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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for JUND

Z-value: 0.93

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Transcription factors associated with JUND

Gene Symbol Gene ID Gene Info
JUND
ENSG00000130522.4 JunD proto-oncogene, AP-1 transcription factor subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
JUNDhg19_v2_chr19_-_18391708_183917390.608.5e-23Click!

Activity profile of JUND motif

Sorted Z-values of JUND motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_84035905 21.77 ENST00000311507.4
PLAC8
placenta-specific 8
chr4_-_84035868 21.00 ENST00000426923.2
ENST00000509973.1
PLAC8
placenta-specific 8
chr3_-_18466026 17.64 ENST00000417717.2
SATB1
SATB homeobox 1
chr5_-_140013275 13.87 ENST00000512545.1
ENST00000302014.6
ENST00000401743.2
CD14
CD14 molecule
chr22_-_37545972 13.70 ENST00000216223.5
IL2RB
interleukin 2 receptor, beta
chr15_+_89182178 12.32 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr16_+_23847339 12.15 ENST00000303531.7
PRKCB
protein kinase C, beta
chr15_+_89181974 11.99 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr12_+_54891495 10.44 ENST00000293373.6
NCKAP1L
NCK-associated protein 1-like
chr1_-_153348067 9.83 ENST00000368737.3
S100A12
S100 calcium binding protein A12
chr1_+_117297007 8.65 ENST00000369478.3
ENST00000369477.1
CD2
CD2 molecule
chr19_+_13842559 8.55 ENST00000586600.1
CCDC130
coiled-coil domain containing 130
chr6_-_24936170 8.41 ENST00000538035.1
FAM65B
family with sequence similarity 65, member B
chr15_+_89182156 8.10 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr1_+_26605618 7.62 ENST00000270792.5
SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr11_-_5255696 7.55 ENST00000292901.3
ENST00000417377.1
HBD
hemoglobin, delta
chr16_+_31366536 7.14 ENST00000562522.1
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr7_+_79998864 7.04 ENST00000435819.1
CD36
CD36 molecule (thrombospondin receptor)
chr21_+_42733870 6.73 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr3_+_46412345 6.69 ENST00000292303.4
CCR5
chemokine (C-C motif) receptor 5 (gene/pseudogene)
chr11_+_67250490 6.59 ENST00000528641.2
ENST00000279146.3
AIP
aryl hydrocarbon receptor interacting protein
chr16_+_31366455 6.10 ENST00000268296.4
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr14_-_25103388 5.91 ENST00000526004.1
ENST00000415355.3
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr14_-_25103472 5.83 ENST00000216341.4
ENST00000382542.1
ENST00000382540.1
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr14_+_58765103 5.80 ENST00000355431.3
ENST00000348476.3
ENST00000395168.3
ARID4A
AT rich interactive domain 4A (RBP1-like)
chr14_-_23426322 5.52 ENST00000555367.1
HAUS4
HAUS augmin-like complex, subunit 4
chr14_-_23426270 5.42 ENST00000557591.1
ENST00000397409.4
ENST00000490506.1
ENST00000554406.1
HAUS4
HAUS augmin-like complex, subunit 4
chrY_+_15016725 5.31 ENST00000336079.3
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr12_+_62654119 5.28 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
USP15
ubiquitin specific peptidase 15
chr14_-_23426337 5.27 ENST00000342454.8
ENST00000555986.1
ENST00000541587.1
ENST00000554516.1
ENST00000347758.2
ENST00000206474.7
ENST00000555040.1
HAUS4
HAUS augmin-like complex, subunit 4
chr20_+_30946106 4.99 ENST00000375687.4
ENST00000542461.1
ASXL1
additional sex combs like 1 (Drosophila)
chr3_-_49395705 4.95 ENST00000419349.1
GPX1
glutathione peroxidase 1
chr18_-_74207146 4.81 ENST00000443185.2
ZNF516
zinc finger protein 516
chr12_+_62654155 4.66 ENST00000312635.6
ENST00000393654.3
ENST00000549237.1
USP15
ubiquitin specific peptidase 15
chr3_-_105588231 4.52 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr22_+_23101182 4.47 ENST00000390312.2
IGLV2-14
immunoglobulin lambda variable 2-14
chr22_+_22707260 4.44 ENST00000390293.1
IGLV5-48
immunoglobulin lambda variable 5-48 (non-functional)
chr12_-_8218997 4.06 ENST00000307637.4
C3AR1
complement component 3a receptor 1
chr16_+_28996114 3.90 ENST00000395461.3
LAT
linker for activation of T cells
chr5_-_141061759 3.43 ENST00000508305.1
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr10_+_17270214 3.27 ENST00000544301.1
VIM
vimentin
chr5_-_141061777 3.26 ENST00000239440.4
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr3_-_52713729 3.12 ENST00000296302.7
ENST00000356770.4
ENST00000337303.4
ENST00000409057.1
ENST00000410007.1
ENST00000409114.3
ENST00000409767.1
ENST00000423351.1
PBRM1
polybromo 1
chr14_-_24711470 3.11 ENST00000559969.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr5_-_138533973 3.06 ENST00000507002.1
ENST00000505830.1
ENST00000508639.1
ENST00000265195.5
SIL1
SIL1 nucleotide exchange factor
chr3_+_30647994 3.03 ENST00000295754.5
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr8_+_128426535 2.90 ENST00000465342.2
POU5F1B
POU class 5 homeobox 1B
chr2_+_201980827 2.82 ENST00000309955.3
ENST00000443227.1
ENST00000341222.6
ENST00000355558.4
ENST00000340870.5
ENST00000341582.6
CFLAR
CASP8 and FADD-like apoptosis regulator
chr9_-_73029540 2.68 ENST00000377126.2
KLF9
Kruppel-like factor 9
chr3_-_122512619 2.62 ENST00000383659.1
ENST00000306103.2
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr19_-_54872556 2.55 ENST00000444687.1
LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr1_-_205744574 2.53 ENST00000367139.3
ENST00000235932.4
ENST00000437324.2
ENST00000414729.1
RAB7L1
RAB7, member RAS oncogene family-like 1
chr1_-_6662919 2.51 ENST00000377658.4
ENST00000377663.3
KLHL21
kelch-like family member 21
chr10_-_81708854 2.50 ENST00000372292.3
SFTPD
surfactant protein D
chr16_-_67281413 2.47 ENST00000258201.4
FHOD1
formin homology 2 domain containing 1
chr3_-_150996239 2.46 ENST00000309170.3
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr11_-_2162162 2.40 ENST00000381389.1
IGF2
insulin-like growth factor 2 (somatomedin A)
chr12_-_8765446 2.40 ENST00000537228.1
ENST00000229335.6
AICDA
activation-induced cytidine deaminase
chrX_-_154563889 2.39 ENST00000369449.2
ENST00000321926.4
CLIC2
chloride intracellular channel 2
chr17_+_1936687 2.39 ENST00000570477.1
DPH1
diphthamide biosynthesis 1
chr12_+_9142131 2.34 ENST00000356986.3
ENST00000266551.4
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr5_-_138534071 2.22 ENST00000394817.2
SIL1
SIL1 nucleotide exchange factor
chrX_-_51797351 2.11 ENST00000375644.3
RP11-114H20.1
RP11-114H20.1
chr14_+_73525144 2.07 ENST00000261973.7
ENST00000540173.1
RBM25
RNA binding motif protein 25
chr2_+_169926047 1.92 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr18_-_19283649 1.88 ENST00000584464.1
ENST00000578270.1
ABHD3
abhydrolase domain containing 3
chr12_+_52695617 1.84 ENST00000293525.5
KRT86
keratin 86
chr1_+_41204506 1.81 ENST00000525290.1
ENST00000530965.1
ENST00000416859.2
ENST00000308733.5
NFYC
nuclear transcription factor Y, gamma
chrX_+_51942963 1.65 ENST00000375625.3
RP11-363G10.2
RP11-363G10.2
chr14_+_73525229 1.57 ENST00000527432.1
ENST00000531500.1
ENST00000525321.1
ENST00000526754.1
RBM25
RNA binding motif protein 25
chr4_-_100356291 1.55 ENST00000476959.1
ENST00000482593.1
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr6_+_149539767 1.48 ENST00000606202.1
ENST00000536230.1
ENST00000445901.1
TAB2
RP1-111D6.3
TGF-beta activated kinase 1/MAP3K7 binding protein 2
RP1-111D6.3
chr1_+_160709029 1.45 ENST00000444090.2
ENST00000441662.2
SLAMF7
SLAM family member 7
chr3_+_127771212 1.35 ENST00000243253.3
ENST00000481210.1
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr2_+_102615416 1.27 ENST00000393414.2
IL1R2
interleukin 1 receptor, type II
chr20_+_48429233 1.26 ENST00000417961.1
SLC9A8
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chrX_-_153718953 1.25 ENST00000369649.4
ENST00000393586.1
SLC10A3
solute carrier family 10, member 3
chr19_+_11546093 1.14 ENST00000591462.1
PRKCSH
protein kinase C substrate 80K-H
chr15_-_42565606 1.12 ENST00000307216.6
ENST00000448392.1
TMEM87A
transmembrane protein 87A
chr20_+_48429356 1.09 ENST00000361573.2
ENST00000541138.1
ENST00000539601.1
SLC9A8
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr19_+_35820064 0.98 ENST00000341773.6
ENST00000600131.1
ENST00000270311.6
ENST00000595780.1
ENST00000597916.1
ENST00000593867.1
ENST00000600424.1
ENST00000599811.1
ENST00000536635.2
ENST00000085219.5
ENST00000544992.2
ENST00000419549.2
CD22
CD22 molecule
chr5_-_135701164 0.96 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
TRPC7
transient receptor potential cation channel, subfamily C, member 7
chr8_-_17752912 0.95 ENST00000398054.1
ENST00000381840.2
FGL1
fibrinogen-like 1
chrX_+_78200829 0.93 ENST00000544091.1
P2RY10
purinergic receptor P2Y, G-protein coupled, 10
chr4_-_100356551 0.92 ENST00000209665.4
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr16_+_28996364 0.86 ENST00000564277.1
LAT
linker for activation of T cells
chr3_+_45067659 0.73 ENST00000296130.4
CLEC3B
C-type lectin domain family 3, member B
chr12_-_8380183 0.59 ENST00000442295.2
ENST00000307435.6
ENST00000538603.1
FAM90A1
family with sequence similarity 90, member A1
chr6_-_44281043 0.59 ENST00000244571.4
AARS2
alanyl-tRNA synthetase 2, mitochondrial
chr10_-_14996070 0.58 ENST00000378258.1
ENST00000453695.2
ENST00000378246.2
DCLRE1C
DNA cross-link repair 1C
chr2_+_161993412 0.56 ENST00000259075.2
ENST00000432002.1
TANK
TRAF family member-associated NFKB activator
chr10_-_14996017 0.55 ENST00000378241.1
ENST00000456122.1
ENST00000418843.1
ENST00000378249.1
ENST00000396817.2
ENST00000378255.1
ENST00000378254.1
ENST00000378278.2
ENST00000357717.2
DCLRE1C
DNA cross-link repair 1C
chr1_+_160709055 0.54 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAMF7
SLAM family member 7
chr1_+_223889310 0.50 ENST00000434648.1
CAPN2
calpain 2, (m/II) large subunit
chr1_+_207262881 0.47 ENST00000451804.2
C4BPB
complement component 4 binding protein, beta
chr8_-_17752996 0.47 ENST00000381841.2
ENST00000427924.1
FGL1
fibrinogen-like 1
chr22_-_39715600 0.47 ENST00000427905.1
ENST00000402527.1
ENST00000216146.4
RPL3
ribosomal protein L3
chr10_-_74114714 0.43 ENST00000338820.3
ENST00000394903.2
ENST00000444643.2
DNAJB12
DnaJ (Hsp40) homolog, subfamily B, member 12
chr18_+_32290218 0.42 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
DTNA
dystrobrevin, alpha
chr17_-_7590745 0.40 ENST00000514944.1
ENST00000503591.1
ENST00000455263.2
ENST00000420246.2
ENST00000445888.2
ENST00000509690.1
ENST00000604348.1
ENST00000269305.4
TP53
tumor protein p53
chr17_-_45899126 0.38 ENST00000007414.3
ENST00000392507.3
OSBPL7
oxysterol binding protein-like 7
chr14_+_73525265 0.32 ENST00000525161.1
RBM25
RNA binding motif protein 25
chr11_-_2162468 0.29 ENST00000434045.2
IGF2
insulin-like growth factor 2 (somatomedin A)
chr17_+_30771279 0.28 ENST00000261712.3
ENST00000578213.1
ENST00000457654.2
ENST00000579451.1
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr1_-_1342617 0.24 ENST00000482352.1
ENST00000344843.7
MRPL20
mitochondrial ribosomal protein L20
chr15_+_75335604 0.18 ENST00000563393.1
PPCDC
phosphopantothenoylcysteine decarboxylase
chr3_+_155860751 0.13 ENST00000471742.1
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr2_+_113670548 0.10 ENST00000263326.3
ENST00000352179.3
ENST00000349806.3
ENST00000353225.3
IL37
interleukin 37
chr17_+_41052808 0.07 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
G6PC
glucose-6-phosphatase, catalytic subunit
chr17_-_59668550 0.07 ENST00000521764.1
NACA2
nascent polypeptide-associated complex alpha subunit 2
chr20_-_17539456 0.05 ENST00000544874.1
ENST00000377868.2
BFSP1
beaded filament structural protein 1, filensin
chr3_+_11178779 0.03 ENST00000438284.2
HRH1
histamine receptor H1
chr12_-_7818474 0.02 ENST00000229304.4
APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr9_-_95432536 0.00 ENST00000287996.3
IPPK
inositol 1,3,4,5,6-pentakisphosphate 2-kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of JUND

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
10.8 32.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
4.0 12.1 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
3.5 13.9 GO:0071727 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
2.6 10.4 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) actin polymerization-dependent cell motility(GO:0070358)
2.5 9.9 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
2.4 42.8 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
2.0 13.7 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
1.7 11.7 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
1.7 5.0 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
1.5 5.8 GO:0097368 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
1.4 8.6 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
1.4 16.2 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
1.2 7.0 GO:0071724 toll-like receptor TLR6:TLR2 signaling pathway(GO:0038124) response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
1.1 6.6 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
1.0 3.0 GO:0002661 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
1.0 5.0 GO:0009608 response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609)
1.0 6.7 GO:0044800 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
1.0 6.7 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.8 2.5 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.6 2.5 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.6 6.7 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.5 3.1 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.5 7.6 GO:0015671 oxygen transport(GO:0015671)
0.4 2.7 GO:0051414 response to cortisol(GO:0051414)
0.4 4.5 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.3 2.4 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.3 1.3 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.3 2.4 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.3 2.7 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.3 3.3 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.3 2.8 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.3 4.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.3 1.4 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.2 2.5 GO:0051660 establishment of centrosome localization(GO:0051660)
0.2 9.8 GO:0050832 defense response to fungus(GO:0050832)
0.2 3.4 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.2 0.4 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
0.2 0.6 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.2 1.9 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2 2.4 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.2 13.2 GO:0034113 heterotypic cell-cell adhesion(GO:0034113)
0.1 2.3 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 4.8 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 16.2 GO:0051225 spindle assembly(GO:0051225)
0.1 7.6 GO:0030834 regulation of actin filament depolymerization(GO:0030834)
0.1 0.7 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.1 1.1 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 2.5 GO:0034629 cellular protein complex localization(GO:0034629)
0.1 5.3 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 0.5 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
0.1 4.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 4.8 GO:0043303 mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.0 1.0 GO:0006828 manganese ion transport(GO:0006828)
0.0 1.1 GO:0006491 N-glycan processing(GO:0006491)
0.0 1.9 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 1.5 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.0 2.3 GO:0006968 cellular defense response(GO:0006968)
0.0 0.4 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 1.8 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 0.4 GO:0071397 cellular response to cholesterol(GO:0071397)
0.0 3.3 GO:0002377 immunoglobulin production(GO:0002377)
0.0 4.5 GO:0038095 Fc-epsilon receptor signaling pathway(GO:0038095)
0.0 0.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 3.1 GO:0006338 chromatin remodeling(GO:0006338)
0.0 5.0 GO:0009615 response to virus(GO:0009615)
0.0 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.4 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.1 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 13.9 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
1.8 16.2 GO:0070652 HAUS complex(GO:0070652)
1.6 6.6 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.7 10.4 GO:0031209 SCAR complex(GO:0031209)
0.6 3.1 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.5 7.6 GO:0005833 hemoglobin complex(GO:0005833)
0.5 5.0 GO:0097413 Lewy body(GO:0097413)
0.5 32.3 GO:0015030 Cajal body(GO:0015030)
0.4 17.6 GO:0005720 nuclear heterochromatin(GO:0005720)
0.4 42.8 GO:0035578 azurophil granule lumen(GO:0035578)
0.3 3.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.3 16.5 GO:0001772 immunological synapse(GO:0001772)
0.3 2.5 GO:0005827 polar microtubule(GO:0005827)
0.3 13.2 GO:0008305 integrin complex(GO:0008305)
0.3 8.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 7.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 0.7 GO:0001652 granular component(GO:0001652)
0.2 1.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 2.8 GO:0097342 ripoptosome(GO:0097342)
0.1 2.5 GO:0032059 bleb(GO:0032059)
0.1 2.5 GO:0042599 lamellar body(GO:0042599)
0.1 1.4 GO:0005577 fibrinogen complex(GO:0005577)
0.1 5.0 GO:0031519 PcG protein complex(GO:0031519)
0.1 2.4 GO:0000178 exosome (RNase complex)(GO:0000178)
0.1 3.1 GO:0090544 BAF-type complex(GO:0090544)
0.1 1.1 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.1 5.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 6.6 GO:0035579 specific granule membrane(GO:0035579)
0.1 17.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.8 GO:0045095 keratin filament(GO:0045095)
0.0 2.4 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 9.3 GO:0034774 secretory granule lumen(GO:0034774)
0.0 5.3 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 6.5 GO:0030027 lamellipodium(GO:0030027)
0.0 3.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 3.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 4.0 GO:0005681 spliceosomal complex(GO:0005681)
0.0 2.4 GO:0005643 nuclear pore(GO:0005643)
0.0 3.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.5 GO:0044215 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
10.8 32.4 GO:0008859 exoribonuclease II activity(GO:0008859)
4.6 13.9 GO:0016019 peptidoglycan receptor activity(GO:0016019)
4.0 12.1 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
3.4 13.7 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
1.7 9.9 GO:0061649 ubiquitinated histone binding(GO:0061649)
1.2 7.0 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.8 3.0 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.6 2.5 GO:0035276 aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
0.6 7.6 GO:0005344 oxygen transporter activity(GO:0005344)
0.5 3.3 GO:1990254 keratin filament binding(GO:1990254)
0.5 7.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.5 6.7 GO:0019957 C-C chemokine binding(GO:0019957)
0.5 9.7 GO:0050786 RAGE receptor binding(GO:0050786)
0.5 6.6 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.4 2.5 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.4 1.9 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.4 5.0 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.3 2.4 GO:0004126 cytidine deaminase activity(GO:0004126)
0.3 1.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.3 4.1 GO:0004875 complement receptor activity(GO:0004875)
0.3 1.9 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.3 6.7 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3 1.3 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.2 7.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 2.3 GO:0015385 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.2 0.6 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 1.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 13.1 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 5.8 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 2.8 GO:0005123 death receptor binding(GO:0005123)
0.1 4.8 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 5.3 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.1 1.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 52.5 GO:0003682 chromatin binding(GO:0003682)
0.1 1.0 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 4.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 3.1 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 0.9 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 15.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.5 GO:0043621 protein self-association(GO:0043621)
0.0 0.5 GO:0008097 5S rRNA binding(GO:0008097)
0.0 1.8 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 5.3 GO:0051082 unfolded protein binding(GO:0051082)
0.0 3.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.1 GO:0005080 protein kinase C binding(GO:0005080)
0.0 1.4 GO:0043022 ribosome binding(GO:0043022)
0.0 5.4 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.1 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.4 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 4.1 GO:0008017 microtubule binding(GO:0008017)
0.0 3.0 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 14.4 GO:0004872 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 16.9 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.4 13.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.4 11.7 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.3 13.2 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.2 12.9 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.2 14.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 2.8 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 4.5 PID CD40 PATHWAY CD40/CD40L signaling
0.1 6.7 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 3.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 2.8 PID IL1 PATHWAY IL1-mediated signaling events
0.1 5.3 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 0.4 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 2.1 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 2.4 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.1 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 2.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.0 PID BCR 5PATHWAY BCR signaling pathway
0.0 2.5 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 8.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.5 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.7 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
1.2 13.9 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.5 5.0 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.4 39.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.4 12.1 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.4 9.7 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.3 2.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.3 12.9 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.2 12.1 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.2 21.9 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.2 14.5 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.2 3.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 4.5 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 1.5 REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.2 3.0 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 4.8 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.1 1.0 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 2.8 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 2.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 8.7 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.1 1.1 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 3.1 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 7.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 6.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.6 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.3 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 2.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism