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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for IRX6_IRX4

Z-value: 0.41

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Transcription factors associated with IRX6_IRX4

Gene Symbol Gene ID Gene Info
IRX6
ENSG00000159387.7 iroquois homeobox 6
IRX4
ENSG00000113430.5 iroquois homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX4hg19_v2_chr5_-_1882858_18830030.082.3e-01Click!

Activity profile of IRX6_IRX4 motif

Sorted Z-values of IRX6_IRX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_46716969 6.82 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr21_-_48024986 6.42 ENST00000291700.4
ENST00000367071.4
S100B
S100 calcium binding protein B
chrX_+_49294472 3.26 ENST00000361446.5
GAGE12B
G antigen 12B
chr15_+_66585555 2.26 ENST00000319194.5
ENST00000525134.2
ENST00000441424.2
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr15_+_66585879 2.25 ENST00000319212.4
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr2_+_58655461 1.91 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
AC007092.1
long intergenic non-protein coding RNA 1122
chr1_+_26644441 1.71 ENST00000374213.2
CD52
CD52 molecule
chr4_+_158142750 1.66 ENST00000505888.1
ENST00000449365.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr20_+_10199468 1.49 ENST00000254976.2
ENST00000304886.2
SNAP25
synaptosomal-associated protein, 25kDa
chr3_-_9994021 1.47 ENST00000411976.2
ENST00000412055.1
PRRT3
proline-rich transmembrane protein 3
chr4_+_158141899 1.41 ENST00000264426.9
ENST00000506284.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr17_-_29641084 1.31 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr14_+_56127989 1.30 ENST00000555573.1
KTN1
kinectin 1 (kinesin receptor)
chr7_-_16844611 1.27 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr17_-_29641104 1.27 ENST00000577894.1
ENST00000330927.4
EVI2B
ecotropic viral integration site 2B
chr12_+_32655048 1.22 ENST00000427716.2
ENST00000266482.3
FGD4
FYVE, RhoGEF and PH domain containing 4
chr1_+_67673297 1.20 ENST00000425614.1
ENST00000395227.1
IL23R
interleukin 23 receptor
chrX_-_15333736 1.12 ENST00000380470.3
ASB11
ankyrin repeat and SOCS box containing 11
chr5_+_54320078 1.11 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chr14_-_21737551 1.09 ENST00000554891.1
ENST00000555883.1
ENST00000553753.1
ENST00000555914.1
ENST00000557336.1
ENST00000555215.1
ENST00000556628.1
ENST00000555137.1
ENST00000556226.1
ENST00000555309.1
ENST00000556142.1
ENST00000554969.1
ENST00000554455.1
ENST00000556513.1
ENST00000557201.1
ENST00000420743.2
ENST00000557768.1
ENST00000553300.1
ENST00000554383.1
ENST00000554539.1
HNRNPC
heterogeneous nuclear ribonucleoprotein C (C1/C2)
chr4_-_143481822 1.00 ENST00000510812.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr22_-_24096562 0.98 ENST00000398465.3
VPREB3
pre-B lymphocyte 3
chr4_-_153303658 0.97 ENST00000296555.5
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chrX_-_19988382 0.97 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
CXorf23
chromosome X open reading frame 23
chr12_-_76462713 0.95 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chr8_+_84824920 0.92 ENST00000523678.1
RP11-120I21.2
RP11-120I21.2
chr8_-_67976509 0.92 ENST00000518747.1
COPS5
COP9 signalosome subunit 5
chr12_-_10282836 0.78 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr1_+_220267429 0.76 ENST00000366922.1
ENST00000302637.5
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr1_+_53308398 0.68 ENST00000371528.1
ZYG11A
zyg-11 family member A, cell cycle regulator
chr8_-_17555164 0.61 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr14_-_23623577 0.57 ENST00000422941.2
ENST00000453702.1
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr4_+_40194609 0.57 ENST00000508513.1
RHOH
ras homolog family member H
chr8_+_27631903 0.54 ENST00000305188.8
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr3_+_171561127 0.52 ENST00000334567.5
ENST00000450693.1
TMEM212
transmembrane protein 212
chr12_-_10282742 0.48 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr10_+_118350468 0.48 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
PNLIPRP1
pancreatic lipase-related protein 1
chr1_-_201438282 0.45 ENST00000367311.3
ENST00000367309.1
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr10_+_118350522 0.45 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
PNLIPRP1
pancreatic lipase-related protein 1
chr5_-_177207634 0.38 ENST00000513554.1
ENST00000440605.3
FAM153A
family with sequence similarity 153, member A
chr4_+_113558612 0.34 ENST00000505034.1
ENST00000324052.6
LARP7
La ribonucleoprotein domain family, member 7
chr9_-_37465396 0.33 ENST00000307750.4
ZBTB5
zinc finger and BTB domain containing 5
chr6_-_52705641 0.29 ENST00000370989.2
GSTA5
glutathione S-transferase alpha 5
chr2_-_231989808 0.24 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr5_+_175490540 0.24 ENST00000515817.1
FAM153B
family with sequence similarity 153, member B
chrX_+_15767971 0.23 ENST00000479740.1
ENST00000454127.2
CA5B
carbonic anhydrase VB, mitochondrial
chr1_-_3566590 0.21 ENST00000424367.1
ENST00000378322.3
WRAP73
WD repeat containing, antisense to TP73
chr8_+_67976593 0.20 ENST00000262210.5
ENST00000412460.1
CSPP1
centrosome and spindle pole associated protein 1
chr1_-_152086556 0.19 ENST00000368804.1
TCHH
trichohyalin
chr2_+_113670548 0.18 ENST00000263326.3
ENST00000352179.3
ENST00000349806.3
ENST00000353225.3
IL37
interleukin 37
chr2_-_183106641 0.14 ENST00000346717.4
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr14_-_106845789 0.13 ENST00000390617.2
IGHV3-35
immunoglobulin heavy variable 3-35 (non-functional)
chrX_+_99899180 0.12 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr7_-_142232071 0.12 ENST00000390364.3
TRBV10-1
T cell receptor beta variable 10-1(gene/pseudogene)
chr21_-_34185944 0.12 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chr3_-_27498235 0.11 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr14_+_22993296 0.09 ENST00000390517.1
TRAJ20
T cell receptor alpha joining 20
chr1_-_3566627 0.09 ENST00000419924.2
ENST00000270708.7
WRAP73
WD repeat containing, antisense to TP73
chr6_-_49834240 0.08 ENST00000335847.4
CRISP1
cysteine-rich secretory protein 1
chr6_-_49834209 0.08 ENST00000507853.1
CRISP1
cysteine-rich secretory protein 1
chr21_-_34186006 0.07 ENST00000490358.1
C21orf62
chromosome 21 open reading frame 62
chr4_-_104119528 0.00 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX6_IRX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.4 GO:2001015 negative regulation of skeletal muscle cell differentiation(GO:2001015)
0.4 6.8 GO:0051639 actin filament network formation(GO:0051639)
0.3 4.5 GO:0016075 rRNA catabolic process(GO:0016075)
0.3 1.2 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.3 1.5 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.3 0.8 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.2 1.3 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.2 1.0 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 3.1 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 1.3 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 0.9 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.2 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 1.1 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0 1.7 GO:0045730 respiratory burst(GO:0045730)
0.0 0.5 GO:0071168 protein localization to chromatin(GO:0071168)
0.0 1.0 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 1.2 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.3 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.4 GO:0015695 organic cation transport(GO:0015695)
0.0 0.1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.6 GO:0034260 negative regulation of GTPase activity(GO:0034260)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.4 1.5 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.3 6.8 GO:0001891 phagocytic cup(GO:0001891)
0.3 1.2 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.3 4.5 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 1.0 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.7 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.9 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 7.6 GO:0001726 ruffle(GO:0001726)
0.0 1.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:0001772 immunological synapse(GO:0001772)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.4 GO:0048156 tau protein binding(GO:0048156)
0.3 1.2 GO:0042020 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.3 3.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.3 0.8 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.2 1.0 GO:0052828 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.1 4.5 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.1 1.0 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.9 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.1 1.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 1.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 1.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.3 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.9 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.4 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.6 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 1.3 GO:0019894 kinesin binding(GO:0019894)
0.0 6.6 GO:0051015 actin filament binding(GO:0051015)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.2 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 1.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.1 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.2 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.0 PID MYC PATHWAY C-MYC pathway
0.0 0.9 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 6.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.1 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.4 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 3.1 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 1.5 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 1.0 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.8 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane