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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HNF1A_HNF1B
Z-value: 2.48
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Transcription factors associated with HNF1A_HNF1B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HNF1A | hg19_v2_chr12_+_121416489_121416552 | 0.52 | 1.0e-16 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HNF1A_HNF1B
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.8 | 117.6 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 9.8 | 98.1 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 1.9 | 89.7 | GO:0051180 | vitamin transport(GO:0051180) |
| 13.4 | 67.1 | GO:0070980 | biphenyl catabolic process(GO:0070980) |
| 7.3 | 51.2 | GO:0008218 | bioluminescence(GO:0008218) |
| 3.6 | 50.9 | GO:0046415 | urate metabolic process(GO:0046415) |
| 2.3 | 46.7 | GO:0034374 | low-density lipoprotein particle remodeling(GO:0034374) |
| 3.1 | 45.8 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 5.8 | 40.9 | GO:0002414 | immunoglobulin transcytosis in epithelial cells(GO:0002414) |
| 0.5 | 38.5 | GO:0006953 | acute-phase response(GO:0006953) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 175.2 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.7 | 159.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 11.3 | 146.6 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 81.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 73.7 | GO:0030133 | transport vesicle(GO:0030133) |
| 3.5 | 67.1 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 64.3 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 3.3 | 56.3 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 6.2 | 37.0 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 3.8 | 34.4 | GO:0005579 | membrane attack complex(GO:0005579) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 129.6 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 1.2 | 128.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.7 | 76.4 | GO:0051087 | chaperone binding(GO:0051087) |
| 9.9 | 59.5 | GO:0005499 | vitamin D binding(GO:0005499) |
| 11.3 | 56.3 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 2.3 | 46.7 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 10.2 | 40.9 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 3.4 | 40.8 | GO:0005436 | sodium:phosphate symporter activity(GO:0005436) |
| 3.8 | 38.4 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.4 | 37.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 175.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 2.5 | 151.7 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 1.9 | 147.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 28.4 | PID FGF PATHWAY | FGF signaling pathway |
| 0.4 | 23.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.4 | 21.2 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 20.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.4 | 17.6 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.3 | 13.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.2 | 12.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.5 | 119.9 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 4.3 | 112.7 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 2.8 | 71.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 2.3 | 61.1 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 1.5 | 56.3 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.4 | 51.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 2.6 | 41.1 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 2.7 | 38.4 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 1.6 | 35.7 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 1.5 | 33.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |