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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXC12_HOXD12

Z-value: 1.25

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Transcription factors associated with HOXC12_HOXD12

Gene Symbol Gene ID Gene Info
ENSG00000123407.3 homeobox C12
ENSG00000170178.5 homeobox D12

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXD12hg19_v2_chr2_+_176964458_176964540-0.196.1e-03Click!

Activity profile of HOXC12_HOXD12 motif

Sorted Z-values of HOXC12_HOXD12 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_220220000 23.37 ENST00000366923.3
glutamyl-prolyl-tRNA synthetase
chr22_-_36924944 21.93 ENST00000405442.1
ENST00000402116.1
eukaryotic translation initiation factor 3, subunit D
chr22_-_36925186 20.15 ENST00000541106.1
ENST00000455547.1
ENST00000432675.1
eukaryotic translation initiation factor 3, subunit D
chr12_+_104337515 16.44 ENST00000550595.1
heat shock protein 90kDa beta (Grp94), member 1
chr2_+_172778952 16.44 ENST00000392584.1
ENST00000264108.4
histone acetyltransferase 1
chr13_+_53030107 16.33 ENST00000490903.1
ENST00000480747.1
cytoskeleton associated protein 2
chr2_-_225362533 15.47 ENST00000451538.1
cullin 3
chr7_+_64838786 15.36 ENST00000450302.2
zinc finger protein 92
chr13_+_53029564 15.04 ENST00000468284.1
ENST00000378034.3
ENST00000258607.5
ENST00000378037.5
cytoskeleton associated protein 2
chr7_+_64838712 14.84 ENST00000328747.7
ENST00000431504.1
ENST00000357512.2
zinc finger protein 92
chr5_-_176433693 14.29 ENST00000507513.1
ENST00000511320.1
ubiquitin interaction motif containing 1
chr12_+_4758264 13.54 ENST00000266544.5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr12_+_6603253 13.52 ENST00000382457.4
ENST00000545962.1
non-SMC condensin I complex, subunit D2
chr1_-_220219775 13.28 ENST00000609181.1
glutamyl-prolyl-tRNA synthetase
chr1_+_158900568 12.67 ENST00000458222.1
pyrin and HIN domain family, member 1
chr19_-_23941680 12.00 ENST00000402377.3
zinc finger protein 681
chr11_+_111896320 11.96 ENST00000531306.1
ENST00000537636.1
dihydrolipoamide S-acetyltransferase
chr1_-_246670519 11.88 ENST00000388985.4
ENST00000490107.1
SET and MYND domain containing 3
chr11_-_104480019 11.21 ENST00000536529.1
ENST00000545630.1
ENST00000538641.1
RP11-886D15.1
chr5_-_180670370 10.63 ENST00000502844.1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
chr15_+_66797627 10.42 ENST00000565627.1
ENST00000564179.1
zwilch kinetochore protein
chr5_-_176433582 10.41 ENST00000506128.1
ubiquitin interaction motif containing 1
chr1_+_158975744 10.38 ENST00000426592.2
interferon, gamma-inducible protein 16
chr17_-_8113542 9.95 ENST00000578549.1
ENST00000535053.1
ENST00000582368.1
aurora kinase B
chr2_-_152146385 9.57 ENST00000414946.1
ENST00000243346.5
N-myc (and STAT) interactor
chr15_+_66797455 9.45 ENST00000446801.2
zwilch kinetochore protein
chr1_-_156308018 9.11 ENST00000496684.2
ENST00000368259.2
ENST00000368261.3
ENST00000472765.2
ENST00000533194.1
ENST00000478640.2
chaperonin containing TCP1, subunit 3 (gamma)
chr19_-_14945933 9.01 ENST00000322301.3
olfactory receptor, family 7, subfamily A, member 5
chr7_+_138145145 8.66 ENST00000415680.2
tripartite motif containing 24
chr10_+_124913930 8.63 ENST00000368858.5
BUB3 mitotic checkpoint protein
chr18_+_12703002 8.63 ENST00000590217.1
proteasome (prosome, macropain) assembly chaperone 2
chr13_+_34392185 8.59 ENST00000380071.3
replication factor C (activator 1) 3, 38kDa
chrY_+_2709527 8.55 ENST00000250784.8
ribosomal protein S4, Y-linked 1
chr11_+_111896090 8.20 ENST00000393051.1
dihydrolipoamide S-acetyltransferase
chr4_-_39367949 8.10 ENST00000503784.1
ENST00000349703.2
ENST00000381897.1
replication factor C (activator 1) 1, 145kDa
chr17_+_56769924 7.98 ENST00000461271.1
ENST00000583539.1
ENST00000337432.4
ENST00000421782.2
RAD51 paralog C
chr3_-_131221790 7.76 ENST00000512877.1
ENST00000264995.3
ENST00000511168.1
ENST00000425847.2
mitochondrial ribosomal protein L3
chr19_+_21265028 7.53 ENST00000291770.7
zinc finger protein 714
chr8_-_144699668 7.37 ENST00000425753.2
tissue specific transplantation antigen P35B
chr19_+_49496705 7.37 ENST00000595090.1
RuvB-like AAA ATPase 2
chr18_+_9103957 7.36 ENST00000400033.1
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
chr8_-_144699628 7.35 ENST00000529048.1
ENST00000529064.1
tissue specific transplantation antigen P35B
chr12_+_113354341 7.31 ENST00000553152.1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr9_+_134065506 7.30 ENST00000483497.2
nucleoporin 214kDa
chr13_-_46543805 7.24 ENST00000378921.2
zinc finger CCCH-type containing 13
chr12_+_32832134 7.19 ENST00000452533.2
dynamin 1-like
chr5_+_169010638 7.18 ENST00000265295.4
ENST00000506574.1
ENST00000515224.1
ENST00000508247.1
ENST00000513941.1
spindle apparatus coiled-coil protein 1
chr10_+_51371390 7.12 ENST00000478381.1
ENST00000451577.2
ENST00000374098.2
ENST00000374097.2
translocase of inner mitochondrial membrane 23 homolog B (yeast)
chr6_+_34725263 7.08 ENST00000374018.1
ENST00000374017.3
small nuclear ribonucleoprotein polypeptide C
chr7_+_138145076 6.93 ENST00000343526.4
tripartite motif containing 24
chr8_-_101718991 6.82 ENST00000517990.1
poly(A) binding protein, cytoplasmic 1
chr2_-_136875712 6.44 ENST00000241393.3
chemokine (C-X-C motif) receptor 4
chr12_+_32832203 6.41 ENST00000553257.1
ENST00000549701.1
ENST00000358214.5
ENST00000266481.6
ENST00000551476.1
ENST00000550154.1
ENST00000547312.1
ENST00000414834.2
ENST00000381000.4
ENST00000548750.1
dynamin 1-like
chr6_-_36515177 6.39 ENST00000229812.7
serine/threonine kinase 38
chr7_-_128049955 6.33 ENST00000419067.2
ENST00000378717.4
IMP (inosine 5'-monophosphate) dehydrogenase 1
chr16_-_88878305 6.30 ENST00000569616.1
ENST00000563655.1
ENST00000567713.1
ENST00000426324.2
ENST00000378364.3
adenine phosphoribosyltransferase
chr19_+_49497121 6.28 ENST00000413176.2
RuvB-like AAA ATPase 2
chr16_+_67906919 6.21 ENST00000358933.5
enhancer of mRNA decapping 4
chr10_+_124913793 6.15 ENST00000368865.4
ENST00000538238.1
ENST00000368859.2
BUB3 mitotic checkpoint protein
chr6_+_34725181 6.04 ENST00000244520.5
small nuclear ribonucleoprotein polypeptide C
chr12_+_10658201 6.00 ENST00000322446.3
Putative eukaryotic translation initiation factor 2 subunit 3-like protein
chr10_+_12238171 6.00 ENST00000378900.2
ENST00000442050.1
cell division cycle 123
chr1_-_101491319 6.00 ENST00000342173.7
ENST00000488176.1
ENST00000370109.3
diphthamide biosynthesis 5
chr2_-_88285309 5.90 ENST00000420840.2
RANBP2-like and GRIP domain containing 2
chr12_-_15114492 5.85 ENST00000541546.1
Rho GDP dissociation inhibitor (GDI) beta
chr4_+_122722466 5.76 ENST00000243498.5
ENST00000379663.3
ENST00000509800.1
exosome component 9
chr10_-_27443294 5.69 ENST00000396296.3
ENST00000375972.3
ENST00000376016.3
ENST00000491542.2
YME1-like 1 ATPase
chr1_+_146714291 5.55 ENST00000431239.1
ENST00000369259.3
ENST00000369258.4
ENST00000361293.5
chromodomain helicase DNA binding protein 1-like
chr2_-_136873735 5.54 ENST00000409817.1
chemokine (C-X-C motif) receptor 4
chr11_-_107729887 5.51 ENST00000525815.1
solute carrier family 35, member F2
chr15_-_66797172 5.32 ENST00000569438.1
ENST00000569696.1
ENST00000307961.6
ribosomal protein L4
chr10_-_74856608 5.30 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
prolyl 4-hydroxylase, alpha polypeptide I
chr5_-_175815565 5.29 ENST00000509257.1
ENST00000507413.1
ENST00000510123.1
NOP16 nucleolar protein
chr1_-_169680745 5.26 ENST00000236147.4
selectin L
chr2_+_74056066 5.12 ENST00000339566.3
ENST00000409707.1
ENST00000452725.1
ENST00000432295.2
ENST00000424659.1
ENST00000394073.1
STAM binding protein
chr2_+_74056147 5.11 ENST00000394070.2
ENST00000536064.1
STAM binding protein
chr17_+_18759612 5.05 ENST00000432893.2
ENST00000414602.1
ENST00000574522.1
ENST00000570450.1
ENST00000419071.2
phosphoribosyl pyrophosphate synthetase-associated protein 2
chr6_-_31681839 5.04 ENST00000409239.1
ENST00000461287.1
lymphocyte antigen 6 complex, locus G6E (pseudogene)
Uncharacterized protein
chr2_-_170430366 4.96 ENST00000453153.2
ENST00000445210.1
FAST kinase domains 1
chr10_+_12237924 4.93 ENST00000429258.2
ENST00000281141.4
cell division cycle 123
chr19_+_49496782 4.92 ENST00000601968.1
ENST00000596837.1
RuvB-like AAA ATPase 2
chr2_+_27435734 4.91 ENST00000419744.1
all-trans retinoic acid-induced differentiation factor
chr2_+_201754050 4.87 ENST00000426253.1
ENST00000416651.1
ENST00000454952.1
ENST00000409020.1
ENST00000359683.4
NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
chr12_-_15114603 4.78 ENST00000228945.4
Rho GDP dissociation inhibitor (GDI) beta
chr15_-_34331243 4.72 ENST00000306730.3
apoptosis, caspase activation inhibitor
chr1_+_202830876 4.66 ENST00000456105.2
RP11-480I12.7
chr7_-_41742697 4.57 ENST00000242208.4
inhibin, beta A
chr14_+_23776167 4.55 ENST00000554635.1
ENST00000557008.1
BCL2-like 2
BCL2L2-PABPN1 readthrough
chr1_+_149230680 4.51 ENST00000443018.1
RP11-403I13.5
chr13_+_50570019 4.42 ENST00000442421.1
tripartite motif containing 13
chr8_-_33370607 4.41 ENST00000360742.5
ENST00000523305.1
TELO2 interacting protein 2
chr7_+_150065278 4.31 ENST00000519397.1
ENST00000479668.1
ENST00000540729.1
replication initiator 1
chr8_-_80942061 4.30 ENST00000519386.1
mitochondrial ribosomal protein S28
chr1_+_15736359 4.22 ENST00000375980.4
EF-hand domain family, member D2
chr4_-_74088800 4.22 ENST00000509867.2
ankyrin repeat domain 17
chr4_-_103790026 4.19 ENST00000338145.3
ENST00000357194.6
ubiquitin-conjugating enzyme E2D 3
chr14_+_23776024 4.16 ENST00000553781.1
ENST00000556100.1
ENST00000557236.1
ENST00000557579.1
BCL2L2-PABPN1 readthrough
BCL2-like 2
chrX_+_49294472 4.14 ENST00000361446.5
G antigen 12B
chr19_+_2785458 4.12 ENST00000307741.6
ENST00000585338.1
thimet oligopeptidase 1
chr3_-_18466026 4.10 ENST00000417717.2
SATB homeobox 1
chr12_+_75874460 4.09 ENST00000266659.3
GLI pathogenesis-related 1
chr7_-_27219849 4.00 ENST00000396344.4
homeobox A10
chr6_+_32812568 3.99 ENST00000414474.1
proteasome (prosome, macropain) subunit, beta type, 9
chr2_+_161993412 3.94 ENST00000259075.2
ENST00000432002.1
TRAF family member-associated NFKB activator
chr14_-_50319758 3.89 ENST00000298310.5
nuclear export mediator factor
chr4_-_83765613 3.88 ENST00000503937.1
SEC31 homolog A (S. cerevisiae)
chr11_+_35160709 3.75 ENST00000415148.2
ENST00000433354.2
ENST00000449691.2
ENST00000437706.2
ENST00000360158.4
ENST00000428726.2
ENST00000526669.2
ENST00000433892.2
ENST00000278386.6
ENST00000434472.2
ENST00000352818.4
ENST00000442151.2
CD44 molecule (Indian blood group)
chr11_-_3400442 3.72 ENST00000429541.2
ENST00000532539.1
zinc finger protein 195
chr14_+_90422239 3.66 ENST00000393452.3
ENST00000554180.1
ENST00000393454.2
ENST00000553617.1
ENST00000335725.4
ENST00000357382.3
ENST00000556867.1
ENST00000553527.1
tyrosyl-DNA phosphodiesterase 1
chr12_-_10875831 3.60 ENST00000279550.7
ENST00000228251.4
Y box binding protein 3
chr12_+_67663056 3.55 ENST00000545606.1
cullin-associated and neddylation-dissociated 1
chr2_+_201754135 3.53 ENST00000409357.1
ENST00000409129.2
NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
chr6_+_30539153 3.45 ENST00000326195.8
ENST00000376545.3
ENST00000396515.4
ENST00000441867.1
ENST00000468958.1
ATP-binding cassette, sub-family F (GCN20), member 1
chr10_-_51623203 3.44 ENST00000444743.1
ENST00000374065.3
ENST00000374064.3
ENST00000260867.4
translocase of inner mitochondrial membrane 23 homolog (yeast)
chr19_+_13885252 3.39 ENST00000221576.4
chromosome 19 open reading frame 53
chr17_-_57784755 3.38 ENST00000537860.1
ENST00000393038.2
ENST00000409433.2
peptidyl-tRNA hydrolase 2
chr11_-_3400330 3.22 ENST00000427810.2
ENST00000005082.9
ENST00000534569.1
ENST00000438262.2
ENST00000528796.1
ENST00000528410.1
ENST00000529678.1
ENST00000354599.6
ENST00000526601.1
ENST00000525502.1
ENST00000533036.1
ENST00000399602.4
zinc finger protein 195
chr1_+_192544857 3.15 ENST00000367459.3
ENST00000469578.2
regulator of G-protein signaling 1
chr14_-_50319482 3.13 ENST00000546046.1
ENST00000555970.1
ENST00000554626.1
ENST00000545773.1
ENST00000556672.1
nuclear export mediator factor
chr7_-_128050027 3.07 ENST00000343214.4
ENST00000354269.5
ENST00000348127.6
ENST00000497868.1
IMP (inosine 5'-monophosphate) dehydrogenase 1
chr21_-_15918618 3.05 ENST00000400564.1
ENST00000400566.1
SAM domain, SH3 domain and nuclear localization signals 1
chr19_+_21579908 2.96 ENST00000596302.1
ENST00000392288.2
ENST00000594390.1
ENST00000355504.4
zinc finger protein 493
chr19_-_54876414 2.95 ENST00000474878.1
ENST00000348231.4
leukocyte-associated immunoglobulin-like receptor 1
chr12_-_10007448 2.89 ENST00000538152.1
C-type lectin domain family 2, member B
chrY_+_26997726 2.89 ENST00000382296.2
deleted in azoospermia 4
chr10_+_31608054 2.85 ENST00000320985.10
ENST00000361642.5
ENST00000560721.2
ENST00000558440.1
ENST00000424869.1
ENST00000542815.3
zinc finger E-box binding homeobox 1
chr3_-_196911002 2.84 ENST00000452595.1
discs, large homolog 1 (Drosophila)
chr14_+_24702127 2.81 ENST00000557854.1
ENST00000348719.7
ENST00000559104.1
ENST00000456667.3
guanosine monophosphate reductase 2
chr4_+_110354928 2.74 ENST00000504968.2
ENST00000399100.2
ENST00000265175.5
SEC24 family member B
chr2_+_27435179 2.74 ENST00000606999.1
ENST00000405489.3
all-trans retinoic acid-induced differentiation factor
chr16_-_18908196 2.73 ENST00000565324.1
ENST00000561947.1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr22_-_29107919 2.72 ENST00000434810.1
ENST00000456369.1
checkpoint kinase 2
chr1_-_78444776 2.70 ENST00000370767.1
ENST00000421641.1
far upstream element (FUSE) binding protein 1
chr9_+_2029019 2.66 ENST00000382194.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr19_-_48752812 2.65 ENST00000359009.4
caspase recruitment domain family, member 8
chr14_+_24702099 2.65 ENST00000420554.2
guanosine monophosphate reductase 2
chrX_+_70503433 2.64 ENST00000276079.8
ENST00000373856.3
ENST00000373841.1
ENST00000420903.1
non-POU domain containing, octamer-binding
chr6_-_34855773 2.58 ENST00000420584.2
ENST00000361288.4
TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
chr22_-_32058166 2.47 ENST00000435900.1
ENST00000336566.4
phosphatidylserine decarboxylase
chrY_+_2709906 2.43 ENST00000430575.1
ribosomal protein S4, Y-linked 1
chr12_-_13248562 2.41 ENST00000457134.2
ENST00000537302.1
germ cell associated 1
chr5_-_156569754 2.38 ENST00000420343.1
mediator complex subunit 7
chr4_-_111119804 2.38 ENST00000394607.3
ENST00000302274.3
ELOVL fatty acid elongase 6
chr19_-_48753104 2.36 ENST00000447740.2
caspase recruitment domain family, member 8
chrX_-_15619076 2.36 ENST00000252519.3
angiotensin I converting enzyme 2
chr21_-_33984456 2.34 ENST00000431216.1
ENST00000553001.1
ENST00000440966.1
Uncharacterized protein
chromosome 21 open reading frame 59
chr6_-_131321863 2.31 ENST00000528282.1
erythrocyte membrane protein band 4.1-like 2
chr12_-_53074182 2.31 ENST00000252244.3
keratin 1
chr17_+_11501816 2.30 ENST00000454412.2
dynein, axonemal, heavy chain 9
chr2_+_27434860 2.29 ENST00000380171.3
all-trans retinoic acid-induced differentiation factor
chr12_-_13248732 2.27 ENST00000396302.3
germ cell associated 1
chr15_+_77224045 2.25 ENST00000320963.5
ENST00000394883.3
reticulocalbin 2, EF-hand calcium binding domain
chr3_-_112127981 2.23 ENST00000486726.2
RP11-231E6.1
chr2_-_85645545 2.23 ENST00000409275.1
capping protein (actin filament), gelsolin-like
chr12_-_13248705 2.19 ENST00000396310.2
germ cell associated 1
chr10_-_98031310 2.17 ENST00000427367.2
ENST00000413476.2
B-cell linker
chr11_+_7618413 2.16 ENST00000528883.1
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr11_-_102668879 2.16 ENST00000315274.6
matrix metallopeptidase 1 (interstitial collagenase)
chr2_+_169312350 2.12 ENST00000305747.6
ceramide synthase 6
chr15_+_77223960 2.11 ENST00000394885.3
reticulocalbin 2, EF-hand calcium binding domain
chr1_-_147599549 2.08 ENST00000369228.5
neuroblastoma breakpoint family, member 24
chr1_-_148347506 2.07 ENST00000369189.3
neuroblastoma breakpoint family, member 20
chr2_-_225811747 2.05 ENST00000409592.3
dedicator of cytokinesis 10
chr9_+_133569108 2.00 ENST00000372358.5
ENST00000546165.1
ENST00000372352.3
ENST00000372351.3
ENST00000372350.3
ENST00000495699.2
exosome component 2
chr17_+_45286706 1.97 ENST00000393450.1
ENST00000572303.1
myosin, light chain 4, alkali; atrial, embryonic
chr12_-_71551652 1.93 ENST00000546561.1
tetraspanin 8
chr1_+_24117693 1.89 ENST00000374503.3
ENST00000374502.3
lysophospholipase II
chr8_+_27950619 1.89 ENST00000542181.1
ENST00000524103.1
ENST00000537665.1
ENST00000380353.4
ENST00000520288.1
elongator acetyltransferase complex subunit 3
chr13_-_79233314 1.87 ENST00000282003.6
ring finger protein 219
chr3_+_179322573 1.86 ENST00000493866.1
ENST00000472629.1
ENST00000482604.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr2_-_27435125 1.85 ENST00000414408.1
ENST00000310574.3
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr6_+_26199737 1.84 ENST00000359985.1
histone cluster 1, H2bf
chr14_+_73634537 1.81 ENST00000406768.1
presenilin 1
chr14_+_24701819 1.78 ENST00000560139.1
ENST00000559910.1
guanosine monophosphate reductase 2
chr1_-_11986442 1.78 ENST00000376572.3
ENST00000376576.3
KIAA2013
chr14_+_24702073 1.77 ENST00000399440.2
guanosine monophosphate reductase 2
chr17_+_11501748 1.73 ENST00000262442.4
ENST00000579828.1
dynein, axonemal, heavy chain 9
chr19_+_18668672 1.71 ENST00000601630.1
ENST00000599000.1
ENST00000595073.1
ENST00000596785.1
KxDL motif containing 1
chr15_+_78441663 1.67 ENST00000299518.2
ENST00000558554.1
ENST00000557826.1
ENST00000561279.1
ENST00000559186.1
ENST00000560770.1
ENST00000559881.1
ENST00000559205.1
ENST00000441490.2
isocitrate dehydrogenase 3 (NAD+) alpha
chr14_+_24701628 1.64 ENST00000355299.4
ENST00000559836.1
guanosine monophosphate reductase 2
chr8_-_38008783 1.63 ENST00000276449.4
steroidogenic acute regulatory protein
chrX_-_102943022 1.62 ENST00000433176.2
mortality factor 4 like 2
chr12_-_30887948 1.61 ENST00000433722.2
caprin family member 2
chr11_-_796197 1.55 ENST00000530360.1
ENST00000528606.1
ENST00000320230.5
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr19_+_21106081 1.51 ENST00000300540.3
ENST00000595854.1
ENST00000601284.1
ENST00000328178.8
ENST00000599885.1
ENST00000596476.1
ENST00000345030.6
zinc finger protein 85
chr5_-_146781153 1.48 ENST00000520473.1
dihydropyrimidinase-like 3
chr6_+_64281906 1.46 ENST00000370651.3
protein tyrosine phosphatase type IVA, member 1
chr19_-_49496557 1.46 ENST00000323798.3
ENST00000541188.1
ENST00000544287.1
ENST00000540532.1
ENST00000263276.6
glycogen synthase 1 (muscle)
chr1_+_117297007 1.43 ENST00000369478.3
ENST00000369477.1
CD2 molecule
chr2_+_234526272 1.41 ENST00000373450.4
UDP glucuronosyltransferase 1 family, polypeptide A8
chr7_-_76247617 1.39 ENST00000441393.1
POM121 and ZP3 fusion
chr22_+_22676808 1.38 ENST00000390290.2
immunoglobulin lambda variable 1-51
chr1_+_24117627 1.35 ENST00000400061.1
lysophospholipase II
chr6_-_106773491 1.34 ENST00000360666.4
autophagy related 5
chr1_+_59775752 1.33 ENST00000371212.1
FGGY carbohydrate kinase domain containing
chr10_-_75226166 1.29 ENST00000544628.1
protein phosphatase 3, catalytic subunit, beta isozyme
chr18_+_616672 1.28 ENST00000338387.7
clusterin-like 1 (retinal)
chr10_-_98031265 1.26 ENST00000224337.5
ENST00000371176.2
B-cell linker
chr16_-_29499154 1.25 ENST00000354563.5
Uncharacterized protein
chr2_+_228336849 1.23 ENST00000409979.2
ENST00000310078.8
ArfGAP with FG repeats 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC12_HOXD12

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
14.0 42.1 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
4.9 14.7 GO:0042350 GDP-L-fucose biosynthetic process(GO:0042350) 'de novo' GDP-L-fucose biosynthetic process(GO:0042351)
4.6 18.6 GO:0090579 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
4.5 13.6 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466) mitochondrial membrane fission(GO:0090149)
4.1 24.7 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
3.9 15.5 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
3.3 9.9 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
3.2 9.6 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
2.7 10.6 GO:0071461 cellular response to redox state(GO:0071461)
2.2 15.6 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
2.1 6.3 GO:0044209 AMP salvage(GO:0044209)
2.1 16.4 GO:0006348 chromatin silencing at telomere(GO:0006348)
1.7 8.6 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
1.7 12.0 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
1.7 13.5 GO:0010032 meiotic chromosome condensation(GO:0010032)
1.6 8.0 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
1.6 9.4 GO:0006177 GMP biosynthetic process(GO:0006177)
1.6 7.8 GO:0000459 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038)
1.5 4.6 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
1.5 13.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
1.2 16.4 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)
1.1 4.2 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.9 5.7 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.9 2.7 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.9 2.7 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.9 3.6 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.9 31.4 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.8 14.8 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.8 7.2 GO:0034501 protein localization to kinetochore(GO:0034501)
0.8 10.2 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.8 6.2 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.7 4.4 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.7 13.5 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.7 23.4 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.7 10.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.7 9.1 GO:1904871 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.7 5.3 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.6 4.5 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.6 3.2 GO:0002084 protein depalmitoylation(GO:0002084)
0.6 36.7 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.6 5.4 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.5 1.6 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
0.5 3.1 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.5 5.0 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.5 3.4 GO:2000210 positive regulation of anoikis(GO:2000210)
0.5 9.9 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.5 2.4 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.5 1.4 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.5 3.7 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.4 1.3 GO:0071500 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034) cellular response to nitrosative stress(GO:0071500)
0.4 10.6 GO:0043101 purine-containing compound salvage(GO:0043101)
0.4 2.6 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.4 3.7 GO:0000012 single strand break repair(GO:0000012)
0.4 2.8 GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
0.4 2.4 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.4 13.8 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.4 1.8 GO:0051182 coenzyme transport(GO:0051182)
0.4 3.5 GO:0010265 SCF complex assembly(GO:0010265)
0.3 4.1 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.3 8.6 GO:0032201 telomere maintenance via semi-conservative replication(GO:0032201)
0.3 2.8 GO:0048752 negative regulation of endothelial cell differentiation(GO:0045602) semicircular canal morphogenesis(GO:0048752)
0.3 11.9 GO:0014904 myotube cell development(GO:0014904)
0.3 1.8 GO:1904796 regulation of core promoter binding(GO:1904796)
0.3 4.4 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.3 1.4 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.3 1.4 GO:0070980 biphenyl catabolic process(GO:0070980)
0.3 0.8 GO:0014016 neuroblast differentiation(GO:0014016)
0.2 1.2 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795)
0.2 1.4 GO:0035803 egg coat formation(GO:0035803)
0.2 5.5 GO:0006293 nucleotide-excision repair, preincision complex stabilization(GO:0006293) nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.2 3.9 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.2 0.9 GO:0061113 pancreas morphogenesis(GO:0061113)
0.2 10.4 GO:0032731 positive regulation of interleukin-1 beta production(GO:0032731)
0.2 1.7 GO:0032418 lysosome localization(GO:0032418)
0.2 5.9 GO:0000042 protein targeting to Golgi(GO:0000042)
0.2 1.1 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.2 2.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.2 1.4 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.2 2.0 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.2 1.5 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.2 2.3 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.2 0.8 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.2 12.1 GO:0070125 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.2 1.3 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.2 9.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 7.3 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA transport(GO:0051031) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.2 5.3 GO:0033198 response to ATP(GO:0033198)
0.1 4.0 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 0.6 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.1 0.6 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 1.2 GO:0001675 acrosome assembly(GO:0001675)
0.1 2.6 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.1 12.6 GO:0007062 sister chromatid cohesion(GO:0007062)
0.1 4.0 GO:0003341 cilium movement(GO:0003341)
0.1 0.7 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 2.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 0.4 GO:0035995 detection of muscle stretch(GO:0035995)
0.1 1.3 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 2.8 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 0.5 GO:2000035 regulation of stem cell division(GO:2000035)
0.1 0.5 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.1 0.7 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.1 15.6 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 7.3 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 1.3 GO:0019321 pentose metabolic process(GO:0019321) neuron cellular homeostasis(GO:0070050)
0.1 2.5 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.1 5.3 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 0.9 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.1 4.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 3.0 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.1 4.2 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 1.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 2.2 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.1 1.2 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.1 2.0 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.1 1.6 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.1 6.7 GO:0045333 cellular respiration(GO:0045333)
0.1 1.1 GO:0042633 molting cycle(GO:0042303) hair cycle(GO:0042633)
0.1 2.7 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.1 0.5 GO:0090656 t-circle formation(GO:0090656)
0.0 4.0 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439)
0.0 0.5 GO:0045116 protein neddylation(GO:0045116)
0.0 7.0 GO:0051168 nuclear export(GO:0051168)
0.0 1.1 GO:0010447 response to acidic pH(GO:0010447)
0.0 1.1 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.5 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0 1.8 GO:0043967 histone H4 acetylation(GO:0043967)
0.0 0.3 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 3.3 GO:0006413 translational initiation(GO:0006413)
0.0 3.4 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.7 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 1.5 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 1.2 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 0.3 GO:0033033 negative regulation of myeloid cell apoptotic process(GO:0033033)
0.0 2.1 GO:0007286 spermatid development(GO:0007286)
0.0 0.1 GO:0007162 negative regulation of cell adhesion(GO:0007162)
0.0 0.1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.5 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.0 0.6 GO:0008210 estrogen metabolic process(GO:0008210)
0.0 0.8 GO:0016337 single organismal cell-cell adhesion(GO:0016337)
0.0 0.1 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.0 2.8 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.6 GO:0007566 embryo implantation(GO:0007566)
0.0 0.4 GO:0060964 regulation of gene silencing by miRNA(GO:0060964)
0.0 0.4 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 36.7 GO:0097452 GAIT complex(GO:0097452)
5.0 20.2 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
5.0 19.9 GO:1990423 RZZ complex(GO:1990423)
4.9 14.8 GO:1990298 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
4.7 42.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
3.4 13.5 GO:0000799 nuclear condensin complex(GO:0000799)
3.1 15.6 GO:0005726 perichromatin fibrils(GO:0005726)
2.4 7.3 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
2.4 16.7 GO:0005663 DNA replication factor C complex(GO:0005663)
2.2 24.7 GO:0070531 BRCA1-A complex(GO:0070531)
1.9 18.5 GO:0097255 R2TP complex(GO:0097255)
1.8 10.6 GO:1902560 GMP reductase complex(GO:1902560)
1.8 5.3 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
1.7 15.5 GO:0005827 polar microtubule(GO:0005827)
1.5 4.6 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
1.5 7.4 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
1.3 8.0 GO:0033061 DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
1.3 5.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
1.2 9.9 GO:0032133 chromosome passenger complex(GO:0032133)
1.1 17.9 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
1.0 13.1 GO:0000243 commitment complex(GO:0000243)
0.9 10.6 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.7 7.8 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.7 9.1 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.6 7.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.5 3.7 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.5 4.0 GO:1990111 spermatoproteasome complex(GO:1990111)
0.4 28.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.4 5.0 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.4 6.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.3 4.3 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.3 2.6 GO:0042382 paraspeckles(GO:0042382)
0.3 6.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.3 15.8 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 4.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 2.8 GO:0097025 lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025)
0.2 14.6 GO:0005844 polysome(GO:0005844)
0.2 1.6 GO:0030061 mitochondrial crista(GO:0030061)
0.2 1.3 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.2 1.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.2 1.9 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.2 7.8 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 1.3 GO:0005955 calcineurin complex(GO:0005955)
0.2 1.1 GO:0097165 nuclear stress granule(GO:0097165)
0.2 1.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.2 4.3 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2 1.7 GO:0031083 BLOC-1 complex(GO:0031083)
0.2 2.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.2 1.8 GO:0070765 gamma-secretase complex(GO:0070765)
0.2 13.6 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 2.2 GO:0008290 F-actin capping protein complex(GO:0008290) Flemming body(GO:0090543)
0.1 20.5 GO:0016363 nuclear matrix(GO:0016363)
0.1 10.2 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 2.7 GO:0071564 npBAF complex(GO:0071564)
0.1 0.5 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 2.8 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 2.3 GO:0099738 cell cortex region(GO:0099738)
0.1 15.7 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1 7.2 GO:0000502 proteasome complex(GO:0000502)
0.1 4.0 GO:0030286 dynein complex(GO:0030286)
0.1 2.4 GO:0016592 mediator complex(GO:0016592)
0.1 28.0 GO:0016607 nuclear speck(GO:0016607)
0.1 1.4 GO:0032982 myosin filament(GO:0032982)
0.1 4.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 5.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.2 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.5 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 4.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.8 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.6 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 3.2 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 2.1 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 15.6 GO:0005635 nuclear envelope(GO:0005635)
0.0 2.7 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 1.5 GO:0016234 inclusion body(GO:0016234)
0.0 0.6 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.7 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 2.0 GO:0043197 dendritic spine(GO:0043197)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 20.2 GO:0016418 S-acetyltransferase activity(GO:0016418)
4.4 13.1 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
3.9 15.5 GO:0031208 POZ domain binding(GO:0031208)
3.1 18.6 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
2.4 16.7 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
2.3 9.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
1.9 36.7 GO:0035613 RNA stem-loop binding(GO:0035613)
1.9 42.1 GO:0000339 RNA cap binding(GO:0000339)
1.8 7.2 GO:0043515 kinetochore binding(GO:0043515)
1.8 10.6 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
1.7 5.0 GO:0032089 NACHT domain binding(GO:0032089)
1.6 6.3 GO:0002060 purine nucleobase binding(GO:0002060)
1.5 4.6 GO:0070699 type II activin receptor binding(GO:0070699)
1.5 16.4 GO:0046790 virion binding(GO:0046790)
1.4 15.6 GO:0034056 estrogen response element binding(GO:0034056)
1.3 11.9 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
1.2 23.8 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
1.1 3.4 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
1.1 11.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
1.1 9.9 GO:0035174 histone serine kinase activity(GO:0035174)
1.1 12.0 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
1.1 5.3 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
1.1 10.6 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
1.0 8.0 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.9 3.7 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.8 5.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.8 2.5 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.8 18.3 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.8 15.8 GO:0051400 BH domain binding(GO:0051400)
0.8 5.3 GO:0043208 glycosphingolipid binding(GO:0043208)
0.7 4.4 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.7 7.3 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.7 5.7 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.7 7.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.6 1.8 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.6 9.7 GO:0008494 translation activator activity(GO:0008494)
0.5 2.0 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.5 1.4 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.5 1.8 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.4 23.1 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 1.7 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.4 3.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.4 2.4 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.4 2.4 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.4 1.5 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.4 4.4 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.4 2.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.3 6.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.3 2.8 GO:0097016 L27 domain binding(GO:0097016)
0.2 9.0 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.2 1.2 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.2 4.0 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.2 1.6 GO:0017127 cholesterol transporter activity(GO:0017127)
0.2 2.3 GO:0042731 PH domain binding(GO:0042731)
0.2 1.3 GO:0019776 Atg8 ligase activity(GO:0019776)
0.2 2.0 GO:0008312 7S RNA binding(GO:0008312)
0.2 0.8 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.2 6.9 GO:0017091 AU-rich element binding(GO:0017091)
0.2 0.8 GO:0033265 acetylcholinesterase activity(GO:0003990) choline binding(GO:0033265)
0.2 3.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 2.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.2 2.6 GO:0042809 vitamin D receptor binding(GO:0042809)
0.2 11.0 GO:0019843 rRNA binding(GO:0019843)
0.2 14.8 GO:0043130 ubiquitin binding(GO:0043130)
0.2 1.4 GO:0032190 acrosin binding(GO:0032190)
0.2 5.5 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 1.5 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 10.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 4.0 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.3 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 3.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.5 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 0.5 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 3.5 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 4.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 9.4 GO:0008135 translation factor activity, RNA binding(GO:0008135)
0.1 4.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 12.7 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.1 0.5 GO:0036310 annealing helicase activity(GO:0036310)
0.1 0.7 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 16.1 GO:0042393 histone binding(GO:0042393)
0.1 4.1 GO:0070063 RNA polymerase binding(GO:0070063)
0.1 2.7 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 1.2 GO:0035198 miRNA binding(GO:0035198)
0.1 12.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 19.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 1.4 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 1.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 3.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.4 GO:0031433 telethonin binding(GO:0031433)
0.0 4.0 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 3.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.3 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 1.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 3.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.7 GO:0008198 ferrous iron binding(GO:0008198)
0.0 2.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 5.3 GO:0003682 chromatin binding(GO:0003682)
0.0 0.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.6 GO:0005504 fatty acid binding(GO:0005504)
0.0 1.7 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.0 2.9 GO:0008134 transcription factor binding(GO:0008134)
0.0 1.1 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 1.9 GO:0005178 integrin binding(GO:0005178)
0.0 0.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 27.4 PID ATM PATHWAY ATM pathway
0.5 31.7 PID AURORA B PATHWAY Aurora B signaling
0.4 18.6 PID MYC PATHWAY C-MYC pathway
0.3 28.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.3 9.0 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 7.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 10.1 PID S1P S1P3 PATHWAY S1P3 pathway
0.2 8.6 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 13.5 PID IL6 7 PATHWAY IL6-mediated signaling events
0.2 3.4 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2 12.0 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 12.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 7.2 PID FAS PATHWAY FAS (CD95) signaling pathway
0.1 4.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 14.1 PID P73PATHWAY p73 transcription factor network
0.1 2.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 3.7 PID ALK1 PATHWAY ALK1 signaling events
0.1 1.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 1.2 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 2.8 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 0.5 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 1.8 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 2.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 2.8 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 2.2 PID ENDOTHELIN PATHWAY Endothelins
0.0 2.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.3 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.5 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.5 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.5 PID ATR PATHWAY ATR signaling pathway
0.0 0.8 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.1 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 1.0 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 12.0 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
1.2 16.4 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
1.0 36.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.9 14.8 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.9 7.8 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.7 27.7 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.7 53.1 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.7 16.9 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.6 9.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.5 14.8 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.5 7.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.4 15.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.3 6.8 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.3 9.1 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.3 4.1 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.3 23.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.3 7.3 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2 22.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 6.6 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2 3.7 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 18.4 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.1 2.7 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 3.7 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.1 4.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 7.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.8 REACTOME SIGNALING BY NOTCH3 Genes involved in Signaling by NOTCH3
0.1 7.1 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 2.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 4.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 1.5 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 4.6 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 2.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 18.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.6 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 4.8 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 8.2 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.1 5.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 22.4 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.1 0.5 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 1.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.6 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.8 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 2.6 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.7 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 4.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.5 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism