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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXC6_HOXA7

Z-value: 0.77

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Transcription factors associated with HOXC6_HOXA7

Gene Symbol Gene ID Gene Info
HOXC6
ENSG00000197757.7 homeobox C6
HOXA7
ENSG00000122592.6 homeobox A7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA7hg19_v2_chr7_-_27196267_271963110.275.4e-05Click!
HOXC6hg19_v2_chr12_+_54422142_54422239-0.143.9e-02Click!

Activity profile of HOXC6_HOXA7 motif

Sorted Z-values of HOXC6_HOXA7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_90248739 19.63 ENST00000468879.1
IGKV1D-43
immunoglobulin kappa variable 1D-43
chr17_+_1674982 14.57 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr19_+_50016610 9.36 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr2_+_90273679 8.87 ENST00000423080.2
IGKV3D-7
immunoglobulin kappa variable 3D-7
chr12_-_91573132 8.00 ENST00000550563.1
ENST00000546370.1
DCN
decorin
chr12_-_91573316 7.25 ENST00000393155.1
DCN
decorin
chr2_+_90211643 6.84 ENST00000390277.2
IGKV3D-11
immunoglobulin kappa variable 3D-11
chr2_-_89327228 6.82 ENST00000483158.1
IGKV3-11
immunoglobulin kappa variable 3-11
chr12_-_91573249 6.74 ENST00000550099.1
ENST00000546391.1
ENST00000551354.1
DCN
decorin
chr14_-_106552755 6.69 ENST00000390600.2
IGHV3-9
immunoglobulin heavy variable 3-9
chr16_-_28937027 5.91 ENST00000358201.4
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr2_-_89340242 5.64 ENST00000480492.1
IGKV1-12
immunoglobulin kappa variable 1-12
chr1_+_202317815 5.54 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr2_+_90198535 5.44 ENST00000390276.2
IGKV1D-12
immunoglobulin kappa variable 1D-12
chr9_+_125132803 5.37 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr3_+_111718036 4.89 ENST00000455401.2
TAGLN3
transgelin 3
chr14_-_106926724 4.69 ENST00000434710.1
IGHV3-43
immunoglobulin heavy variable 3-43
chr14_-_101295407 4.38 ENST00000596284.1
AL117190.2
AL117190.2
chr7_-_150020578 4.35 ENST00000478393.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr14_-_106668095 4.28 ENST00000390606.2
IGHV3-20
immunoglobulin heavy variable 3-20
chr3_+_111718173 4.06 ENST00000494932.1
TAGLN3
transgelin 3
chr2_+_25015968 3.79 ENST00000380834.2
ENST00000473706.1
CENPO
centromere protein O
chr4_+_155484155 3.78 ENST00000509493.1
FGB
fibrinogen beta chain
chr3_+_111717600 3.78 ENST00000273368.4
TAGLN3
transgelin 3
chr3_+_111717511 3.62 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr7_+_150020363 3.47 ENST00000359623.4
ENST00000493307.1
LRRC61
leucine rich repeat containing 61
chr7_+_150020329 3.42 ENST00000323078.7
LRRC61
leucine rich repeat containing 61
chr13_+_53602894 3.24 ENST00000219022.2
OLFM4
olfactomedin 4
chr5_+_66300446 3.19 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr5_+_40909354 3.10 ENST00000313164.9
C7
complement component 7
chr18_+_32558208 3.09 ENST00000436190.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr11_+_121447469 2.87 ENST00000532694.1
ENST00000534286.1
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr1_-_92952433 2.85 ENST00000294702.5
GFI1
growth factor independent 1 transcription repressor
chr16_+_12059091 2.81 ENST00000562385.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr19_+_50016411 2.78 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr4_-_8873531 2.77 ENST00000400677.3
HMX1
H6 family homeobox 1
chr15_+_25068773 2.74 ENST00000400100.1
ENST00000400098.1
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr1_-_211307404 2.73 ENST00000367007.4
KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr13_+_31309645 2.67 ENST00000380490.3
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr6_+_114178512 2.39 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr17_-_73663245 2.23 ENST00000584999.1
ENST00000317905.5
ENST00000420326.2
ENST00000340830.5
RECQL5
RecQ protein-like 5
chr12_+_26348246 2.21 ENST00000422622.2
SSPN
sarcospan
chr3_-_39321512 2.19 ENST00000399220.2
CX3CR1
chemokine (C-X3-C motif) receptor 1
chr16_+_12059050 2.18 ENST00000396495.3
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chrX_+_43515467 2.13 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr7_-_105029812 2.05 ENST00000482897.1
SRPK2
SRSF protein kinase 2
chr6_+_26365443 2.02 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr9_+_125133315 1.95 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr19_+_55043977 1.89 ENST00000335056.3
KIR3DX1
killer cell immunoglobulin-like receptor, three domains, X1
chr4_+_155484103 1.81 ENST00000302068.4
FGB
fibrinogen beta chain
chr19_-_5903714 1.79 ENST00000586349.1
ENST00000585661.1
ENST00000308961.4
ENST00000592634.1
ENST00000418389.2
ENST00000252675.5
AC024592.12
NDUFA11
FUT5
Uncharacterized protein
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr19_-_36304201 1.77 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr12_-_112279694 1.73 ENST00000443596.1
ENST00000442119.1
MAPKAPK5-AS1
MAPKAPK5 antisense RNA 1
chr14_-_90085458 1.70 ENST00000345097.4
ENST00000555855.1
ENST00000555353.1
FOXN3
forkhead box N3
chr11_-_49230144 1.70 ENST00000343844.4
FOLH1
folate hydrolase (prostate-specific membrane antigen) 1
chr11_-_49230184 1.65 ENST00000340334.7
ENST00000256999.2
FOLH1
folate hydrolase (prostate-specific membrane antigen) 1
chr4_-_87281196 1.63 ENST00000359221.3
MAPK10
mitogen-activated protein kinase 10
chr12_-_10022735 1.61 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr14_-_94789663 1.60 ENST00000557225.1
ENST00000341584.3
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chrX_-_130423200 1.45 ENST00000361420.3
IGSF1
immunoglobulin superfamily, member 1
chrX_-_106362013 1.44 ENST00000372487.1
ENST00000372479.3
ENST00000203616.8
RBM41
RNA binding motif protein 41
chr4_+_71108300 1.41 ENST00000304954.3
CSN3
casein kappa
chr11_-_49230084 1.38 ENST00000356696.3
FOLH1
folate hydrolase (prostate-specific membrane antigen) 1
chr8_-_93115445 1.37 ENST00000523629.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr11_+_66276550 1.35 ENST00000419755.3
CTD-3074O7.11
Bardet-Biedl syndrome 1 protein
chr4_-_120243545 1.34 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr9_-_95166841 1.34 ENST00000262551.4
OGN
osteoglycin
chr12_-_89920030 1.33 ENST00000413530.1
ENST00000547474.1
GALNT4
POC1B-GALNT4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
POC1B-GALNT4 readthrough
chrX_-_14047996 1.28 ENST00000380523.4
ENST00000398355.3
GEMIN8
gem (nuclear organelle) associated protein 8
chr2_-_25391507 1.28 ENST00000380794.1
POMC
proopiomelanocortin
chr8_+_77593448 1.23 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr12_+_4385230 1.22 ENST00000536537.1
CCND2
cyclin D2
chr4_-_80329356 1.20 ENST00000358842.3
GK2
glycerol kinase 2
chr12_+_26348429 1.18 ENST00000242729.2
SSPN
sarcospan
chr4_-_87281224 1.18 ENST00000395169.3
ENST00000395161.2
MAPK10
mitogen-activated protein kinase 10
chr6_+_26440700 1.18 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr5_-_86534822 1.10 ENST00000445770.2
AC008394.1
Uncharacterized protein
chr2_-_25391772 1.09 ENST00000405623.1
POMC
proopiomelanocortin
chr3_+_149191723 1.09 ENST00000305354.4
TM4SF4
transmembrane 4 L six family member 4
chr7_+_129906660 1.04 ENST00000222481.4
CPA2
carboxypeptidase A2 (pancreatic)
chr12_-_10151773 0.99 ENST00000298527.6
ENST00000348658.4
CLEC1B
C-type lectin domain family 1, member B
chr2_-_25391468 0.97 ENST00000395826.2
POMC
proopiomelanocortin
chr6_+_44355257 0.97 ENST00000371477.3
CDC5L
cell division cycle 5-like
chr6_+_26402465 0.97 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr8_-_41166953 0.96 ENST00000220772.3
SFRP1
secreted frizzled-related protein 1
chr9_-_5339873 0.94 ENST00000223862.1
ENST00000223858.4
RLN1
relaxin 1
chr16_+_28565230 0.89 ENST00000317058.3
CCDC101
coiled-coil domain containing 101
chr21_-_31538971 0.89 ENST00000286808.3
CLDN17
claudin 17
chr12_-_52761262 0.86 ENST00000257901.3
KRT85
keratin 85
chr7_-_44580861 0.84 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1L1
NPC1-like 1
chr6_+_96969672 0.84 ENST00000369278.4
UFL1
UFM1-specific ligase 1
chr1_-_38019878 0.83 ENST00000296215.6
SNIP1
Smad nuclear interacting protein 1
chr7_+_134528635 0.80 ENST00000445569.2
CALD1
caldesmon 1
chr2_+_202047843 0.79 ENST00000272879.5
ENST00000374650.3
ENST00000346817.5
ENST00000313728.7
ENST00000448480.1
CASP10
caspase 10, apoptosis-related cysteine peptidase
chr17_-_4938712 0.78 ENST00000254853.5
ENST00000424747.1
SLC52A1
solute carrier family 52 (riboflavin transporter), member 1
chr2_-_25391425 0.77 ENST00000264708.3
ENST00000449220.1
POMC
proopiomelanocortin
chr1_+_117963209 0.74 ENST00000449370.2
MAN1A2
mannosidase, alpha, class 1A, member 2
chr18_-_61329118 0.73 ENST00000332821.8
ENST00000283752.5
SERPINB3
serpin peptidase inhibitor, clade B (ovalbumin), member 3
chr12_+_81110684 0.73 ENST00000228644.3
MYF5
myogenic factor 5
chr10_-_112678976 0.72 ENST00000448814.1
BBIP1
BBSome interacting protein 1
chr3_-_54962100 0.70 ENST00000273286.5
LRTM1
leucine-rich repeats and transmembrane domains 1
chrX_+_144908928 0.70 ENST00000408967.2
TMEM257
transmembrane protein 257
chr15_-_55657428 0.70 ENST00000568543.1
CCPG1
cell cycle progression 1
chr11_-_128894053 0.69 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr11_-_63376013 0.69 ENST00000540943.1
PLA2G16
phospholipase A2, group XVI
chrX_-_138724994 0.67 ENST00000536274.1
MCF2
MCF.2 cell line derived transforming sequence
chr10_+_90424196 0.66 ENST00000394375.3
ENST00000608620.1
ENST00000238983.4
ENST00000355843.2
LIPF
lipase, gastric
chr3_+_152552685 0.66 ENST00000305097.3
P2RY1
purinergic receptor P2Y, G-protein coupled, 1
chr14_+_72399833 0.66 ENST00000553530.1
ENST00000556437.1
RGS6
regulator of G-protein signaling 6
chr2_+_132479948 0.64 ENST00000355171.4
C2orf27A
chromosome 2 open reading frame 27A
chr2_+_169757750 0.63 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
G6PC2
glucose-6-phosphatase, catalytic, 2
chr1_+_62439037 0.63 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr17_-_64225508 0.60 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr11_+_33061543 0.59 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
TCP11L1
t-complex 11, testis-specific-like 1
chr11_+_59824127 0.59 ENST00000278865.3
MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr12_+_56435637 0.58 ENST00000356464.5
ENST00000552361.1
RPS26
ribosomal protein S26
chr12_-_10282836 0.56 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr11_-_13517565 0.55 ENST00000282091.1
ENST00000529816.1
PTH
parathyroid hormone
chr3_-_167191814 0.54 ENST00000466903.1
ENST00000264677.4
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr7_-_32338917 0.53 ENST00000396193.1
PDE1C
phosphodiesterase 1C, calmodulin-dependent 70kDa
chr6_+_28092338 0.53 ENST00000340487.4
ZSCAN16
zinc finger and SCAN domain containing 16
chr5_+_54455946 0.49 ENST00000503787.1
ENST00000296734.6
ENST00000515370.1
GPX8
glutathione peroxidase 8 (putative)
chr6_-_33160231 0.49 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
COL11A2
collagen, type XI, alpha 2
chr20_+_43849941 0.48 ENST00000372769.3
SEMG2
semenogelin II
chr8_+_77593474 0.48 ENST00000455469.2
ENST00000050961.6
ZFHX4
zinc finger homeobox 4
chr17_-_10372875 0.47 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr15_+_35270552 0.45 ENST00000391457.2
AC114546.1
HCG37415; PRO1914; Uncharacterized protein
chr5_-_22853429 0.45 ENST00000504376.2
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr11_+_2405833 0.44 ENST00000527343.1
ENST00000464784.2
CD81
CD81 molecule
chr10_+_18549645 0.43 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr5_-_20575959 0.43 ENST00000507958.1
CDH18
cadherin 18, type 2
chrX_-_18690210 0.38 ENST00000379984.3
RS1
retinoschisin 1
chr19_+_49404041 0.37 ENST00000263273.5
ENST00000424608.1
NUCB1
nucleobindin 1
chr19_+_49199209 0.37 ENST00000522966.1
ENST00000425340.2
ENST00000391876.4
FUT2
fucosyltransferase 2 (secretor status included)
chr11_+_59824060 0.35 ENST00000395032.2
ENST00000358152.2
MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr12_+_60083118 0.32 ENST00000261187.4
ENST00000543448.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr6_+_26402517 0.31 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr17_-_72772462 0.29 ENST00000582870.1
ENST00000581136.1
ENST00000357814.3
ENST00000579218.1
ENST00000583476.1
ENST00000580301.1
ENST00000583757.1
ENST00000582524.1
NAT9
N-acetyltransferase 9 (GCN5-related, putative)
chr2_+_152214098 0.29 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr11_-_124670550 0.28 ENST00000239614.4
MSANTD2
Myb/SANT-like DNA-binding domain containing 2
chr11_-_77791156 0.27 ENST00000281031.4
NDUFC2
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
chr13_-_36050819 0.26 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr11_-_89541743 0.25 ENST00000329758.1
TRIM49
tripartite motif containing 49
chr2_+_234826016 0.21 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr11_+_89764274 0.21 ENST00000448984.1
ENST00000432771.1
TRIM49C
tripartite motif containing 49C
chr4_-_170533723 0.21 ENST00000510533.1
ENST00000439128.2
ENST00000511633.1
ENST00000512193.1
ENST00000507142.1
NEK1
NIMA-related kinase 1
chr1_+_221051699 0.19 ENST00000366903.6
HLX
H2.0-like homeobox
chr14_+_50234309 0.18 ENST00000298307.5
KLHDC2
kelch domain containing 2
chr3_+_45927994 0.17 ENST00000357632.2
ENST00000395963.2
CCR9
chemokine (C-C motif) receptor 9
chr19_-_54618650 0.16 ENST00000391757.1
TFPT
TCF3 (E2A) fusion partner (in childhood Leukemia)
chr4_-_119759795 0.15 ENST00000419654.2
SEC24D
SEC24 family member D
chr6_+_152128371 0.15 ENST00000443427.1
ESR1
estrogen receptor 1
chr2_+_202047596 0.14 ENST00000286186.6
ENST00000360132.3
CASP10
caspase 10, apoptosis-related cysteine peptidase
chr7_+_93551011 0.13 ENST00000248564.5
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr8_-_30670384 0.13 ENST00000221138.4
ENST00000518243.1
PPP2CB
protein phosphatase 2, catalytic subunit, beta isozyme
chr8_-_57123815 0.12 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chr19_-_54619006 0.11 ENST00000391759.1
TFPT
TCF3 (E2A) fusion partner (in childhood Leukemia)
chrX_+_9431324 0.10 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr4_+_169418255 0.09 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr8_+_24151620 0.08 ENST00000437154.2
ADAM28
ADAM metallopeptidase domain 28
chr12_-_86650045 0.04 ENST00000604798.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr15_+_58430567 0.03 ENST00000536493.1
AQP9
aquaporin 9
chr6_-_133035185 0.02 ENST00000367928.4
VNN1
vanin 1
chr7_+_148936732 0.02 ENST00000335870.2
ZNF212
zinc finger protein 212
chr6_+_153552455 0.00 ENST00000392385.2
AL590867.1
Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC6_HOXA7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 14.6 GO:0071279 cellular response to cobalt ion(GO:0071279)
1.8 22.0 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
1.7 12.1 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
1.0 2.9 GO:1902771 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
1.0 2.9 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.8 4.7 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.7 2.2 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.7 2.2 GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
0.6 5.6 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.5 4.1 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.5 3.2 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.4 2.1 GO:0035063 nuclear speck organization(GO:0035063)
0.4 7.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.4 2.7 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.4 2.8 GO:0007258 JUN phosphorylation(GO:0007258)
0.3 1.0 GO:1990637 response to prolactin(GO:1990637)
0.3 1.0 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.3 1.2 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.3 2.7 GO:2001300 lipoxin metabolic process(GO:2001300)
0.3 1.8 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.2 36.7 GO:0006958 complement activation, classical pathway(GO:0006958)
0.2 0.5 GO:1902573 positive regulation of serine-type endopeptidase activity(GO:1900005) positive regulation of serine-type peptidase activity(GO:1902573)
0.2 34.5 GO:0002377 immunoglobulin production(GO:0002377)
0.2 0.8 GO:0032218 riboflavin transport(GO:0032218)
0.2 0.7 GO:0035425 autocrine signaling(GO:0035425)
0.2 0.5 GO:1900158 hormone-mediated apoptotic signaling pathway(GO:0008628) positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.2 2.2 GO:0042355 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.1 0.7 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 2.1 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 3.3 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 0.7 GO:0060406 positive regulation of penile erection(GO:0060406)
0.1 0.7 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.1 0.5 GO:0060023 soft palate development(GO:0060023)
0.1 0.8 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 2.4 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.4 GO:0043128 regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128)
0.1 0.7 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 0.7 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 4.3 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 1.7 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.1 1.2 GO:0071481 cellular response to X-ray(GO:0071481)
0.1 0.4 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.1 1.3 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 5.0 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.1 1.0 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.1 0.6 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.1 1.8 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 0.7 GO:0006108 malate metabolic process(GO:0006108)
0.1 1.6 GO:0008211 glucocorticoid metabolic process(GO:0008211)
0.1 1.0 GO:0030220 platelet formation(GO:0030220)
0.0 0.8 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0 0.4 GO:0072718 response to cisplatin(GO:0072718)
0.0 0.2 GO:0050955 thermoception(GO:0050955)
0.0 0.1 GO:0060736 prostate gland growth(GO:0060736)
0.0 0.3 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.2 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.4 GO:0009642 response to light intensity(GO:0009642)
0.0 1.3 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 1.3 GO:0016266 O-glycan processing(GO:0016266)
0.0 1.4 GO:0007595 lactation(GO:0007595)
0.0 0.2 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.0 0.3 GO:0030728 ovulation(GO:0030728)
0.0 0.1 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.0 0.2 GO:0001562 response to protozoan(GO:0001562) defense response to protozoan(GO:0042832)
0.0 1.1 GO:0042246 tissue regeneration(GO:0042246)
0.0 0.6 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.0 3.5 GO:0006937 regulation of muscle contraction(GO:0006937)
0.0 1.2 GO:0002456 T cell mediated immunity(GO:0002456)
0.0 16.1 GO:0007417 central nervous system development(GO:0007417)
0.0 0.5 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.0 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 22.0 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
1.2 14.6 GO:0043203 axon hillock(GO:0043203)
0.4 5.6 GO:0005577 fibrinogen complex(GO:0005577)
0.3 3.1 GO:0005579 membrane attack complex(GO:0005579)
0.2 4.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 1.2 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.2 2.9 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 9.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 1.3 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.2 2.4 GO:0043073 germ cell nucleus(GO:0043073)
0.1 0.4 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 2.7 GO:0005686 U2 snRNP(GO:0005686)
0.1 0.8 GO:0030478 actin cap(GO:0030478)
0.1 3.4 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 1.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 2.2 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1 5.5 GO:0031672 A band(GO:0031672)
0.1 12.3 GO:0072562 blood microparticle(GO:0072562)
0.1 1.9 GO:0035371 microtubule plus-end(GO:0035371)
0.1 6.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 1.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 14.3 GO:0043209 myelin sheath(GO:0043209)
0.0 3.4 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.8 GO:0097342 ripoptosome(GO:0097342)
0.0 0.5 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.6 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.5 GO:0032982 myosin filament(GO:0032982)
0.0 52.1 GO:0005615 extracellular space(GO:0005615)
0.0 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 2.7 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.2 GO:0031968 mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.0 0.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 2.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.2 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.0 5.8 GO:0005769 early endosome(GO:0005769)
0.0 0.8 GO:0031526 brush border membrane(GO:0031526)
0.0 0.2 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.3 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.9 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.4 GO:0001772 immunological synapse(GO:0001772)
0.0 1.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.0 GO:0017053 transcriptional repressor complex(GO:0017053)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 12.1 GO:0019770 IgG receptor activity(GO:0019770)
1.8 7.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
1.2 4.7 GO:1904493 Ac-Asp-Glu binding(GO:1904492) tetrahydrofolyl-poly(glutamate) polymer binding(GO:1904493)
1.0 4.1 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.9 2.7 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.7 2.2 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
0.5 2.8 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.5 2.7 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.4 1.8 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.4 2.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.4 1.8 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.3 69.3 GO:0003823 antigen binding(GO:0003823)
0.3 22.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 2.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 1.0 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.2 0.8 GO:0032217 riboflavin transporter activity(GO:0032217)
0.2 1.5 GO:0034711 inhibin binding(GO:0034711)
0.2 2.9 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.2 0.7 GO:0031685 adenosine receptor binding(GO:0031685)
0.2 17.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 1.4 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.2 0.6 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.2 0.8 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1 0.7 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 0.6 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 1.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.3 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.3 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 18.3 GO:0051015 actin filament binding(GO:0051015)
0.1 0.5 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.1 2.3 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 0.7 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 0.7 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.1 0.5 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 5.6 GO:0051087 chaperone binding(GO:0051087)
0.0 1.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.4 GO:0070492 phosphatidylinositol-5-phosphate binding(GO:0010314) oligosaccharide binding(GO:0070492)
0.0 0.4 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 7.3 GO:0008083 growth factor activity(GO:0008083)
0.0 0.8 GO:0031489 myosin V binding(GO:0031489)
0.0 0.5 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.8 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.5 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0001093 TFIIB-class transcription factor binding(GO:0001093)
0.0 0.7 GO:0070888 E-box binding(GO:0070888)
0.0 5.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0003924 GTPase activity(GO:0003924)
0.0 0.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 3.7 GO:0003779 actin binding(GO:0003779)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 23.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 4.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 5.6 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 2.8 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 15.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 1.0 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 2.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.5 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 22.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.3 5.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.3 4.1 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.2 2.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 2.8 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 2.1 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 1.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 6.3 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 3.1 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 2.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.7 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 1.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 2.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.7 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 1.8 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.9 REACTOME CELL CELL JUNCTION ORGANIZATION Genes involved in Cell-cell junction organization
0.0 0.8 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.3 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.6 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.6 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport