ISMARA results: HOXB6

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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXB6_PRRX2

Z-value: 2.62

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Transcription factors associated with HOXB6_PRRX2

Gene Symbol	Gene ID	Gene Info
HOXB6 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000108511.8	homeobox B6
PRRX2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000167157.9	paired related homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PRRX2	hg19_v2_chr9_+_132427883_132427951	0.49	2.0e-14	Click!
HOXB6	hg19_v2_chr17_-_46682321_46682362	-0.06	3.6e-01	Click!

Activity profile of HOXB6_PRRX2 motif

Sorted Z-values of HOXB6_PRRX2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_16761007 Show fit	140.21	ENST00000354662.1 ENST00000441439.2	LMO3 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain only 3 (rhombotin-like 2)
chr4_-_176733897 Show fit	133.83	ENST00000393658.2	GPM6A Ensembl NCBI GeneCards UniProt NextProt Show fit	glycoprotein M6A
chr2_-_175711133 Show fit	74.69	ENST00000409597.1 ENST00000413882.1	CHN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	chimerin 1
chr12_-_16759711 Show fit	64.75	ENST00000447609.1	LMO3 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain only 3 (rhombotin-like 2)
chr16_+_7382745 Show fit	62.91	ENST00000436368.2 ENST00000311745.5 ENST00000355637.4 ENST00000340209.4	RBFOX1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RNA binding protein, fox-1 homolog (C. elegans) 1
chr2_-_50201327 Show fit	58.09	ENST00000412315.1	NRXN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	neurexin 1
chr18_-_53089723 Show fit	56.11	ENST00000561992.1 ENST00000562512.2	TCF4 Ensembl NCBI GeneCards UniProt NextProt Show fit	transcription factor 4
chr1_+_50569575 Show fit	52.82	ENST00000371827.1	ELAVL4 Ensembl NCBI GeneCards UniProt NextProt Show fit	ELAV like neuron-specific RNA binding protein 4
chr5_-_88179302 Show fit	52.26	ENST00000504921.2	MEF2C Ensembl NCBI GeneCards UniProt NextProt Show fit	myocyte enhancer factor 2C
chr13_-_67802549 Show fit	47.29	ENST00000328454.5 ENST00000377865.2	PCDH9 Ensembl NCBI GeneCards UniProt NextProt Show fit	protocadherin 9

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB6_PRRX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
45.7	273.9	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.7	188.7	GO:0065004	protein-DNA complex assembly(GO:0065004)
1.2	186.3	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
12.2	146.6	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
3.0	121.2	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
1.8	101.0	GO:0003254	regulation of membrane depolarization(GO:0003254)
4.3	86.1	GO:0071420	cellular response to histamine(GO:0071420)
27.5	82.5	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
1.3	68.7	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
1.2	66.4	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)

Showing 1 to 10 of 363 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	218.9	GO:0060076	excitatory synapse(GO:0060076)
0.1	189.5	GO:0016021	integral component of membrane(GO:0016021)
0.8	186.9	GO:0043209	myelin sheath(GO:0043209)
0.7	157.0	GO:0032993	protein-DNA complex(GO:0032993)
10.3	144.8	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
6.1	133.7	GO:0044295	axonal growth cone(GO:0044295)
3.3	115.6	GO:1902711	GABA-A receptor complex(GO:1902711)
1.0	88.5	GO:0044291	cell-cell contact zone(GO:0044291)
16.5	82.5	GO:0060200	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
1.0	68.6	GO:0042734	presynaptic membrane(GO:0042734)

Showing 1 to 10 of 133 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
17.0	220.6	GO:0001011	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
2.2	159.2	GO:0050840	extracellular matrix binding(GO:0050840)
1.2	155.0	GO:0005262	calcium channel activity(GO:0005262)
0.2	137.3	GO:0005509	calcium ion binding(GO:0005509)
0.9	136.7	GO:0044325	ion channel binding(GO:0044325)
0.6	123.9	GO:0051015	actin filament binding(GO:0051015)
3.2	107.8	GO:0017091	AU-rich element binding(GO:0017091)
16.5	82.5	GO:0030348	syntaxin-3 binding(GO:0030348)
6.0	71.4	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
3.1	68.3	GO:0035198	miRNA binding(GO:0035198)

Showing 1 to 10 of 226 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	166.2	PID AR PATHWAY	Coregulation of Androgen receptor activity
2.4	134.1	NABA PROTEOGLYCANS	Genes encoding proteoglycans
2.0	116.3	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
1.8	93.0	PID NCADHERIN PATHWAY	N-cadherin signaling events
1.3	88.1	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
1.0	71.1	PID FGF PATHWAY	FGF signaling pathway
1.2	63.5	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.2	51.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.7	41.2	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.5	40.4	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes

Showing 1 to 10 of 62 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.5	295.0	REACTOME MYOGENESIS	Genes involved in Myogenesis
5.0	136.0	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
3.6	110.6	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
5.5	98.5	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
2.5	83.7	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
2.6	71.4	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
2.4	61.2	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.3	55.1	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
1.4	41.5	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.4	27.6	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions

Showing 1 to 10 of 96 entries

Results for HOXB6_PRRX2

Z-value: 2.62

Motif logo

Transcription factors associated with HOXB6_PRRX2

Activity-expression correlation:

Activity profile of HOXB6_PRRX2 motif

Sorted Z-values of HOXB6_PRRX2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB6_PRRX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: