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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HNF1A_HNF1B

Z-value: 2.48

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Transcription factors associated with HNF1A_HNF1B

Gene Symbol Gene ID Gene Info
ENSG00000135100.13 HNF1 homeobox A
ENSG00000108753.8 HNF1 homeobox B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HNF1Ahg19_v2_chr12_+_121416489_1214165520.521.0e-16Click!

Activity profile of HNF1A_HNF1B motif

Sorted Z-values of HNF1A_HNF1B motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_64225508 56.35 ENST00000205948.6
apolipoprotein H (beta-2-glycoprotein I)
chr4_-_72649763 56.27 ENST00000513476.1
group-specific component (vitamin D binding protein)
chr4_+_74301880 45.80 ENST00000395792.2
ENST00000226359.2
alpha-fetoprotein
chr4_+_155484155 41.46 ENST00000509493.1
fibrinogen beta chain
chr19_-_36304201 37.30 ENST00000301175.3
proline dehydrogenase (oxidase) 2
chr14_-_94854926 37.12 ENST00000402629.1
ENST00000556091.1
ENST00000554720.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_+_161123270 37.00 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
plasminogen
chr4_-_155511887 36.16 ENST00000302053.3
ENST00000403106.3
fibrinogen alpha chain
chr4_+_155484103 34.96 ENST00000302068.4
fibrinogen beta chain
chr4_+_74269956 31.37 ENST00000295897.4
ENST00000415165.2
ENST00000503124.1
ENST00000509063.1
ENST00000401494.3
albumin
chr2_+_234601512 31.01 ENST00000305139.6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr2_+_234668894 30.43 ENST00000305208.5
ENST00000608383.1
ENST00000360418.3
UDP glucuronosyltransferase 1 family, polypeptide A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr9_-_123812542 29.58 ENST00000223642.1
complement component 5
chr7_-_50633078 26.77 ENST00000444124.2
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr15_+_58724184 26.73 ENST00000433326.2
lipase, hepatic
chr19_+_50016610 25.12 ENST00000596975.1
Fc fragment of IgG, receptor, transporter, alpha
chr4_+_74347400 22.53 ENST00000226355.3
afamin
chr10_+_5135981 22.23 ENST00000380554.3
aldo-keto reductase family 1, member C3
chr2_+_234637754 21.75 ENST00000482026.1
ENST00000609767.1
UDP glucuronosyltransferase 1 family, polypeptide A3
UDP glucuronosyltransferase 1 family, polypeptide A8
chr5_+_176513868 21.24 ENST00000292408.4
fibroblast growth factor receptor 4
chr1_+_207277590 21.18 ENST00000367070.3
complement component 4 binding protein, alpha
chr2_+_88047606 20.63 ENST00000359481.4
plasminogen-like B2
chr8_-_17752996 20.12 ENST00000381841.2
ENST00000427924.1
fibrinogen-like 1
chr6_-_161085291 19.96 ENST00000316300.5
lipoprotein, Lp(a)
chr2_-_88427568 19.46 ENST00000393750.3
ENST00000295834.3
fatty acid binding protein 1, liver
chr7_+_45927956 17.97 ENST00000275525.3
ENST00000457280.1
insulin-like growth factor binding protein 1
chr14_-_94759408 17.57 ENST00000554723.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_-_87248975 17.53 ENST00000409310.2
ENST00000355705.3
plasminogen-like B1
chr5_+_176513895 17.20 ENST00000503708.1
ENST00000393648.2
ENST00000514472.1
ENST00000502906.1
ENST00000292410.3
ENST00000510911.1
fibroblast growth factor receptor 4
chr14_-_94759361 16.93 ENST00000393096.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_94759595 16.70 ENST00000261994.4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr10_+_115312766 16.33 ENST00000351270.3
hyaluronan binding protein 2
chr7_+_45928079 16.17 ENST00000468955.1
insulin-like growth factor binding protein 1
chr3_+_186383741 15.94 ENST00000232003.4
histidine-rich glycoprotein
chr4_+_3443614 15.79 ENST00000382774.3
ENST00000511533.1
HGF activator
chr19_+_50016411 15.73 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
Fc fragment of IgG, receptor, transporter, alpha
chr22_-_30970560 15.52 ENST00000402369.1
ENST00000406361.1
galactose-3-O-sulfotransferase 1
chr11_+_64323098 15.30 ENST00000301891.4
solute carrier family 22 (organic anion/urate transporter), member 11
chr6_-_25930819 15.25 ENST00000360488.3
solute carrier family 17, member 2
chr14_+_95027772 14.98 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr14_+_65171099 14.97 ENST00000247226.7
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr12_-_91574142 14.44 ENST00000547937.1
decorin
chr19_+_11350278 14.35 ENST00000252453.8
chromosome 19 open reading frame 80
chr17_+_41052808 14.10 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
glucose-6-phosphatase, catalytic subunit
chr14_+_21156915 13.92 ENST00000397990.4
ENST00000555597.1
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr17_+_1646130 13.91 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr20_+_42187682 13.89 ENST00000373092.3
ENST00000373077.1
serum/glucocorticoid regulated kinase 2
chr6_-_25930904 13.86 ENST00000377850.3
solute carrier family 17, member 2
chr9_-_98079965 13.23 ENST00000289081.3
Fanconi anemia, complementation group C
chr11_-_117695449 12.71 ENST00000292079.2
FXYD domain containing ion transport regulator 2
chr4_-_110723335 12.33 ENST00000394634.2
complement factor I
chr1_+_17906970 12.17 ENST00000375415.1
Rho guanine nucleotide exchange factor (GEF) 10-like
chr10_+_135340859 12.10 ENST00000252945.3
ENST00000421586.1
ENST00000418356.1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr11_+_46740730 11.86 ENST00000311907.5
ENST00000530231.1
ENST00000442468.1
coagulation factor II (thrombin)
chr6_-_52628271 11.86 ENST00000493422.1
glutathione S-transferase alpha 2
chr4_-_100212132 11.80 ENST00000209668.2
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr20_+_42187608 11.61 ENST00000373100.1
serum/glucocorticoid regulated kinase 2
chr4_-_110723194 11.60 ENST00000394635.3
complement factor I
chr14_-_57960545 10.92 ENST00000526336.1
ENST00000216445.3
chromosome 14 open reading frame 105
chr2_+_234627424 10.58 ENST00000373409.3
UDP glucuronosyltransferase 1 family, polypeptide A4
chr11_+_64323156 10.49 ENST00000377585.3
solute carrier family 22 (organic anion/urate transporter), member 11
chrX_-_105282712 10.24 ENST00000372563.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr8_-_70745575 10.16 ENST00000524945.1
solute carrier organic anion transporter family, member 5A1
chr9_-_94712434 9.97 ENST00000375708.3
receptor tyrosine kinase-like orphan receptor 2
chr7_-_44580861 9.91 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1-like 1
chr16_+_20462783 9.83 ENST00000574251.1
ENST00000576361.1
ENST00000417235.2
ENST00000573854.1
ENST00000424070.1
ENST00000536134.1
ENST00000219054.6
ENST00000575690.1
ENST00000571894.1
acyl-CoA synthetase medium-chain family member 2A
chr4_-_110723134 9.81 ENST00000510800.1
ENST00000512148.1
complement factor I
chr14_+_65171315 9.67 ENST00000394691.1
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr21_-_47575481 9.62 ENST00000291670.5
ENST00000397748.1
ENST00000359679.2
ENST00000355384.2
ENST00000397746.3
ENST00000397743.1
formimidoyltransferase cyclodeaminase
chr16_-_20587599 9.62 ENST00000566384.1
ENST00000565232.1
ENST00000567001.1
ENST00000565322.1
ENST00000569344.1
ENST00000329697.6
ENST00000414188.2
ENST00000568882.1
acyl-CoA synthetase medium-chain family member 2B
chr10_+_101542462 9.56 ENST00000370449.4
ENST00000370434.1
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr8_-_95220775 9.41 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
cadherin 17, LI cadherin (liver-intestine)
chr8_+_21911054 8.93 ENST00000519850.1
ENST00000381470.3
dematin actin binding protein
chr6_+_7541845 8.85 ENST00000418664.2
desmoplakin
chr12_-_91546926 8.77 ENST00000550758.1
decorin
chr10_-_52645379 8.77 ENST00000395489.2
APOBEC1 complementation factor
chr17_-_202579 8.48 ENST00000577079.1
ENST00000331302.7
ENST00000536489.2
rabphilin 3A-like (without C2 domains)
chr2_+_234621551 8.46 ENST00000608381.1
ENST00000373414.3
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A5
chr20_+_42984330 8.11 ENST00000316673.4
ENST00000609795.1
ENST00000457232.1
ENST00000609262.1
hepatocyte nuclear factor 4, alpha
chr10_-_52645416 8.07 ENST00000374001.2
ENST00000373997.3
ENST00000373995.3
ENST00000282641.2
ENST00000395495.1
ENST00000414883.1
APOBEC1 complementation factor
chr16_+_20775024 7.82 ENST00000289416.5
acyl-CoA synthetase medium-chain family member 3
chr10_+_74451883 7.45 ENST00000373053.3
ENST00000357157.6
mitochondrial calcium uniporter
chr1_+_119911425 7.28 ENST00000361035.4
ENST00000325945.3
hydroxyacid oxidase 2 (long chain)
chr2_-_228244013 7.16 ENST00000304568.3
transmembrane 4 L six family member 20
chr16_-_66952742 7.11 ENST00000565235.2
ENST00000568632.1
ENST00000565796.1
cadherin 16, KSP-cadherin
chr6_+_126070726 6.98 ENST00000368364.3
hes-related family bHLH transcription factor with YRPW motif 2
chr4_+_100495864 6.97 ENST00000265517.5
ENST00000422897.2
microsomal triglyceride transfer protein
chr4_-_76944621 6.67 ENST00000306602.1
chemokine (C-X-C motif) ligand 10
chr2_+_234526272 6.45 ENST00000373450.4
UDP glucuronosyltransferase 1 family, polypeptide A8
chr17_+_26800296 6.29 ENST00000444914.3
ENST00000314669.5
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr1_-_20141763 6.20 ENST00000375121.2
ring finger protein 186
chr6_+_25754927 6.14 ENST00000377905.4
ENST00000439485.2
solute carrier family 17, member 4
chr22_-_30968813 5.95 ENST00000443111.2
ENST00000443136.1
ENST00000426220.1
galactose-3-O-sulfotransferase 1
chr1_+_63063152 5.89 ENST00000371129.3
angiopoietin-like 3
chr9_+_82186682 5.62 ENST00000376552.2
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr12_-_102874416 5.61 ENST00000392904.1
ENST00000337514.6
insulin-like growth factor 1 (somatomedin C)
chr6_-_25874440 5.58 ENST00000361703.6
ENST00000397060.4
solute carrier family 17 (organic anion transporter), member 3
chr16_+_89696692 5.55 ENST00000261615.4
dipeptidase 1 (renal)
chr17_+_26800648 5.53 ENST00000545060.1
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr6_+_131571535 5.39 ENST00000474850.2
A kinase (PRKA) anchor protein 7
chr2_+_27719697 5.38 ENST00000264717.2
ENST00000424318.2
glucokinase (hexokinase 4) regulator
chr15_+_48498480 5.34 ENST00000380993.3
ENST00000396577.3
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
chr16_-_66952779 5.32 ENST00000570262.1
ENST00000394055.3
ENST00000299752.4
cadherin 16, KSP-cadherin
chr11_+_560956 5.28 ENST00000397582.3
ENST00000344375.4
ENST00000397583.3
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr6_+_31707725 5.26 ENST00000375755.3
ENST00000375742.3
ENST00000375750.3
ENST00000425703.1
ENST00000534153.4
ENST00000375703.3
ENST00000375740.3
mutS homolog 5
chr22_-_22337154 5.17 ENST00000413067.2
ENST00000437929.1
ENST00000456075.1
ENST00000434517.1
ENST00000424393.1
ENST00000449704.1
ENST00000437103.1
topoisomerase (DNA) III beta
chr3_-_137893721 5.15 ENST00000505015.2
ENST00000260803.4
debranching RNA lariats 1
chr4_-_1166954 5.06 ENST00000514490.1
ENST00000431380.1
ENST00000503765.1
spondin 2, extracellular matrix protein
chr5_+_175976324 4.98 ENST00000261944.5
cadherin-related family member 2
chr13_-_103719196 4.97 ENST00000245312.3
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr17_+_26800756 4.97 ENST00000537681.1
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr8_-_87755878 4.95 ENST00000320005.5
cyclic nucleotide gated channel beta 3
chr14_-_65409438 4.91 ENST00000557049.1
glutathione peroxidase 2 (gastrointestinal)
chr12_+_70132632 4.83 ENST00000378815.6
ENST00000483530.2
ENST00000325555.9
RAB3A interacting protein
chr1_+_57320437 4.79 ENST00000361249.3
complement component 8, alpha polypeptide
chr16_+_20775358 4.70 ENST00000440284.2
acyl-CoA synthetase medium-chain family member 3
chr7_+_130126012 4.69 ENST00000341441.5
mesoderm specific transcript
chr20_-_7921090 4.63 ENST00000378789.3
hydroxyacid oxidase (glycolate oxidase) 1
chr1_+_104293028 4.61 ENST00000370079.3
amylase, alpha 1C (salivary)
chr12_-_102874378 4.52 ENST00000456098.1
insulin-like growth factor 1 (somatomedin C)
chr7_-_27219849 4.50 ENST00000396344.4
homeobox A10
chr21_+_39628655 4.49 ENST00000398925.1
ENST00000398928.1
ENST00000328656.4
ENST00000443341.1
potassium inwardly-rectifying channel, subfamily J, member 15
chr12_-_102874330 4.42 ENST00000307046.8
insulin-like growth factor 1 (somatomedin C)
chr22_-_22337204 4.39 ENST00000430142.1
ENST00000357179.5
topoisomerase (DNA) III beta
chr21_+_39628852 4.31 ENST00000398938.2
potassium inwardly-rectifying channel, subfamily J, member 15
chr12_+_100897130 4.30 ENST00000551379.1
ENST00000188403.7
ENST00000551184.1
nuclear receptor subfamily 1, group H, member 4
chr8_-_124749609 4.28 ENST00000262219.6
ENST00000419625.1
annexin A13
chr7_+_141695633 4.13 ENST00000549489.2
maltase-glucoamylase (alpha-glucosidase)
chr13_+_96085847 3.91 ENST00000376873.3
claudin 10
chr7_-_150020578 3.82 ENST00000478393.1
ARP3 actin-related protein 3 homolog C (yeast)
chr22_+_31002779 3.81 ENST00000215838.3
transcobalamin II
chr7_+_130126165 3.75 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
mesoderm specific transcript
chr6_-_127840453 3.70 ENST00000556132.1
SOGA family member 3
chr22_+_31003190 3.68 ENST00000407817.3
transcobalamin II
chr22_+_45098067 3.64 ENST00000336985.6
ENST00000403696.1
ENST00000457960.1
ENST00000361473.5
proline rich 5 (renal)
PRR5-ARHGAP8 readthrough
chr12_+_100867694 3.64 ENST00000392986.3
ENST00000549996.1
nuclear receptor subfamily 1, group H, member 4
chr14_-_65409502 3.62 ENST00000389614.5
glutathione peroxidase 2 (gastrointestinal)
chr9_+_102861515 3.60 ENST00000262457.2
ENST00000541287.1
ENST00000262456.2
ENST00000374921.3
inversin
chr2_-_162931052 3.60 ENST00000360534.3
dipeptidyl-peptidase 4
chr6_-_29013017 3.55 ENST00000377175.1
olfactory receptor, family 2, subfamily W, member 1
chr4_-_69536346 3.49 ENST00000338206.5
UDP glucuronosyltransferase 2 family, polypeptide B15
chr7_+_141695671 3.46 ENST00000497673.1
ENST00000475668.2
maltase-glucoamylase (alpha-glucosidase)
chr22_+_31003133 3.45 ENST00000405742.3
transcobalamin II
chr19_-_42133420 3.38 ENST00000221954.2
ENST00000600925.1
carcinoembryonic antigen-related cell adhesion molecule 4
chrX_+_16668278 3.26 ENST00000380200.3
S100 calcium binding protein G
chr12_+_21284118 3.20 ENST00000256958.2
solute carrier organic anion transporter family, member 1B1
chr6_+_167704838 3.12 ENST00000366829.2
unc-93 homolog A (C. elegans)
chr12_-_102874102 3.08 ENST00000392905.2
insulin-like growth factor 1 (somatomedin C)
chr6_+_106534192 2.91 ENST00000369091.2
ENST00000369096.4
PR domain containing 1, with ZNF domain
chr7_+_120629653 2.77 ENST00000450913.2
ENST00000340646.5
cadherin-like and PC-esterase domain containing 1
chr17_+_68071458 2.73 ENST00000589377.1
potassium inwardly-rectifying channel, subfamily J, member 16
chr14_+_24590560 2.72 ENST00000558325.1
RP11-468E2.6
chr12_+_100867486 2.71 ENST00000548884.1
nuclear receptor subfamily 1, group H, member 4
chr16_-_87970122 2.67 ENST00000309893.2
carbonic anhydrase VA, mitochondrial
chr10_-_72648541 2.58 ENST00000299299.3
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
chr1_+_207262170 2.47 ENST00000367078.3
complement component 4 binding protein, beta
chr12_-_18243075 2.45 ENST00000536890.1
RERG/RAS-like
chr4_-_69434245 2.40 ENST00000317746.2
UDP glucuronosyltransferase 2 family, polypeptide B17
chr17_+_68071389 2.36 ENST00000283936.1
ENST00000392671.1
potassium inwardly-rectifying channel, subfamily J, member 16
chr12_-_18243119 2.15 ENST00000538724.1
ENST00000229002.2
RERG/RAS-like
chr5_-_35195338 2.13 ENST00000509839.1
prolactin receptor
chr20_+_35973080 2.10 ENST00000445403.1
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr11_-_128894053 2.00 ENST00000392657.3
Rho GTPase activating protein 32
chr6_+_167704798 1.94 ENST00000230256.3
unc-93 homolog A (C. elegans)
chr6_-_117747015 1.91 ENST00000368508.3
ENST00000368507.3
c-ros oncogene 1 , receptor tyrosine kinase
chr1_+_104159999 1.91 ENST00000414303.2
ENST00000423678.1
amylase, alpha 2A (pancreatic)
chr2_-_47572105 1.86 ENST00000419035.1
ENST00000448713.1
ENST00000450550.1
ENST00000413185.2
AC073283.4
chr13_+_27825706 1.85 ENST00000272274.4
ENST00000319826.4
ENST00000326092.4
ribosomal protein L21
chr1_+_36789335 1.81 ENST00000373137.2
RP11-268J15.5
chr1_+_207262881 1.74 ENST00000451804.2
complement component 4 binding protein, beta
chr15_+_58430368 1.70 ENST00000558772.1
ENST00000219919.4
aquaporin 9
chr4_+_169013666 1.64 ENST00000359299.3
annexin A10
chr4_-_70518941 1.63 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr20_+_43029911 1.60 ENST00000443598.2
ENST00000316099.4
ENST00000415691.2
hepatocyte nuclear factor 4, alpha
chr6_-_29343068 1.60 ENST00000396806.3
olfactory receptor, family 12, subfamily D, member 3
chr16_-_420514 1.57 ENST00000199706.8
mitochondrial ribosomal protein L28
chr1_+_205197304 1.51 ENST00000358024.3
transmembrane and coiled-coil domain family 2
chrX_+_1710484 1.49 ENST00000313871.3
ENST00000381261.3
A kinase (PRKA) anchor protein 17A
chr16_-_420338 1.48 ENST00000450882.1
ENST00000441883.1
ENST00000447696.1
ENST00000389675.2
mitochondrial ribosomal protein L28
chr1_+_207262627 1.36 ENST00000391923.1
complement component 4 binding protein, beta
chr3_-_169587621 1.34 ENST00000523069.1
ENST00000316428.5
ENST00000264676.5
leucine rich repeat containing 31
chr1_-_159684371 1.33 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
C-reactive protein, pentraxin-related
chr10_-_38146510 1.30 ENST00000395867.3
zinc finger protein 248
chr1_-_207206092 1.27 ENST00000359470.5
ENST00000461135.2
chromosome 1 open reading frame 116
chr3_+_38307293 1.26 ENST00000311856.4
solute carrier family 22 (organic anion/urate transporter), member 13
chr3_-_192445289 1.16 ENST00000430714.1
ENST00000418610.1
ENST00000448795.1
ENST00000445105.2
fibroblast growth factor 12
chr4_-_987217 1.06 ENST00000361661.2
ENST00000398516.2
solute carrier family 26 (anion exchanger), member 1
chr12_-_8693539 0.94 ENST00000299663.3
C-type lectin domain family 4, member E
chr4_+_187187098 0.90 ENST00000403665.2
ENST00000264692.4
coagulation factor XI
chr19_-_11639931 0.89 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
ECSIT signalling integrator
chr10_-_101690650 0.83 ENST00000543621.1
dynamin binding protein
chr12_+_20963647 0.83 ENST00000381545.3
solute carrier organic anion transporter family, member 1B3
chrX_+_120181457 0.78 ENST00000328078.1
glutamate dehydrogenase 2
chr7_-_122840015 0.77 ENST00000194130.2
solute carrier family 13 (sodium/sulfate symporter), member 1
chr21_-_19775973 0.76 ENST00000284885.3
transmembrane protease, serine 15
chr12_+_60058458 0.69 ENST00000548610.1
solute carrier family 16 (monocarboxylate transporter), member 7
chr12_+_20963632 0.69 ENST00000540853.1
ENST00000261196.2
solute carrier organic anion transporter family, member 1B3
chr22_+_32439019 0.63 ENST00000266088.4
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr11_+_1860200 0.62 ENST00000381911.1
troponin I type 2 (skeletal, fast)
chr11_-_83393457 0.61 ENST00000404783.3
discs, large homolog 2 (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF1A_HNF1B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
13.4 67.1 GO:0070980 biphenyl catabolic process(GO:0070980)
12.3 37.0 GO:2000048 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
11.8 117.6 GO:0043152 induction of bacterial agglutination(GO:0043152)
10.6 10.6 GO:0006789 bilirubin conjugation(GO:0006789)
10.5 31.4 GO:0019836 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
9.9 29.6 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
9.8 98.1 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
8.9 26.8 GO:0052314 serotonin biosynthetic process(GO:0042427) phytoalexin metabolic process(GO:0052314)
7.7 38.4 GO:1903412 response to bile acid(GO:1903412)
7.4 22.2 GO:0016095 polyprenol catabolic process(GO:0016095)
7.3 51.2 GO:0008218 bioluminescence(GO:0008218)
6.2 37.3 GO:0010133 proline catabolic process to glutamate(GO:0010133)
5.8 40.9 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
5.0 15.1 GO:0016999 antibiotic metabolic process(GO:0016999)
4.4 31.0 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
3.6 50.9 GO:0046415 urate metabolic process(GO:0046415)
3.6 10.7 GO:0090294 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
3.5 17.6 GO:1904073 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
3.2 9.6 GO:0019557 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
3.1 45.8 GO:0001542 ovulation from ovarian follicle(GO:0001542)
3.0 27.4 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
3.0 15.0 GO:0061107 seminal vesicle development(GO:0061107)
2.8 16.8 GO:0016554 cytidine to uridine editing(GO:0016554)
2.8 13.9 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
2.4 21.5 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
2.4 9.4 GO:0002314 germinal center B cell differentiation(GO:0002314)
2.3 46.7 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
2.3 7.0 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
2.2 15.6 GO:0055091 phospholipid homeostasis(GO:0055091)
2.1 23.2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
2.0 12.1 GO:0010193 response to ozone(GO:0010193)
2.0 10.0 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
1.9 19.5 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
1.9 89.7 GO:0051180 vitamin transport(GO:0051180)
1.9 7.6 GO:0000023 maltose metabolic process(GO:0000023)
1.9 35.3 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
1.8 8.9 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
1.7 5.0 GO:0090675 intermicrovillar adhesion(GO:0090675)
1.5 4.6 GO:0009441 glycolate metabolic process(GO:0009441)
1.3 6.7 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
1.3 8.8 GO:0071896 protein localization to adherens junction(GO:0071896)
1.2 7.5 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
1.2 11.8 GO:0006069 ethanol oxidation(GO:0006069)
1.1 13.4 GO:0070327 thyroid hormone transport(GO:0070327)
1.1 34.1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.9 9.9 GO:0030299 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.9 3.6 GO:0036343 psychomotor behavior(GO:0036343)
0.9 9.8 GO:0036112 medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.9 7.0 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.8 12.7 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.7 13.2 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.6 6.2 GO:0052695 cellular glucuronidation(GO:0052695)
0.6 5.3 GO:0051026 chiasma assembly(GO:0051026)
0.6 2.9 GO:0033078 extrathymic T cell differentiation(GO:0033078)
0.6 2.3 GO:0015722 canalicular bile acid transport(GO:0015722)
0.6 9.6 GO:0006265 DNA topological change(GO:0006265)
0.5 38.5 GO:0006953 acute-phase response(GO:0006953)
0.5 2.1 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.5 1.9 GO:0010966 regulation of phosphate transport(GO:0010966)
0.4 12.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.4 0.8 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.4 11.1 GO:0010107 potassium ion import(GO:0010107)
0.4 2.1 GO:0038161 prolactin signaling pathway(GO:0038161)
0.3 10.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.3 3.6 GO:0038203 TORC2 signaling(GO:0038203)
0.3 0.9 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.3 2.6 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.3 38.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.3 5.0 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.3 1.8 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.2 12.5 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.2 37.6 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.2 7.0 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.2 4.5 GO:0060065 uterus development(GO:0060065)
0.2 0.7 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.2 8.5 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.2 14.5 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.1 5.4 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 3.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.7 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 5.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 8.5 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.1 9.6 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.1 0.6 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.1 5.1 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 7.3 GO:0009062 fatty acid catabolic process(GO:0009062)
0.1 3.4 GO:0006909 phagocytosis(GO:0006909)
0.1 2.7 GO:0015701 bicarbonate transport(GO:0015701)
0.0 5.3 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.4 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.0 22.9 GO:0006979 response to oxidative stress(GO:0006979)
0.0 2.2 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 1.1 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 2.0 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 6.7 GO:0007498 mesoderm development(GO:0007498)
0.0 5.3 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 1.5 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 7.2 GO:0045861 negative regulation of proteolysis(GO:0045861)
0.0 3.6 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 1.0 GO:0051341 regulation of oxidoreductase activity(GO:0051341)
0.0 0.0 GO:0002276 basophil activation involved in immune response(GO:0002276)
0.0 0.9 GO:0002292 T cell differentiation involved in immune response(GO:0002292)
0.0 1.8 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 1.1 GO:0006903 vesicle targeting(GO:0006903)
0.0 0.6 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.8 GO:0006898 receptor-mediated endocytosis(GO:0006898)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
11.3 146.6 GO:0005577 fibrinogen complex(GO:0005577)
6.2 37.0 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
5.6 16.8 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
5.0 15.0 GO:0036030 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
3.8 34.4 GO:0005579 membrane attack complex(GO:0005579)
3.5 67.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
3.3 56.3 GO:0031089 platelet dense granule lumen(GO:0031089)
2.5 17.6 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
2.4 19.5 GO:0045179 apical cortex(GO:0045179)
2.3 13.9 GO:0032311 angiogenin-PRI complex(GO:0032311)
1.9 13.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
1.9 13.2 GO:0046581 intercellular canaliculus(GO:0046581)
1.9 7.5 GO:1990246 uniplex complex(GO:1990246)
1.7 23.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
1.1 9.6 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
1.0 5.0 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
1.0 26.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.8 20.0 GO:0034358 plasma lipoprotein particle(GO:0034358) lipoprotein particle(GO:1990777)
0.7 159.2 GO:0072562 blood microparticle(GO:0072562)
0.6 12.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.6 8.8 GO:0005916 fascia adherens(GO:0005916)
0.5 175.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.5 8.9 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.3 5.3 GO:0032300 mismatch repair complex(GO:0032300)
0.3 7.0 GO:0016580 Sin3 complex(GO:0016580)
0.3 5.5 GO:0031528 microvillus membrane(GO:0031528)
0.3 10.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.3 16.1 GO:0031526 brush border membrane(GO:0031526)
0.2 11.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 3.6 GO:0031932 TORC2 complex(GO:0031932)
0.2 7.7 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.2 73.7 GO:0030133 transport vesicle(GO:0030133)
0.2 26.2 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.1 31.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 2.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 7.6 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.1 10.9 GO:0043202 lysosomal lumen(GO:0043202)
0.1 32.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 21.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 2.1 GO:0031904 endosome lumen(GO:0031904)
0.1 81.3 GO:0005615 extracellular space(GO:0005615)
0.1 32.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 4.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.5 GO:0001739 sex chromatin(GO:0001739)
0.0 64.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 5.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 28.7 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 3.1 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.6 GO:0005861 troponin complex(GO:0005861)
0.0 5.1 GO:0000793 condensed chromosome(GO:0000793)
0.0 1.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 3.6 GO:0005819 spindle(GO:0005819)
0.0 1.9 GO:0009986 cell surface(GO:0009986)
0.0 2.9 GO:0005576 extracellular region(GO:0005576)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
11.3 56.3 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
10.2 40.9 GO:0019770 IgG receptor activity(GO:0019770)
9.9 59.5 GO:0005499 vitamin D binding(GO:0005499)
9.3 37.3 GO:0004657 proline dehydrogenase activity(GO:0004657)
5.6 22.5 GO:0008431 vitamin E binding(GO:0008431)
5.6 16.8 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
5.6 22.2 GO:0047718 enone reductase activity(GO:0035671) androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
4.6 37.0 GO:1990405 protein antigen binding(GO:1990405)
4.0 11.9 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
3.8 38.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
3.6 32.0 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
3.6 10.7 GO:0038181 bile acid receptor activity(GO:0038181) chenodeoxycholic acid binding(GO:1902122)
3.5 14.1 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
3.4 34.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
3.4 40.8 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
3.2 129.6 GO:0001972 retinoic acid binding(GO:0001972)
3.1 21.5 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
2.9 25.8 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
2.8 19.5 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
2.4 9.6 GO:0016841 ammonia-lyase activity(GO:0016841)
2.4 9.5 GO:0016160 amylase activity(GO:0016160)
2.4 9.4 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
2.3 46.7 GO:0034185 apolipoprotein binding(GO:0034185)
2.3 13.9 GO:0004522 ribonuclease A activity(GO:0004522)
2.0 11.8 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
2.0 31.4 GO:0015643 toxic substance binding(GO:0015643)
1.7 7.0 GO:0035939 microsatellite binding(GO:0035939)
1.7 10.0 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
1.6 9.6 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
1.3 6.7 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
1.2 5.0 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
1.2 128.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.2 9.6 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
1.2 11.9 GO:0070053 thrombospondin receptor activity(GO:0070053)
1.1 25.5 GO:0017081 chloride channel regulator activity(GO:0017081)
1.1 5.4 GO:0070095 fructose-6-phosphate binding(GO:0070095)
1.0 10.9 GO:0031419 cobalamin binding(GO:0031419)
1.0 8.8 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.8 12.7 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.8 5.5 GO:0070573 metallodipeptidase activity(GO:0070573)
0.8 13.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.8 8.5 GO:0030274 LIM domain binding(GO:0030274)
0.7 76.4 GO:0051087 chaperone binding(GO:0051087)
0.7 4.9 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.7 29.6 GO:0008009 chemokine activity(GO:0008009)
0.6 2.6 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.6 12.1 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.6 33.7 GO:0005044 scavenger receptor activity(GO:0005044)
0.6 2.3 GO:0015265 glycerol channel activity(GO:0015254) urea channel activity(GO:0015265)
0.5 16.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.5 26.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.4 2.1 GO:0004925 prolactin receptor activity(GO:0004925)
0.4 5.3 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.4 9.9 GO:0031489 myosin V binding(GO:0031489)
0.4 37.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3 23.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 8.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.3 1.3 GO:0033265 choline binding(GO:0033265)
0.3 5.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.3 2.1 GO:0071253 connexin binding(GO:0071253)
0.2 5.9 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.2 9.7 GO:0005504 fatty acid binding(GO:0005504)
0.2 1.8 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.2 5.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.2 7.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 0.8 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.2 8.9 GO:0043621 protein self-association(GO:0043621)
0.2 5.1 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.2 3.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 5.1 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.2 0.7 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.2 8.3 GO:0005158 insulin receptor binding(GO:0005158)
0.2 16.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 2.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 4.8 GO:0001848 complement binding(GO:0001848)
0.1 5.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 33.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 7.0 GO:0005548 phospholipid transporter activity(GO:0005548)
0.1 5.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 26.1 GO:0030674 protein binding, bridging(GO:0030674)
0.1 2.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.6 GO:0031014 troponin T binding(GO:0031014)
0.0 1.5 GO:0051018 protein kinase A binding(GO:0051018)
0.0 4.5 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 8.2 GO:0016787 hydrolase activity(GO:0016787)
0.0 1.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 1.9 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 2.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.0 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.0 1.4 GO:0005262 calcium channel activity(GO:0005262)
0.0 2.0 GO:0035091 phosphatidylinositol binding(GO:0035091)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 151.7 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
1.9 147.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.7 175.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 21.2 PID CD40 PATHWAY CD40/CD40L signaling
0.4 23.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.4 17.6 PID IGF1 PATHWAY IGF1 pathway
0.4 8.8 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.3 28.4 PID FGF PATHWAY FGF signaling pathway
0.3 10.0 PID WNT SIGNALING PATHWAY Wnt signaling network
0.3 13.2 PID BARD1 PATHWAY BARD1 signaling events
0.2 10.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 4.9 PID CONE PATHWAY Visual signal transduction: Cones
0.2 5.1 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 12.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.2 6.7 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 4.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 7.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 8.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 8.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 6.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 20.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 5.9 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.1 3.6 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 6.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 2.1 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 2.0 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 2.0 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 8.5 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 0.8 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 2.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
7.5 119.9 REACTOME COMMON PATHWAY Genes involved in Common Pathway
4.3 112.7 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
2.8 71.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
2.7 38.4 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
2.6 41.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
2.3 61.1 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
1.6 35.7 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
1.5 33.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
1.5 56.3 REACTOME STEROID HORMONES Genes involved in Steroid hormones
1.5 11.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
1.2 20.0 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
1.2 25.8 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
1.2 18.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
1.2 12.8 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
1.2 26.8 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.9 23.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.7 12.1 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.5 21.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.5 13.2 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.5 8.8 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.4 13.9 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.4 51.2 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.4 19.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.3 11.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.3 9.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.3 9.6 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.3 3.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 12.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.2 9.6 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.2 2.7 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.2 2.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 9.0 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 2.1 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 19.5 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 2.1 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 6.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.9 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 16.8 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.1 0.9 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 3.5 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 5.3 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 14.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 6.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 3.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation