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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for IRF6_IRF4_IRF5
Z-value: 1.48
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Transcription factors associated with IRF6_IRF4_IRF5
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000117595.6 | interferon regulatory factor 6 | |
| ENSG00000137265.10 | interferon regulatory factor 4 | |
| ENSG00000128604.14 | interferon regulatory factor 5 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF5 | hg19_v2_chr7_+_128577972_128578047 | 0.18 | 8.9e-03 | Click! |
| IRF6 | hg19_v2_chr1_-_209979375_209979389 | 0.17 | 1.0e-02 | Click! |
| IRF4 | hg19_v2_chr6_+_391739_391759 | 0.12 | 8.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_321050 Show fit | 35.16 |
ENST00000399808.4
|
interferon induced transmembrane protein 3 |
|
| chr11_-_615942 Show fit | 31.35 |
ENST00000397562.3
ENST00000330243.5 ENST00000397570.1 ENST00000397574.2 |
interferon regulatory factor 7 |
|
| chr12_+_113344755 Show fit | 30.94 |
ENST00000550883.1
|
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chr3_-_146262428 Show fit | 30.36 |
ENST00000486631.1
|
phospholipid scramblase 1 |
|
| chr3_-_146262488 Show fit | 29.85 |
ENST00000487389.1
|
phospholipid scramblase 1 |
|
| chr3_-_146262365 Show fit | 27.98 |
ENST00000448787.2
|
phospholipid scramblase 1 |
|
| chr3_-_146262352 Show fit | 24.00 |
ENST00000462666.1
|
phospholipid scramblase 1 |
|
| chr3_-_146262637 Show fit | 23.14 |
ENST00000472349.1
ENST00000342435.4 |
phospholipid scramblase 1 |
|
| chr11_-_104817919 Show fit | 22.97 |
ENST00000533252.1
|
caspase 4, apoptosis-related cysteine peptidase |
|
| chr21_+_42792442 Show fit | 22.33 |
ENST00000398600.2
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF6_IRF4_IRF5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 19.7 | 157.6 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 1.0 | 71.8 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 2.3 | 59.0 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 5.1 | 56.5 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 8.7 | 43.6 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) negative regulation of macrophage apoptotic process(GO:2000110) |
| 7.6 | 30.3 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 2.1 | 23.0 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 0.5 | 21.9 | GO:0033198 | response to ATP(GO:0033198) |
| 0.3 | 16.4 | GO:0080171 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 0.2 | 13.2 | GO:0070206 | protein trimerization(GO:0070206) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 165.7 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.5 | 68.5 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 53.8 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 42.3 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.2 | 34.3 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 3.8 | 23.0 | GO:0072557 | IPAF inflammasome complex(GO:0072557) |
| 0.1 | 21.4 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.1 | 18.8 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.1 | 16.8 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.2 | 13.2 | GO:0015030 | Cajal body(GO:0015030) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.3 | 157.6 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 6.0 | 59.7 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.2 | 54.7 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.5 | 50.9 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.3 | 30.0 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.1 | 25.0 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 1.6 | 23.0 | GO:0050700 | CARD domain binding(GO:0050700) |
| 3.1 | 21.9 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.0 | 14.7 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 14.3 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 47.4 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 33.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 22.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.7 | 21.9 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.7 | 10.0 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.2 | 8.6 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.2 | 7.1 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 5.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.1 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 4.0 | PID EPHA FWDPATHWAY | EPHA forward signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 189.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 3.8 | 72.0 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.5 | 22.3 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.2 | 21.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 13.3 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.3 | 8.5 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.5 | 8.2 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.2 | 6.1 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.2 | 6.1 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.3 | 5.6 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |