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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for LHX3

Z-value: 0.55

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Transcription factors associated with LHX3

Gene Symbol Gene ID Gene Info
LHX3
ENSG00000107187.11 LIM homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX3hg19_v2_chr9_-_139094988_139095012,
hg19_v2_chr9_-_139096955_139096979		-0.426.8e-11Click!

Activity profile of LHX3 motif

Sorted Z-values of LHX3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_24126023 6.16 ENST00000429356.1
GALE
UDP-galactose-4-epimerase
chr1_-_150208320 6.10 ENST00000534220.1
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr1_-_150208412 5.87 ENST00000532744.1
ENST00000369114.5
ENST00000369115.2
ENST00000369116.4
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr1_-_150208363 5.83 ENST00000436748.2
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr6_+_26104104 5.34 ENST00000377803.2
HIST1H4C
histone cluster 1, H4c
chr3_-_141747950 5.31 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chrX_+_107288197 5.13 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr1_-_150208291 4.79 ENST00000533654.1
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr4_+_113568207 4.60 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chrX_+_107288239 4.56 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr15_+_65843130 3.95 ENST00000569894.1
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr17_-_60142609 3.29 ENST00000397786.2
MED13
mediator complex subunit 13
chr5_-_43557791 3.22 ENST00000338972.4
ENST00000511321.1
ENST00000515338.1
PAIP1
poly(A) binding protein interacting protein 1
chr9_-_128246769 3.15 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr3_+_141106643 3.01 ENST00000514251.1
ZBTB38
zinc finger and BTB domain containing 38
chr14_+_39583427 2.98 ENST00000308317.6
ENST00000396249.2
ENST00000250379.8
ENST00000534684.2
ENST00000527381.1
GEMIN2
gem (nuclear organelle) associated protein 2
chrX_-_55057403 2.93 ENST00000396198.3
ENST00000335854.4
ENST00000455688.1
ENST00000330807.5
ALAS2
aminolevulinate, delta-, synthase 2
chr3_-_141719195 2.90 ENST00000397991.4
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr15_+_64680003 2.88 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr17_+_35851570 2.79 ENST00000394386.1
DUSP14
dual specificity phosphatase 14
chr12_-_118628350 2.78 ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr1_-_45988542 2.60 ENST00000424390.1
PRDX1
peroxiredoxin 1
chr3_+_138340049 2.48 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chr17_-_27418537 2.42 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr3_+_69812877 2.38 ENST00000457080.1
ENST00000328528.6
MITF
microphthalmia-associated transcription factor
chr4_+_41937131 2.31 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
TMEM33
transmembrane protein 33
chrX_-_106243451 2.29 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr16_+_15489603 2.25 ENST00000568766.1
ENST00000287594.7
RP11-1021N1.1
MPV17L
Uncharacterized protein
MPV17 mitochondrial membrane protein-like
chr3_+_157827841 2.18 ENST00000295930.3
ENST00000471994.1
ENST00000464171.1
ENST00000312179.6
ENST00000475278.2
RSRC1
arginine/serine-rich coiled-coil 1
chr16_-_28634874 2.13 ENST00000395609.1
ENST00000350842.4
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr11_-_67980744 1.85 ENST00000401547.2
ENST00000453170.1
ENST00000304363.4
SUV420H1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chr5_+_67586465 1.81 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr3_+_138340067 1.77 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr7_+_107224364 1.74 ENST00000491150.1
BCAP29
B-cell receptor-associated protein 29
chr5_-_78809950 1.63 ENST00000334082.6
HOMER1
homer homolog 1 (Drosophila)
chr12_+_64798095 1.58 ENST00000332707.5
XPOT
exportin, tRNA
chr12_+_4385230 1.47 ENST00000536537.1
CCND2
cyclin D2
chr14_-_21566731 1.39 ENST00000360947.3
ZNF219
zinc finger protein 219
chr9_-_75567962 1.36 ENST00000297785.3
ENST00000376939.1
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr15_-_20193370 1.21 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr7_-_22862406 1.16 ENST00000372879.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr2_-_99279928 1.16 ENST00000414521.2
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr2_-_145278475 1.15 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr19_+_48949030 1.14 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr11_+_59824127 1.12 ENST00000278865.3
MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr4_-_41884620 1.11 ENST00000504870.1
LINC00682
long intergenic non-protein coding RNA 682
chr5_-_88119580 1.11 ENST00000539796.1
MEF2C
myocyte enhancer factor 2C
chr11_+_59824060 1.10 ENST00000395032.2
ENST00000358152.2
MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr12_-_7656357 1.05 ENST00000396620.3
ENST00000432237.2
ENST00000359156.4
CD163
CD163 molecule
chrX_-_13835147 1.05 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr18_+_72201829 1.02 ENST00000582365.1
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr6_+_83072923 0.91 ENST00000535040.1
TPBG
trophoblast glycoprotein
chrX_+_9431324 0.89 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr7_-_36764142 0.86 ENST00000258749.5
ENST00000535891.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr3_+_63953415 0.85 ENST00000484332.1
ATXN7
ataxin 7
chr12_+_59989918 0.82 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr4_-_185275104 0.82 ENST00000317596.3
RP11-290F5.2
RP11-290F5.2
chr19_-_49149553 0.81 ENST00000084798.4
CA11
carbonic anhydrase XI
chrX_+_108779004 0.80 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr12_-_10282836 0.78 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr18_-_21891460 0.72 ENST00000357041.4
OSBPL1A
oxysterol binding protein-like 1A
chr14_+_22963806 0.69 ENST00000390493.1
TRAJ44
T cell receptor alpha joining 44
chr4_+_158142750 0.68 ENST00000505888.1
ENST00000449365.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr3_-_47517302 0.63 ENST00000441517.2
ENST00000545718.1
SCAP
SREBF chaperone
chr5_-_16916624 0.62 ENST00000513882.1
MYO10
myosin X
chr4_+_158141899 0.58 ENST00000264426.9
ENST00000506284.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr12_-_86650077 0.57 ENST00000552808.2
ENST00000547225.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr4_+_155484103 0.55 ENST00000302068.4
FGB
fibrinogen beta chain
chr7_-_122840015 0.54 ENST00000194130.2
SLC13A1
solute carrier family 13 (sodium/sulfate symporter), member 1
chr1_+_81771806 0.52 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
LPHN2
latrophilin 2
chr1_+_168250194 0.52 ENST00000367821.3
TBX19
T-box 19
chr12_-_53994805 0.45 ENST00000328463.7
ATF7
activating transcription factor 7
chr4_-_23891693 0.41 ENST00000264867.2
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr18_-_21852143 0.40 ENST00000399443.3
OSBPL1A
oxysterol binding protein-like 1A
chr9_-_215744 0.39 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr9_+_125132803 0.38 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr9_-_100000957 0.31 ENST00000366109.2
ENST00000607322.1
RP11-498P14.5
RP11-498P14.5
chr19_+_49199209 0.27 ENST00000522966.1
ENST00000425340.2
ENST00000391876.4
FUT2
fucosyltransferase 2 (secretor status included)
chr12_-_10282742 0.27 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr14_-_107049312 0.23 ENST00000390627.2
IGHV3-53
immunoglobulin heavy variable 3-53
chr12_-_42631529 0.23 ENST00000548917.1
YAF2
YY1 associated factor 2
chr4_+_74301880 0.22 ENST00000395792.2
ENST00000226359.2
AFP
alpha-fetoprotein
chr18_+_616672 0.21 ENST00000338387.7
CLUL1
clusterin-like 1 (retinal)
chr9_+_125133315 0.21 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr17_-_72772462 0.17 ENST00000582870.1
ENST00000581136.1
ENST00000357814.3
ENST00000579218.1
ENST00000583476.1
ENST00000580301.1
ENST00000583757.1
ENST00000582524.1
NAT9
N-acetyltransferase 9 (GCN5-related, putative)
chr1_+_115572415 0.16 ENST00000256592.1
TSHB
thyroid stimulating hormone, beta
chr4_+_158141843 0.12 ENST00000509417.1
ENST00000296526.7
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr8_+_119294456 0.12 ENST00000366457.2
AC023590.1
Uncharacterized protein
chr1_+_244214577 0.11 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr17_-_10372875 0.11 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr5_+_140529630 0.10 ENST00000543635.1
PCDHB6
protocadherin beta 6
chr6_+_153019023 0.07 ENST00000367245.5
ENST00000529453.1
MYCT1
myc target 1
chr19_-_43969796 0.07 ENST00000244333.3
LYPD3
LY6/PLAUR domain containing 3
chr12_+_49740700 0.06 ENST00000549441.2
ENST00000395069.3
DNAJC22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr12_-_86650045 0.03 ENST00000604798.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr8_-_57123815 0.02 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.6 2.2 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.5 1.6 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.5 3.1 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.5 9.7 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.5 6.2 GO:0019388 galactose catabolic process(GO:0019388)
0.5 1.4 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.4 22.6 GO:0043486 histone exchange(GO:0043486)
0.3 1.1 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.3 1.1 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.2 2.9 GO:0032364 oxygen homeostasis(GO:0032364)
0.2 1.7 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.2 7.3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 0.4 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) regulation of progesterone biosynthetic process(GO:2000182)
0.1 0.6 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1 2.8 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 1.8 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.1 1.2 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.1 1.0 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 0.8 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 1.5 GO:0071481 cellular response to X-ray(GO:0071481)
0.1 2.1 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 2.6 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 3.3 GO:0070328 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.1 0.9 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 2.8 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 3.0 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 3.2 GO:0048255 mRNA stabilization(GO:0048255)
0.1 2.9 GO:0045661 regulation of myoblast differentiation(GO:0045661)
0.1 1.1 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 1.1 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 2.4 GO:0030318 melanocyte differentiation(GO:0030318)
0.1 0.5 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.0 1.2 GO:0006491 N-glycan processing(GO:0006491)
0.0 1.4 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.6 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 1.6 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.3 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 2.2 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 1.1 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.2 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 1.1 GO:0006953 acute-phase response(GO:0006953)
0.0 3.0 GO:0006275 regulation of DNA replication(GO:0006275)
0.0 0.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.2 GO:0033189 response to vitamin A(GO:0033189)
0.0 0.6 GO:0051489 regulation of filopodium assembly(GO:0051489)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 22.6 GO:0000812 Swr1 complex(GO:0000812)
0.5 1.8 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.4 3.0 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.3 1.4 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.2 1.5 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.2 1.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.2 3.1 GO:0031932 TORC2 complex(GO:0031932)
0.1 3.3 GO:0016592 mediator complex(GO:0016592)
0.0 8.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.6 GO:0043034 costamere(GO:0043034)
0.0 3.9 GO:0005643 nuclear pore(GO:0005643)
0.0 0.6 GO:0032433 filopodium tip(GO:0032433)
0.0 2.9 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.2 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.4 GO:0097440 apical dendrite(GO:0097440)
0.0 3.8 GO:0072562 blood microparticle(GO:0072562)
0.0 2.2 GO:0035579 specific granule membrane(GO:0035579)
0.0 0.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.9 GO:0005876 spindle microtubule(GO:0005876)
0.0 2.6 GO:0043209 myelin sheath(GO:0043209)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0003974 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
1.0 2.9 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.4 22.6 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.3 2.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.3 2.1 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.3 0.9 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.3 1.4 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.3 1.8 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.2 1.8 GO:0043559 insulin binding(GO:0043559)
0.2 0.8 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.2 3.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.2 3.2 GO:0008494 translation activator activity(GO:0008494)
0.2 2.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.6 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 3.1 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 3.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 3.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 1.1 GO:0004969 histamine receptor activity(GO:0004969)
0.1 1.4 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 1.6 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 1.2 GO:0015266 protein channel activity(GO:0015266)
0.1 2.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.6 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.5 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.1 1.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 1.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.8 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 1.0 GO:0016805 dipeptidase activity(GO:0016805)
0.0 1.1 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 1.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 1.1 GO:0015248 sterol transporter activity(GO:0015248)
0.0 1.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 2.8 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.3 GO:0070888 E-box binding(GO:0070888)
0.0 1.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.6 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.3 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 8.7 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.4 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.9 GO:0008013 beta-catenin binding(GO:0008013)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 PID IL5 PATHWAY IL5-mediated signaling events
0.1 2.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 8.2 PID E2F PATHWAY E2F transcription factor network
0.1 5.4 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 3.1 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 2.6 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 3.4 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.4 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.6 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.1 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.6 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 5.0 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.1 2.9 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 5.3 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 3.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 1.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.1 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.8 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.4 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 1.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 3.0 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 1.5 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.8 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 6.2 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.0 1.2 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling