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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HNF4A

Z-value: 1.35

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Transcription factors associated with HNF4A

Gene Symbol Gene ID Gene Info
HNF4A
ENSG00000101076.12 hepatocyte nuclear factor 4 alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HNF4Ahg19_v2_chr20_+_42984330_429844450.624.1e-24Click!

Activity profile of HNF4A motif

Sorted Z-values of HNF4A motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_42811986 33.87 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
SEPP1
selenoprotein P, plasma, 1
chr5_-_42812143 33.56 ENST00000514985.1
SEPP1
selenoprotein P, plasma, 1
chr6_+_31949801 25.88 ENST00000428956.2
ENST00000498271.1
C4A
complement component 4A (Rodgers blood group)
chr6_+_31982539 25.55 ENST00000435363.2
ENST00000425700.2
C4B
complement component 4B (Chido blood group)
chr20_+_56136136 17.36 ENST00000319441.4
ENST00000543666.1
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr16_+_8768422 16.40 ENST00000268251.8
ENST00000564714.1
ABAT
4-aminobutyrate aminotransferase
chr9_+_139839711 15.67 ENST00000224181.3
C8G
complement component 8, gamma polypeptide
chr9_+_139839686 15.17 ENST00000371634.2
C8G
complement component 8, gamma polypeptide
chr19_+_35629702 13.81 ENST00000351325.4
FXYD1
FXYD domain containing ion transport regulator 1
chr17_+_41857793 13.62 ENST00000449302.3
C17orf105
chromosome 17 open reading frame 105
chr19_+_35630022 13.08 ENST00000589209.1
FXYD1
FXYD domain containing ion transport regulator 1
chr19_+_45449228 12.03 ENST00000252490.4
APOC2
apolipoprotein C-II
chr10_-_17171817 11.97 ENST00000377833.4
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr19_+_45449301 11.69 ENST00000591597.1
APOC2
apolipoprotein C-II
chr17_+_41052808 11.52 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
G6PC
glucose-6-phosphatase, catalytic subunit
chr19_+_45449266 11.48 ENST00000592257.1
APOC2
apolipoprotein C-II
chr20_+_57875457 11.29 ENST00000337938.2
ENST00000311585.7
ENST00000371028.2
EDN3
endothelin 3
chr10_+_96698406 11.06 ENST00000260682.6
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr19_+_39616410 10.87 ENST00000602004.1
ENST00000599470.1
ENST00000321944.4
ENST00000593480.1
ENST00000358301.3
ENST00000593690.1
ENST00000599386.1
PAK4
p21 protein (Cdc42/Rac)-activated kinase 4
chr3_+_37284824 10.64 ENST00000431105.1
GOLGA4
golgin A4
chr2_-_28113217 10.07 ENST00000444339.2
RBKS
ribokinase
chr10_+_96443378 9.67 ENST00000285979.6
CYP2C18
cytochrome P450, family 2, subfamily C, polypeptide 18
chr10_+_96443204 9.66 ENST00000339022.5
CYP2C18
cytochrome P450, family 2, subfamily C, polypeptide 18
chr6_+_43265992 9.56 ENST00000449231.1
ENST00000372589.3
ENST00000372585.5
SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chr3_-_194072019 9.50 ENST00000429275.1
ENST00000323830.3
CPN2
carboxypeptidase N, polypeptide 2
chr10_+_96522361 9.25 ENST00000371321.3
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr2_-_21266935 9.21 ENST00000233242.1
APOB
apolipoprotein B
chr17_+_4675175 9.02 ENST00000270560.3
TM4SF5
transmembrane 4 L six family member 5
chr4_+_159593271 8.89 ENST00000512251.1
ENST00000511912.1
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr19_-_36304201 8.78 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr12_+_109273806 8.57 ENST00000228476.3
ENST00000547768.1
DAO
D-amino-acid oxidase
chr19_-_15235906 8.36 ENST00000600984.1
ILVBL
ilvB (bacterial acetolactate synthase)-like
chr13_+_52586517 8.11 ENST00000523764.1
ENST00000521508.1
ALG11
ALG11, alpha-1,2-mannosyltransferase
chr16_-_16317321 8.10 ENST00000205557.7
ENST00000575728.1
ABCC6
ATP-binding cassette, sub-family C (CFTR/MRP), member 6
chr18_+_29769978 8.00 ENST00000269202.6
ENST00000581447.1
MEP1B
meprin A, beta
chr14_-_76447494 7.79 ENST00000238682.3
TGFB3
transforming growth factor, beta 3
chr2_+_44502597 7.63 ENST00000260649.6
ENST00000409387.1
SLC3A1
solute carrier family 3 (amino acid transporter heavy chain), member 1
chr7_+_45927956 7.62 ENST00000275525.3
ENST00000457280.1
IGFBP1
insulin-like growth factor binding protein 1
chr22_-_42526802 7.62 ENST00000359033.4
ENST00000389970.3
ENST00000360608.5
CYP2D6
cytochrome P450, family 2, subfamily D, polypeptide 6
chr19_+_41594377 7.53 ENST00000330436.3
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr1_+_180601139 7.52 ENST00000367590.4
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr1_-_161193349 7.45 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
APOA2
apolipoprotein A-II
chr6_+_30594619 7.39 ENST00000318999.7
ENST00000376485.4
ENST00000376478.2
ENST00000319027.5
ENST00000376483.4
ENST00000329992.8
ENST00000330083.5
ATAT1
alpha tubulin acetyltransferase 1
chr17_+_27369918 7.17 ENST00000323372.4
PIPOX
pipecolic acid oxidase
chr19_-_12886327 7.07 ENST00000397668.3
ENST00000587178.1
ENST00000264827.5
HOOK2
hook microtubule-tethering protein 2
chr13_+_113777105 7.07 ENST00000409306.1
ENST00000375551.3
ENST00000375559.3
F10
coagulation factor X
chr17_-_38256973 7.07 ENST00000246672.3
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr2_-_222436988 7.04 ENST00000409854.1
ENST00000281821.2
ENST00000392071.4
ENST00000443796.1
EPHA4
EPH receptor A4
chr15_+_101142722 6.61 ENST00000332783.7
ENST00000558747.1
ENST00000343276.4
ASB7
ankyrin repeat and SOCS box containing 7
chr1_+_94884023 6.56 ENST00000315713.5
ABCD3
ATP-binding cassette, sub-family D (ALD), member 3
chr8_-_98290087 6.54 ENST00000322128.3
TSPYL5
TSPY-like 5
chr11_-_73720276 6.53 ENST00000348534.4
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr10_-_96829246 6.50 ENST00000371270.3
ENST00000535898.1
ENST00000539050.1
CYP2C8
cytochrome P450, family 2, subfamily C, polypeptide 8
chr7_+_45928079 6.48 ENST00000468955.1
IGFBP1
insulin-like growth factor binding protein 1
chr1_-_60392452 6.47 ENST00000371204.3
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr1_+_78511586 6.41 ENST00000370759.3
GIPC2
GIPC PDZ domain containing family, member 2
chr3_-_124653579 6.37 ENST00000478191.1
ENST00000311075.3
MUC13
mucin 13, cell surface associated
chr17_+_1646130 6.18 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chrX_+_38211777 6.12 ENST00000039007.4
OTC
ornithine carbamoyltransferase
chr1_-_161207875 6.06 ENST00000512372.1
ENST00000437437.2
ENST00000442691.2
ENST00000412844.2
ENST00000428574.2
ENST00000505005.1
ENST00000508740.1
ENST00000508387.1
ENST00000504010.1
ENST00000511676.1
ENST00000502985.1
ENST00000367981.3
ENST00000515621.1
ENST00000511944.1
ENST00000511748.1
ENST00000367984.4
ENST00000367985.3
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr2_-_228244013 6.06 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chr17_+_44039704 5.94 ENST00000420682.2
ENST00000415613.2
ENST00000571987.1
ENST00000574436.1
ENST00000431008.3
MAPT
microtubule-associated protein tau
chr12_-_54121212 5.85 ENST00000548263.1
ENST00000430117.2
ENST00000550804.1
ENST00000549173.1
ENST00000551900.1
ENST00000546619.1
ENST00000548177.1
ENST00000549349.1
CALCOCO1
calcium binding and coiled-coil domain 1
chr15_-_41120896 5.84 ENST00000299174.5
ENST00000427255.2
PPP1R14D
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chrX_+_118108601 5.73 ENST00000371628.3
LONRF3
LON peptidase N-terminal domain and ring finger 3
chr12_-_54121261 5.58 ENST00000549784.1
ENST00000262059.4
CALCOCO1
calcium binding and coiled-coil domain 1
chr20_+_57875658 5.58 ENST00000371025.3
EDN3
endothelin 3
chr12_+_121163538 5.43 ENST00000242592.4
ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr11_+_27076764 5.42 ENST00000525090.1
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr17_-_2614927 5.41 ENST00000435359.1
CLUH
clustered mitochondria (cluA/CLU1) homolog
chr3_+_46919235 5.40 ENST00000449590.1
PTH1R
parathyroid hormone 1 receptor
chr12_+_56114151 5.26 ENST00000547072.1
ENST00000552930.1
ENST00000257895.5
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr1_+_196857144 5.25 ENST00000367416.2
ENST00000251424.4
ENST00000367418.2
CFHR4
complement factor H-related 4
chr1_-_161207953 5.25 ENST00000367982.4
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr9_+_27109133 5.20 ENST00000519097.1
ENST00000380036.4
TEK
TEK tyrosine kinase, endothelial
chr7_-_37956409 5.14 ENST00000436072.2
SFRP4
secreted frizzled-related protein 4
chrX_+_118108571 5.14 ENST00000304778.7
LONRF3
LON peptidase N-terminal domain and ring finger 3
chr4_+_113152881 5.04 ENST00000274000.5
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr12_+_56114189 5.01 ENST00000548082.1
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr1_-_161208013 4.99 ENST00000515452.1
ENST00000367983.4
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr17_-_44896047 4.95 ENST00000225512.5
WNT3
wingless-type MMTV integration site family, member 3
chr17_-_7082668 4.89 ENST00000573083.1
ENST00000574388.1
ASGR1
asialoglycoprotein receptor 1
chr2_-_43019698 4.78 ENST00000431905.1
ENST00000294973.6
HAAO
3-hydroxyanthranilate 3,4-dioxygenase
chr1_+_43855560 4.78 ENST00000562955.1
SZT2
seizure threshold 2 homolog (mouse)
chr19_+_4639514 4.64 ENST00000327473.4
TNFAIP8L1
tumor necrosis factor, alpha-induced protein 8-like 1
chr18_+_54318566 4.61 ENST00000589935.1
ENST00000357574.3
WDR7
WD repeat domain 7
chr11_+_74870818 4.58 ENST00000525845.1
ENST00000534186.1
ENST00000428359.2
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chrX_+_66764375 4.57 ENST00000374690.3
AR
androgen receptor
chr9_-_136605042 4.49 ENST00000371872.4
ENST00000298628.5
ENST00000422262.2
SARDH
sarcosine dehydrogenase
chr4_-_10023095 4.35 ENST00000264784.3
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr20_-_44485835 4.16 ENST00000457981.1
ENST00000426915.1
ENST00000217455.4
ACOT8
acyl-CoA thioesterase 8
chr11_+_63137251 4.09 ENST00000310969.4
ENST00000279178.3
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr16_+_19429018 4.03 ENST00000542583.2
TMC5
transmembrane channel-like 5
chr19_-_10687983 4.00 ENST00000587069.1
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr20_+_57875758 3.81 ENST00000395654.3
EDN3
endothelin 3
chr1_-_161207986 3.77 ENST00000506209.1
ENST00000367980.2
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr2_+_219433281 3.65 ENST00000273064.6
ENST00000509807.2
ENST00000542068.1
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr11_-_32456891 3.53 ENST00000452863.3
WT1
Wilms tumor 1
chr18_+_54318616 3.51 ENST00000254442.3
WDR7
WD repeat domain 7
chr4_+_113152978 3.46 ENST00000309703.6
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr19_-_49339080 3.45 ENST00000595764.1
HSD17B14
hydroxysteroid (17-beta) dehydrogenase 14
chr1_+_241695424 3.43 ENST00000366558.3
ENST00000366559.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr16_-_87970122 3.39 ENST00000309893.2
CA5A
carbonic anhydrase VA, mitochondrial
chr17_+_61554413 3.37 ENST00000538928.1
ENST00000290866.4
ENST00000428043.1
ACE
angiotensin I converting enzyme
chr19_-_10687948 3.35 ENST00000592285.1
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr2_-_62733476 3.35 ENST00000335390.5
TMEM17
transmembrane protein 17
chr17_-_7082861 3.26 ENST00000269299.3
ASGR1
asialoglycoprotein receptor 1
chr11_-_45939565 3.22 ENST00000525192.1
ENST00000378750.5
PEX16
peroxisomal biogenesis factor 16
chr10_+_102106829 3.19 ENST00000370355.2
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr19_+_1205740 3.11 ENST00000326873.7
STK11
serine/threonine kinase 11
chr11_-_45939374 3.10 ENST00000533151.1
ENST00000241041.3
PEX16
peroxisomal biogenesis factor 16
chr3_+_123813509 3.07 ENST00000460856.1
ENST00000240874.3
KALRN
kalirin, RhoGEF kinase
chr10_-_103815874 2.91 ENST00000370033.4
ENST00000311122.5
C10orf76
chromosome 10 open reading frame 76
chr19_+_49055332 2.86 ENST00000201586.2
SULT2B1
sulfotransferase family, cytosolic, 2B, member 1
chr6_-_32145861 2.78 ENST00000336984.6
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr3_+_124303539 2.73 ENST00000428018.2
KALRN
kalirin, RhoGEF kinase
chr12_+_121416489 2.71 ENST00000541395.1
ENST00000544413.1
HNF1A
HNF1 homeobox A
chr11_-_73720122 2.69 ENST00000426995.2
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr19_+_39881951 2.65 ENST00000315588.5
ENST00000594368.1
ENST00000599213.2
ENST00000596297.1
MED29
mediator complex subunit 29
chr6_+_43739697 2.60 ENST00000230480.6
VEGFA
vascular endothelial growth factor A
chr20_+_62694461 2.55 ENST00000343484.5
ENST00000395053.3
TCEA2
transcription elongation factor A (SII), 2
chr19_-_41256207 2.53 ENST00000598485.2
ENST00000470681.1
ENST00000339153.3
ENST00000598729.1
C19orf54
chromosome 19 open reading frame 54
chr1_+_241695670 2.52 ENST00000366557.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr1_-_11863171 2.51 ENST00000376592.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr1_-_41131326 2.50 ENST00000372684.3
RIMS3
regulating synaptic membrane exocytosis 3
chr7_+_33765593 2.48 ENST00000311067.3
RP11-89N17.1
HCG1643653; Uncharacterized protein
chr6_-_29343068 2.45 ENST00000396806.3
OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr6_-_31864977 2.35 ENST00000395728.3
ENST00000375528.4
EHMT2
euchromatic histone-lysine N-methyltransferase 2
chr2_+_73441350 2.32 ENST00000389501.4
SMYD5
SMYD family member 5
chr1_+_145727681 2.29 ENST00000417171.1
ENST00000451928.2
PDZK1
PDZ domain containing 1
chr12_+_53497263 2.26 ENST00000551896.1
ENST00000301466.3
SOAT2
sterol O-acyltransferase 2
chr2_+_48796120 2.16 ENST00000394754.1
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr1_-_15911510 2.16 ENST00000375826.3
AGMAT
agmatine ureohydrolase (agmatinase)
chr5_-_32444828 2.08 ENST00000265069.8
ZFR
zinc finger RNA binding protein
chr3_+_123813543 2.07 ENST00000360013.3
KALRN
kalirin, RhoGEF kinase
chr15_+_63340775 2.05 ENST00000559281.1
ENST00000317516.7
TPM1
tropomyosin 1 (alpha)
chr1_-_155271213 2.04 ENST00000342741.4
PKLR
pyruvate kinase, liver and RBC
chr3_+_108541545 2.02 ENST00000295756.6
TRAT1
T cell receptor associated transmembrane adaptor 1
chr1_+_199996702 2.01 ENST00000367362.3
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr14_-_101295407 1.96 ENST00000596284.1
AL117190.2
AL117190.2
chr12_-_7125770 1.91 ENST00000261407.4
LPCAT3
lysophosphatidylcholine acyltransferase 3
chr22_+_25003626 1.90 ENST00000451366.1
ENST00000406383.2
ENST00000428855.1
GGT1
gamma-glutamyltransferase 1
chr6_+_43266063 1.79 ENST00000372574.3
SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chr20_-_3644046 1.76 ENST00000290417.2
ENST00000319242.3
GFRA4
GDNF family receptor alpha 4
chr1_-_155270770 1.73 ENST00000392414.3
PKLR
pyruvate kinase, liver and RBC
chr14_+_100485712 1.70 ENST00000544450.2
EVL
Enah/Vasp-like
chr17_-_17494972 1.69 ENST00000435340.2
ENST00000255389.5
ENST00000395781.2
PEMT
phosphatidylethanolamine N-methyltransferase
chr19_+_751122 1.59 ENST00000215582.6
MISP
mitotic spindle positioning
chr2_-_208994548 1.59 ENST00000282141.3
CRYGC
crystallin, gamma C
chr12_-_21757774 1.53 ENST00000261195.2
GYS2
glycogen synthase 2 (liver)
chr11_-_61659006 1.51 ENST00000278829.2
FADS3
fatty acid desaturase 3
chr2_-_31637560 1.48 ENST00000379416.3
XDH
xanthine dehydrogenase
chr3_+_108541608 1.45 ENST00000426646.1
TRAT1
T cell receptor associated transmembrane adaptor 1
chr17_-_28618867 1.37 ENST00000394819.3
ENST00000577623.1
BLMH
bleomycin hydrolase
chr12_+_121416340 1.32 ENST00000257555.6
ENST00000400024.2
HNF1A
HNF1 homeobox A
chr2_-_11810284 1.22 ENST00000306928.5
NTSR2
neurotensin receptor 2
chr7_-_15601595 1.15 ENST00000342526.3
AGMO
alkylglycerol monooxygenase
chr15_+_63340858 1.12 ENST00000560615.1
TPM1
tropomyosin 1 (alpha)
chr11_-_116694009 1.10 ENST00000357780.3
APOA4
apolipoprotein A-IV
chr3_-_187009646 1.09 ENST00000296280.6
ENST00000392470.2
ENST00000169293.6
ENST00000439271.1
ENST00000392472.2
ENST00000392475.2
MASP1
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
chr19_+_35862192 1.08 ENST00000597214.1
GPR42
G protein-coupled receptor 42 (gene/pseudogene)
chr7_-_75452673 1.08 ENST00000416943.1
CCL24
chemokine (C-C motif) ligand 24
chr20_-_36661826 1.01 ENST00000373448.2
ENST00000373447.3
TTI1
TELO2 interacting protein 1
chr6_+_31926857 1.01 ENST00000375394.2
ENST00000544581.1
SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr4_-_120243545 0.99 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr1_-_29508321 0.98 ENST00000546138.1
SRSF4
serine/arginine-rich splicing factor 4
chr11_-_63536113 0.95 ENST00000433688.1
ENST00000546282.2
C11orf95
RP11-466C23.4
chromosome 11 open reading frame 95
RP11-466C23.4
chr5_+_79950463 0.90 ENST00000265081.6
MSH3
mutS homolog 3
chr10_+_52152766 0.84 ENST00000596442.1
AC069547.2
Uncharacterized protein
chrX_+_65382433 0.82 ENST00000374727.3
HEPH
hephaestin
chr1_+_199996733 0.69 ENST00000236914.3
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr5_-_102455801 0.67 ENST00000508629.1
ENST00000399004.2
GIN1
gypsy retrotransposon integrase 1
chr11_+_119056178 0.64 ENST00000525131.1
ENST00000531114.1
ENST00000355547.5
ENST00000322712.4
PDZD3
PDZ domain containing 3
chr6_+_31691121 0.56 ENST00000480039.1
ENST00000375810.4
ENST00000375805.2
ENST00000375809.3
ENST00000375804.2
ENST00000375814.3
ENST00000375806.2
C6orf25
chromosome 6 open reading frame 25
chrX_+_65382381 0.56 ENST00000519389.1
HEPH
hephaestin
chrX_-_77041685 0.52 ENST00000373344.5
ENST00000395603.3
ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr1_-_43855479 0.52 ENST00000290663.6
ENST00000372457.4
MED8
mediator complex subunit 8
chr14_+_38677123 0.51 ENST00000267377.2
SSTR1
somatostatin receptor 1
chr4_+_95376396 0.47 ENST00000508216.1
ENST00000514743.1
PDLIM5
PDZ and LIM domain 5
chr15_+_63340734 0.44 ENST00000560959.1
TPM1
tropomyosin 1 (alpha)
chr5_-_16509101 0.44 ENST00000399793.2
FAM134B
family with sequence similarity 134, member B
chr22_+_19950060 0.33 ENST00000449653.1
COMT
catechol-O-methyltransferase
chr19_+_10196981 0.32 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr4_-_76928641 0.31 ENST00000264888.5
CXCL9
chemokine (C-X-C motif) ligand 9
chr10_+_104404218 0.31 ENST00000302424.7
TRIM8
tripartite motif containing 8
chr3_-_187009798 0.18 ENST00000337774.5
MASP1
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
chr19_+_35861831 0.18 ENST00000454971.1
GPR42
G protein-coupled receptor 42 (gene/pseudogene)

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF4A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
11.7 35.2 GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902)
5.2 20.7 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
4.5 26.9 GO:0010731 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
4.3 17.4 GO:0006114 glycerol biosynthetic process(GO:0006114) response to methionine(GO:1904640)
4.1 16.4 GO:1904450 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
4.0 27.9 GO:0016098 monoterpenoid metabolic process(GO:0016098)
4.0 51.4 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
3.4 10.1 GO:0006014 D-ribose metabolic process(GO:0006014)
2.9 8.6 GO:0006522 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080)
2.8 8.5 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
2.5 7.5 GO:0060621 regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
2.4 7.2 GO:0019477 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
2.4 7.1 GO:0060086 circadian temperature homeostasis(GO:0060086)
2.3 7.0 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
2.1 10.7 GO:0019805 quinolinate biosynthetic process(GO:0019805)
2.1 6.3 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
2.1 10.3 GO:0034371 chylomicron remodeling(GO:0034371)
2.0 6.1 GO:0070781 arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
2.0 39.8 GO:0019373 epoxygenase P450 pathway(GO:0019373)
1.9 7.8 GO:1905071 ossification involved in bone remodeling(GO:0043932) frontal suture morphogenesis(GO:0060364) occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
1.7 5.0 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339) Spemann organizer formation(GO:0060061)
1.6 11.5 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
1.6 7.9 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
1.5 4.6 GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599)
1.5 4.5 GO:1901053 sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053)
1.5 5.9 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
1.5 8.8 GO:0006562 proline catabolic process(GO:0006562)
1.4 30.8 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.3 7.6 GO:1990822 L-cystine transport(GO:0015811) basic amino acid transmembrane transport(GO:1990822)
1.3 7.5 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
1.2 12.0 GO:0015889 cobalamin transport(GO:0015889)
1.1 3.4 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
1.0 7.9 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.9 5.4 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.9 7.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.9 6.2 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.9 3.5 GO:0072166 posterior mesonephric tubule development(GO:0072166) negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
0.9 2.6 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.8 3.4 GO:1903597 negative regulation of gap junction assembly(GO:1903597)
0.8 3.8 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.7 5.2 GO:0048014 Tie signaling pathway(GO:0048014)
0.7 7.4 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.7 2.9 GO:0000103 sulfate assimilation(GO:0000103)
0.6 5.4 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.6 8.9 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.6 3.5 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.5 2.7 GO:0061113 pancreas morphogenesis(GO:0061113)
0.5 2.2 GO:1901162 primary amino compound biosynthetic process(GO:1901162)
0.5 9.2 GO:1990845 adaptive thermogenesis(GO:1990845)
0.5 4.1 GO:0015747 urate transport(GO:0015747)
0.5 2.5 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.5 1.5 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.5 4.3 GO:0046415 urate metabolic process(GO:0046415)
0.5 1.4 GO:0043418 homocysteine catabolic process(GO:0043418)
0.5 15.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.5 3.6 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.5 8.1 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.4 14.1 GO:0036499 PERK-mediated unfolded protein response(GO:0036499)
0.4 4.2 GO:0016559 peroxisome fission(GO:0016559)
0.4 6.4 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.3 10.3 GO:0042572 retinol metabolic process(GO:0042572)
0.3 7.2 GO:0000042 protein targeting to Golgi(GO:0000042)
0.3 0.8 GO:0035565 regulation of pronephros size(GO:0035565) renal glucose absorption(GO:0035623)
0.3 1.9 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.3 3.4 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.2 2.3 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.2 1.7 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.2 5.4 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.2 7.1 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.2 2.8 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.2 20.1 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.2 1.1 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.2 8.0 GO:1901998 toxin transport(GO:1901998)
0.2 1.2 GO:0046485 ether lipid metabolic process(GO:0046485)
0.2 4.6 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.1 1.7 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.1 2.3 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.1 8.1 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 1.5 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 0.5 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.1 14.8 GO:0030449 regulation of complement activation(GO:0030449)
0.1 1.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 1.0 GO:0032006 regulation of TOR signaling(GO:0032006)
0.1 6.5 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.1 1.0 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.1 10.9 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.1 5.6 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.1 2.3 GO:0015879 carnitine transport(GO:0015879)
0.1 11.4 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.1 0.5 GO:0038170 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.1 11.3 GO:0060996 dendritic spine development(GO:0060996)
0.1 0.9 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
0.1 3.2 GO:0046949 fatty-acyl-CoA biosynthetic process(GO:0046949)
0.1 1.9 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.1 0.7 GO:0015074 DNA integration(GO:0015074)
0.1 0.3 GO:0016036 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) positive regulation of homocysteine metabolic process(GO:0050668)
0.1 3.4 GO:0015701 bicarbonate transport(GO:0015701)
0.0 2.4 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.6 GO:0031282 regulation of guanylate cyclase activity(GO:0031282)
0.0 0.3 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.9 GO:0006825 copper ion transport(GO:0006825)
0.0 1.0 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 2.3 GO:0032259 methylation(GO:0032259)
0.0 3.3 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 1.5 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 5.4 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 1.1 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.0 5.6 GO:0045861 negative regulation of proteolysis(GO:0045861)
0.0 1.2 GO:0007218 neuropeptide signaling pathway(GO:0007218)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 44.4 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
4.1 16.4 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
3.4 30.8 GO:0005579 membrane attack complex(GO:0005579)
2.0 12.0 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
1.8 7.1 GO:0070695 FHF complex(GO:0070695)
1.3 26.9 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
1.2 5.9 GO:0045298 tubulin complex(GO:0045298)
0.8 4.8 GO:1990130 Iml1 complex(GO:1990130)
0.7 7.4 GO:0097427 microtubule bundle(GO:0097427)
0.7 7.5 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.6 3.1 GO:0036398 TCR signalosome(GO:0036398)
0.5 1.0 GO:0031931 TORC1 complex(GO:0031931)
0.5 6.2 GO:0005577 fibrinogen complex(GO:0005577)
0.4 5.0 GO:1990909 Wnt signalosome(GO:1990909)
0.3 7.0 GO:0044295 axonal growth cone(GO:0044295)
0.3 8.9 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.3 7.1 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.3 0.9 GO:0032302 MutSbeta complex(GO:0032302)
0.3 62.0 GO:0072562 blood microparticle(GO:0072562)
0.3 1.0 GO:0055087 Ski complex(GO:0055087)
0.2 6.3 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.2 3.3 GO:0036038 MKS complex(GO:0036038)
0.2 14.9 GO:0031526 brush border membrane(GO:0031526)
0.2 3.6 GO:0032059 bleb(GO:0032059)
0.1 7.5 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 5.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 5.2 GO:0009925 basal plasma membrane(GO:0009925)
0.1 11.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 1.5 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 3.5 GO:0042101 T cell receptor complex(GO:0042101)
0.1 10.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 29.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 93.0 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 1.6 GO:0005938 cell cortex(GO:0005938)
0.1 6.4 GO:0005796 Golgi lumen(GO:0005796)
0.1 25.9 GO:0000790 nuclear chromatin(GO:0000790)
0.1 16.6 GO:0030133 transport vesicle(GO:0030133)
0.0 6.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 6.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 8.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 18.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 31.4 GO:0005615 extracellular space(GO:0005615)
0.0 1.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.7 GO:0030027 lamellipodium(GO:0030027)
0.0 25.2 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.0 1.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:0005903 brush border(GO:0005903)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
7.0 35.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
5.8 17.4 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
4.1 20.7 GO:0031708 endothelin B receptor binding(GO:0031708)
4.1 24.6 GO:0004882 androgen receptor activity(GO:0004882)
4.1 16.4 GO:0003867 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
3.5 17.6 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
3.2 25.9 GO:0001849 complement component C1q binding(GO:0001849)
2.9 40.9 GO:0070330 aromatase activity(GO:0070330)
2.9 11.5 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
2.7 8.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
2.6 7.8 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
2.3 9.2 GO:0035473 lipase binding(GO:0035473)
2.2 8.8 GO:0004657 proline dehydrogenase activity(GO:0004657)
2.1 8.5 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
2.1 56.4 GO:0001848 complement binding(GO:0001848)
1.9 7.5 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
1.9 7.5 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
1.5 4.5 GO:0046997 sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
1.5 5.9 GO:0099609 microtubule lateral binding(GO:0099609)
1.5 8.9 GO:0048039 ubiquinone binding(GO:0048039)
1.5 7.4 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
1.4 5.4 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
1.3 9.2 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
1.3 14.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
1.3 7.6 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
1.2 7.2 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
1.1 12.0 GO:0031419 cobalamin binding(GO:0031419)
1.1 5.4 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
1.1 3.2 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
1.0 8.1 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.9 3.8 GO:0004743 pyruvate kinase activity(GO:0004743)
0.9 8.4 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.8 8.4 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.8 9.2 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.7 3.5 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.7 7.0 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005) PH domain binding(GO:0042731)
0.7 8.1 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.6 14.5 GO:0071949 FAD binding(GO:0071949)
0.6 10.3 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.6 3.4 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.6 2.3 GO:0005124 scavenger receptor binding(GO:0005124)
0.6 11.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.6 1.7 GO:0004608 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.6 3.4 GO:0008240 tripeptidyl-peptidase activity(GO:0008240) peptidyl-dipeptidase activity(GO:0008241)
0.6 6.1 GO:0042301 phosphate ion binding(GO:0042301)
0.5 15.9 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.5 2.5 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.5 26.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.5 2.3 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.4 7.1 GO:0001222 transcription corepressor binding(GO:0001222)
0.4 2.6 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.4 11.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.4 5.4 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.4 2.9 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.4 1.9 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.4 6.0 GO:0048018 receptor agonist activity(GO:0048018)
0.3 9.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.3 7.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.3 10.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.3 0.9 GO:0000404 heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.3 1.5 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups(GO:0016725)
0.3 10.1 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.3 7.1 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.3 1.8 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.2 5.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 3.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 1.2 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.2 6.2 GO:0008198 ferrous iron binding(GO:0008198)
0.2 1.1 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2 3.5 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 0.5 GO:0015616 DNA translocase activity(GO:0015616)
0.2 2.8 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2 2.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 1.9 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 1.5 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 3.1 GO:0030275 LRR domain binding(GO:0030275)
0.1 0.5 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 1.7 GO:0005522 profilin binding(GO:0005522)
0.1 0.6 GO:0030249 guanylate cyclase regulator activity(GO:0030249)
0.1 2.3 GO:0008374 O-acyltransferase activity(GO:0008374)
0.1 0.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 1.9 GO:0044325 ion channel binding(GO:0044325)
0.1 3.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 1.4 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 5.3 GO:0005319 lipid transporter activity(GO:0005319)
0.1 5.2 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 6.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 6.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 2.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.3 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 1.2 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 8.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 3.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.0 GO:0005504 fatty acid binding(GO:0005504)
0.0 2.1 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 6.3 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 1.0 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 2.3 GO:0008168 methyltransferase activity(GO:0008168)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 47.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 33.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.4 10.3 PID CONE PATHWAY Visual signal transduction: Cones
0.3 5.9 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 7.1 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.3 7.9 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.3 20.7 PID ENDOTHELIN PATHWAY Endothelins
0.2 10.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 7.8 PID ALK1 PATHWAY ALK1 signaling events
0.2 20.1 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.2 7.0 PID EPHA FWDPATHWAY EPHA forward signaling
0.2 11.4 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.2 5.0 PID WNT SIGNALING PATHWAY Wnt signaling network
0.2 7.1 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 2.6 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 8.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 3.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 5.2 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 5.1 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 3.5 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 2.3 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 10.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 6.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 61.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
2.4 51.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
1.3 17.4 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
1.3 27.1 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
1.1 30.8 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.8 10.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.7 11.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.7 12.0 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.5 7.1 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.5 14.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.5 16.4 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.4 5.6 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.4 33.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 8.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.3 6.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.3 8.1 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.3 5.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3 4.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 4.6 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.2 3.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.2 4.2 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.2 11.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.2 7.6 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 4.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.2 5.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 5.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.2 2.8 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 1.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 7.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 6.5 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 3.1 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 1.9 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.1 22.7 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 14.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 3.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 2.9 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 10.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 2.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 19.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 1.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 3.5 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.1 1.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 1.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 1.4 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 3.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.3 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 3.9 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 5.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.5 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism