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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for IRF6_IRF4_IRF5

Z-value: 1.48

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Transcription factors associated with IRF6_IRF4_IRF5

Gene Symbol Gene ID Gene Info
IRF6
ENSG00000117595.6 interferon regulatory factor 6
IRF4
ENSG00000137265.10 interferon regulatory factor 4
IRF5
ENSG00000128604.14 interferon regulatory factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF5hg19_v2_chr7_+_128577972_1285780470.188.9e-03Click!
IRF6hg19_v2_chr1_-_209979375_2099793890.171.0e-02Click!
IRF4hg19_v2_chr6_+_391739_3917590.128.7e-02Click!

Activity profile of IRF6_IRF4_IRF5 motif

Sorted Z-values of IRF6_IRF4_IRF5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_321050 35.16 ENST00000399808.4
IFITM3
interferon induced transmembrane protein 3
chr11_-_615942 31.35 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr12_+_113344755 30.94 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr3_-_146262428 30.36 ENST00000486631.1
PLSCR1
phospholipid scramblase 1
chr3_-_146262488 29.85 ENST00000487389.1
PLSCR1
phospholipid scramblase 1
chr3_-_146262365 27.98 ENST00000448787.2
PLSCR1
phospholipid scramblase 1
chr3_-_146262352 24.00 ENST00000462666.1
PLSCR1
phospholipid scramblase 1
chr3_-_146262637 23.14 ENST00000472349.1
ENST00000342435.4
PLSCR1
phospholipid scramblase 1
chr11_-_104817919 22.97 ENST00000533252.1
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr21_+_42792442 22.33 ENST00000398600.2
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr3_-_146262293 22.26 ENST00000448205.1
PLSCR1
phospholipid scramblase 1
chr1_-_169680745 21.93 ENST00000236147.4
SELL
selectin L
chr11_-_321340 17.93 ENST00000526811.1
IFITM3
interferon induced transmembrane protein 3
chr12_+_113344582 17.47 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr21_+_42798094 17.45 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr21_+_42733870 16.76 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr9_-_32526184 15.55 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr17_-_20370847 14.22 ENST00000423676.3
ENST00000324290.5
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr9_-_32526299 13.96 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr12_+_113344811 13.63 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr11_+_5710919 13.18 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr11_-_615570 12.23 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr17_+_25958174 10.54 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
LGALS9
lectin, galactoside-binding, soluble, 9
chr7_-_138794081 9.23 ENST00000464606.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr22_+_23247030 9.13 ENST00000390324.2
IGLJ3
immunoglobulin lambda joining 3
chr7_+_12250833 8.94 ENST00000396668.3
TMEM106B
transmembrane protein 106B
chr1_-_59043166 8.83 ENST00000371225.2
TACSTD2
tumor-associated calcium signal transducer 2
chr6_-_82462425 8.71 ENST00000369754.3
ENST00000320172.6
ENST00000369756.3
FAM46A
family with sequence similarity 46, member A
chr17_+_18380051 7.84 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
LGALS9C
lectin, galactoside-binding, soluble, 9C
chr6_+_89791507 7.71 ENST00000354922.3
PNRC1
proline-rich nuclear receptor coactivator 1
chr7_+_12250886 7.15 ENST00000444443.1
ENST00000396667.3
TMEM106B
transmembrane protein 106B
chr17_+_46908350 7.08 ENST00000258947.3
ENST00000509507.1
ENST00000448105.2
ENST00000570513.1
ENST00000509415.1
ENST00000513119.1
ENST00000416445.2
ENST00000508679.1
ENST00000505071.1
CALCOCO2
calcium binding and coiled-coil domain 2
chrX_+_49028265 6.76 ENST00000376322.3
ENST00000376327.5
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr3_-_149095652 6.55 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr1_+_948803 6.20 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr7_+_43798270 6.07 ENST00000265523.4
ENST00000402924.1
BLVRA
biliverdin reductase A
chr12_+_75874460 5.95 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr7_-_138794394 5.68 ENST00000242351.5
ENST00000471652.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr2_-_191878874 5.66 ENST00000392322.3
ENST00000392323.2
ENST00000424722.1
ENST00000361099.3
STAT1
signal transducer and activator of transcription 1, 91kDa
chr12_+_69004619 5.58 ENST00000250559.9
ENST00000393436.5
ENST00000425247.2
ENST00000489473.2
ENST00000422358.2
ENST00000541167.1
ENST00000538283.1
ENST00000341355.5
ENST00000537460.1
ENST00000450214.2
ENST00000545270.1
ENST00000538980.1
ENST00000542018.1
ENST00000543393.1
RAP1B
RAP1B, member of RAS oncogene family
chr10_-_91174215 5.30 ENST00000371837.1
LIPA
lipase A, lysosomal acid, cholesterol esterase
chr12_+_53491220 5.25 ENST00000548547.1
ENST00000301464.3
IGFBP6
insulin-like growth factor binding protein 6
chr12_+_113376157 5.14 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chrX_+_23801280 5.03 ENST00000379251.3
ENST00000379253.3
ENST00000379254.1
ENST00000379270.4
SAT1
spermidine/spermine N1-acetyltransferase 1
chr16_+_28962128 5.02 ENST00000564978.1
ENST00000320805.4
NFATC2IP
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
chr7_-_77045617 4.90 ENST00000257626.7
GSAP
gamma-secretase activating protein
chr12_+_75874580 4.34 ENST00000456650.3
GLIPR1
GLI pathogenesis-related 1
chr13_-_46961580 4.33 ENST00000378787.3
ENST00000378797.2
ENST00000429979.1
ENST00000378781.3
KIAA0226L
KIAA0226-like
chr12_-_51664058 4.27 ENST00000605627.1
SMAGP
small cell adhesion glycoprotein
chr12_+_75874984 4.26 ENST00000550491.1
GLIPR1
GLI pathogenesis-related 1
chr7_+_106809406 4.06 ENST00000468410.1
ENST00000478930.1
ENST00000464009.1
ENST00000222574.4
HBP1
HMG-box transcription factor 1
chr2_-_191878681 4.03 ENST00000409465.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr12_+_62654119 4.00 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
USP15
ubiquitin specific peptidase 15
chr14_+_94577074 3.87 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
IFI27
interferon, alpha-inducible protein 27
chr11_+_128563652 3.80 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr2_+_201981527 3.47 ENST00000441224.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr14_+_22931924 3.42 ENST00000390477.2
TRDC
T cell receptor delta constant
chr4_-_39529180 3.39 ENST00000515021.1
ENST00000510490.1
ENST00000316423.6
UGDH
UDP-glucose 6-dehydrogenase
chr2_-_198299726 3.38 ENST00000409915.4
ENST00000487698.1
ENST00000414963.2
ENST00000335508.6
SF3B1
splicing factor 3b, subunit 1, 155kDa
chr2_-_89417335 3.34 ENST00000490686.1
IGKV1-17
immunoglobulin kappa variable 1-17
chr1_-_160990886 3.13 ENST00000537746.1
F11R
F11 receptor
chr19_+_10196781 3.13 ENST00000253110.11
C19orf66
chromosome 19 open reading frame 66
chr11_-_126138808 3.08 ENST00000332118.6
ENST00000532259.1
SRPR
signal recognition particle receptor (docking protein)
chr15_-_85259330 3.04 ENST00000560266.1
SEC11A
SEC11 homolog A (S. cerevisiae)
chr2_-_37384175 3.02 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr15_-_85259294 2.96 ENST00000558217.1
ENST00000558196.1
ENST00000558134.1
SEC11A
SEC11 homolog A (S. cerevisiae)
chr11_-_57335280 2.96 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr16_-_67970990 2.88 ENST00000358514.4
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr7_+_94023873 2.86 ENST00000297268.6
COL1A2
collagen, type I, alpha 2
chr19_-_17516449 2.84 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr2_-_47572105 2.80 ENST00000419035.1
ENST00000448713.1
ENST00000450550.1
ENST00000413185.2
AC073283.4
AC073283.4
chr2_+_68961934 2.77 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr2_+_201981119 2.75 ENST00000395148.2
CFLAR
CASP8 and FADD-like apoptosis regulator
chr2_+_68961905 2.72 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr12_-_51663959 2.71 ENST00000604188.1
ENST00000398453.3
SMAGP
small cell adhesion glycoprotein
chr17_-_36981556 2.66 ENST00000536127.1
ENST00000225428.5
CWC25
CWC25 spliceosome-associated protein homolog (S. cerevisiae)
chr11_-_118134997 2.64 ENST00000278937.2
MPZL2
myelin protein zero-like 2
chr12_-_51663728 2.58 ENST00000603864.1
ENST00000605426.1
SMAGP
small cell adhesion glycoprotein
chr1_+_221051699 2.57 ENST00000366903.6
HLX
H2.0-like homeobox
chr6_+_32605195 2.56 ENST00000374949.2
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr7_-_148823387 2.54 ENST00000483014.1
ENST00000378061.2
ZNF425
zinc finger protein 425
chr9_+_112542591 2.44 ENST00000483909.1
ENST00000314527.4
ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
PALM2
PALM2-AKAP2
AKAP2
paralemmin 2
PALM2-AKAP2 readthrough
A kinase (PRKA) anchor protein 2
chr14_+_39736582 2.42 ENST00000556148.1
ENST00000348007.3
CTAGE5
CTAGE family, member 5
chr3_-_15374033 2.40 ENST00000253688.5
ENST00000383791.3
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr12_+_121131970 2.30 ENST00000535656.1
MLEC
malectin
chr19_+_36705504 2.27 ENST00000456324.1
ZNF146
zinc finger protein 146
chr15_-_85259360 2.20 ENST00000559729.1
SEC11A
SEC11 homolog A (S. cerevisiae)
chr9_-_100881466 2.13 ENST00000341469.2
ENST00000342043.3
ENST00000375098.3
TRIM14
tripartite motif containing 14
chr19_-_9546227 2.10 ENST00000361451.2
ENST00000361151.1
ZNF266
zinc finger protein 266
chr3_-_15374659 2.08 ENST00000426925.1
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr17_+_6659153 2.06 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr4_+_109541772 2.05 ENST00000506397.1
ENST00000394668.2
RPL34
ribosomal protein L34
chr17_-_7164410 2.05 ENST00000574070.1
CLDN7
claudin 7
chr18_-_812231 1.92 ENST00000314574.4
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr17_-_76778339 1.91 ENST00000591455.1
ENST00000446868.3
ENST00000361101.4
ENST00000589296.1
CYTH1
cytohesin 1
chr1_-_25558963 1.91 ENST00000354361.3
SYF2
SYF2 pre-mRNA-splicing factor
chr19_-_9546177 1.89 ENST00000592292.1
ENST00000588221.1
ZNF266
zinc finger protein 266
chr2_-_160473114 1.88 ENST00000392783.2
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr4_+_95373037 1.88 ENST00000359265.4
ENST00000437932.1
ENST00000380180.3
ENST00000318007.5
ENST00000450793.1
ENST00000538141.1
ENST00000317968.4
ENST00000512274.1
ENST00000503974.1
ENST00000504489.1
ENST00000542407.1
PDLIM5
PDZ and LIM domain 5
chr18_+_3262954 1.85 ENST00000584539.1
MYL12B
myosin, light chain 12B, regulatory
chr4_-_103748271 1.84 ENST00000343106.5
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr4_-_77134742 1.83 ENST00000452464.2
SCARB2
scavenger receptor class B, member 2
chr16_+_3068393 1.82 ENST00000573001.1
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr11_+_130029457 1.78 ENST00000278742.5
ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr13_-_76056250 1.78 ENST00000377636.3
ENST00000431480.2
ENST00000377625.2
ENST00000425511.1
TBC1D4
TBC1 domain family, member 4
chr6_+_64282447 1.75 ENST00000370650.2
ENST00000578299.1
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr18_-_812517 1.72 ENST00000584307.1
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr16_-_88851618 1.71 ENST00000301015.9
PIEZO1
piezo-type mechanosensitive ion channel component 1
chr1_-_89357179 1.69 ENST00000448623.1
ENST00000418217.1
ENST00000370500.5
GTF2B
general transcription factor IIB
chr12_+_70133152 1.68 ENST00000550536.1
ENST00000362025.5
RAB3IP
RAB3A interacting protein
chr11_+_695614 1.67 ENST00000608174.1
ENST00000397512.3
TMEM80
transmembrane protein 80
chr20_-_20033052 1.67 ENST00000536226.1
CRNKL1
crooked neck pre-mRNA splicing factor 1
chr18_+_42260861 1.58 ENST00000282030.5
SETBP1
SET binding protein 1
chr7_-_20256965 1.55 ENST00000400331.5
ENST00000332878.4
MACC1
metastasis associated in colon cancer 1
chr2_+_7017796 1.55 ENST00000382040.3
RSAD2
radical S-adenosyl methionine domain containing 2
chr16_+_3062457 1.52 ENST00000445369.2
CLDN9
claudin 9
chr12_+_124069070 1.47 ENST00000262225.3
ENST00000438031.2
TMED2
transmembrane emp24 domain trafficking protein 2
chr19_+_52264104 1.46 ENST00000340023.6
FPR2
formyl peptide receptor 2
chr1_-_54355430 1.44 ENST00000371399.1
ENST00000072644.1
ENST00000412288.1
YIPF1
Yip1 domain family, member 1
chr19_+_12273866 1.41 ENST00000425827.1
ENST00000439995.1
ENST00000343979.4
ENST00000398616.2
ENST00000418338.1
ZNF136
zinc finger protein 136
chr15_+_41136586 1.40 ENST00000431806.1
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr4_-_77135046 1.36 ENST00000264896.2
SCARB2
scavenger receptor class B, member 2
chr10_+_91174314 1.33 ENST00000371795.4
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr1_+_179262905 1.31 ENST00000539888.1
ENST00000540564.1
ENST00000535686.1
ENST00000367619.3
SOAT1
sterol O-acyltransferase 1
chr2_+_201980827 1.29 ENST00000309955.3
ENST00000443227.1
ENST00000341222.6
ENST00000355558.4
ENST00000340870.5
ENST00000341582.6
CFLAR
CASP8 and FADD-like apoptosis regulator
chr3_-_155572164 1.27 ENST00000392845.3
ENST00000359479.3
SLC33A1
solute carrier family 33 (acetyl-CoA transporter), member 1
chr11_+_809961 1.26 ENST00000530797.1
RPLP2
ribosomal protein, large, P2
chr3_-_185655795 1.25 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
TRA2B
transformer 2 beta homolog (Drosophila)
chr16_+_30751953 1.21 ENST00000483578.1
RP11-2C24.4
RP11-2C24.4
chr2_+_68962014 1.20 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr11_+_809647 1.20 ENST00000321153.4
RPLP2
ribosomal protein, large, P2
chr6_+_32605134 1.18 ENST00000343139.5
ENST00000395363.1
ENST00000496318.1
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr12_+_52643077 1.17 ENST00000553310.2
ENST00000544024.1
KRT86
keratin 86
chr16_+_68119324 1.15 ENST00000349223.5
NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr10_+_71561649 1.14 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
COL13A1
collagen, type XIII, alpha 1
chr16_+_12058961 1.13 ENST00000053243.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr17_-_39677971 1.11 ENST00000393976.2
KRT15
keratin 15
chr19_+_52264449 1.10 ENST00000599326.1
ENST00000598953.1
FPR2
formyl peptide receptor 2
chr4_-_89080003 1.07 ENST00000237612.3
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chrX_-_77041685 1.06 ENST00000373344.5
ENST00000395603.3
ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr5_-_61699698 1.06 ENST00000506390.1
ENST00000199320.4
DIMT1
DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
chr12_-_50616382 1.05 ENST00000552783.1
LIMA1
LIM domain and actin binding 1
chrX_+_47420516 1.03 ENST00000377045.4
ENST00000290277.6
ENST00000377039.2
ARAF
v-raf murine sarcoma 3611 viral oncogene homolog
chr12_+_14518598 1.03 ENST00000261168.4
ENST00000538511.1
ENST00000545723.1
ENST00000543189.1
ENST00000536444.1
ATF7IP
activating transcription factor 7 interacting protein
chr5_-_95297534 1.02 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr5_-_95297678 1.02 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr3_-_182880541 1.02 ENST00000470251.1
ENST00000265598.3
LAMP3
lysosomal-associated membrane protein 3
chr16_+_68119247 1.01 ENST00000575270.1
NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr2_-_55920952 1.01 ENST00000447944.2
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr1_+_46016703 1.01 ENST00000481885.1
ENST00000351829.4
ENST00000471651.1
AKR1A1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr8_-_22926623 1.00 ENST00000276431.4
TNFRSF10B
tumor necrosis factor receptor superfamily, member 10b
chr19_-_4723761 0.99 ENST00000597849.1
ENST00000598800.1
ENST00000602161.1
ENST00000597726.1
ENST00000601130.1
ENST00000262960.9
DPP9
dipeptidyl-peptidase 9
chr16_+_12059050 0.95 ENST00000396495.3
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr10_+_71562180 0.95 ENST00000517713.1
ENST00000522165.1
ENST00000520133.1
COL13A1
collagen, type XIII, alpha 1
chr2_+_208423840 0.94 ENST00000539789.1
CREB1
cAMP responsive element binding protein 1
chr11_-_66056596 0.92 ENST00000471387.2
ENST00000359461.6
ENST00000376901.4
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr1_+_221054584 0.92 ENST00000549319.1
HLX
H2.0-like homeobox
chr2_+_85811525 0.90 ENST00000306384.4
VAMP5
vesicle-associated membrane protein 5
chr15_-_30113676 0.89 ENST00000400011.2
TJP1
tight junction protein 1
chr11_+_32851487 0.89 ENST00000257836.3
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr2_+_163175394 0.88 ENST00000446271.1
ENST00000429691.2
GCA
grancalcin, EF-hand calcium binding protein
chr19_-_47616992 0.86 ENST00000253048.5
ZC3H4
zinc finger CCCH-type containing 4
chr11_+_126173647 0.85 ENST00000263579.4
DCPS
decapping enzyme, scavenger
chr16_+_12059091 0.83 ENST00000562385.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr10_-_72648541 0.83 ENST00000299299.3
PCBD1
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
chr10_+_71561704 0.81 ENST00000520267.1
COL13A1
collagen, type XIII, alpha 1
chr15_+_90544532 0.80 ENST00000268154.4
ZNF710
zinc finger protein 710
chr2_+_99797542 0.78 ENST00000338148.3
ENST00000512183.2
MRPL30
C2orf15
mitochondrial ribosomal protein L30
chromosome 2 open reading frame 15
chr19_-_50528584 0.77 ENST00000594092.1
ENST00000443401.2
ENST00000594948.1
ENST00000377011.2
ENST00000593919.1
ENST00000601324.1
ENST00000316763.3
ENST00000601341.1
ENST00000600259.1
VRK3
vaccinia related kinase 3
chr2_-_163175133 0.76 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr11_-_67141090 0.74 ENST00000312438.7
CLCF1
cardiotrophin-like cytokine factor 1
chr19_+_10196981 0.72 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr10_+_121410882 0.71 ENST00000369085.3
BAG3
BCL2-associated athanogene 3
chr19_+_55897297 0.70 ENST00000431533.2
ENST00000428193.2
ENST00000558815.1
ENST00000560583.1
ENST00000560055.1
ENST00000559463.1
RPL28
ribosomal protein L28
chr4_-_48782259 0.68 ENST00000507711.1
ENST00000358350.4
ENST00000537810.1
ENST00000264319.7
FRYL
FRY-like
chr22_-_31688431 0.67 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr6_+_43738444 0.66 ENST00000324450.6
ENST00000417285.2
ENST00000413642.3
ENST00000372055.4
ENST00000482630.2
ENST00000425836.2
ENST00000372064.4
ENST00000372077.4
ENST00000519767.1
VEGFA
vascular endothelial growth factor A
chr1_+_78769549 0.66 ENST00000370758.1
PTGFR
prostaglandin F receptor (FP)
chr1_+_236687881 0.66 ENST00000526634.1
LGALS8
lectin, galactoside-binding, soluble, 8
chr11_-_66056478 0.60 ENST00000431556.2
ENST00000528575.1
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr3_+_156544057 0.58 ENST00000498839.1
ENST00000470811.1
ENST00000356539.4
ENST00000483177.1
ENST00000477399.1
ENST00000491763.1
LEKR1
leucine, glutamate and lysine rich 1
chr1_-_25558984 0.56 ENST00000236273.4
SYF2
SYF2 pre-mRNA-splicing factor
chr10_+_114710516 0.55 ENST00000542695.1
ENST00000346198.4
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr9_+_112542572 0.53 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr2_-_197664366 0.51 ENST00000409364.3
ENST00000263956.3
GTF3C3
general transcription factor IIIC, polypeptide 3, 102kDa
chr16_+_89642120 0.50 ENST00000268720.5
ENST00000319518.8
CPNE7
copine VII
chr3_-_46037299 0.50 ENST00000296137.2
FYCO1
FYVE and coiled-coil domain containing 1
chr2_-_70780572 0.45 ENST00000450929.1
TGFA
transforming growth factor, alpha
chr19_-_52511334 0.43 ENST00000602063.1
ENST00000597747.1
ENST00000594083.1
ENST00000593650.1
ENST00000599631.1
ENST00000598071.1
ENST00000601178.1
ENST00000376716.5
ENST00000391795.3
ZNF615
zinc finger protein 615
chr17_+_78965624 0.41 ENST00000325167.5
CHMP6
charged multivesicular body protein 6
chr5_+_133707252 0.41 ENST00000506787.1
ENST00000507277.1
UBE2B
ubiquitin-conjugating enzyme E2B
chr9_+_97488939 0.39 ENST00000277198.2
ENST00000297979.5
C9orf3
chromosome 9 open reading frame 3
chr3_+_118892362 0.36 ENST00000497685.1
ENST00000264234.3
UPK1B
uroplakin 1B
chr1_+_241695424 0.34 ENST00000366558.3
ENST00000366559.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr13_-_113242439 0.33 ENST00000375669.3
ENST00000261965.3
TUBGCP3
tubulin, gamma complex associated protein 3
chr6_-_94129244 0.33 ENST00000369303.4
ENST00000369297.1
EPHA7
EPH receptor A7
chr1_+_241695670 0.32 ENST00000366557.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chrX_-_48755030 0.32 ENST00000490755.2
ENST00000465150.2
ENST00000495490.2
TIMM17B
translocase of inner mitochondrial membrane 17 homolog B (yeast)
chr19_+_18942720 0.29 ENST00000262803.5
UPF1
UPF1 regulator of nonsense transcripts homolog (yeast)
chr12_-_56753858 0.29 ENST00000314128.4
ENST00000557235.1
ENST00000418572.2
STAT2
signal transducer and activator of transcription 2, 113kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF6_IRF4_IRF5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
19.7 157.6 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
8.7 43.6 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) negative regulation of macrophage apoptotic process(GO:2000110)
7.6 30.3 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
5.1 56.5 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
3.5 10.5 GO:0032831 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
2.4 9.7 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697)
2.3 59.0 GO:0035456 response to interferon-beta(GO:0035456)
2.1 23.0 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
2.1 12.4 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
1.3 7.6 GO:1901096 regulation of autophagosome maturation(GO:1901096) positive regulation of autophagosome maturation(GO:1901098)
1.1 8.8 GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
1.0 71.8 GO:0045071 negative regulation of viral genome replication(GO:0045071)
1.0 3.0 GO:0009447 putrescine catabolic process(GO:0009447)
1.0 4.0 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
1.0 7.7 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.8 3.2 GO:1905123 regulation of endosome organization(GO:1904978) regulation of glucosylceramidase activity(GO:1905123)
0.7 7.1 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.6 3.5 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.6 1.7 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.6 3.4 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.5 21.9 GO:0033198 response to ATP(GO:0033198)
0.4 1.8 GO:0060671 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.4 1.8 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.4 6.1 GO:0042167 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.4 1.1 GO:1901350 cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.4 8.2 GO:0006465 signal peptide processing(GO:0006465)
0.4 1.5 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.4 1.1 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.3 1.7 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.3 1.0 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853)
0.3 1.3 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.3 1.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.3 16.4 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.3 5.6 GO:0032486 Rap protein signal transduction(GO:0032486)
0.3 2.5 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.3 3.1 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.3 1.3 GO:0051182 coenzyme transport(GO:0051182)
0.2 13.2 GO:0070206 protein trimerization(GO:0070206)
0.2 0.7 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.2 0.7 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.2 4.9 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.2 2.7 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.2 3.8 GO:0035855 megakaryocyte development(GO:0035855)
0.2 4.6 GO:0036120 cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.2 9.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 0.5 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.2 0.3 GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay(GO:0000294)
0.1 5.2 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 1.2 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.1 0.9 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.3 GO:0060948 cardiac vascular smooth muscle cell development(GO:0060948)
0.1 5.3 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.1 5.1 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.1 0.7 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 2.1 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 0.7 GO:1904977 lymphatic endothelial cell migration(GO:1904977)
0.1 2.1 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.1 2.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 3.0 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.7 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.1 2.2 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.1 1.9 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 1.4 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 1.1 GO:0015886 heme transport(GO:0015886) xenobiotic transport(GO:0042908)
0.1 0.8 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.1 8.7 GO:0030193 regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.1 0.7 GO:0071799 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.1 0.9 GO:0035455 response to interferon-alpha(GO:0035455)
0.1 0.5 GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.1 0.2 GO:0032242 regulation of nucleoside transport(GO:0032242)
0.1 1.9 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.8 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.1 1.2 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.1 0.2 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 4.3 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.1 0.3 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.1 1.1 GO:0031167 rRNA methylation(GO:0031167)
0.1 3.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 0.7 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.1 GO:0001172 transcription, RNA-templated(GO:0001172)
0.0 0.3 GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 2.9 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.0 0.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 4.7 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.0 3.0 GO:0030574 collagen catabolic process(GO:0030574)
0.0 5.0 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.3 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 1.0 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.3 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.3 GO:0072178 nephric duct morphogenesis(GO:0072178)
0.0 2.9 GO:0031295 T cell costimulation(GO:0031295)
0.0 0.5 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.9 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 2.9 GO:0038095 Fc-epsilon receptor signaling pathway(GO:0038095)
0.0 0.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 1.0 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.0 2.5 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 9.0 GO:0019216 regulation of lipid metabolic process(GO:0019216)
0.0 0.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 1.0 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 2.3 GO:0070268 cornification(GO:0070268)
0.0 1.5 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 0.7 GO:1903146 regulation of mitophagy(GO:1903146)
0.0 2.8 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.5 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 1.5 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 3.7 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 0.3 GO:0006825 copper ion transport(GO:0006825)
0.0 0.8 GO:0070126 mitochondrial translational termination(GO:0070126)
0.0 0.1 GO:0000733 DNA strand renaturation(GO:0000733)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 23.0 GO:0072557 IPAF inflammasome complex(GO:0072557)
1.2 8.2 GO:0005787 signal peptidase complex(GO:0005787)
0.8 3.0 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.5 5.2 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.5 68.5 GO:0031902 late endosome membrane(GO:0031902)
0.4 7.3 GO:0097342 ripoptosome(GO:0097342)
0.4 3.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.4 165.7 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.4 2.9 GO:1990111 spermatoproteasome complex(GO:1990111)
0.3 1.7 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.3 8.3 GO:0009925 basal plasma membrane(GO:0009925)
0.3 1.0 GO:0097208 alveolar lamellar body(GO:0097208)
0.2 34.3 GO:0005923 bicellular tight junction(GO:0005923)
0.2 3.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 0.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059)
0.2 2.9 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 1.7 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.2 11.6 GO:0035577 azurophil granule membrane(GO:0035577)
0.2 6.3 GO:0000421 autophagosome membrane(GO:0000421)
0.2 13.2 GO:0015030 Cajal body(GO:0015030)
0.2 1.7 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 3.4 GO:0005686 U2 snRNP(GO:0005686) U2-type prespliceosome(GO:0071004)
0.1 1.0 GO:0042788 polysomal ribosome(GO:0042788)
0.1 16.8 GO:0005643 nuclear pore(GO:0005643)
0.1 0.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 42.3 GO:0031965 nuclear membrane(GO:0031965)
0.1 0.9 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 11.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 1.5 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.1 2.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 1.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.5 GO:0033503 HULC complex(GO:0033503)
0.1 0.9 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 0.3 GO:0043296 apical junction complex(GO:0043296)
0.1 1.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 3.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 18.8 GO:0030667 secretory granule membrane(GO:0030667)
0.1 0.3 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.1 0.3 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 21.4 GO:0010008 endosome membrane(GO:0010008)
0.1 7.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 5.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.8 GO:0099738 cell cortex region(GO:0099738)
0.0 1.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 3.3 GO:0072562 blood microparticle(GO:0072562)
0.0 2.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 4.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.9 GO:0014704 intercalated disc(GO:0014704)
0.0 53.8 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 3.4 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.2 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.5 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 9.7 GO:0030424 axon(GO:0030424)
0.0 1.1 GO:0005882 intermediate filament(GO:0005882)
0.0 0.1 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 1.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.1 GO:0000974 Prp19 complex(GO:0000974)
0.0 2.6 GO:0005856 cytoskeleton(GO:0005856)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.9 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.7 GO:0030427 site of polarized growth(GO:0030427)
0.0 1.4 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.2 GO:0001726 ruffle(GO:0001726)
0.0 1.7 GO:0030027 lamellipodium(GO:0030027)
0.0 1.2 GO:0005884 actin filament(GO:0005884)
0.0 0.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.4 GO:0016592 mediator complex(GO:0016592)
0.0 0.3 GO:0031594 neuromuscular junction(GO:0031594)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
14.3 157.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
6.0 59.7 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
3.5 10.5 GO:0048030 disaccharide binding(GO:0048030)
3.1 21.9 GO:0043208 glycosphingolipid binding(GO:0043208)
1.6 23.0 GO:0050700 CARD domain binding(GO:0050700)
1.5 6.1 GO:0004074 biliverdin reductase activity(GO:0004074)
1.1 5.3 GO:0004771 sterol esterase activity(GO:0004771)
1.0 3.0 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.9 11.2 GO:0031386 protein tag(GO:0031386)
0.7 4.0 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.6 2.6 GO:0005124 scavenger receptor binding(GO:0005124)
0.5 11.6 GO:0070403 NAD+ binding(GO:0070403)
0.5 5.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.5 50.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.4 1.3 GO:0051185 coenzyme transporter activity(GO:0051185)
0.4 1.1 GO:0015616 DNA translocase activity(GO:0015616)
0.3 1.0 GO:0034046 poly(G) binding(GO:0034046)
0.3 30.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.3 1.7 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.3 3.7 GO:0032395 MHC class II receptor activity(GO:0032395)
0.3 6.9 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.2 0.7 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.2 1.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.2 0.8 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.2 2.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 6.6 GO:0019956 chemokine binding(GO:0019956)
0.2 1.2 GO:0045569 TRAIL binding(GO:0045569)
0.2 54.7 GO:0008017 microtubule binding(GO:0008017)
0.2 3.9 GO:0005521 lamin binding(GO:0005521)
0.2 0.5 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.1 0.7 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 0.3 GO:0035939 microsatellite binding(GO:0035939)
0.1 1.1 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.1 0.9 GO:1990763 arrestin family protein binding(GO:1990763)
0.1 1.8 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 2.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.0 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.7 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.9 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 1.3 GO:0000339 RNA cap binding(GO:0000339)
0.1 0.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 2.9 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 25.0 GO:0030246 carbohydrate binding(GO:0030246)
0.1 7.4 GO:0001618 virus receptor activity(GO:0001618)
0.1 1.9 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 5.6 GO:0019003 GDP binding(GO:0019003)
0.1 1.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 3.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 2.9 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 5.0 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.1 1.7 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 1.3 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 2.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.0 1.0 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 14.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 14.3 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 3.8 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.3 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.7 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 1.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 1.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.5 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 1.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.3 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.7 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 1.5 GO:0043621 protein self-association(GO:0043621)
0.0 1.0 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.3 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 0.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.9 GO:0051287 NAD binding(GO:0051287)
0.0 2.7 GO:0008201 heparin binding(GO:0008201)
0.0 11.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.2 GO:0005123 death receptor binding(GO:0005123)
0.0 1.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 2.4 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.7 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.6 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 10.0 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.7 21.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4 3.9 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.3 47.4 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 7.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2 22.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.2 8.6 PID NECTIN PATHWAY Nectin adhesion pathway
0.2 33.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 1.3 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 3.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 4.0 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 1.8 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 4.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 3.0 NABA COLLAGENS Genes encoding collagen proteins
0.1 2.6 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 1.2 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 4.0 PID BCR 5PATHWAY BCR signaling pathway
0.1 2.2 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.1 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 2.6 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 1.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.0 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.1 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 5.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.0 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.5 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.3 PID CERAMIDE PATHWAY Ceramide signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 72.0 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
2.3 189.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.5 8.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.5 22.3 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.3 8.5 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.3 2.9 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.3 5.6 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.3 3.5 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.2 3.7 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 21.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 6.1 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 4.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 3.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 6.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 3.0 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 2.3 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.1 13.3 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 0.9 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 1.1 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 1.5 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 4.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.7 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 2.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 3.0 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 3.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.7 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.1 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 2.9 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 3.0 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.9 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 1.6 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.7 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.7 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 5.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.3 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.4 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 2.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 2.6 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters