermediate chain 2
chrX_-_153523462 2.00 ENST00000361930.3
ENST00000369926.1
testis expressed 28
chr11_-_130786400 2.00 ENST00000265909.4
sorting nexin 19
chr2_+_172544182 1.99 ENST00000409197.1
ENST00000456808.1
ENST00000409317.1
ENST00000409773.1
ENST00000411953.1
ENST00000409453.1
dynein, cytoplasmic 1, intermediate chain 2
chr3_+_193853927 1.93 ENST00000232424.3
hes family bHLH transcription factor 1
chr12_+_18414446 1.89 ENST00000433979.1
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr6_-_32908765 1.82 ENST00000416244.2
major histocompatibility complex, class II, DM beta
chr14_-_94759408 1.74 ENST00000554723.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr15_+_84904525 1.71 ENST00000510439.2
golgin A6 family-like 4
chr14_-_94759361 1.62 ENST00000393096.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr5_-_135290705 1.61 ENST00000274507.1
leukocyte cell-derived chemotaxin 2
chr11_+_60260248 1.58 ENST00000526784.1
ENST00000016913.4
ENST00000537076.1
ENST00000530007.1
membrane-spanning 4-domains, subfamily A, member 12
chr14_+_50291993 1.56 ENST00000595378.1
HCG1786899; PRO2610; Uncharacterized protein
chr17_-_26220366 1.45 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
LYR motif containing 9
Uncharacterized protein
chr14_-_94759595 1.43 ENST00000261994.4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_+_172544011 1.39 ENST00000508530.1
dynein, cytoplasmic 1, intermediate chain 2
chr18_+_11851383 1.38 ENST00000526991.2
charged multivesicular body protein 1B
chr2_-_183387430 1.37 ENST00000410103.1
phosphodiesterase 1A, calmodulin-dependent
chr19_-_38146289 1.21 ENST00000392144.1
ENST00000591444.1
ENST00000351218.2
ENST00000587809.1
ZFP30 zinc finger protein
chr11_+_69455855 1.17 ENST00000227507.2
ENST00000536559.1
cyclin D1
chr19_+_44455368 1.16 ENST00000591168.1
ENST00000587682.1
ENST00000251269.5
zinc finger protein 221
chrX_-_23926004 1.16 ENST00000379226.4
ENST00000379220.3
apolipoprotein O
chr2_+_220144052 1.03 ENST00000425450.1
ENST00000392086.4
ENST00000421532.1
DnaJ (Hsp40) homolog, subfamily B, member 2
chr6_+_29426230 1.00 ENST00000442615.1
olfactory receptor, family 2, subfamily H, member 1
chr6_+_26156551 0.94 ENST00000304218.3
histone cluster 1, H1e
chr14_+_45553296 0.90 ENST00000355765.6
ENST00000553605.1
pre-mRNA processing factor 39
chr14_-_65409438 0.89 ENST00000557049.1
glutathione peroxidase 2 (gastrointestinal)
chr8_+_9911778 0.87 ENST00000317173.4
ENST00000441698.2
methionine sulfoxide reductase A
chr15_+_28623784 0.68 ENST00000526619.2
ENST00000337838.7
ENST00000532622.2
golgin A8 family, member F
chr9_-_86955598 0.66 ENST00000376238.4
solute carrier family 28 (concentrative nucleoside transporter), member 3
chr15_+_83098710 0.66 ENST00000561062.1
ENST00000358583.3
golgin A6 family-like 20
chrX_+_117480036 0.52 ENST00000371822.5
ENST00000254029.3
ENST00000371825.3
WD repeat domain 44
chr21_+_38792602 0.50 ENST00000398960.2
ENST00000398956.2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr15_+_82722225 0.45 ENST00000300515.8
golgin A6 family-like 9
chr1_+_144989309 0.43 ENST00000596396.1
Uncharacterized protein
chr6_-_52926539 0.42 ENST00000350082.5
ENST00000356971.3
intestinal cell (MAK-like) kinase
chr14_-_65409502 0.42 ENST00000389614.5
glutathione peroxidase 2 (gastrointestinal)
chr17_-_50236039 0.41 ENST00000451037.2
carbonic anhydrase X
chr12_-_8765446 0.39 ENST00000537228.1
ENST00000229335.6
activation-induced cytidine deaminase
chr19_-_11456935 0.31 ENST00000590788.1
ENST00000586590.1
ENST00000589555.1
ENST00000586956.1
ENST00000593256.2
ENST00000447337.1
ENST00000591677.1
ENST00000586701.1
ENST00000589655.1
transmembrane protein 205
RAB3D, member RAS oncogene family
chr2_-_183387064 0.22 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
phosphodiesterase 1A, calmodulin-dependent
chr2_-_183387283 0.18 ENST00000435564.1
phosphodiesterase 1A, calmodulin-dependent
chr2_+_177134201 0.16 ENST00000452865.1
metaxin 2

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.8 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
1.5 4.6 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
1.1 7.8 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.9 3.6 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.9 2.7 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.8 4.8 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.8 2.3 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.7 7.9 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.7 7.6 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.7 4.8 GO:0008218 bioluminescence(GO:0008218)
0.7 2.0 GO:1990502 dense core granule maturation(GO:1990502)
0.7 2.6 GO:0072660 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.6 1.9 GO:0021558 midbrain-hindbrain boundary morphogenesis(GO:0021555) trochlear nerve development(GO:0021558) regulation of timing of neuron differentiation(GO:0060164)
0.6 14.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.5 5.8 GO:0006600 creatine metabolic process(GO:0006600)
0.5 3.3 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.3 4.7 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372) phosphatidylcholine catabolic process(GO:0034638)
0.2 2.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.2 5.8 GO:0042572 retinol metabolic process(GO:0042572)
0.1 3.8 GO:0006590 thyroid hormone generation(GO:0006590)
0.1 4.5 GO:0035082 axoneme assembly(GO:0035082)
0.1 0.7 GO:0015860 pyrimidine nucleobase transport(GO:0015855) purine nucleoside transmembrane transport(GO:0015860) purine nucleobase transmembrane transport(GO:1904823)
0.1 0.9 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.1 1.2 GO:0070141 response to UV-A(GO:0070141)
0.1 1.4 GO:1904903 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.1 0.4 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.1 1.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.9 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.9 GO:0030091 protein repair(GO:0030091)
0.1 0.4 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.1 0.3 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 5.9 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 1.9 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.1 2.7 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 1.2 GO:0042407 cristae formation(GO:0042407)
0.0 0.5 GO:0090312 positive regulation of protein deacetylation(GO:0090312)
0.0 1.0 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 1.2 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 4.1 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 2.8 GO:0010212 response to ionizing radiation(GO:0010212)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.8 7.6 GO:0071439 clathrin complex(GO:0071439)
0.7 2.8 GO:0070876 SOSS complex(GO:0070876)
0.4 5.8 GO:0005577 fibrinogen complex(GO:0005577)
0.3 7.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.2 1.2 GO:0061617 MICOS complex(GO:0061617)
0.2 2.6 GO:0043194 axon initial segment(GO:0043194)
0.1 4.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 1.4 GO:0000815 ESCRT III complex(GO:0000815)
0.1 2.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 1.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.9 GO:0000243 commitment complex(GO:0000243)
0.1 5.8 GO:0005811 lipid particle(GO:0005811)
0.1 14.1 GO:0072562 blood microparticle(GO:0072562)
0.1 4.5 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 2.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 10.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.4 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 0.4 GO:0097542 ciliary tip(GO:0097542)
0.0 0.3 GO:0042588 zymogen granule(GO:0042588)
0.0 4.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.0 GO:0031901 early endosome membrane(GO:0031901)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0036080 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
1.3 7.8 GO:0018636 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
1.2 4.8 GO:0004657 proline dehydrogenase activity(GO:0004657)
1.1 4.3 GO:0051734 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.8 2.3 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.7 5.8 GO:0004111 creatine kinase activity(GO:0004111)
0.6 3.8 GO:0004447 iodide peroxidase activity(GO:0004447)
0.6 14.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.5 3.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 10.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.4 7.9 GO:0045504 dynein heavy chain binding(GO:0045504)
0.3 0.9 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.3 1.9 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.3 1.8 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2 2.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.2 0.7 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.2 0.9 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.2 0.9 GO:0032564 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.1 2.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 2.7 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 5.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 5.8 GO:0016504 peptidase activator activity(GO:0016504)
0.1 1.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 2.7 GO:0001671 ATPase activator activity(GO:0001671)
0.1 2.0 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.4 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 2.6 GO:0030507 spectrin binding(GO:0030507)
0.0 4.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 2.5 GO:0019843 rRNA binding(GO:0019843)
0.0 0.5 GO:0048156 tau protein binding(GO:0048156)
0.0 1.9 GO:0051087 chaperone binding(GO:0051087)
0.0 1.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.8 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 2.3 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 1.9 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 3.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.9 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 4.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 14.1 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.2 5.8 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 4.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 5.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 2.3 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.2 3.8 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 1.9 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 7.9 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 2.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.2 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 1.9 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.9 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 3.0 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 11.4 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.5 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 1.0 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.7 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 4.7 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway