ISMARA results: HNF4G

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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HNF4G

Z-value: 1.61

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Transcription factors associated with HNF4G

Gene Symbol	Gene ID	Gene Info
HNF4G Ensembl NCBI GeneCards UniProt NextProt	ENSG00000164749.7	hepatocyte nuclear factor 4 gamma

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HNF4G	hg19_v2_chr8_+_76452097_76452126	-0.23	6.1e-04	Click!

Activity profile of HNF4G motif

Sorted Z-values of HNF4G motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_+_6309963 Show fit	17.57	ENST00000382515.2	CD9 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD9 molecule
chr2_+_201170770 Show fit	17.42	ENST00000409988.3 ENST00000409385.1	SPATS2L Ensembl NCBI GeneCards UniProt NextProt Show fit	spermatogenesis associated, serine-rich 2-like
chr2_+_201170596 Show fit	17.29	ENST00000439084.1 ENST00000409718.1	SPATS2L Ensembl NCBI GeneCards UniProt NextProt Show fit	spermatogenesis associated, serine-rich 2-like
chr1_-_24126892 Show fit	17.03	ENST00000374497.3 ENST00000425913.1	GALE Ensembl NCBI GeneCards UniProt NextProt Show fit	UDP-galactose-4-epimerase
chr8_-_145641864 Show fit	16.45	ENST00000276833.5	SLC39A4 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 39 (zinc transporter), member 4
chr1_-_211752073 Show fit	15.33	ENST00000367001.4	SLC30A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 30 (zinc transporter), member 1
chr8_-_145642267 Show fit	14.81	ENST00000301305.3	SLC39A4 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 39 (zinc transporter), member 4
chr11_+_32112431 Show fit	14.55	ENST00000054950.3	RCN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	reticulocalbin 1, EF-hand calcium binding domain
chr22_+_38071615 Show fit	14.45	ENST00000215909.5	LGALS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	lectin, galactoside-binding, soluble, 1
chr16_+_29690358 Show fit	14.10	ENST00000395384.4 ENST00000562473.1	QPRT Ensembl NCBI GeneCards UniProt NextProt Show fit	quinolinate phosphoribosyltransferase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF4G

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.3	51.3	GO:0009439	cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
4.7	46.6	GO:0071578	zinc II ion transmembrane import(GO:0071578)
2.1	36.2	GO:0000920	cell separation after cytokinesis(GO:0000920)
0.1	28.1	GO:0007160	cell-matrix adhesion(GO:0007160)
5.3	26.4	GO:0002415	immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1	24.2	GO:0043488	regulation of mRNA stability(GO:0043488)
0.4	22.7	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
2.8	22.1	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
7.0	20.9	GO:2000521	negative regulation of immunological synapse formation(GO:2000521)
3.7	18.4	GO:1904977	lymphatic endothelial cell migration(GO:1904977)

Showing 1 to 10 of 253 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	167.6	GO:0070062	extracellular exosome(GO:0070062)
0.2	67.5	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.6	48.5	GO:0055038	recycling endosome membrane(GO:0055038)
0.1	32.6	GO:0005925	focal adhesion(GO:0005925)
0.6	32.3	GO:0005871	kinesin complex(GO:0005871)
0.1	28.4	GO:0005743	mitochondrial inner membrane(GO:0005743)
3.4	27.0	GO:0016012	sarcoglycan complex(GO:0016012)
0.1	24.5	GO:0031965	nuclear membrane(GO:0031965)
3.0	23.6	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.4	23.4	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Showing 1 to 10 of 118 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	52.2	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
10.4	41.7	GO:0016784	3-mercaptopyruvate sulfurtransferase activity(GO:0016784)
0.2	40.3	GO:0005178	integrin binding(GO:0005178)
0.4	34.3	GO:0003777	microtubule motor activity(GO:0003777)
0.4	27.4	GO:0019003	GDP binding(GO:0019003)
0.0	26.8	GO:0005509	calcium ion binding(GO:0005509)
4.4	22.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.7	22.0	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
1.2	21.3	GO:0001054	RNA polymerase I activity(GO:0001054)
2.6	20.9	GO:0019863	IgE binding(GO:0019863)

Showing 1 to 10 of 204 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	67.8	PID AURORA B PATHWAY	Aurora B signaling
0.7	33.4	PID RAS PATHWAY	Regulation of Ras family activation
0.3	30.2	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.1	27.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	20.1	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	15.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	14.6	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	13.1	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.2	13.0	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.2	12.6	PID HNF3A PATHWAY	FOXA1 transcription factor network

Showing 1 to 10 of 40 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.3	52.2	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.3	37.0	REACTOME MUSCLE CONTRACTION	Genes involved in Muscle contraction
1.3	34.5	REACTOME KINESINS	Genes involved in Kinesins
1.5	33.3	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.2	32.0	REACTOME DIABETES PATHWAYS	Genes involved in Diabetes pathways
0.9	24.6	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3	24.3	REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX	Genes involved in CDT1 association with the CDC6:ORC:origin complex
0.2	23.9	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.7	22.5	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.3	21.7	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors

Showing 1 to 10 of 86 entries

Results for HNF4G

Z-value: 1.61

Motif logo

Transcription factors associated with HNF4G

Activity-expression correlation:

Activity profile of HNF4G motif

Sorted Z-values of HNF4G motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF4G

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: